The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice
Open accessAbstract
An alternate route for metastatic cells: Metastatic tumor cells are thought to reach distant organs by traveling through the blood circulation or the lymphatic system. Two studies of mouse models now suggest a hybrid route for tumor cell dissemination. Pereira et al. and Brown et al. used distinct methodologies to monitor the fate of tumor cells in lymph nodes. They found that tumor cells could invade local blood vessels within a node, exit the node by entering the blood circulation, then go on to colonize the lung. Whether this dissemination route occurs in cancer patients is unknown; the answer could potentially change the way that affected lymph nodes are treated in cancer. Science , this issue p. 1403 , p. 1408
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Cited by
Molecular principles of metastasis: a hallmark of cancer revisited
Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A., & Fares, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0134-x · Cited by 2,379
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Keller, L., & Pantel, K. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0180-2 · Cited by 544
Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges
Martin, J. D., Seano, G., & Jain, R. K. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114700 · Cited by 530
Self-citationLymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
Brown, M., Assen, F. P., Leithner, A., Abe, J., Schachner, H., Asfour, G., Bago-Horvath, Z., Stein, J. V., Uhrin, P., Sixt, M., et al. (2018) · Science · doi:10.1126/science.aal3662 · Cited by 417
Metastasis-Initiating Cells and Ecosystems
Massagué, J., & Ganesh, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0010 · Cited by 372
Metadata
- Authors
- Pereira, E. R., Kedrin, D., Seano, G., Gautier, O., Meijer, E. F. J., Jones, D., Chin, S.-M., Kitahara, S., Bouta, E. M., Chang, J., Beech, E., Jeong, H.-S., Carroll, M. C., Taghian, A. G., & Padera, T. P.
- Venue
- Science
- Published
- 2018-03-23
- Volume
- 359
- Issue
- 6382
- Pages
- 1403-1407
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2789838322
- Cited by
- 477
- References
- 35
- FWCI
- 18.79
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. https://app.cochat.ai/papers/10.1126/science.aal3622
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- Pereira, E. R., Kedrin, D., Seano, G., Gautier, O., Meijer, E. F. J., Jones, D., Chin, S.-M., Kitahara, S., Bouta, E. M., Chang, J., Beech, E., Jeong, H.-S., Carroll, M. C., Taghian, A. G., & Padera, T. P. (2018). Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Science. https://doi.org/10.1126/science.aal3622
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
