Cited by 429Amyotrophic Lateral Sclerosis ResearchSingle-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration Mechanisms

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Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

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Maniatis, Silas, Äijö, Tarmo, Vickovic, Sanja, Braine, Catherine, Kang, Kristy, Mollbrink, Annelie, Fagegaltier, Delphine, Andrusivová, Žaneta, Saarenpää, Sami, Saiz-Castro, Gonzalo, Cuevas, Miguel, Watters, Aaron, Lundeberg, Joakim, Bonneau, Richard, Phatnani, Hemali·2019·Science

DOI 10.1126/science.aav9776

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Abstract

Spatiotemporal gene expression in ALS: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that affects nerve cells in the brain and the spinal cord. It has proven difficult to identify the early stages of disease and where it spreads within the body. Maniatis et al. used RNA sequencing to define transcriptomic changes over the course of disease in different regions of the spinal cord of a mouse ALS model and a postmortem human ALS spinal cord. From changes in gene expression, they identified disease-associated pathways and established the key steps in motor neuron degeneration observed in ALS. Science , this issue p. 89

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Authors: Maniatis, S., Äijö, T., Vickovic, S., Braine, C., Kang, K., Mollbrink, A., Fagegaltier, D., Andrusivová, Ž., Saarenpää, S., Saiz-Castro, G., Cuevas, M., Watters, A., Lundeberg, J., Bonneau, R., & Phatnani, H.
Affiliations: New York Genome Center (US)
Flatiron Institute (US)
Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Science for Life Laboratory (SE)
Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
Corresponding author: Lundeberg, Joakim
Bonneau, Richard
Phatnani, Hemali
ORCID: Maniatis, Silas
Äijö, Tarmo
Vickovic, Sanja
Braine, Catherine
Kang, Kristy
Mollbrink, Annelie
Fagegaltier, Delphine
Andrusivová, Žaneta
Saarenpää, Sami
Saiz-Castro, Gonzalo
Cuevas, Miguel
Watters, Aaron
Lundeberg, Joakim
Bonneau, Richard
Phatnani, Hemali
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-04-05
Volume: 364
Issue: 6435
Pages: 89-93
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aav9776
OpenAlex: W2952459265
Cited by: 429
References: 55
Citations by year: 2026: 38 · 2025: 62 · 2024: 56 · 2023: 58 · 2022: 76 · 2021: 74 · 2020: 50 · 2019: 13
FWCI: 36.20
Type: journal article
Language: en
Open access: green
doi.org
Licence: cc-by-nc-nd
Locations: Science (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Simons Foundation
Target ALS
Knut och Alice Wallenbergs Stiftelse (2016.0454)
the ALS Association (15-LGCA-234)
The Tow Foundation
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyotrophic lateral sclerosis, motor neuron degeneration, spinal cord transcriptome, microglia, astrocytes, glial interactions, disease progression, gene expression dynamics, transcriptional pathways
MeSH terms: Amyotrophic Lateral Sclerosis, Animals, Astrocytes, Disease Models, Animal, Humans, Motor Neurons, Nerve Degeneration, Neuroglia, Postmortem Changes, Spinal Cord, Gene Expression, Microglia, Muscle, Skeletal, Gene Expression Profiling, Mice, Transcriptome, Spatio-Temporal Analysis

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Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

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