Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.

Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337

Alternative activation of macrophages: mechanism and functions

Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

Metsalu, T., & Vilo, J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv468 · Cited by 3,770

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-González, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., & Locksley, R. M. (2011) · Science · doi:10.1126/science.1201475 · Cited by 1,411

Diversity, Mechanisms, and Significance of Macrophage Plasticity

Locati, M., Curtale, G., & Mantovani, A. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012718 · Cited by 2,199

Type 2 immunity in tissue repair and fibrosis

Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055

The clearance of dead cells by efferocytosis

Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0232-1 · Cited by 924

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

Wen, Y., Lambrecht, J., Ju, C., & Tacke, F. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00558-8 · Cited by 695

Macrophages in health and disease

Park, M. D., Silvin, A., Ginhoux, F., & Merad, M. (2022) · Cell · doi:10.1016/j.cell.2022.10.007 · Cited by 644

The Coming Decade of Cell Death Research: Five Riddles

Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.04.024 · Cited by 575

Macrophages in wound healing: activation and plasticity

Kim, S. Y., & Nair, M. G. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12236 · Cited by 536

The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

Johnson, B. Z., Stevenson, A. W., Prêle, C. M., Fear, M. W., & Wood, F. M. (2020) · Biomedicines · doi:10.3390/biomedicines8050101 · Cited by 557

Inflammation and fibrosis

Mack, M. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.11.010 · Cited by 535

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.004 · Cited by 485

The initiation of oxidative stress and therapeutic strategies in wound healing

Wang, G., Yang, F., Zhou, W., Xiao, N., Luo, M., & Tang, Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114004 · Cited by 451

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

Morioka, S., Maueröder, C., & Ravichandran, K. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.018 · Cited by 391

Type 2 immunity in allergic diseases

Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Ardıçlı, S., Li, M., D’Avino, P., Beha, C., Babayev, H., Zhao, B., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01261-2 · Cited by 453

Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity

Hirao, H., Nakamura, K., & Kupiec‐Weglinski, J. W. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00549-8 · Cited by 384

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Gerlach, B. D., Ampomah, P. B., Yurdagul, A., Liu, C., Lauring, M. C., Wang, X., Kasikara, C., Kong, N., Shi, J., Tao, W., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.015 · Cited by 360

Immunomodulatory Biomaterials for Tissue Repair

Whitaker, R. C., Hernaez‐Estrada, B., Hernández, R. M., Santos‐Vizcaíno, E., & Spiller, K. L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00895 · Cited by 347

Type 2 immunity: Expanding our view

Lloyd, C. M., & Snelgrove, R. J. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat1604 · Cited by 338

Metabolic orchestration of the wound healing response

Eming, S. A., Murray, P. J., & Pearce, E. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.017 · Cited by 326

Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Kumari, N., & Choi, S. H. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02272-x · Cited by 331

Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis

Rodríguez-Morales, P., & Franklin, R. A. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.10.004 · Cited by 341

Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

Willenborg, S., Sanin, D. E., Jais, A., Ding, X., Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J. L., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.004 · Cited by 310

Integrative Physiology of Pneumonia

Quinton, L. J., Walkey, A. J., & Mizgerd, J. P. (2018) · Physiological Reviews · doi:10.1152/physrev.00032.2017 · Cited by 330

Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling

Sun, X., Gao, J., Meng, X. L., Lu, X., Zhang, L., & Chen, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763334 · Cited by 309

Biofilm Microenvironment‐Responsive Self‐Assembly Nanoreactors for All‐Stage Biofilm Associated Infection through Bacterial Cuproptosis‐like Death and Macrophage Re‐Rousing

Mei, J., Xu, D., Wang, L., Kong, L., Liu, Q., Li, Q., Zhang, X., Su, Z., Hu, X., Zhu, W., et al. (2023) · Advanced Materials · doi:10.1002/adma.202303432 · Cited by 280

Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission

Kurowska‐Stolarska, M., & Alivernini, S. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00790-8 · Cited by 279

Innate immune cell–epithelial crosstalk during wound repair

Brazil, J. C., Quirós, M., Nusrat, A., & Parkos, C. A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124618 · Cited by 273

Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs

Hui, S. P., Sheng, D. Z., Sugimoto, K., González-Rajal, Á., Nakagawa, S., Hesselson, D., & Kikuchi, K. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.010 · Cited by 272

Acute Inflammation in Tissue Healing

Soliman, A. M., & Barreda, D. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010641 · Cited by 301

Harnessing innate immune pathways for therapeutic advancement in cancer

Hu, A.-K., Sun, L., Lin, H., Liao, Y., Yang, H., & Mao, Y. Q. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01765-9 · Cited by 286

Arachidonic acid and other unsaturated fatty acids and some of their metabolites function as endogenous antimicrobial molecules: A review

Das, U. N. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.01.001 · Cited by 256

Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

van der Vlist, M., Raoof, R., Willemen, H. L. D. M., Prado, J., Versteeg, S., Gil, C. M., Vos, M. W., Lokhorst, R. E., Pasterkamp, R. J., Kojima, T., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.020 · Cited by 278

MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury

DeBerge, M., Yeap, X. Y., Dehn, S., Zhang, S., Grigoryeva, L. S., Misener, S., Procissi, D., Zhou, X., Lee, D. C., Müller, W. A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.311327 · Cited by 250

Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts.

Mahmoud, N. N., Hamad, K. M., Shibitini, A. A., Juma, S., Sharifi, S., Gould, L., & Mahmoudi, M. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00336 · Cited by 210

The Neutrophil’s Choice: Phagocytose vs Make Neutrophil Extracellular Traps

Manfredi, A. A., Ramirez, G. A., Rovere, P. Q., & Maugeri, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00288 · Cited by 224

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

Svedberg, F. R., Brown, S. L., Krauss, M. Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G. J., Clark, H. W., Madsen, J., Evans, C. M., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0352-y · Cited by 218

Tumor-associated myeloid cells: diversity and therapeutic targeting

Mantovani, A., Marchesi, F., Jaillon, S., Garlanda, C., & Allavena, P. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00613-4 · Cited by 230

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Liu, W., Taso, O., Wang, R., Bayram, S., Graham, A. C., Garcia-Reitboeck, P., Mallach, A., Andrews, W. D., Piers, T. M., Botia, J. A., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa209 · Cited by 214

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

Harris, N. L., & Loke, P. (2017) · Immunity · doi:10.1016/j.immuni.2017.11.015 · Cited by 219

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

Malainou, C., Abdin, S. M., Lachmann, N., Matt, U., & Herold, S. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170501 · Cited by 215

Deep insight into cytokine storm: from pathogenesis to treatment

Nie, J., Zhou, L., Tian, W., Liu, X., Yang, L., Yang, X., Zhang, Y., Wei, S., Wang, D. W., & Wei, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02178-y · Cited by 251

Macrophage Clearance of Apoptotic Cells: A Critical Assessment

Gordon, S., & Plüddemann, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00127 · Cited by 201

Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

Maehara, T., Kaneko, N., Perugino, C. A., Mattoo, H., Kers, J., Allard‐Chamard, H., Mahajan, V. S., Liu, H., Murphy, S. J. H., Ghebremichael, M. S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci131700 · Cited by 202

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

Amici, S. A., Dong, J., & Guerau‐de‐Arellano, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01520 · Cited by 200

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

Shlomovitz, I., Speir, M., & Gerlic, M. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0437-0 · Cited by 189

M2 macrophages in kidney disease: biology, therapies, and perspectives

Chen, T., Cao, Q., Wang, Y., & Harris, D. C. H. (2019) · Kidney International · doi:10.1016/j.kint.2018.10.041 · Cited by 190

Development of an Accurate and Proactive Immunomodulatory Strategy to Improve Bone Substitute Material-Mediated Osteogenesis and Angiogenesis

Zheng, Z., Chen, Y., Wu, D., Wang, J., Lv, M.-M., Wang, X., Sun, J., & Zhang, Z. (2018) · Theranostics · doi:10.7150/thno.28315 · Cited by 189

Adaptation and memory in immune responses

Natoli, G., & Ostuni, R. (2019) · Nature Immunology · doi:10.1038/s41590-019-0399-9 · Cited by 203

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype

Sodir, N. M., Kortlever, R. M., Barthet, V. J. A., Campos, T., Pellegrinet, L., Kupczak, S., Anastasiou, P., Swigart, L. B., Soucek, L., Arends, M. J., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0435 · Cited by 188

The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation

Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. A. (2023) · Immunological Reviews · doi:10.1111/imr.13214 · Cited by 184

Metabolic adaptations of tissue-resident immune cells

Caputa, G., Castoldi, Â., & Pearce, E. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0407-0 · Cited by 179

Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice

Carestia, A., Mena, H. A., Olexen, C. M., Wilczyński, J., Negrotto, S., Errasti, A. E., Gomez, R. M., Jenne, C. N., Silva, E. A. C., & Schattner, M. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.062 · Cited by 175

Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair

Boothby, I. C., Cohen, J. N., & Rosenblum, M. D. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz9631 · Cited by 182

Regulation and Functions of 15-Lipoxygenases in Human Macrophages

Snodgrass, R. G., & Brüne, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00719 · Cited by 167

Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms

Zhang, C., Yang, M. J., & Ericsson, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.620510 · Cited by 181

IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation

Satyanarayanan, S. K., Kebir, D. E., Soboh, S., Butenko, S., Sekheri, M., Saadi, J., Peled, N., Assi, S., Othman, A., Schif‐Zuck, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10903-9 · Cited by 165

Airway macrophages as the guardians of tissue repair in the lung

Puttur, F. K., Gregory, L. G., & Lloyd, C. M. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12235 · Cited by 167

Disease Tolerance as an Inherent Component of Immunity

Martins, R., Carlos, A. R., Braza, F., Thompson, J. A., Bastos-Amador, P., Ramos, S., & Soares, M. P. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041739 · Cited by 151

A common framework of monocyte-derived macrophage activation

Sanin, D. E., Ge, Y., Marinković, E., Kabat, A. M., Castoldi, Â., Caputa, G., Grzes, K. M., Curtis, J. D., Thompson, E. A., Willenborg, S., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abl7482 · Cited by 161

Role of Macrophages in Wound HealingPreprint

Willenborg, S., Injarabian, L., & Eming, S. A. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041216 · Cited by 150

Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice

Shen, T., Dai, K., Yu, Y., Wang, J., & Liu, C. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.035 · Cited by 147

Reactive oxygen species–degradable polythioketal urethane foam dressings to promote porcine skin wound repair

Patil, P., Russo, K. A., McCune, J. T., Pollins, A. C., Cottam, M. A., Dollinger, B. R., DeJulius, C. R., Gupta, M. K., d’Arcy, R., Colazo, J. M., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm6586 · Cited by 144

IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection

Frisbee, A. L., Saleh, M. M., Young, M. K., Leslie, J. L., Simpson, M. D., Abhyankar, M. M., Cowardin, C. A., Ma, J. Z., Pramoonjago, P., Turner, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10733-9 · Cited by 134

Th1, Th2, and Th17 cytokines in systemic lupus erythematosus

Yusoff, F. M., Wong, K. K., & Redzwan, N. M. (2019) · Autoimmunity · doi:10.1080/08916934.2019.1693545 · Cited by 138

Synovial tissue macrophages: friend or foe?

Kurowska‐Stolarska, M., & Alivernini, S. (2017) · RMD Open · doi:10.1136/rmdopen-2017-000527 · Cited by 140

Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation

Ortega, R. H., Cerezo, A. B., de Pablos, R. M., Krisa, S., Richard, T., García-Parrilla, M. C., & Troncoso, A. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00373 · Cited by 136

The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense

Snyder, A. G., & Oberst, A. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-112019-072301 · Cited by 129

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

Cabeza-Cabrerizo, M., van Blijswijk, J., Wienert, S., Heim, D., Jenkins, R. P., Chakravarty, P., Rogers, N. C., Frederico, B., Acton, S. E., Beerling, E., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw1941 · Cited by 125

Induction of M2‐Type Macrophage Differentiation for Bone Defect Repair via an Interpenetration Network Hydrogel with a GO‐Based Controlled Release System

Zou, M., Sun, J., & Xiang, Z. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001502 · Cited by 122

Tuning the Tumor Myeloid Microenvironment to Fight Cancer

Jahchan, N. S., Mujal, A. M., Pollack, J. L., Binnewies, M., Sriram, V., Reyno, L. M., & Krummel, M. F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01611 · Cited by 124

Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment

Lee, S. H., Charmoy, M., Romano, A., Paun, A., Chaves, M. M., Cope, F. O., Ralph, D. A., & Sacks, D. L. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171389 · Cited by 120

Neutrophil–macrophage cooperation and its impact on tissue repair

Bouchery, T., & Harris, N. L. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12241 · Cited by 120

Heterogeneity in the initiation, development and function of type 2 immunity

Gause, W. C., Rothlin, C. V., & Loke, P. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0301-x · Cited by 118

Mechanisms of urodele limb regeneration

Stocum, D. L. (2017) · Regeneration · doi:10.1002/reg2.92 · Cited by 119

Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium

Sharkey, K. A., Beck, P. L., & McKay, D. M. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0051-4 · Cited by 117

Intestinal Mucosal Wound Healing and Barrier Integrity in IBD–Crosstalk and Trafficking of Cellular Players

Sommer, K., Wiendl, M., Müller, T. M., Heidbreder, K., Voskens, C., Neurath, M. F., & Zundler, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.643973 · Cited by 125

Mechanosensing regulates tissue repair program in macrophages

Meizlish, M. L., Kimura, Y., Pope, S. D., Matta, R., Kim, C., Philip, N. H., Meyaard, L., Gonzalez, A., & Medzhitov, R. (2024) · Science Advances · doi:10.1126/sciadv.adk6906 · Cited by 114

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

Mata, R., Yao, Y., Cao, W., Ding, J., Zhou, T., Zhai, Z., & Gao, C. (2021) · Research · doi:10.34133/2021/4189516 · Cited by 116

Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

Schloesser, D., Lindenthal, L., Sauer, J., Chung, K., Chavakis, T., Griesser, E., Baskaran, P., Maier-Habelsberger, U., Fundel‐Clemens, K., Schlotthauer, I., et al. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202207097 · Cited by 117

Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-Induced Cardiomyopathy Through the SR-A1-c-Myc Axis

Zhang, H., Xu, A.-D., Sun, X., Yang, Y., Zhang, L., Bai, H., Ben, J., Zhu, X., Li, X., Yang, Q., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316428 · Cited by 109

Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis

Chakraborty, S., Singh, A., Wang, L. X., Wang, X., Sanborn, M. A., Ye, Z., Maienschein‐Cline, M., Mukhopadhyay, A., Ganesh, B. B., Malik, A. B., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221388 · Cited by 112

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

Campana, L., Starkey Lewis, P. J., Pellicoro, A., Aucott, R. L., Man, J., O’Duibhir, E., Mok, S. E., Ferreira-Gonzalez, S., Livingstone, E., Greenhalgh, S. N., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701247 · Cited by 107

Blockade of lncRNA‐ASLNCS5088–enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation

Chen, J., Zhou, R., Liang, Y., Fu, X., Wang, D., & Wang, C. (2019) · The FASEB Journal · doi:10.1096/fj.201901610 · Cited by 106

The expanding world of tissue‐resident macrophages

Jenkins, S. J., & Allen, J. E. (2021) · European Journal of Immunology · doi:10.1002/eji.202048881 · Cited by 114

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway

Perry, J. S. A., Morioka, S., Medina, C. B., Etchegaray, J. I., Barron, B. J., Raymond, M. H., Lucas, C. D., Önengüt-Gümüşcü, S., Delpire, E. J., & Ravichandran, K. S. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0431-1 · Cited by 108

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Wang, Y., Trzeciak, A. J., Rojas, W. S., Saavedra, P. H. V., Chen, Y., Chirayil, R., Etchegaray, J. I., Lucas, C. D., Puleston, D. J., Keshari, K. R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.005 · Cited by 110

Here, there and everywhere: Resistin-like molecules in infection, inflammation, and metabolic disorders

Pine, G. M., Batugedara, H., & Nair, M. G. (2018) · Cytokine · doi:10.1016/j.cyto.2018.05.014 · Cited by 108

First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis

Trzeciak, A. J., Wang, Y., & Perry, J. S. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.001 · Cited by 109

α‐Linolenic acid‐derived metabolites from gut lactic acid bacteria induce differentiation of anti‐inflammatory M2 macrophages through G protein‐coupled receptor 40

Ohue‐Kitano, R., Watanabe‐Yasuoka, Y., Goto, T., Kitamura, N., Park, S., Kishino, S., Kimura, I., Kasubuchi, M., Takahashi, H., Li, Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700273r · Cited by 105

Reparative and Maladaptive Inflammation in Tendon Healing

Arvind, V., & Huang, A. H. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.719047 · Cited by 107

Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

Merlin, J., Ivanov, S., Dumont, A., Sergushichev, A., Gall, J., Stunault, M. I., Ayrault, M., Vaillant, N., Castiglione, A., Swain, A., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00471-y · Cited by 108

Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response

Sacco, A., Battaglia, A. M., Botta, C., Aversa, I., Mancuso, S., Costanzo, F. S., & Biamonte, F. (2021) · Cells · doi:10.3390/cells10020303 · Cited by 102

Is the Macrophage Phenotype Determinant for Fibrosis Development?

Lis-López, L., Bauset, C., Seco-Cervera, M., & Cosín‐Roger, J. (2021) · Biomedicines · doi:10.3390/biomedicines9121747 · Cited by 104

Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages

Liebold, I., Al Jawazneh, A., Casar, C., Lanzloth, C., Leyk, S., Hamley, M., Wong, M. N., Kylies, D., Gräfe, S. K., Edenhofer, I., et al. (2024) · Science · doi:10.1126/science.abo7027 · Cited by 96

PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation

Wu, M.-Y., Liu, L., Wang, E., Xiao, H., Cai, C.-Z., Wang, J., Su, H., Wang, Y., Tan, J., Zhang, Z., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1741332 · Cited by 98

The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases

Zheng, H., Zhang, Y., Pan, J., Liu, N., Qin, Y., Qiu, L., Liu, M., & Wang, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.586078 · Cited by 101

Tuft cells act as regenerative stem cells in the human intestine

Huang, L., Bernink, J. H., Giladi, A., Krueger, D., van Son, G. J. F., Geurts, M. H., Busslinger, G. A., Lin, L., Begthel, H., Zandvliet, M. M. J. M., et al. (2024) · Nature · doi:10.1038/s41586-024-07952-6 · Cited by 101

Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment

Kumar, S., Calianese, D. C., & Birge, R. B. (2017) · Immunological Reviews · doi:10.1111/imr.12587 · Cited by 93

Mast Cells in Cardiac Fibrosis: New Insights Suggest Opportunities for Intervention

Legere, S. A., Haidl, I. D., Légaré, J.-F., & Marshall, J. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00580 · Cited by 92

Macrophage Phenotypes in Normal and Diabetic Wound Healing and Therapeutic Interventions

Sadoun, H. A. (2022) · Cells · doi:10.3390/cells11152430 · Cited by 96

Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages

Liebold, I., Al Jawazneh, A., Casar, C., Lanzloth, C., Leyk, S., Hamley, M., Wong, M. N., Kylies, D., Gräfe, S. K., Edenhofer, I., et al. (2024) · Science · doi:10.1126/science.abo7027 · Cited by 96

Local macrophage clean-up

Ash, C., & Mueller, K. L. (2017) · Science · doi:10.1126/science.356.6342.1040-f

Synergistic action of apoptotic cells and surfactant protein A in boosting IL-4-dependent alternative activation of alveolar macrophages.

Tenreiro, P., García-Fojeda, B., & Casals, C. (2022) · doi:10.1183/23120541.lsc-2022.245

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

Minutti, C. M., Jackson-Jones, L. H., García-Fojeda, B., Knipper, J. A., Sutherland, T. E., Logan, N., Ringqvist, E. E., Guillamat‐Prats, R., Ferenbach, D. A., Artigas, A., et al. (2017) · Science · doi:10.1126/science.aaj2067 · Cited by 193

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

Dyken, S. J. V., & Locksley, R. M. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095906 · Cited by 743