The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
Open accessAbstract
Mapping ADP-ribosylation by PARPs: During many cell processes, ADP-ribose is transferred from NAD + onto protein substrates by poly(ADP-ribose) polymerases (PARPs). Gibson et al. developed a method to track ribose transfer events and mapped hundreds of sites of ADP-ribosylation for PARPs 1, 2, and 3 across the proteome and genome. One PARP-1 target is NELF, a protein complex that regulates pausing by RNA polymerase II. If NELF is ribosylated, pausing is released and productive transcription elongation resumes. Science , this issue p. 45
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Cited by
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Ray Chaudhuri, A., & Nussenzweig, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.53 · Cited by 1,786
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
Gupte, R., Liu, Z., & Kraus, W. L. (2017) · Genes & Development · doi:10.1101/gad.291518.116 · Cited by 681
“The PARP-1, PARP-2, and PARP-3 ADP-ribosylated proteomes identified in this study showed an enrichment for proteins involved in transcription and RNA biology, thus supporting a role for these PARPs beyond DNA damage repair (Gibson et al. 2016).”
BackgroundMethodInfluentialSelf-citationQuantitative Analysis of NAD Synthesis-Breakdown Fluxes
Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.018 · Cited by 564
Born to run: control of transcription elongation by RNA polymerase II
Chen, F. X., Smith, E. R., & Shilatifard, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0010-5 · Cited by 447
Serine ADP-ribosylation depends on HPF1
Bonfiglio, J. J., Fontana, P., Zhang, Q., Colby, T., Gibbs-Seymour, I., Atanassov, I., Bartlett, E., Zaja, R., Ahel, I., & Matic, I. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.01.003 · Cited by 352
Metadata
- Authors
- Gibson, B. A., Zhang, Y., Jiang, H., Hussey, K. M., Shrimp, J. H., Lin, H., Schwede, F., Yu, Y., & Kraus, W. L.
- Venue
- Science
- Published
- 2016-07
- Volume
- 353
- Issue
- 6294
- Pages
- 45-50
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2416703957
- Cited by
- 367
- References
- 46
- FWCI
- 21.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Gibson, B. A., Zhang, Y., Jiang, H., Hussey, K. M., Shrimp, J. H., Lin, H., Schwede, F., Yu, Y., & Kraus, W. L. (2016). Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. https://doi.org/10.1126/science.aaf7865
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