A new era for functional labeling of neurons: activity-dependent promoters have come of age
Open accessAbstract
Genetic labeling of neurons with a specific response feature is an emerging technology for precise dissection of brain circuits that are functionally heterogeneous at the single-cell level. While immediate early gene mapping has been widely used for decades to identify brain regions which are activated by external stimuli, recent characterization of the promoter and enhancer elements responsible for neuronal activity-dependent transcription have opened new avenues for live imaging of active neurons. Indeed, these advancements provided the basis for a growing repertoire of novel experiments to address the role of active neuronal networks in cognitive behaviors. In this review, we summarize the current literature on the usage and development of activity-dependent promoters and discuss the future directions of this expanding new field.
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Central Fos-ir reflects rapid adaptation of neuronal and synaptic physiology in response to synaptic input through robust transcriptional regulation, and has been linked with depolarization in many, but not all, neuronal phenotypes.
“Thus, central Fos-ir is thought to reflect rapid adaptation of neuronal and synaptic physiology in response to synaptic input through robust transcriptional regulation, and has been linked with depolarization in many, but not all, neuronal phenotypes.”
From Oxytocin receptors modulate a social salience neural network in male prairie voles (2017) · cites this paper as Kawashima et al., 2014
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Stimulus-specific combinatorial functionality of neuronal c-fos enhancers
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A Brief Introduction to the Transduction of Neural Activity into Fos Signal
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“In addition to the detection of mRNA and protein, recently other molecular markers or functional tools could be attached to the Fos gene to amplify the Fos signal detection or to provide other manipulations including optogenetic and chemogenetic stimulations (Kawashima et al., 2014).”
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Oxytocin receptors modulate a social salience neural network in male prairie voles
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Emerging applications for DNA writers and molecular recorders
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- Authors
- Kawashima, T., Okuno, H., & Bito, H.
- Affiliations
- The University of Tokyo (JP)
- Howard Hughes Medical Institute (US)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Bito, Haruhiko
- Venue
- Frontiers in Neural Circuits
- Publisher
- Frontiers Media SA
- Published
- 2014-04-23
- Volume
- 8
- Pages
- 37-37
- ISSN
- 1662-5110 (ISSN-L)
- PMC
- PMC4005930
- OpenAlex
- W2112350473
- Cited by
- 165
- References
- 92
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 16 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 16 · 2019: 17 · 2018: 16 · 2017: 17 · 2016: 21 · 2015: 10 · 2014: 2
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neural Circuits (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Johns Hopkins University
- Ministry of Education, Culture, Sports, Science and Technology (CREST)
- Japan Society for the Promotion of Science (CREST, 24300117)
- Japan Science and Technology Agency (CREST)
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- immediate early genes, enhancers, single-cell heterogeneity, neuronal network activity, cognitive behavior
- MeSH terms
- Animals, Neurons, Promoter Regions, Genetic, Genes, Immediate-Early
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