Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

Walton, Russell T., Christie, Kathleen A., Whittaker, Madelynn N., Kleinstiver, Benjamin P.·2020·Science

Cited by (1,002)

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  3. Insights into the Mechanism of CRISPR/Cas9-Based Genome Editing from Molecular Dynamics Simulations
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  11. Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing
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  14. PAM-repeat associations and spacer selection preferences in single and co-occurring CRISPR-Cas systems
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  62. Base editor screens for in situ mutational scanning at scale
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  66. Research progress in gene editing technology
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  68. A Tale of Two Moieties: Rapidly Evolving CRISPR/Cas-Based Genome Editing
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  69. Mutation-specific reporter for optimization and enrichment of prime editing
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  70. Prime Editing: An All-Rounder for Genome Editing
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  71. Current advances of CRISPR-Cas technology in cell therapy
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  72. CRISPR techniques and potential for the detection and discrimination of SARS-CoV-2 variants of concern
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  77. Template-independent genome editing in the Pcdh15 mouse, a model of human DFNB23 nonsyndromic deafness
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  78. Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified SgRNAs
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  79. The type V effectors for CRISPR/Cas-mediated genome engineering in plants
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  80. Assessing and engineering the IscB–ωRNA system for programmed genome editing
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  87. Development and application of CRISPR-based genetic tools in Bacillus species and Bacillus phages
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