Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.

Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337

Alternative activation of macrophages: mechanism and functions

Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

Metsalu, T., & Vilo, J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv468 · Cited by 3,770

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-González, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., & Locksley, R. M. (2011) · Science · doi:10.1126/science.1201475 · Cited by 1,411

Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

Weinberger, T., Esfandyari, D., Messerer, D., Perçin, G. I., Schleifer, C., Thaler, R., Liu, L., Stremmel, C., Schneider, V., Vagnozzi, R. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18287-x · Cited by 93

M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis

Lee, S. H., Chaves, M. M., Kamenyeva, O., Gazzinelli-Guimarães, P. H., Kang, B., Pessenda, G., Passelli, K., Tacchini‐Cottier, F., Kabát, J., Jacobsen, E. A., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz4415 · Cited by 88

Resolving inflammation by TAM receptor activation

Vago, J. P., Amaral, F. A., & van de Loo, F. A. J. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107893 · Cited by 92

The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells

Rai, V., Wood, M. B., Feng, H., Schabla, N. M., Tu, S., & Zuo, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-72181-6 · Cited by 88

Human interleukin-4–treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model

Jayme, T. S., Leung, G., Wang, A., Workentine, M. L., Rajeev, S., Shute, A., Callejas, B. E., Mancini, N. L., Beck, P. L., Panaccione, R., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba4376 · Cited by 88

Basophils balance healing after myocardial infarction via IL-4/IL-13

Sicklinger, F., Meyer, I. S., Li, X., Radtke, D., Dicks, S., Kornadt, M. P., Mertens, C., Meier, J. K., Lavine, K. J., Zhang, Y., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci136778 · Cited by 88

Tissue-specific immunity in helminth infections

Vacca, F., & Gros, G. S. L. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00531-w · Cited by 90

Contribution of adaptive immunity to human COPD and experimental models of emphysema

Kheradmand, F., Zhang, Y., & Corry, D. B. (2022) · Physiological Reviews · doi:10.1152/physrev.00036.2021 · Cited by 87

The Mononuclear Phagocytic System. Generation of Diversity

Gordon, S., & Plüddemann, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01893 · Cited by 89

Intestinal Macrophages in Resolving Inflammation

Hine, A. M., & Loke, P. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900345 · Cited by 85

Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation

Snodgrass, R. G., Benatzy, Y., Schmid, T., Namgaladze, D., Mainka, M., Schebb, N. H., Lütjohann, D., & Brüne, B. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00652-4 · Cited by 90

Lifting the innate immune barriers to antitumor immunity

Rothlin, C. V., & Ghosh, S. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000695 · Cited by 83

First Responders: Innate Immunity to Helminths

Inclan-Rico, J. M., & Siracusa, M. C. (2018) · Trends in Parasitology · doi:10.1016/j.pt.2018.08.007 · Cited by 83

Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity

Jarjour, N. N., Schwarzkopf, E. A., Bradstreet, T. R., Shchukina, I., Lin, C., Huang, S. C., Lai, C., Cook, M. E., Taneja, R., Stappenbeck, T. S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0382-5 · Cited by 82

Injectable, antibacterial, ROS scavenging and pro-angiogenic hydrogel adhesives promote chronic wound healing in diabetes via synergistic release of NMN and Mg2+

Liang, Z., Luo, J., Liu, S., Gu, Y., Cui, Z., Zhu, Y., Zhou, Y. J., Zhao, X., Guo, B., & Song, B. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.146092 · Cited by 81

Emerging role of immune cells as drivers of pulmonary fibrosis

Mutsaers, S. E., Miles, T., Prêle, C. M., & Hoyne, G. F. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108562 · Cited by 89

The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis

Hou, X., Chen, G., Bracamonte-Baran, W., Choi, H. S., Diny, N. L., Sung, J., Hughes, D., Won, T., Wood, M. K., Talor, M. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.007 · Cited by 83

Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells

McCubbrey, A. L., McManus, S. A., McClendon, J. D., Thomas, S. M., Chatwin, H. B., Reisz, J. A., D’Alessandro, A., Mould, K. J., Bratton, D. L., Henson, P. M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110222 · Cited by 81

Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development

Munro, D. A. D., Wineberg, Y., Tarnick, J., Vink, C. S., Li, Z., Pridans, C., Dzierzak, E. A., Tomer Kalisky, C., Hohenstein, P., & Davies, J. A. (2019) · eLife · doi:10.7554/elife.43271 · Cited by 82

IL-33–mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury

Liu, Q., Dwyer, G. K., Zhao, Y., Li, H., Mathews, L. R., Chakka, A. B., Chandran, U. R., Demetris, J. A., Alcorn, J. F., Robinson, K. M., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123919 · Cited by 80

The Src-family Kinase Lyn in Immunoreceptor Signaling

Brian, B. F., & Freedman, T. S. (2021) · Endocrinology · doi:10.1210/endocr/bqab152 · Cited by 79

Early human lung immune cell development and its role in epithelial cell fate

Barnes, J. L., Yoshida, M., He, P., Worlock, K. B., Lindeboom, R. G. H., Suo, C., Pett, J. P., Wilbrey-Clark, A., Dann, E., Mamanova, L., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adf9988 · Cited by 79

The Role of Collectins and Galectins in Lung Innate Immune Defense

Casals, C., Campanero‐Rhodes, M. A., García-Fojeda, B., & Solı́s, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01998 · Cited by 77

Epithelial Cells and Inflammation in Pulmonary Wound Repair

Lucchini, A. C., Gachanja, N. N., Rossi, A. G., Dorward, D. A., & Lucas, C. D. (2021) · Cells · doi:10.3390/cells10020339 · Cited by 79

Liver Injury and the Macrophage Issue: Molecular and Mechanistic Facts and Their Clinical Relevance

Roohani, S., & Tacke, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147249 · Cited by 79

Collagen Fibril Density Modulates Macrophage Activation and Cellular Functions during Tissue Repair

Sapudom, J., Mohamed, W. K. E. A., Garcia‐Sabaté, A., Alatoom, A., Karaman, S., Mahtani, N., & Teo, J. C. M. (2020) · Bioengineering · doi:10.3390/bioengineering7020033 · Cited by 72

Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease

Horst, A. K., Tiegs, G., & Diehl, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02670 · Cited by 74

Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease

Arnold, I. C., & Munitz, A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01048-y · Cited by 81

Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1

Nąckiewicz, D., Dan, M., Speck, M., Chow, S., Chen, Y., Pospisilik, J. A., Verchere, C. B., & Ehses, J. A. (2019) · iScience · doi:10.1016/j.isci.2019.100775 · Cited by 71

Tumor-Associated Macrophages as Major Immunosuppressive Cells in the Tumor Microenvironment

Ghebremedhin, A., Athavale, D., Zhang, Y.-T. Y., Yao, X., Balch, C., & Song, S. (2024) · Cancers · doi:10.3390/cancers16193410 · Cited by 79

Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4

O’Brien, E. M., & Spiller, K. L. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0520-338r · Cited by 75

The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis

Pervizaj-Oruqaj, L., Ferrero, M. R., Matt, U., & Herold, S. (2024) · European Respiratory Review · doi:10.1183/16000617.0263-2023 · Cited by 78

Soluble defense collagens: Sweeping up immune threats

Casals, C., García-Fojeda, B., & Minutti, C. M. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.06.007 · Cited by 69

The potential of exosomes in the therapy of the cartilage and bone complications; emphasis on osteoarthritis

Pourakbari, R., Khodadadi, M., Aghebati‐Maleki, A., Maleki, L. A., & Yousefi, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116861 · Cited by 70

CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer

Cheng, M., Chen, S., Li, K., Wang, G., Xiong, G., Ling, R., Zhang, C., Zhang, Z., Han, H., Zhi, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46735-5 · Cited by 76

The role of dermis resident macrophages and their interaction with neutrophils in the early establishment of Leishmania major infection transmitted by sand fly bite

Chaves, M. M., Lee, S. H., Kamenyeva, O., Ghosh, K., Peters, N. C., & Sacks, D. L. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008674 · Cited by 70

Eosinophils and Macrophages within the Th2-Induced Granuloma: Balancing Killing and Healing in a Tight Space

Ariyaratne, A., & Finney, C. A. M. (2019) · Infection and Immunity · doi:10.1128/iai.00127-19 · Cited by 68

Determining the effector response to cell death

Rothlin, C. V., Hille, T. D., & Ghosh, S. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00456-0 · Cited by 69

Pro-Resolving Factors Released by Macrophages After Efferocytosis Promote Mucosal Wound Healing in Inflammatory Bowel Disease

Martin-Rodriguez, O., Gauthier, T., Bonnefoy, F., Couturier, M., Daoui, A., Chagué, C., Valmary‐Degano, S., Gay, C., Saas, P., & Perruche, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.754475 · Cited by 71

Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

Salina, A. C. G., dos-Santos, D., Rodrigues, T. S., Fortes-Rocha, M., Filho, E. G. F., Alzamora-Terrel, D. L., de Castro, Í. M. S., Fraga‐Silva, T. F. D. C., de Lima, M. H., Nascimento, D. C., et al. (2022) · eLife · doi:10.7554/elife.74443 · Cited by 73

Basophils promote barrier dysfunction and resolution in the atopic skin

Pellefigues, C., Naidoo, K., Mehta, P. H., Schmidt, A., Jagot, F., Roussel, E., Cait, A., Yumnam, B., Chappell, S., Meijlink, K. J., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.02.018 · Cited by 66

Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair

Zuo, S., Wang, Y., Bao, H., Zhang, Z., Yang, N., Jia, M., Zhang, Q., Jian, A., Ji, R., Zhang, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51736-5 · Cited by 73

Delivery of cellular factors to regulate bone healing

Haumer, A., Bourgine, P. E., Occhetta, P., Born, G., Tasso, R., & Martín, I. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.01.010 · Cited by 71

Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity

Kumar, N. P., Fukutani, K. F., Shruthi, B. S., Alves, T., Silveira-Mattos, P. S., Rocha, M. S., West, K., Natarajan, M., Viswanathan, V., Babu, S., et al. (2019) · eLife · doi:10.7554/elife.46477 · Cited by 66

Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

Chen, F., El-Naccache, D. W., Ponessa, J. J., Lemenze, A. D., Espinosa, V., Wu, W., Lothstein, K. E., Jin, L., Antao, O. Q., Weinstein, J. S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110215 · Cited by 63

An immunologically active, adipose-derived extracellular matrix biomaterial for soft tissue reconstruction: concept to clinical trial

Anderson, A. E., Wu, I., Parrillo, A. J., Wolf, M. T., Maestas, D. R., Graham, I., Tam, A. J., Payne, R. M., Aston, J. W., Cooney, C. M. M., et al. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-021-00197-1 · Cited by 72

Endothelial Dysfunction in Systemic Sclerosis

Patnaik, E., Lyons, M. I., Tran, K., & Pattanaik, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814385 · Cited by 63

Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury

Ruscitti, C., Abinet, J., Maréchal, P., Meunier, M., meeûs, C. D., Vanneste, D., Janssen, P., Dourcy, M., Thiry, M., Bureau, F., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.ado1227 · Cited by 63

Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse

Rolot, M., & Dewals, B. G. (2018) · Journal of Immunology Research · doi:10.1155/2018/2790627 · Cited by 64

Cardiac macrophages and emerging roles for their metabolism after myocardial infarction

Thorp, E. B. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171953 · Cited by 66

The long pentraxin PTX 3: A prototypical sensor of tissue injury and a regulator of homeostasis

Erreni, M., Manfredi, A. A., Garlanda, C., Mantovani, A., & Rovere, P. Q. (2017) · Immunological Reviews · doi:10.1111/imr.12570 · Cited by 61

Spatiotemporal On–Off Immunomodulatory Hydrogel Targeting NLRP3 Inflammasome for the Treatment of Biofilm‐Infected Diabetic Wounds

Zhou, J. Y., Mei, J., Liu, Q., Xu, D., Wang, X., Zhang, X., Zhu, W., Zhu, C., & Wang, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202211811 · Cited by 60

Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages

Lu, Y., Basatemur, G., Scott, I. C., Chiarugi, D., Clément, M., Harrison, J. E., Jugdaohsingh, R., Yu, X., Newland, S. A., Jolin, H. E., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.006 · Cited by 59

Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction

Daseke, M. J., Tenkorang, M. A. A., Ma, Y., Chalise, U., Konfrst, S. R., Garrett, M. R., DeLeon‐Pennell, K. Y., & Lindsey, M. L. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.06.006 · Cited by 59

TAM receptors in phagocytosis: Beyond the mere internalization of particles

Burstyn‐Cohen, T., & Fresia, R. (2023) · Immunological Reviews · doi:10.1111/imr.13267 · Cited by 61

Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model

Miyake, K., Ito, J., Takahashi, K., Nakabayashi, J., Brombacher, F., Shichino, S., Yoshikawa, S., Miyake, S., & Karasuyama, H. (2024) · Nature Communications · doi:10.1038/s41467-024-46148-4 · Cited by 55

Rethinking Phagocytes: Clues from the Retina and Testes

Penberthy, K. K., Lysiak, J. J., & Ravichandran, K. S. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.01.004 · Cited by 57

Reduced inflammatory response by incorporating magnesium into porous TiO2 coating on titanium substrate

Li, X., Huang, Q., Liu, L., Zhu, W., Elkhooly, T. A., Liu, Y., Feng, Q., Li, Q., Zhou, S., Liu, Y., et al. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.07.032 · Cited by 58

The counter-intuitive role of the neutrophil in the acute respiratory distress syndrome

Vassallo, A. M., Wood, A. J. T., Subburayalu, J., Summers, C., & Chilvers, E. R. (2019) · British Medical Bulletin · doi:10.1093/bmb/ldz024 · Cited by 59

Mitochondria orchestrate macrophage effector functions in atherosclerosis

Dumont, A., Lee, M., Barouillet, T., Murphy, A. J., & Yvan‐Charvet, L. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100922 · Cited by 60

Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

Weinstock, A., Rahman, K., Yaacov, O., Nishi, H., Menon, P., Nikain, C. A., Garabedian, M. L., Pena, S., Akbar, N., Sansbury, B. E., et al. (2021) · eLife · doi:10.7554/elife.67932 · Cited by 57

Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation

Medina, C. B., Chiu, Y., Stremska, M. E., Lucas, C. D., Poon, I. K. H., Tung, K. S. K., Elliott, M. R., Desai, B. N., Lorenz, U. M., Bayliss, D. A., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.06.014 · Cited by 54

Multifunctional Cu 2 Se/F127 Hydrogel with SOD‐Like Enzyme Activity for Efficient Wound Healing

He, J. W., Zhang, W., Cui, Y., Cheng, L., Chen, X., & Wang, X. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303599 · Cited by 57

Iron Handling in Tumor-Associated Macrophages—Is There a New Role for Lipocalin-2?

Jung, M., Weigert, A., Mertens, C., Rehwald, C., & Brüne, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01171 · Cited by 54

TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD

Liebold, I., Meyer, S., Heine, M., Kuhl, A., Witt, J., Eissing, L., Fischer, A., Koop, A., Kluwe, J., Schulze zur Wiesch, J., et al. (2023) · Cells · doi:10.3390/cells12030341 · Cited by 55

Host Immunity and Inflammation to Pulmonary Helminth Infections

Weatherhead, J. E., Gazzinelli-Guimarães, P. H., Knight, J. M., Fujiwara, R. T., Hotez, P. J., Bottazzi, M. E., & Corry, D. B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594520 · Cited by 55

Cellular crosstalk in fibrosis: Insights into macrophage and fibroblast dynamics

Froom, Z. S. C. S., Callaghan, N. I., & Huyer, L. D. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110203 · Cited by 64

RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection

Krljanac, B., Schubart, C., Naumann, R., Wirtz, S. J., Culemann, S., Krönke, G., & Voehringer, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau3814 · Cited by 55

Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment

Xia, C., Wang, T., Cheng, H., Dong, Y., Weng, Q., Sun, G., Zhou, P., Wang, K., Liu, X., Geng, Y., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0775-3 · Cited by 54

The role of Interleukin-4 in COVID-19 associated male infertility – A hypothesis

Renu, K., Subramaniam, M. D., Chakraborty, R., Myakala, H., Iyer, M., Bharathi, G., Siva, K., Vellingiri, B., & Gopalakrishnan, A. V. (2020) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2020.103213 · Cited by 55

The accumulation of T cells within acellular nerve allografts is length-dependent and critical for nerve regeneration

Pan, D., Hunter, D. A., Schellhardt, L., Jo, S., Santosa, K. B., Larson, E. L., Fuchs, A. G., Snyder‐Warwick, A. K., Mackinnon, S. E., & Wood, M. D. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.05.009 · Cited by 54

Traditional Chinese medicine in regulating macrophage polarization in immune response of inflammatory diseases

Chen, S., Zeng, J., Li, R., Zhang, Y., Tao, Y., Hou, Y., Lu, Y., Zhang, Y., Wu, J., & Meng, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117838 · Cited by 56

AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia

Tirado‐González, I., Descot, A., Soetopo, D., Nevmerzhitskaya, A., Schäffer, A., Kur, I.-M., Członka, E., Wachtel, C., Tsoukala, I., Müller, L., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1378 · Cited by 54

Apoptosis recognition receptors regulate skin tissue repair in mice

Justynski, O., Bridges, K., Krause, W., Forni, M. F., Phan, Q. M., Sandoval-Schaefer, T., Carter, K. A., King, D. E., Hsia, H. C., Gazes, M. I., et al. (2023) · eLife · doi:10.7554/elife.86269 · Cited by 57

Immunometabolism of Phagocytes and Relationships to Cardiac Repair

Zhang, S., Bories, G. F. P., Lantz, C. W., Emmons, R., Becker, A., Liu, E., Abecassis, M. M., Yvan‐Charvet, L., & Thorp, E. B. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00042 · Cited by 54

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation

Saas, P., Vetter, M., Maraux, M., Bonnefoy, F., & Perruche, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1021413 · Cited by 53

Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review

Yang, T., Fang, Z., Zhang, J., & Zheng, S. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1640560 · Cited by 50

Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE−/− Mice

Qiu, S., Liu, J., Chen, J., Li, Y., Bu, T., Li, Z., Zhang, L., Sun, W., Zhou, T., Hu, W., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02463-y · Cited by 54

Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue

Hou, B., Zhao, Y., He, P., Xu, C., Ma, P., Lam, S. M., Li, B., Gil, V., Shui, G., Qiang, G., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117352 · Cited by 53

Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease

Wu, K., Kamimoto, K., Zhang, Y., Yang, K., Keeler, S. P., Gerovac, B. J., Agapov, E. V., Austin, S. R., Yantis, J., Gissy, K. A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149336 · Cited by 50

Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells

Atkin‐Smith, G. K. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200696 · Cited by 50

IL-4 expressing cells are recruited to nerve after injury and promote regeneration

Pan, D., Schellhardt, L., Acevedo-Cintrón, J. A., Hunter, D. A., Snyder‐Warwick, A. K., Mackinnon, S. E., & Wood, M. D. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113909 · Cited by 47

Oxidative Stimuli‐Responsive “Pollen‐Like” Exosomes from Silver Nanoflowers Remodeling Diabetic Wound Microenvironment for Accelerating Wound Healing

Chen, Y., Younis, M. R., He, G., Zheng, Z., Wang, Y., Xue, K., Sun, J., Liu, K., Huang, P., & Wang, X. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300456 · Cited by 48

Healing action of Interleukin-4 (IL-4) in acute and chronic inflammatory conditions: Mechanisms and therapeutic strategies

Pan, K., Li, Q., Guo, Z., & Li, Z. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108760 · Cited by 53

VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response

Agarwal, S., Sharma, A., Bouzeyen, R., Deep, A., Sharma, H., Mangalaparthi, K. K., Datta, K. K., Kidwai, S., Gowda, H., Varadarajan, R., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba6944 · Cited by 48

A Biomaterial‐Based Hedging Immune Strategy for Scarless Tendon Healing

Wang, Z., Xiang, L., Lin, F. H., Tang, Y., Deng, L., & Cui, W. (2022) · Advanced Materials · doi:10.1002/adma.202200789 · Cited by 47

ZEB2 is a master switch controlling the tumor-associated macrophage program

Sheban, F., Phan, T. S., Xie, K., Ingelfinger, F., Gur, C., Itai, Y. S., Blecher‐Gonen, R., Yu, C., Avellino, R., Chalan, P., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.03.021 · Cited by 50

Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation

Tsuyama, J., Nakamura, A., Ooboshi, H., Yoshimura, A., & Shichita, T. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0707-8 · Cited by 45

Gas6/AXL pathway: immunological landscape and therapeutic potential

Zhai, X., Pu, D., Wang, R.-L., Zhang, J., Lin, Y., Wang, Y., Zhai, N., Peng, X., Zhou, Q., & Li, L. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1121130 · Cited by 46

Cell Death in the Tumor Microenvironment: Implications for Cancer Immunotherapy

Gadiyar, V., Lahey, K. C., Calianese, D. C., Devoe, C., Mehta, D., Bono, K. R., Desind, S. Z., Davra, V., & Birge, R. B. (2020) · Cells · doi:10.3390/cells9102207 · Cited by 44

Macrophage regulation & function in helminth infection

Lechner, A., Bohnacker, S., & Bieren, J. E. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101526 · Cited by 42

Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection

Wang, Z., Li, S., & Huang, B. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01106-8 · Cited by 48

Pannexin 1 drives efficient epithelial repair after tissue injury

Lucas, C. D., Medina, C. B., Bruton, F. A., Dorward, D. A., Raymond, M. H., Tufan, T., Etchegaray, J. I., Barron, B. J., Oremek, M. E. M., Arandjelovic, S., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm4032 · Cited by 42

Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease

Wang, E.-J., Wu, M.-Y., Ren, Z., Zheng, Y., Ye, R. D., Tan, C. S. H., Wang, Y., & Lu, J. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad004 · Cited by 45

The Study of Host Immune Responses Elicited by the Model Murine Hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus

Bouchery, T., Volpe, B., Shah, K., Lebon, L., Filbey, K. J., Gros, G. S. L., & Harris, N. L. (2017) · Current Protocols in Mouse Biology · doi:10.1002/cpmo.34 · Cited by 39

Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease

Karmele, E. P., Pasricha, T. S., Ramalingam, T. R., Thompson, R. W., Gieseck, R. L., Knilans, K. J., Hegen, M., Farmer, M., Jin, F., Kleinman, A., et al. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0189-6 · Cited by 43

Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases

de Sousa, J. R., Vasconcelos, P. F. D. C., & Quaresma, J. A. S. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s208576 · Cited by 48

Targeting helminths: The expanding world of type 2 immune effector mechanisms

Maizels, R. M., & Gause, W. C. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221381 · Cited by 46

Wound Healing versus Metastasis: Role of Oxidative Stress

Lopez, T. E., Wendremaire, M., Lagarde, J., Duquet, O., Alibert, L., Paquette, B., Garrido, C., & Lirussi, F. (2022) · Biomedicines · doi:10.3390/biomedicines10112784 · Cited by 44

Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility

Yap, G. S., & Gause, W. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02135 · Cited by 43

Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages

Liebold, I., Al Jawazneh, A., Casar, C., Lanzloth, C., Leyk, S., Hamley, M., Wong, M. N., Kylies, D., Gräfe, S. K., Edenhofer, I., et al. (2024) · Science · doi:10.1126/science.abo7027 · Cited by 96

Local macrophage clean-up

Ash, C., & Mueller, K. L. (2017) · Science · doi:10.1126/science.356.6342.1040-f

Synergistic action of apoptotic cells and surfactant protein A in boosting IL-4-dependent alternative activation of alveolar macrophages.

Tenreiro, P., García-Fojeda, B., & Casals, C. (2022) · doi:10.1183/23120541.lsc-2022.245

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

Minutti, C. M., Jackson-Jones, L. H., García-Fojeda, B., Knipper, J. A., Sutherland, T. E., Logan, N., Ringqvist, E. E., Guillamat‐Prats, R., Ferenbach, D. A., Artigas, A., et al. (2017) · Science · doi:10.1126/science.aaj2067 · Cited by 193

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

Dyken, S. J. V., & Locksley, R. M. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095906 · Cited by 743