The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Emerging applications for DNA writers and molecular recorders
Open accessAbstract
Natural life is encoded by evolvable, DNA-based memory. Recent advances in dynamic genome-engineering technologies, which we collectively refer to as in vivo DNA writing, have opened new avenues for investigating and engineering biology. This Review surveys these technological advances, outlines their prospects and emerging applications, and discusses the features and current limitations of these technologies for building various genetic circuits for processing and recording information in living cells.
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“Amplified material was pure and ready for re-encapsulation into silica particles, which could be re-introduced directly back into the data pool and thereby represents a complete write-store-access-read cycle that in principle may be applied larger-scale datasets, with periodic renewal of single-stranded DNA barcodes and bacterial replication of DNA data following reading25–27.”
From Random access DNA memory using Boolean search in an archival file storage system (2021) · cites this paper as [27]
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Metadata
- Authors
- Farzadfard, F., & Lu, T. K.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Science
- Published
- 2018-08-31
- Volume
- 361
- Issue
- 6405
- Pages
- 870-875
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6995688
- OpenAlex
- W2888880210
- Cited by
- 102
- References
- 28
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 11 · 2021: 20 · 2020: 15 · 2019: 19 · 2018: 1
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (P50GM098792)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- genome editing, synthetic gene circuits, synthetic biology, living cells, information processing in cells
- MeSH terms
- Gene Editing, CRISPR-Associated Protein 9, RNA, Guide, CRISPR-Cas Systems, Animals, Bacterial Proteins, Brain Mapping, DNA, Endonucleases, Genetic Engineering, Humans, Recombination, Genetic, Biosensing Techniques, Information Storage and Retrieval, Genome, Directed Molecular Evolution, Cell Engineering
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