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Multivascular networks and functional intravascular topologies within biocompatible hydrogels

Open access
Grigoryan, Bagrat, Paulsen, Samantha J., Corbett, Daniel C., Sazer, Daniel W., Fortin, Chelsea L., Zaita, Alexander J., Greenfield, Paul T., Calafat, Nicholas J., Gounley, John P., Ta, Anderson H., Johansson, Fredrik, Randles, Amanda, Rosenkrantz, Jessica E., Louis-Rosenberg, Jesse D., Galie, Peter A., Stevens, Kelly R., Miller, Jordan S.·2019·Science

Abstract

Routes to independent vessel networks: In air-breathing vertebrates, the circulatory and pulmonary systems contain separate networks of channels that intertwine but do not intersect with each other. Recreating such structures within cell-compatible materials has been a major challenge; even a single vasculature system can be a burden to create. Grigoryan et al. show that natural and synthetic food dyes can be used as photoabsorbers that enable stereolithographic production of hydrogels containing intricate and functional vascular architectures. Using this approach, they demonstrate functional vascular topologies for studies of fluid mixers, valves, intervascular transport, nutrient delivery, and host engraftment. Science , this issue p. 458

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Metadata

Authors
Grigoryan, B., Paulsen, S. J., Corbett, D. C., Sazer, D. W., Fortin, C. L., Zaita, A. J., Greenfield, P. T., Calafat, N. J., Gounley, J. P., Ta, A. H., Johansson, F., Randles, A., Rosenkrantz, J. E., Louis-Rosenberg, J. D., Galie, P. A., Stevens, K. R., & Miller, J. S.
Venue
Science
Published
2019-05-03
Volume
364
Issue
6439
Pages
458-464
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W4252179483
Cited by
1,396
References
4
FWCI
58.13
Type
journal article
Language
en
Open access
green
Funders
  • National Science Foundation (1450681, 1250104, 1728239)
  • National Institutes of Health (DP2HL137188, T32GM095421, T32EB001650)
  • National Institute of General Medical Sciences (T32GM095421)
  • Rice University (Nettie S. Autry Fellowship)
  • National Heart, Lung, and Blood Institute (HL134295, DP2HL137188)
  • Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation
  • NIH Office of the Director (DP5OD019876)

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CoChat. (2026). Citation check: Multivascular networks and functional intravascular topologies within biocompatible hydrogels. https://app.cochat.ai/papers/10.1126/science.aav9750
The paper
Grigoryan, B., Paulsen, S. J., Corbett, D. C., Sazer, D. W., Fortin, C. L., Zaita, A. J., Greenfield, P. T., Calafat, N. J., Gounley, J. P., Ta, A. H., Johansson, F., Randles, A., Rosenkrantz, J. E., Louis-Rosenberg, J. D., Galie, P. A., Stevens, K. R., & Miller, J. S. (2019). Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science. https://doi.org/10.1126/science.aav9750

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.