Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

Cited by (1,002)

Items 301–400 of 1,002

1. Engineering Cas9 for human genome editing
   Ian M. Slaymaker, Nicole M. Gaudelli · 2021 · Current Opinion in Structural Biology
2. The application of genome editing technology in fish
   Jianguo Lü, Wenyu Fang, Junrou Huang, Shi‐Zhu Li · 2021 · Marine Life Science & Technology
3. Engineering a PAM-flexible SpdCas9 variant as a universal gene repressor
   Jian Wang, Yuxi Teng, Ruihua Zhang, Yifei Wu, Lei Lou, Yusong Zou, Michelle Li, Zhong‐Ru Xie, Yajun Yan · 2021 · Nature Communications
4. Harnessing tissue-specific genome editing in plants through CRISPR/Cas system: current state and future prospects
   Dhanawantari L. Singha, Debajit Das, Yogita N. Sarki, Naimisha Chowdhury, Monica Sharma, Jitendra Maharana, Channakeshavaiah Chikkaputtaiah · 2021 · Planta
5. Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction
   Alex Cornean, Jakob Gierten, Bettina Welz, Juan Luis Mateo, Thomas Thumberger, Joachim Wittbrodt · 2022 · eLife
6. Genome-scale CRISPRi screening: A powerful tool in engineering microbiology
   Letian Sun, Ping Zheng, Jibin Sun, Volker F. Wendisch, Yu Wang · 2023 · Engineering Microbiology
7. Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification
   Jayoung Ryu, Sam Barkal, Tian Yu, Martin Jankowiak, Yunzhuo Zhou, Matthew Francoeur, Quang Vinh Phan, Zhijian Li, Manuel Tognon, Lara Brown et al. · 2024 · Nature Genetics
8. Multimodal scanning of genetic variants with base and prime editing
   Olivier Belli, Kyriaki Karava, Rick Farouni, Randall J. Platt · 2024 · Nature Biotechnology
9. Recent advances in the application of CRISPR/Cas-based gene editing technology in Filamentous Fungi
   Xu-Hong Li, Huizhi Lu, Ji-Bao Yao, Chi Zhang, Tian‐Qiong Shi, He Huang · 2025 · Biotechnology Advances
10. The dawn of non-human primate models for neurodevelopmental disorders
    Tomomi Aida, Guoping Feng · 2020 · Current Opinion in Genetics & Development
11. Expanding base editing scope to near-PAMless with engineered CRISPR/Cas9 variants in plants
    Chengwei Zhang, Yao Wang, Feipeng Wang, Si Zhao, Jinling Song, Feng Feng, Jiuran Zhao, Jinxiao Yang · 2020 · Molecular Plant
12. The efficacy of CRISPR-mediated cytosine base editing with the RPS5a promoter in Arabidopsis thaliana
    Min‐Kyeung Choi, Jae‐Young Yun, Jun‐Hyuk Kim, Sang‐Tae Kim, Sang‐Tae Kim · 2021 · Scientific Reports
13. CRISPR/Cas genome editing in grapevine: recent advances, challenges and future prospects
    Chong Ren, Yanping Lin, Zhenchang Liang · 2022 · Fruit Research
14. Improved Dual Base Editor Systems (iACBEs) for Simultaneous Conversion of Adenine and Cytosine in the Bacterium Escherichia coli
    Rahul Mahadev Shelake, Dibyajyoti Pramanik, Jae‐Yean Kim · 2023 · mBio
15. Promoter editing for the genetic improvement of crops
    Lu Shi, Jing Su, Myeong‐Je Cho, Hao Song, Oliver Xiaoou Dong, Ying Liang, Zhiyong Zhang · 2023 · Journal of Experimental Botany
16. Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice
    Yuanbojiao Zuo, Chen Zhang, Yuan Zhou, Haiwen Li, Weidong Xiao, Roland W. Herzog, Jie Xu, Jifeng Zhang, Y. Eugene Chen, Renzhi Han · 2023 · Cell & Bioscience
17. Design of efficacious somatic cell genome editing strategies for recessive and polygenic diseases
    Carlson-Stevermer, Jared, Das, Amritava, Abdeen, Amr A., Fiflis, David, Grindel, Benjamin I, Saxena, Shivani, Akcan, Tugce, Alam, Tausif, Kletzien, Heidi, Kohlenberg, Lucille et al. · 2020 · Nature Communications
18. Base editors: development and applications in biomedicine
    Yanhui Liang, Fangbing Chen, Kepin Wang, Liangxue Lai · 2023 · Frontiers of Medicine
19. CRISPR Tools for Engineering Prokaryotic Systems: Recent Advances and New Applications
    Diego Alba Burbano, Cholpisit Kiattisewee, Ava V. Karanjia, Ryan A. L. Cardiff, Ian Faulkner, Widianti Sugianto, James M. Carothers · 2024 · Annual Review of Chemical and Biomolecular Engineering
20. CRISPR/Cas-Mediated Genome Engineering in Plants: Application and Prospectives
    Swetaleena Mishra, Subhendu Nayak, Narendra Tuteja, Sowmya Poosapati, Durga Madhab Swain, Ranjan Kumar Sahoo · 2024 · Plants
21. The rise and future of CRISPR-based approaches for high-throughput genomics
    Silke Vercauteren, Simon Fiesack, Laetitia Maroc, Natalie Verstraeten, Liselot Dewachter, Jan Jacques Michiels, Sibylle Chantal Vonesch · 2024 · FEMS Microbiology Reviews
22. Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis
    Yutong Zou, Siyao Guo, Lili Wen, Dongming Lv, Jian Tu, Yan Liao, Wei‐Dong Chen, Ziyun Chen, Hongbo Li, Junkai Chen et al. · 2024 · Cell Reports Medicine
23. Current Non-Viral-Based Strategies to Manufacture CAR-T Cells
    Leon Gehrke, Vasco Dos Reis Gonçalves, Dominik Andrae, Tamás Raskó, Patrick Ho, Hermann Einsele, Michael Hudecek, Sabrina R. Friedel · 2024 · International Journal of Molecular Sciences
24. Harnessing artificial intelligence to advance CRISPR-based genome editing technologies
    Tyler Thomson, Gen Lin Li, Amy W. Strilchuk, Haotian Cui, Bo Wang, Bowen Li · 2025 · Nature Reviews Genetics
25. Current advances in overcoming obstacles of CRISPR/Cas9 off-target genome editing
    Guillermo Aquino‐Jarquín · 2021 · Molecular Genetics and Metabolism
26. Competitive dCas9 binding as a mechanism for transcriptional control
    Daniel A. Anderson, Christopher A. Voigt · 2021 · Molecular Systems Biology
27. Prime Editing for Inherited Retinal Diseases
    Bruna Lopes da Costa, Sarah R. Levi, Eric Eulau, Yi-Ting Tsai, Peter M. J. Quinn · 2021 · Frontiers in Genome Editing
28. CRISPR and cardiovascular diseases
    Kiran Musunuru · 2022 · Cardiovascular Research
29. Allele-specific silencing of the gain-of-function mutation in Huntington’s disease using CRISPR/Cas9
    Jun Wan Shin, Eun Pyo Hong, Seri S. Park, Doo Eun Choi, Ihn Sik Seong, Madelynn N. Whittaker, Benjamin P. Kleinstiver, Richard Z. Chen, Jong‐Min Lee · 2022 · JCI Insight
30. Application of CRISPR/Cas system in cereal improvement for biotic and abiotic stress tolerance
    Theivanayagam Maharajan, T. P. Ajeesh Krishna, Kasinathan Rakkammal, Stanislaus Antony Ceasar, Manikandan Ramesh · 2022 · Planta
31. Base Editing and Prime Editing: Potential Therapeutic Options for Rare and Common Diseases
    Lauren C. Testa, Kiran Musunuru · 2023 · BioDrugs
32. Directed evolution rice genes with randomly multiplexed sgRNAs assembly of base editors
    Ao Zhang, Tiaofeng Shan, Yan Sun, Zhipeng Chen, Jianjian Hu, Zhichao Hu, Ziheng Ming, Zhitao Zhu, Xue Li, Jun He et al. · 2023 · Plant Biotechnology Journal
33. PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells
    Takafumi Hiramoto, Yuji Kashiwakura, Morisada Hayakawa, Nemekhbayar Baatartsogt, Nobuhiko Kamoshita, Tomoyuki Abe, Hiroshi Inaba, Hiroshi Nishimasu, Hideki Uosaki, Yutaka Hanazono et al. · 2023 · Communications Medicine
34. Targeted genome editing in polyploids: lessons from Brassica
    Niaz Ahmad, Samia Fatima, Muhammad Aamer Mehmood, Qamar U. Zaman, Rana Muhammad Atif, Weijun Zhou, Mehboob‐ur‐ Rahman, Rafaqat A. Gill · 2023 · Frontiers in Plant Science
35. The pAblo · pCasso self-curing vector toolset for unconstrained cytidine and adenine base-editing in Gram-negative bacteria
    Ekaterina Kozaeva, Zacharias S. Nielsen, Manuel Nieto‐Domínguez, Pablo I. Nikel · 2024 · Nucleic Acids Research
36. Robust genome and cell engineering via in vitro and in situ circularized RNAs
    Michael Tong, Nathan D. Palmer, Amir Dailamy, Aditya Kumar, Hammza Khaliq, Sangwoo Han, Emma N Finburgh, Madeleine K. Wing, Camilla Hong, Yichen Xiang et al. · 2024 · Nature Biomedical Engineering
37. A selectable all-in-one CRISPR prime editing piggyBac transposon allows for highly efficient gene editing in human cell lines
    Reto Eggenschwiler, Thomas Gschwendtberger, Christian Felski, Christopher Jahn, Florian Peter Länger, Jared L. Sterneckert, Andreas Hermann, Jonathan Lukas Lühmann, Doris Steinemann, Alexandra Haase et al. · 2021 · Scientific Reports
38. Phase-separated DropCRISPRa platform for efficient gene activation in mammalian cells and mice
    Shufeng Ma, Kaitong Liao, Mengrao Li, Xinlong Wang, Jie Lv, Xin Zhang, Hongxin Huang, Lian Li, Tao Huang, Xiaohua Guo et al. · 2023 · Nucleic Acids Research
39. Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells
    Heon Seok Kim, Susan M. Grimes, Tianqi Chen, Anuja Sathe, Billy T. Lau, Gue‐Ho Hwang, Sangsu Bae, Hanlee P. Ji · 2023 · Nature Biotechnology
40. In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans
    Bing Yang, Matthew L. Schwartz, Katherine McJunkin · 2020 · Genes & Development
41. Next-generation forward genetic screens: uniting high-throughput perturbations with single-cell analysis
    John A. Morris, Jennifer S. Sun, Neville E. Sanjana · 2023 · Trends in Genetics
42. Breaking genetic shackles: The advance of base editing in genetic disorder treatment
    Fang Xu, Caiyan Zheng, Weihui Xu, Shiyao Zhang, Shanshan Liu, Xiaopeng Chen, Kai Yao · 2024 · Frontiers in Pharmacology
43. The Interface of Gene Editing with Regenerative Medicine
    Veronica E. Farag, Elsie Devey, Kam W. Leong · 2024 · Engineering
44. Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing
    Honglue Shi, Noor Al-Sayyad, Kevin M. Wasko, Marena I. Trinidad, Erin Doherty, Kamakshi Vohra, Ron S. Boger, David Colognori, Joshua C. Cofsky, Petr Skopintsev et al. · 2025 · Molecular Cell
45. New Insights into the Therapeutic Applications of CRISPR/Cas9 Genome Editing in Breast Cancer
    Munazza Ahmed, Grace Hope Daoud, Asmaa Mohamed, Rania Harati · 2021 · Genes
46. Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins
    Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matías Morin, Almudena Fernández, Logan T. Hille, Rachel A. Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver et al. · 2023 · Nature Microbiology
47. Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington’s disease
    Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe, Vanessa C. Wheeler, Hannah E. Stutzman, Ben Kleinstiver, Jong‐Min Lee · 2023 · eLife
48. Expanding plant genome editing scope and profiles with CRISPR‐FrCas9 systems targeting palindromic TA sites
    Yao He, Yangshuo Han, Yanqin Ma, Shishi Liu, Tingting Fan, Yanling Liang, Xu Tang, Xuelian Zheng, Yuechao Wu, Tao Zhang et al. · 2024 · Plant Biotechnology Journal
49. ABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish
    Wei Qin, Fang Liang, Sheng‐Jia Lin, Cassidy Petree, Kevin Huang, Yu Zhang, Lin Li, Pratishtha Varshney, Philippe Mourrain, Yanmei Liu et al. · 2024 · Nature Communications
50. Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations
    Bing Shao Chia, Samantha Seah, Bolun Wang, Kimberle Shen, Diya Srivastava, Wei Leong Chew · 2025 · ACS Synthetic Biology
51. Site-specific DNA insertion into the human genome with engineered recombinases
    Alison Fanton, Liam J. Bartie, Juliana Q. Martins, Vincent Q. Tran, Laine Goudy, Courtney Kernick, Matthew G. Durrant, Jingyi Wei, Zev Armour-Garb, April Pawluk et al. · 2025 · Nature Biotechnology
52. Genome Editing as A Versatile Tool to Improve Horticultural Crop Qualities
    Yating Chen, Wenwen Mao, Ting Liu, Qianqian Feng, Li Li, Bingbing Li · 2020 · Horticultural Plant Journal
53. Recent Progress and Future Prospective in HBV Cure by CRISPR/Cas
    Yu-Chan Yang, Hung‐Chih Yang · 2021 · Viruses
54. Expansion of the prime editing modality with Cas9 from Francisella novicida
    Yeounsun Oh, Wi-jae Lee, Junho K. Hur, Woojeung Song, Youngjeon Lee, Hanseop Kim, Lee Wha Gwon, Younghyun Kim, Young‐Ho Park, Chan Hyoung Kim et al. · 2022 · Genome biology
55. A base editing strategy using mRNA-LNPs for in vivo correction of the most frequent phenylketonuria variant
    Dominique L. Brooks, Madelynn N. Whittaker, Hooda Said, Garima Dwivedi, Ping Qü, Kiran Musunuru, Rebecca C. Ahrens‐Nicklas, Mohamad‐Gabriel Alameh, Xiao Wang · 2023 · Human Genetics and Genomics Advances
56. Applications of CRISPR in a Microbial Cell Factory: From Genome Reconstruction to Metabolic Network Reprogramming
    Yaokang Wu, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu · 2020 · ACS Synthetic Biology
57. CRISPR/Cas-mediated germplasm improvement and new strategies for crop protection
    Ganggang Dong, Zaifeng Fan · 2024 · Crop Health
58. CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders
    Júlia-Jié Cabré-Romans, Raquel Cuella-Martin · 2025 · Frontiers in Genome Editing
59. CRISPR-based therapeutic genome editing for inherited blood disorders
    Sébastien Levesque, Daniel E. Bauer · 2025 · Nature Reviews Drug Discovery
60. Genome editing using CRISPR/Cas9 to treat hereditary hematological disorders
    Yan Chen, Ruiting Wen, Zhigang Yang, Zhanghui Chen · 2021 · Gene Therapy
61. Base editing repairs an SGCA mutation in human primary muscle stem cells
    Helena Escobar, Anne Krause, Sandra Keiper, Janine Kieshauer, Stefanie Müthel, Manuel García de Paredes, Eric Metzler, Ralf Kühn, Florian Heyd, Simone Spuler · 2021 · JCI Insight
62. The heat is on: a simple method to increase genome editing efficiency in plants
    Jonas Blomme, Ward Develtere, Ayşe Köse, Júlia Arraiza Ribera, Christophe Brugmans, Jessica Jaraba-Wallace, Ward Decaestecker, Debbie Rombaut, Alexandra Baekelandt, Álvaro D. Fernández-Fernández et al. · 2022 · BMC Plant Biology
63. Advances of engineered microfluidic biosensors via CRISPR/Cas in bacteria and virus monitoring
    Xintong Li, Tingya Wang, Xiaohui Liu, Hui Jiang, Xuemei Wang · 2024 · Chemical Engineering Journal
64. High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease
    Vera Bzhilyanskaya, Linyuan Ma, Siyuan Liu, Lauren R. Fox, Madelynn N. Whittaker, Ronald J. Meis, Uimook Choi, Amanda Lawson, Michelle Ma, Narda Theobald et al. · 2024 · Science Translational Medicine
65. Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders
    Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei · 2025 · Cell Proliferation
66. Mutation-Independent Allele-Specific Editing by CRISPR-Cas9, a Novel Approach to Treat Autosomal Dominant Disease
    Kathleen A. Christie, Louise J. Robertson, Caroline Conway, Kevin Blighe, Larry DeDionisio, Connie Chao-Shern, Amanda M. Kowalczyk, John Marshall, Douglass M. Turnbull, M. Andrew Nesbit et al. · 2020 · Molecular Therapy
67. CRISPR/Cas9 for the treatment of haematological diseases: a journey from bacteria to the bedside
    Olivier Humbert, Clare Samuelson, Hans‐Peter Kiem · 2020 · British Journal of Haematology
68. A luciferase reporter mouse model to optimize in vivo gene editing validated by lipid nanoparticle delivery of adenine base editors
    Si-Yue Yu, Tiffany Carlaw, Tyler Thomson, Alexandra Birkenshaw, Genc Basha, Daniel Z. Kurek, Cassie Huang, Jayesh A. Kulkarni, Linhua Zhang, Colin J. Ross · 2023 · Molecular Therapy
69. Recent advances in therapeutic CRISPR-Cas9 genome editing: mechanisms and applications
    Lifang Zhou, Shaohua Yao · 2023 · Molecular Biomedicine
70. Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death
    Denisa Weis, Liangguang Leo Lin, Huilun Helen Wang, Zexin Jason Li, Katarína Kušíková, Peter Čižnár, Hermann M. Wolf, Alexander Leiss-Piller, Zhihong Wang, Xiaoqiong Wei et al. · 2023 · Journal of Clinical Investigation
71. Recent Therapeutic Progress and Future Perspectives for the Treatment of Hearing Loss
    Joey Lye, Derek S. Delaney, Fiona K. Leith, Varda S. Sardesai, Samuel McLenachan, Fred Kuanfu Chen, Marcus David Atlas, Elaine Y.M. Wong · 2023 · Biomedicines
72. Leveraging the sugarcane CRISPR/Cas9 technique for genetic improvement of non-cultivated grasses
    Chunjia Li, Muhammad Aamir Iqbal · 2024 · Frontiers in Plant Science
73. Expanding the scope of genome editing with SpG and SpRY variants in rice
    Jun Ren, Xiangbing Meng, Fengyue Hu, Qing Liu, Yuexuan Cao, Huiying Li, Changjie Yan, Jiayang Li, Kejian Wang, Hong Jun Yu et al. · 2021 · Science China Life Sciences
74. Automated design of CRISPR prime editors for 56,000 human pathogenic variants
    John A. Morris, Jahan A. Rahman, Xinyi Guo, Neville E. Sanjana · 2021 · iScience
75. Correction of DMD in human iPSC-derived cardiomyocytes by base-editing-induced exon skipping
    Peipei Wang, Philip L. Bailin, Mandi Zhu, Rena Y. Han, Shuliang Guo, Renzhi Han · 2022 · Molecular Therapy — Methods & Clinical Development
76. Development of multiplexed orthogonal base editor (MOBE) systems
    Cowan, Quinn T., Gu, Sifeng, Gu, Wanjun, Ranzau, Brodie L., Simonson, Tatum S., Komor, Alexis C. · 2025 · Nature Biotechnology
77. Recent advances in enzyme-free and enzyme-mediated single-nucleotide variation assay in vitro
    Erhu Xiong, Pengfei Liu, Ruijie Deng, Kaixiang Zhang, Ronghua Yang, Jinghong Li · 2024 · National Science Review
78. Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads
    Kevin Leandro, David Rufino‐Ramos, Koen Breyne, Emilio Di Ianni, Sara Lopes, Rui Jorge Nobre, Benjamin P. Kleinstiver, Pedro R.L. Perdigão, Xandra O. Breakefield, Luís Pereira de Almeida · 2024 · Advanced Drug Delivery Reviews
79. The FXR1 network acts as a signaling scaffold for actomyosin remodeling
    Xiuzhen Chen, Mervin M. Fansler, Urška Janjoš, Jernej Ule, Christine Mayr · 2024 · Cell
80. Directed evolution expands CRISPR–Cas12a genome-editing capacity
    Enbo Ma, Kai Chen, Honglue Shi, Kevin M. Wasko, Isabel Esain-Garcia, Marena I. Trinidad, Kaihong Zhou, Jinjuan Ye, Jennifer A. Doudna · 2025 · Nucleic Acids Research
81. Engineered base editors with reduced bystander editing through directed evolution
    Ramiro M. Perrotta, Svenja Vinke, Raphaël Ferreira, Michaël Moret, Ahmed Mahas, Anush Chiappino-Pepe, Lisa Maria Riedmayr, Anna-Thérèse Mehra, Louisa S. Lehmann, George McDonald Church · 2025 · Nature Biotechnology
82. Cytosine Base Editor (hA3A-BE3-NG)-Mediated Multiple Gene Editing for Pyramid Breeding in Pigs
    Yu Wang, Dengfeng Bi, Guosong Qin, Ruigao Song, Jing Tao Yao, Chunwei Cao, Qiantao Zheng, Naipeng Hou, Yanfang Wang, Jianguo Zhao · 2020 · Frontiers in Genetics
83. Basic Principles and Clinical Applications of CRISPR-Based Genome Editing
    Jung Min Lim, Seokjoong Kim · 2022 · Yonsei Medical Journal
84. CRISPR/Cas therapeutic strategies for autosomal dominant disorders
    Salvatore Marco Caruso, Peter M. J. Quinn, Bruna Lopes da Costa, Stephen H. Tsang · 2022 · Journal of Clinical Investigation
85. Harnessing stepping-stone hosts to engineer, select, and reboot synthetic bacteriophages in one pot
    Cheng Li, Ziqing Deng, Haoran Tao, Wenchen Song, Bo Xing, Wenfeng Liu, Lingxin Kong, Shengjian Yuan, Yingfei Ma, Yayun Wu et al. · 2022 · Cell Reports Methods
86. How to Completely Squeeze a Fungus—Advanced Genome Mining Tools for Novel Bioactive Substances
    Andreas Schüller, Lena Studt, Joseph Strauss · 2022 · Pharmaceutics
87. Automated high-throughput genome editing platform with an AI learning in situ prediction model
    Siwei Li, Jingjing An, Yaqiu Li, Xiagu Zhu, Dongdong Zhao, Lixian Wang, Yonghui Sun, Yuanzhao Yang, Changhao Bi, Xueli Zhang et al. · 2022 · Nature Communications
88. Engineering Cas9: next generation of genomic editors
    Maxim A. Kovalev, Artem I. Davletshin, Dmitry S. Karpov · 2024 · Applied Microbiology and Biotechnology
89. Strategies for improving the genome-editing efficiency of class 2 CRISPR/Cas system
    Linli Wang, Hongbing Han · 2024 · Heliyon
90. Cryptic variation fuels plant phenotypic change through hierarchical epistasis
    Sophia G. Zebell, Carlos Martí‐Gómez, Blaine Fitzgerald, Camila Pinto da Cunha, Michael Lach, Brooke M. Seman, Anat Hendelman, Simon Sretenovic, Yiping Qi, Madelaine Elisabeth Bartlett et al. · 2025 · Nature
91. Engineered dual selection for directed evolution of SpCas9 PAM specificity
    Gregory W. Goldberg, Jeffrey M. Spencer, David O. Giganti, Brendan R. Camellato, Neta Agmon, David M. Ichikawa, Jef D. Boeke, Marcus B. Noyes · 2021 · Nature Communications
92. Approaches to Enhance Precise CRISPR/Cas9-Mediated Genome Editing
    Christopher E. Denes, Alexander J. Cole, Yagiz Alp Aksoy, Geng Li, G. Gregory Neely, Daniel Hesselson · 2021 · International Journal of Molecular Sciences
93. Enhancing glycosylase base-editor activity by fusion to transactivation modules
    Xingxiao Dong, Chao Yang, Zhenzhen Ma, Ming Chen, Xueli Zhang, Changhao Bi · 2022 · Cell Reports
94. Base editor enables rational genome-scale functional screening for enhanced industrial phenotypes in Corynebacterium glutamicum
    Ye Liu, Ruoyu Wang, Jiahui Liu, Hui Lu, Haoran Li, Yu Wang, Xiaomeng Ni, Junwei Li, Yanmei Guo, Hongwu Ma et al. · 2022 · Science Advances
95. Development of Base Editors for Simultaneously Editing Multiple Loci in Lactococcus lactis
    Kairen Tian, Xia Hong, Manman Guo, Yanni Li, Hao Wu, Qinggele Caiyin, Jianjun Qiao · 2022 · ACS Synthetic Biology
96. Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells
    Mario Escobar, Jing Li, Aditi Patel, Shizhe Liu, Qi Xu, Isaac B. Hilton · 2022 · ACS Synthetic Biology
97. Gene editing innovations and their applications in cardiomyopathy research
    Eirini Kyriakopoulou, Thomas Monnikhof, Eva van Rooij · 2023 · Disease Models & Mechanisms
98. STAT1 gain-of-function heterozygous cell models reveal diverse interferon-signature gene transcriptional responses
    Ori Scott, Kyle Lindsay, Steven Erwood, Antonio Mollica, Chaim M. Roifman, Ronald D. Cohn, Evgueni A. Ivakine · 2021 · npj Genomic Medicine
99. Genome-scale targeted mutagenesis in Brassica napus using a pooled CRISPR library
    Jianjie He, Kai Zhang, Shuxiang Yan, Mi Tang, Weixian Zhou, Yongtai Yin, Kang Chen, Chunyu Zhang, Maoteng Li · 2023 · Genome Research
100. Correction of human nonsense mutation via adenine base editing for Duchenne muscular dystrophy treatment in mouse
     Ming Jin, Jiajia Lin, Haisen Li, Zhifang Li, Yang Dong, Yin Wang, Yuyang Yu, Zhurui Shao, Long Chen, Zhiqiang Wang et al. · 2024 · Molecular Therapy — Nucleic Acids