The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells
Open accessAbstract
(IL-)2 be or not to be?: Immunological T follicular helper (T FH ) cells are a subpopulation of CD4 + T cells that support B cell antibody production and the establishment of B cell memory. By contrast, non-T FH cells orchestrate enhanced innate immune cell functions at sites of pathogen encounter. The factors underlying differentiation into a T FH or non-T FH cell remain poorly understood, though there is evidence to suggest that the T cell growth factor interleukin-2 (IL-2) may play a role. Using IL-2 reporter mice, DiToro et al. show that naïve CD4 + T cells that produce IL-2 are fated to become T FH cells, whereas nonproducers, which receive IL-2, become non-T FH cells. The CD4 + T cell–fate decision was linked to T cell receptor strength—only those naïve CD4 + T cells that received the highest T cell receptor signals were able to produce IL-2. Science , this issue p. eaao2933
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Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
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Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591
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Elsner, R. A., & Shlomchik, M. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.11.006 · Cited by 526
In Vivo CD4 + T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
Ruterbusch, M., Pruner, K. B., Shehata, L., & Pepper, M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-103019-085803 · Cited by 550
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Dendritic Cell Regulation of T Helper Cells
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Metadata
- Authors
- DiToro, D., Winstead, C. J., Pham, D., Witte, S., Andargachew, R., Singer, J. R., Wilson, C. G., Zindl, C. L., Luther, R. J., Silberger, D. J., Weaver, B. T., Kolawole, E. M., Martinez, R. J., Turner, H., Hatton, R. D., Moon, J. J., Way, S. S., Evavold, B. D., & Weaver, C. T.
- Venue
- Science
- Published
- 2018-09-14
- Volume
- 361
- Issue
- 6407
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2890141820
- Cited by
- 243
- References
- 6
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- green
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- DiToro, D., Winstead, C. J., Pham, D., Witte, S., Andargachew, R., Singer, J. R., Wilson, C. G., Zindl, C. L., Luther, R. J., Silberger, D. J., Weaver, B. T., Kolawole, E. M., Martinez, R. J., Turner, H., Hatton, R. D., Moon, J. J., Way, S. S., Evavold, B. D., & Weaver, C. T. (2018). Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science. https://doi.org/10.1126/science.aao2933
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
