Axonal transport: Driving synaptic function

Molecular anatomy of a trafficking organelle

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Kinesin Transports RNA

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Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

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Quantitative ultrastructural analysis of hippocampal excitatory synapses

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Mutant dynactin in motor neuron disease

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The Biology of Huntingtin

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Control of microtubule organization and dynamics: Two ends in the limelight

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The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

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Activity-driven local ATP synthesis is required for synaptic function

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Neuropeptide Transmission in Brain Circuits

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The tubulin code and its role in controlling microtubule properties and functions

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Mechanisms of microtubule organization in differentiated animal cells

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Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies

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Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

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Oligodendrocytes support axonal transport and maintenance via exosome secretion

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Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

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Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes

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Structure and Mechanics of Dynein Motors

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Molecular Pathophysiological Mechanisms in Huntington’s Disease

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Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

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Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport

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The Cell Biology of LRRK2 in Parkinson's Disease

Usmani, A., Shavarebi, F., & Hiniker, A. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00660-20 · Cited by 107

Anterograde Axonal Transport in Neuronal Homeostasis and Disease

Guillaud, L., El-Agamy, S. E., Otsuki, M., & Terenzio, M. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.556175 · Cited by 103

Axonal energy metabolism, and the effects in aging and neurodegenerative diseases

Yang, S., Park, J. H., & Lu, H.-C. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00634-3 · Cited by 94

Mitochondrial Behavior in Axon Degeneration and Regeneration

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Mechanism and regulation of kinesin motors.

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Huntingtin and the Synapse

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Short-distance vesicle transport via phase separation

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Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?

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Neuronal maturation and axon regeneration: unfixing circuitry to enable repair

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Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010–2020)

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Monoamines: Dopamine, Norepinephrine, and Serotonin, Beyond Modulation, “Switches” That Alter the State of Target Networks

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Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons

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RNA Modifications and RNA Metabolism in Neurological Disease Pathogenesis

Chatterjee, B., Shen, C.-K. J., & Majumder, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111870 · Cited by 68

A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

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Microtubule Organization Is Essential for Maintaining Cellular Morphology and Function

Huang, L., Peng, Y., Tao, X., Ding, X., Li, R., Jiang, Y., & Zuo, W. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1623181 · Cited by 64

Mitochondria in Alzheimer’s Disease Pathogenesis

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Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model

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Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients

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Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain

Jankowska-Kulawy, A., Klimaszewska‐Łata, J., Gul‐Hinc, S., Ronowska, A., & Szutowicz, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710073 · Cited by 59

Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration

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Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function

Ivanova, D., & Cousin, M. A. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.826098 · Cited by 55

Mechanical injuries of neurons induce tau mislocalization to dendritic spines and tau-dependent synaptic dysfunction

Braun, N. J., Yao, K. R., Alford, P. W., & Liao, D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008306117 · Cited by 54

Synaptic Damage and Its Clinical Correlates in People With Early Huntington Disease

Delva, A., Michiels, L., Koole, M. J. B., Laere, K. V., & Vandenberghe, W. (2021) · Neurology · doi:10.1212/wnl.0000000000012969 · Cited by 51

Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport

Radwitz, J., Hausrat, T. J., Heisler, F. F., Janiesch, P. C., Pechmann, Y., Rübhausen, M., & Kneussel, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04607-5 · Cited by 55

LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes

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AP-4-mediated axonal transport controls endocannabinoid production in neurons

Davies, A. K., Alecu, J. E., Ziegler, M., Vasilopoulou, C. G., Merciai, F., Jumo, H., Saber, W. A., Şahin, M., Ebrahimi‐Fakhari, D., & Borner, G. H. H. (2022) · Nature Communications · doi:10.1038/s41467-022-28609-w · Cited by 50

JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport

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Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial

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Developmental regulation of microtubule‐based trafficking and anchoring of axonal mitochondria in health and diseases

Cheng, X., & Sheng, Z. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22748 · Cited by 50

Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses

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The synaptic life of microtubules

Waites, C. L., Qu, X., & Bartolini, F. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.03.004 · Cited by 45

Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease

Saroja, S. R., Sharma, A., Hof, P. R., & Pereira, A. C. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12518 · Cited by 45

Dynamic microtubules at the synapse

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Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence

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The Role of Axonal Transport in Glaucoma

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Neuronal innervation regulates the secretion of neurotrophic myokines and exosomes from skeletal muscle

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Rab2 Drives Axonal Transport of Dense Core Vesicles and Lysosomal Organelles

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Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria

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Tubulin polyglutamylation, a regulator of microtubule functions, can cause neurodegeneration

Bodakuntla, S., Janke, C., & Magiera, M. M. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135656 · Cited by 40

Molecular and cellular mechanisms of spastin in neural development and disease (Review)

Liu, Q., Zhang, G., Ji, Z., & Lin, H. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5051 · Cited by 40

The Role of Spastin in Axon Biology

Costa, A. C., & Sousa, M. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.934522 · Cited by 36

DNA damage response in neurodevelopment and neuromaintenance

Qing, X., Zhang, G., & Wang, Z. (2022) · FEBS Journal · doi:10.1111/febs.16535 · Cited by 42

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import

Mann, J. R., McKenna, E. D., Mawrie, D., Papakis, V., Alessandrini, F., Anderson, E. N., Mayers, R., Ball, H. E., Kaspi, E., Lubinski, K., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi5548 · Cited by 39

The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway

Collura, K. M., Niu, J., Sanders, S. S., Montersino, A., Holland, S. M., & Thomas, G. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013815 · Cited by 37

Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology

Perrone‐Capano, C., Volpicelli, F., Penna, E., Chun, J. T., & Crispino, M. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102051 · Cited by 37

The role of RGC degeneration in the pathogenesis of glaucoma

Si, Z., Fan, Y., Wang, M., Zhao, J., Zhang, Y., Liu, D., & Zheng, Y. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.103222 · Cited by 46

A Functional Dissection of the mRNA and Locally Synthesized Protein Population in Neuronal Dendrites and Axons

Perez, J. D., Fusco, C. M., & Schuman, E. M. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-030321-054851 · Cited by 36

Axonal plasticity in response to active forces generated through magnetic nano-pulling

Falconieri, A., Vincentiis, S. D., Cappello, V., Convertino, D., Das, R., Ghignoli, S., Figoli, S., Luin, S., Català-Castro, F., Marchetti, L., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111912 · Cited by 35

Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance

Saez, T. M. M., Bessone, I. F., Rodriguez, M. S., Alloatti, M., Otero, M. G., Cromberg, L. E., Devoto, V. M. P., Oubiña, G., Sosa, L. J., Buffone, M. G., et al. (2020) · Development · doi:10.1242/dev.184069 · Cited by 34

The Rab11-regulated endocytic pathway and BDNF/TrkB signaling: Roles in plasticity changes and neurodegenerative diseases

Moya‐Alvarado, G., Guerra, M. V., Tiburcio, R., Bravo, E., & Bronfman, F. C. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105796 · Cited by 32

Mechanism and prospects of mitochondrial transplantation for spinal cord injury treatment

Wang, Q., Wang, X., Shang, Z., & Zhao, L. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04077-5 · Cited by 32

Cargo-Mediated Activation of Cytoplasmic Dynein in vivo

Xiang, X., & Qiu, R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.598952 · Cited by 32

Understanding how kinesin motor proteins regulate postsynaptic function in neuron

Fan, R., & Lai, K. (2021) · FEBS Journal · doi:10.1111/febs.16285 · Cited by 32

Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation

Hou, M., Shao, Z., Zhang, S., Liu, X., Fan, P., Jiang, M., Zhao, Y., Xiao, R., & Yuan, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04836-3 · Cited by 33

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

Aiken, J., & Holzbaur, E. L. F. (2024) · Current Biology · doi:10.1016/j.cub.2024.03.010 · Cited by 31

Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model

Wang, W., Cao, Q., Tan, T., Yang, F., Williams, J. B., & Yan, Z. (2021) · Aging Cell · doi:10.1111/acel.13456 · Cited by 30

Adult Mouse Retina Explants: From ex vivo to in vivo Model of Central Nervous System Injuries

Schaeffer, J., Delpech, C., Albert, F., Belin, S., & Nawabi, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.599948 · Cited by 29

Smart motors and cargo steering drive kinesin-mediated selective transport

Nabb, A. T., Frank, M., & Bentley, M. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103464 · Cited by 29

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

Yang, S., Niou, Z., Enriquez, A., LaMar, J., Huang, J.-Y., Ling, K., Jafar‐Nejad, P., Gilley, J., Coleman, M. P., Tennessen, J. M., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00690-9 · Cited by 30

Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity

Espadas, I., Wingfield, J. L., Nakahata, Y., Chanda, K., Grinman, E., Ghosh, I., Bauer, K. E., Raveendra, B., Kiebler, M. A., Yasuda, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46972-8 · Cited by 28

Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders

Xiong, G.-J., & Sheng, Z. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202401145 · Cited by 29

Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus

Scaramuzzino, C., Cuoc, E. C., Pla, P., Humbert, S., & Saudou, F. (2022) · Science Advances · doi:10.1126/sciadv.abj8812 · Cited by 27

How neurons maintain their axons long-term: an integrated view of axon biology and pathology

Smith, G. A., Sweeney, S. T., O’Kane, C. J., & Prokop, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1236815 · Cited by 28

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice

Sleigh, J. N., Villarroel‐Campos, D., Surana, S., Wickenden, T., Tong, Y., Simkin, R. L., Vargas, J. N. S., Rhymes, E. R., Tosolini, A. P., West, S. J., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.157191 · Cited by 26

Anterograde transport of α-herpesviruses in neuronal axons

DuRaine, G. D., & Johnson, D. C. (2021) · Virology · doi:10.1016/j.virol.2021.02.011 · Cited by 25

Dyneins

Yıldız, A., & Zhao, Y. (2023) · Current Biology · doi:10.1016/j.cub.2023.10.064 · Cited by 22

Cross-talk between α-synuclein and the microtubule cytoskeleton in neurodegeneration

Mazzetti, S., Calogero, A. M., Pezzoli, G., & Cappelletti, G. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114251 · Cited by 22

Homeostasis of carbohydrates and reactive oxygen species is critically changed in the brain of middle-aged mice: Molecular mechanisms and functional reasons

Bayliak, M. M., Gospodaryov, D. V., & Lushchak, V. I. (2023) · BBA Advances · doi:10.1016/j.bbadva.2023.100077 · Cited by 24

Peripheral neuropathy in mitochondrial disease

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Genetic risk factors underlying white matter hyperintensities and cortical atrophy

Patel, Y., Shin, J., Sliz, E., Tang, A., Mishra, A., Xia, R., Hofer, E., Rajula, H. S. R., Wang, R., Beyer, F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53689-1 · Cited by 24

Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes

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Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila

del Castillo, U., Norkett, R., Lü, W., Serpinskaya, A. S., & Gelfand, V. I. (2021) · iScience · doi:10.1016/j.isci.2021.103536 · Cited by 20

Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport

Kumari, D., & Ray, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.873164 · Cited by 21

The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease

Smith, J. K., Mellick, G. D., & Sykes, A. M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1081426 · Cited by 22

MINFLUX reveals dynein stepping in live neurons

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Coordination between Transport and Local Translation in Neurons

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