The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Liver homeostasis is maintained by midlobular zone 2 hepatocytes
Open accessAbstract
Zoning in on liver growth: For organ homeostasis or regrowth after injury or disease, one or more stem cell populations is needed to rebuild lost tissue. There is considerable debate about the source of new cells in the liver. Two groups now identify the source of new hepatocytes (see the Perspective by Andersson). Although the liver may seem to lack major variation across its structure, its lobule is organized into concentric zones where hepatocytes express different metabolic enzymes. Wei et al. sought to systematically define the source of new liver cells by comparing 14 fate-mapping mice that label different liver cell types. They found that different regions of the liver lobule exhibit differences in hepatocyte turnover, with zone 2 representing a primary source of new hepatocytes during homeostasis and regeneration. Similarly, He et al. designed a genetic approach to record cell proliferation in vivo with high spatial and temporal resolution to enable continuous recording of proliferative events of any specific cell type at the whole-cell population level. Using this method, they identified zone 2 as having the highest proliferative activity and contributing the most to liver regrowth. These findings have implications for the cellular basis of chronic disease pathogenesis, cancer development, and regenerative medicine strategies. Science , this issue p. eabb1625 , p. eabc4346 ; see also p. 887
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“To annotate clusters by zone and cell type, known marker genes were used (18), including markers for hepatic zones (zone-specific genes), bile duct cells, Kupffer cells, endothelial cells, hepatic stellate cells, and lymphocytes.”
From The origin of hepatocellular carcinoma depends on metabolic zonation (2026) · cites this paper as [18]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Instead, EdU incorporation suggested that knocking CreERT2 into the endogenous Axin2 locus increases proliferation of hepatocytes due to heterozygous Axin2 deletion.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, sparsely labelled hepatocytes, marked by novel Cre-expressing transgenes from the Hamp2 and Mup3 promoters, also expanded during homeostasis, demonstrating that proliferation is not limited to the high telomerase-expressing population.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, injury to zone 1 by allyl alcohol injection or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet was compensated by proliferation of hepatocytes in zones 2 and 3.85,86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Zone 2 hepatocytes labelled by AAV8-TBG-Cre or CreERT2 expressed from the Hamp2 or Mup3 promoters also proliferated and clonally expanded.86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, hepatocytes traced from the Hamp2 and Mup3 promoters readily gave rise to hepatocyte clusters after CCl4 and DDC injury.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“recent studies have demonstrated that hepatocytes are primarily maintained by the proliferation of pre-existing hepatocytes during liver homeostasis and regeneration14–19”
From Multimodal decoding of human liver regeneration (2024) · cites this paper as [18]
The cited source says what the claim attributes to it.
In the citing paper
“Analysis using qPCR and IHC suggested that this effect was mediated by RSPO3-dependent regulation of the WNT target CCND1 (Fig. 4a and Extended Data Figs. 7a and 10b), a key driver of liver regeneration23,42.”
From Hepatic stellate cells control liver zonation, size and functions via R-spondin 3 (2025) · cites this paper as [42]
The cited source says what the claim attributes to it.
In the citing paper
“Corresponding to the predominantly midzonal alterations in WNT-target genes as a result of a condensed zone 3 and an expanded zone 1 (Fig. 3i and Extended Data Fig. 8c), the alterations in proliferation and liver injury in Rspo3ΔHSC mice were most pronounced in the hepatic midzone (Fig. 4e and Extended Data Fig. 10b), which is pivotal for hepatocyte regeneration42.”
From Hepatic stellate cells control liver zonation, size and functions via R-spondin 3 (2025) · cites this paper as [42]
The cited source says what the claim attributes to it.
In the citing paper
“The recent generation of mice with Cre recombinase activity in distinct zonal populations permitted us to induce HCC mutations in a variety of normal cell types (18).”
From The origin of hepatocellular carcinoma depends on metabolic zonation (2026) · cites this paper as [18]
The cited source says what the claim attributes to it.
In the citing paper
“Cyp1a2-CreER mice recombine loci in zones 2 and 3, but more frequently in zone 3 (18).”
From The origin of hepatocellular carcinoma depends on metabolic zonation (2026) · cites this paper as [18]
The cited source says what the claim attributes to it.
In the citing paper
“During homeostasis, zone 2 hepatocytes rather than a defined subpopulation seem to have increased proliferative potential.”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
The cited source says what the claim attributes to it.
In the citing paper
“Nevertheless, hepatocytes do not proliferate equally over time, as results obtained via three independent experimental approaches have led to the same conclusion, namely that zone 2 hepatocytes proliferate more than hepatocytes from the other zones.75,86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
The cited source says what the claim attributes to it.
In the citing paper
“Hepatocyte proliferation in zone 2 hepatocytes is mediated by the IGFBP2-mTOR-CCND1 axis.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
The cited source says what the claim attributes to it.
In the citing paper
“A comprehensive study using several new mouse transgenic lines to label different portions of the lobule also demonstrated that zone 2 hepatocytes expand during homeostasis, with a corresponding contraction of the areas originally occupied by zone 1 or 3 hepatocytes.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
The cited source says what the claim attributes to it.
In the citing paper
“Alternative zone 3 labelling with other gene promoters also did not show that zone 3 hepatocytes give rise to hepatocytes in other zones during homeostasis.44,50,86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fast unfolding of communities in large networks
Blondel, V. D., Guillaume, J.-L., Lambiotte, R., & Lefebvre, E. (2008) · Journal of Statistical Mechanics: Theory and Experiment · doi:10.1088/1742-5468/2008/10/p10008 · Cited by 21,424
SCANPY: large-scale single-cell gene expression data analysis
Wolf, F. A., Angerer, P., & Theis, F. J. (2018) · Genome Biology · doi:10.1186/s13059-017-1382-0 · Cited by 8,881
From Louvain to Leiden: guaranteeing well-connected communities
Traag, V. A., Waltman, L., & van Eck, N. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-41695-z · Cited by 5,635
Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
Haghverdi, L., Lun, A. T. L., Morgan, M. D., & Marioni, J. C. (2018) · Nature Biotechnology · doi:10.1038/nbt.4091 · Cited by 2,416
Epidemiology and Management of Hepatocellular Carcinoma
Kulik, L., & El‐Serag, H. B. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.08.065 · Cited by 1,764
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552
A human liver cell atlas reveals heterogeneity and epithelial progenitors
Aizarani, N., Saviano, A., Sagar, Mailly, L., Durand, S., Herman, J. S., Pessaux, P., Baumert, T. F., & Grün, D. (2019) · Nature · doi:10.1038/s41586-019-1373-2 · Cited by 1,147
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
Halpern, K. B., Shenhav, R., Matcovitch-Natan, O., Tóth, B., Lemze, D., Golan, M., Massasa, E. E., Baydatch, S., Landen, S., Moor, A. E., et al. (2017) · Nature · doi:10.1038/nature21065 · Cited by 1,059
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2010) · Nature Genetics · doi:10.1038/ng.722 · Cited by 841
Sadana, P., Geyer, R., Pezoldt, J., Helmsing, S., Huehn, J., Hust, M., Dersch, P., & Scrima, A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001068 · Cited by 721
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–291 of 291
Hu, S., Liu, S., Bian, Y., Poddar, M., Singh, S., Cao, C., McGaughey, J. J., Bell, A. W., Blazer, L. L., Adams, J., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4071020 · Cited by 2
How the liver keeps itself in shape
May, S., & Bird, T. G. (2023) · eLife · doi:10.7554/elife.85606 · Cited by 2
Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signalingPreprint
Trinh, V. Q., Lee, T., Lemoinne, S., Ray, K. C., Ybanez, M. D., Tsuchida, T., Carter, J. K., Agudo, J., Brown, B. D., Akat, K. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.03.531042 · Cited by 2
Drasdo, D., & Zhao, J. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.05.016 · Cited by 2
Self-supervised Benchmarking for scRNAseq ClusteringPreprint
Tyler, S. R., Schadt, E. E., & Guccione, E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.07.548158 · Cited by 2
Breinig, M., Lomakin, A., Heidari, E., Ritter, M. A., Rukhovich, G. D., Böse, L., Butthof, L., Wendler-Link, L., Wiethoff, H., Poth, T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.14.593940 · Cited by 2
Dysregulated RNA splicing induces regeneration failure in alcohol-associated liver diseasePreprint
Chembazhi, U. V., Bangru, S., Dutta, R. K., Das, D., Peiffer, B. J., Natua, S., Toohill, K., Leona, A., Purwar, I., Bhowmik, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.29.626099 · Cited by 2
Liver Lymphatic Dysfunction as a Driver of Fibrosis and Cirrhosis ProgressionPreprint
Jeong, J., Hsu, S., Horikami, D., Utsumi, T., Yang, Y., Arefyev, N., Zhang, X., Cai, S., Boyer, J. L., Garcia-Milan, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.11.632552 · Cited by 2
Li, L., Wu, Q., Lin, Z., Liang, S., Fu, Q., Wei, Y., Wang, B., & Su, T. (2026) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2025.111225 · Cited by 1
Self-citationLiu, H., Sun, Z., Jiang, H., Li, X.-D., Jiang, Y., Liu, P., Huang, W., Lv, Q., Zhang, X.-L., & Li, R.-K. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i24.3793 · Cited by 1
Cavasin, J. P. (2025) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2025.07.006 · Cited by 1
Setd4-expressing cells drive regenerative recovery in chronic liver injury
Jia, X.-Z., Zhuang, T.-T., Yang, R.-S., Gu, Y.-W., Zeng, Y.-Z., Wood, C., Yang, J., & Yang, W. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.09.034 · Cited by 1
Xu, J., Chen, X., Ma, Y., Ren, J., Xu, G., Zhang, P., Jia, W., Deng, Q., Xiao, Y., Yao, J., et al. (2026) · Exploration · doi:10.1002/exp2.70142 · Cited by 1
Lipids at the helm: a metabolic playbook for liver regeneration
Weiskirchen, R., & Lonardo, A. (2026) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2025.222 · Cited by 1
Wang, Y., Xu, J., Zhu, Z., Zhang, Y., Hu, H., Gao, Y., Tao, Y., Yao, F., Zhou, S., Zhong, W., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70695 · Cited by 1
Self-citationYu, B., Yang, Z., Lu, Z., Wang, Z., Ye, Q., Lee, J., Zhang, Q., Zeng, W., Hong, J., He, B., et al. (2026) · Advanced Functional Materials · doi:10.1002/adfm.76420 · Cited by 1
Self-citationHaemodynamic control of zonated liver function via instructive vascular Wnt signalling
Lee, K. H., Jakab, M., Uvarovskii, A., Papageorgiou, D. N., Inverso, D., Shi, J., Riedel, M., Gehrs, S., Kulkarni, S., Bobe, S., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76966-7 · Cited by 1
Advances and applications in liver organoid technology
Lin, L., Miao, L. E. I., JiaMan, L. I. N., & Hu, W. (2021) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0283 · Cited by 1
Preparation of Functional Human Hepatocytes Ex Vivo
Okumura, A., & Tanimizu, N. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2557-6_20 · Cited by 1
[The liver remains a young organ even in old age !]
Gilgenkrantz, H. (2022) · Medecine sciences : M/S · doi:10.1051/medsci/2022137 · Cited by 1
Gilgenkrantz, H. (2023) · médecine/sciences · doi:10.1051/medsci/2023168 · Cited by 1
Dong, J., Viswanathan, S., Adami, E., Schäfer, S., Kuthubudeen, F. F., Widjaja, A. A., & Cook, S. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.05.438446 · Cited by 1
Valle-Encinas, E., Dawes, M., Martinez, C. V., McSweeney, K., Müller, M., Bird, T., & Dale, T. C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.01.438073 · Cited by 1
Passman, A. M., Haughey, M. J., Carlotti, E., Williams, M. J., Cereser, B., Lin, M., Devkumar, S., Gabriel, J. P., Russo, F. P., Hoare, M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.02.450704 · Cited by 1
Cantore, A., Starinieri, F., Milani, M., Beretta, S., Canepari, C., Fabiano, A., Simoni, C., Cammarota, E., Volpin, M., Bortolussi, G., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3138832/v1 · Cited by 1
Wu, H., Yang, A., Stelloo, S., Roos, F. J. M., Morsche, R. H. M. T., Verkerk, A. H., Velez, M. V. L., Wingens, L. J. A., de Wilt, J. H. W., Sauerwein, R. W., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.05.570132 · Cited by 1
Puri, M. (2024) · Preprints.org · doi:10.20944/preprints202401.0361.v1 · Cited by 1
Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cellsPreprint
Yu, G., Zhang, S., Romo, A., Biswas, S., Li, B., & Li, J. (2024) · eLife · doi:10.7554/elife.92531 · Cited by 1
Self-citationLi, L., Li, Z., Yin, X., & Xu, X. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.15.589470 · Cited by 1
Self-citationMitosis of Hepatitis B virus-infected cells results in uninfected daughter cellsPreprint
Tu, T., Zehnder, B., Wettengel, J. M., Zhang, H., Coulter, S., Ho, V., Douglas, M. W., Protzer, U., George, J., & Urban, S. (2022) · Research Square · doi:10.21203/rs.3.rs-1325894/v1
Modelling of a wide variety of disease using adult stem cell-derived organoids
van der Vaart, J. Y. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/930
A spatial atlas of Wnt and Frizzled receptor expression in adult mouse liverPreprint
Gayden, J. D., Hu, S., Joseph, P., Delgado, E. R., Liu, S., Bell, A. W., Puig, S., Monga, S. P., & Freyberg, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.23.509269
Wang, Y., Rong, R., Wei, Y., Wang, T., Xiao, G., & Zhu, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.12.511979
Self-citationMarker-free quantification of progenitor population reveals incipient cell fate commitmentsPreprint
He, X., Deng, S., Gong, H., Zhang, D., & Liu, L. (2022) · Research Square · doi:10.21203/rs.3.rs-2325305/v1
Mouse models of hepatocyte biology – Known unknowns
Hoare, M. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.002
Kaneko, K., Liang, Y., Liu, Q., Zhang, S., Song, D., & Feng, G. (2023) · eLife · doi:10.7554/elife.86824.1
Self-citationKaneko, K., Liang, Y., Qing, L., et al. (2023) · eLife · doi:10.7554/elife.86824.1.sa1
Kaneko, K., Liang, Y., Liu, Q., Zhang, S., Song, D., & Feng, G. (2023) · eLife · doi:10.7554/elife.86824.1.sa3
Self-citationKaneko, K., Liang, Y., Qing, L., et al. (2023) · eLife · doi:10.7554/elife.86824.1.sa0
Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growthPreprint
Nagai, H., Nagai, L. A. E., Tasaki, S., Nakato, R., Umetsu, D., Kuranaga, E., Miura, M., & Nakajima, Y.-I. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.08.539820
Keshvari, S., Masson, J. J. R., Ferrari-Cestari, M., Bodea, L., Nooru‐Mohamed, F., Tse, B. W.-C., Sokolowski, K. A., Batoon, L., Patkar, O. L., Sullivan, M. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.17.538022
A Notch between vascular morphogenesis and transcriptional identity
Gómez-Salinero, J. M., & Rafii, S. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00282-2
Kaneko, K., Liang, Y., Liu, Q., Zhang, S., Scheiter, A., Song, D., & Feng, G. (2023) · eLife · doi:10.7554/elife.86824.2
Self-citationCuring Classical Homocysteinuria with Pediatric in vitro engineered Liver Organoid Transplantation?
Bittmann, S., Luchter, E., Bittmann, L., Moschüring-Alieva, E., & Villalon, G. (2023) · Neurology and Neuroscience · doi:10.33425/2692-7918.1047
Cheng, H., Shi, Y., Li, X., Jin, N. Y., Liang, Y., Liu, Z., & Xie, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3613161/v1
Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cellsPreprint
Yu, G., Zhang, S., Romo, A., Biswas, S., Li, B., & Li, J. (2024) · eLife · doi:10.7554/elife.92531.1
Self-citationThe liver sinusoid at single-cell level
Parhar, R., & Ramachandran, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00006-1
Zheng, Q., Li, X., Xu, Z., Cai, Y., Li, F., Xue, X., Li, S., Sun, R., Fan, G., Wu, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.07.602368
Two types of regeneration mechanism in acute liver injuryPreprint
Aoyagi, T., Goya, T., Imoto, K., Azuma, Y., Hioki, T., Kohjima, M., Tanaka, M., Oda, Y., & Ogawa, Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.04.606468
Cao, Z., Qin, L., Liu, K., Yao, C., Li, E., Hao, X., Wang, Μ., Jiang, B., Zou, Y., Hu, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.28.610033
Wang, L., Pang, L., Guo, X. D., Li, W., Wu, R., & Yao, C. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113522
Approaches to the End of Life: Disease Trajectories
Shaw, P. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-70495-6_4
Animal models for studying liver regeneration
Kaur, S., & Tripathi, D. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99478-1.00002-x
Антонова, Е. И., Omarova, D. I., Firsova, N. V., & Ачилов, А. Б. (2025) · Biological Communications · doi:10.21638/spbu03.2024.403
Tong, Y., Gu, Q., Dong, B., Ying, H., Ji, T., Shen, X., Shen, B., Yu, H., Feng, L., Cai, X., et al. (2025) · Surgery · doi:10.1016/j.surg.2025.109343
Yang, X., & Yan, J. (2025) · Springer eBooks · doi:10.1007/978-981-96-7364-3_22
Apte, U. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-823524-9.00017-4
Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury
Zhu, Y., Deng, C., Chen, B., He, J., Liu, Y., Lei, S., Lu, W., Peng, C., & Shan, Z. (2026) · eLife · doi:10.1101/2025.08.21.671501
Yamamoto, T., Yamaguchi, J., Kokuryo, T., Yokoyama, Y., Mizuno, T., Onoe, S., Sunagawa, M., Baba, T., & Ebata, T. (2025) · Cells · doi:10.3390/cells14171323
Acute Pericentral Liver Injury Induces a Novel Transient Hepatocyte PopulationPreprint
Abidi, S. N. F., Seidel, K., Li, G. X., Fernandez, M., Piskol, R., Shamir, E. R., Siebel, C. W., & Vermeulen, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.17.676911
Postnatal hepatocyte proliferation – challenge and opportunity for gene therapy
Chen, F., & Tchorz, J. S. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.09.025
Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injuryPreprint
Zhu, Y., Deng, C., Chen, B., He, J., Liu, Y., Lei, S., Lu, W., Peng, C., & Shan, Z. (2025) · eLife · doi:10.7554/elife.108646
Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injuryPreprint
Zhu, Y., Deng, C., Chen, B., He, J., Liu, Y., Peng, C., & Shan, Z. (2025) · eLife · doi:10.7554/elife.108646.1
Engineering Cancer with Next-Generation Genome Editing Tools
Roth, J. F., Chen, E., Cevasco, H., & Rivera, F. J. S. (2025) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070824-123431
Liu, J., Yu, X., Luo, J., Wang, D., & Yin, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1679981
Akiyama, S., Saku, N., Miyata, S., Ite, K., Toyoda, M., Kimura, T., Kuroda, M., Nakazawa, A., Kasahara, M., Nonaka, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19351367
Faouder, P. L., Kulyk, H., Melentev, P., Clement, C., Leulier, F., Bertrand‐Michel, J., & Bellvert, F. (2025) · HAL
Wang, Y., Zhao, R., Yuan, Z., Zhai, L., Ning, X., Lv, M., Jin, Z., Iqbal, H., Ur-Rehman, U., Yi, Z., et al. (2026) · iScience · doi:10.1016/j.isci.2026.115389 · Cited by 2
Self-citationFeng, X., Feng, Y., Raza, S. H. A., Ma, Y. P., & Deng, H. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1781941 · Cited by 1
Zhao, W., JIAO, X., Du, K., Sun, Q., Duan, J., Cao, Y., Shen, X., Said, Z., Karri, S. S., Ellsworth, P. N., et al. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156630 · Cited by 1
Research progress on the regulatory mechanisms of gluconeogenesis in the liver of dairy cows
Wang, G., Qiao, J., JiangXin, W. A. N. G., & Lu, D. E. N. G. (2026) · Scientia Sinica Vitae · doi:10.1360/ssv-2025-0380
An organismal view of newborn cell dynamics in mammalian agingPreprint
Lu, Z., Zhou, W. Y., & Cao, J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.26.728032
Linking tissue morphology and tissue healing in a cell-fate model
Mani, S., & Tlusty, T. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1845953
Fletcher, R. B., Deshmukh, S., Phipps, J. L., Shah, D., Fisher, T., Patel, M., Newman, M. R., Broderick, C., Baribault, H., Ye, J., et al. (2026) · Gastro Hep Advances · doi:10.1016/j.gastha.2026.101061
Liu, L., Yang, Z., Xie, C., Zeng, D., Zhang, M., Wu, B., Shao, H.-R., Lang, L., Wang, Y., Wang, K., et al. (2026) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2026.100467
Self-citationZhang, H., Li, B., Zou, Y., Yao, F., Su, W., & Li, B. (2026) · The FASEB Journal · doi:10.1096/fj.202504206rr · Cited by 1
Selective ablation of p16Ink4a-lineage hepatocytes attenuates hepatic steatosis in diet-induced MASH
Zhang, Z., Kumamoto, S., Johmura, Y., & Nakano, Y. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154400
Cellular senescence is associated with age-related loss of liver zonation and hepatocyte functionPreprint
Laux, L., Aristel, A., Ali, S., Lande, K., Li, M., Evensen, K. G., Havas, A. P., Miao, Z., Zhang, J., Peters, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.08.743614
Self-citationSlabber, C. F., Lenkeit, F., Grove, K. J., Aebi, A., Orsini, V., Reyes, A., Ludwig, V., Crochemore, C., Bergling, S., Wild, S., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106429
Tian, T., Xue, Y., Sun, C., Yang, L., Wang, J., Jin-Smith, B., Barkin, J., Nzegwu, M., Jia, L., Zhou, H., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-77089-9
Hu, H., Han, T., Huang, Q., Gong, P., Liu, J., Wang, H., Ling, X., Wang, K., Liu, S., Yu, Y., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00526-0
Zhong, Z., Jin, R., Zhong, Y., Fu, Y., Zhu, R., Zhang, L., Jiao, Z., Zhou, F., Meng, L., Zhu, J., et al. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.08.006
Self-citationZonated cholesterol sensing by SIRT2 drives MASLD-HCC
Zhang, Y., 龙喜带, Fu, Y., Tang, X., Luo, H., Zou, Z., He, W., Han, L., Li, Y., Luo, J., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.08.015
Self-citationMid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injuryPreprint
Zhu, Y., Deng, C., Chen, B., He, J., Liu, Y., Lei, S., Lu, W., Peng, C., & Shan, Z. (2026) · eLife · doi:10.7554/elife.108646.3
Yu, X., Ma, H., Wang, C., Feng, K., Sun, P., Zhang, J., Lu, J., Zhang, H., Wang, C., Wang, C., et al. (2026) · Biology · doi:10.3390/biology15191725
Self-citation张一帆, Lu, Y., Yang, Y., Luo, X., Wang, N., Hao, F., Li, W., Chen, Y., & Wang, J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1906245
Iron Homeostasis and Liver Diseases
Yang, P., Shi, Z. X., Huang, Q., Tu, Z., Sun, Y., Wang, L., & Wei, Y. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71412
Self-citationJu, G., Wu, T., Wu, Y., Zhou, X., Yang, Y., Meng, X., Jin, C., Chen, H., 孙科, Yu, M., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-337845
Feng, G., Wang, X., Li, P., Wang, Y., Wan, H., Dong, K., Deng, H., 邹愚, Hu, Y., Jiang, S., et al. (2026) · JHEP Reports · doi:10.1016/j.jhepr.2026.102077
Self-citation
Metadata
- Authors
- Wei, Y., Wang, Y. G., Jia, Y., Li, L., Yoon, J., Zhang, S., Wang, Z., Zhang, Y., Zhu, M., Sharma, T., Lin, Y.-H., Hsieh, M.-H., Albrecht, J. H., Le, P. T., Rosen, C. J., Wang, T., & Zhu, H.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- University of Minnesota (US)
- Maine Medical Center (US)
- Corresponding author
- Zhu, Hao
- ORCID
- Venue
- Science
- Published
- 2021-02-26
- Volume
- 371
- Issue
- 6532
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8496420
- OpenAlex
- W3132549301
- Cited by
- 292
- References
- 43
- Citations by year
- 2026: 37 · 2025: 60 · 2024: 39 · 2023: 73 · 2022: 53 · 2021: 30
- FWCI
- 27.13
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01 CA251928)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK111588)
- National Institute of Environmental Health Sciences (R03ES026397-01)
- Burroughs Wellcome Fund
- Cancer Prevention and Research Institute of Texas (RP150596, RP190208)
- Stand Up To Cancer (SU2C-AACR-IRG 10-16)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- liver homeostasis, hepatocyte proliferation, liver regeneration, hepatocyte turnover, fate mapping, cell proliferation imaging, liver stem cells
- MeSH terms
- Animals, Biliary Tract, Biliary Tract Diseases, Homeostasis, Liver, Liver Regeneration, Insulin-Like Growth Factor Binding Protein 2, Cyclin D1, Hepatocytes, Cell Proliferation, Mice, Gene Knock-In Techniques, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
