Cited by 561Phagocytosis and Immune RegulationImmune cells in cancerParasites and Host Interactions

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Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

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Bosurgi, Lidia, Cao, Y. Grace, Cabeza-Cabrerizo, Mar, Tucci, Andrea, Hughes, Lindsey D., Kong, Yong, Weinstein, Jason S., Licona-Limon, Paula, Schmid, Edward T., Pelorosso, Facundo, Gagliani, Nicola, Craft, Joseph E., Flavell, Richard A., Ghosh, Sourav, Rothlin, Carla V.·2017·Science

DOI 10.1126/science.aai8132PMC PMC5556699

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Abstract

Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)- and IL-13-dependent host responses during helminth infection. Here we show that IL-4 or IL-13 alone was not sufficient, but IL-4 or IL-13 together with apoptotic cells induced the tissue repair program in macrophages. Genetic ablation of sensors of apoptotic cells impaired the proliferation of tissue-resident macrophages and the induction of anti-inflammatory and tissue repair genes in the lungs after helminth infection or in the gut after induction of colitis. By contrast, the recognition of apoptotic cells was dispensable for cytokine-dependent induction of pattern recognition receptor, cell adhesion, or chemotaxis genes in macrophages. Detection of apoptotic cells can therefore spatially compartmentalize or prevent premature or ectopic activity of pleiotropic, soluble cytokines such as IL-4 or IL-13.

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Authors: Bosurgi, L., Cao, Y. G., Cabeza-Cabrerizo, M., Tucci, A., Hughes, L. D., Kong, Y., Weinstein, J. S., Licona-Limon, P., Schmid, E. T., Pelorosso, F., Gagliani, N., Craft, J. E., Flavell, R. A., Ghosh, S., & Rothlin, C. V.
Affiliations: Yale University (US)
Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.
Universidad de Buenos Aires (AR)
University Medical Center Hamburg-Eppendorf (DE)
Howard Hughes Medical Institute (US)
Corresponding author: Ghosh, Sourav
Rothlin, Carla V.
ORCID: Bosurgi, Lidia
Cao, Y. Grace
Cabeza-Cabrerizo, Mar
Tucci, Andrea
Hughes, Lindsey D.
Kong, Yong
Weinstein, Jason S.
Licona-Limon, Paula
Schmid, Edward T.
Gagliani, Nicola
Craft, Joseph E.
Flavell, Richard A.
Ghosh, Sourav
Rothlin, Carla V.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2017-06-09
Volume: 356
Issue: 6342
Pages: 1072-1076
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aai8132
PMC: PMC5556699
OpenAlex: W2612072527
Cited by: 560
References: 33
Citations by year: 2026: 46 · 2025: 66 · 2024: 53 · 2023: 61 · 2022: 67 · 2021: 76 · 2020: 69 · 2019: 57 · 2018: 38 · 2017: 27
FWCI: 23.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation (award305303, DGE-1122492)
National Institutes of Health (award305299, R01 AI089824, award305300, R01CA212376, award309995, R37 AR40072, award305301, T32AI007019)
Howard Hughes Medical Institute (award305304)
American Italian Cancer Foundation (award305302)
NIH (award309994, R37 AR40072)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords: macrophage function, tissue repair, tissue remodeling, IL-4, IL-13, apoptotic cells, phagocytosis, helminthiasis, colitis, tissue-resident macrophages, anti-inflammatory genes, pattern recognition receptors, cytokine signaling, lung, intestine
MeSH terms: Animals, Inflammation, Macrophages, Nippostrongylus, Regeneration, Thioglycolates, Interleukin-4, Strongylida Infections, Apoptosis, Interleukin-13, Mice

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Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

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