The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Pulmonary neuroendocrine cells amplify allergic asthma responses
Open accessAbstract
Finding a role for PNECs in asthma: Pulmonary neuroendocrine cells (PNECs) are a rare cell type located in airway and alveolar epithelia and are often in contact with sensory nerve fibers. They have a wide phylogenic distribution and are found even in the relatively primitive lungs of amphibia and reptiles, suggesting a critical function. Sui et al. found that mice lacking PNECs have suppressed type 2 (allergic) immune responses. PNECs were observed in close proximity to group 2 innate lymphoid cells (ILC2s) around airway branch points. The PNECs enhanced ILC2 activity by secreting CGRP (calcitonin gene-related peptide). They also induced goblet-cell hyperplasia via the neurotransmitter GABA (γ-aminobutyric acid). Interestingly, human asthma patients were found to have increased PNEC numbers, suggesting a potential therapeutic target for the treatment of asthma. Science , this issue p. eaan8546
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Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation
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Metadata
- Authors
- Sui, P., Wiesner, D. L., Xu, J., Zhang, Y., Lee, J., Van Dyken, S., Lashua, A., Yu, C., Klein, B. S., Locksley, R. M., Deutsch, G., & Sun, X.
- Venue
- Science
- Published
- 2018-06-08
- Volume
- 360
- Issue
- 6393
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2794691708
- Cited by
- 428
- References
- 45
- FWCI
- 26.72
- Type
- journal article
- Language
- en
- Open access
- green
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