The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms
Open accessAbstract
Continuing the resolution revolution: The living cell contains dynamic, spatially complex subassemblies that are sensitive to external perturbations. To minimize such perturbations, cells should be imaged in their native multicellular environments, under as gentle illumination as possible. However, achieving the spatiotemporal resolution needed to follow three-dimensional subcellular processes in detail under these conditions is challenging: Sample-induced aberrations degrade resolution and sensitivity, and high resolution usually requires intense excitation. Liu et al. combined noninvasive lattice light-sheet microscopy with aberration-correcting adaptive optics to study a variety of delicate subcellular events in vivo, including organelle remodeling during mitosis and growth cone dynamics during spinal cord development. Science , this issue p. eaaq1392
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Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
Yushkevich, P. A., Piven, J., Hazlett, H. C., Smith, R. G., Ho, S., Gee, J. C., & Gerig, G. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.015 · Cited by 8,868
The third dimension bridges the gap between cell culture and live tissue
Pampaloni, F., Reynaud, E. G., & Stelzer, E. H. K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2236 · Cited by 2,817
Crossing the endothelial barrier during metastasis
Reymond, N., d'Água, B. B., & Ridley, A. J. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3628 · Cited by 922
Pittet, M. J., & Weissleder, R. (2011) · Cell · doi:10.1016/j.cell.2011.11.004 · Cited by 466
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Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-09043-x · Cited by 510
Light sheet fluorescence microscopy
Stelzer, E. H. K., Strobl, F., Chang, B.-J., Preusser, F., Preibisch, S., McDole, K., & Fiolka, R. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00069-4 · Cited by 334
Light-sheet microscopy in the near-infrared II window
Wang, F., Wan, H., Ma, Z., Zhong, Y., Sun, Q., Tian, Y., Qu, L., Du, H., Zhang, M., Li, L., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0398-7 · Cited by 237
Peng, H.-Q., Liu, B., Wei, P., Zhang, P., Zhang, H., Zhang, J., Li, K., Li, Y., Cheng, Y., Lam, J. W. Y., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b08358 · Cited by 94
Metadata
- Authors
- Liu, T.-L., Upadhyayula, S., Milkie, D. E., Singh, V., Wang, K., Swinburne, I. A., Mosaliganti, K. R., Collins, Z. M., Hiscock, T. W., Shea, J., Kohrman, A. Q., Medwig, T. N., Dambournet, D., Forster, R., Cunniff, B., Ruan, Y., Yashiro, H., Scholpp, S., Meyerowitz, E. M., Hockemeyer, D., Drubin, D. G., Martin, B. L., Matus, D. Q., Koyama, M., Megason, S. G., Kirchhausen, T., & Betzig, E.
- Venue
- Science
- Published
- 2018-04-20
- Volume
- 360
- Issue
- 6386
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2784692733
- Cited by
- 570
- References
- 6
- FWCI
- 39.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, T.-L., Upadhyayula, S., Milkie, D. E., Singh, V., Wang, K., Swinburne, I. A., Mosaliganti, K. R., Collins, Z. M., Hiscock, T. W., Shea, J., Kohrman, A. Q., Medwig, T. N., Dambournet, D., Forster, R., Cunniff, B., Ruan, Y., Yashiro, H., Scholpp, S., Meyerowitz, E. M., . . . Betzig, E. (2018). Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science. https://doi.org/10.1126/science.aaq1392
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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