Tipping the metabolic scales towards increased longevity in mammals

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works

Reactive Oxygen Species and the Central Nervous System

Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947 · see citing works

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442 · see citing works

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works

Mitochondrial dysfunction and type 2 diabetes

Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works

From endoplasmic-reticulum stress to the inflammatory response

Zhang, K., & Kaufman, R. J. (2008) · Nature · doi:10.1038/nature07203 · Cited by 2,010 · see citing works

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935 · see citing works

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735 · see citing works

Extension of murine life span by overexpression of catalase targeted to mitochondria

Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724 · see citing works

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382 · see citing works

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,348 · see citing works

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340 · see citing works

Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging

Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245 · see citing works

AMPK and PPARδ Agonists Are Exercise Mimetics

Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222 · see citing works

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., et al. (2012) · Science · doi:10.1126/science.1215135 · Cited by 1,199 · see citing works

Fusion and fission: interlinked processes critical for mitochondrial health

Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196 · see citing works

Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes &amp; Development · doi:10.1101/gad.1432206 · Cited by 1,188 · see citing works

Rates of Behavior and Aging Specified by Mitochondrial Function During Development

Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121 · see citing works

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS

Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · see citing works

The role of mitochondria in aging

Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087 · see citing works

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works

Mitonuclear protein imbalance as a conserved longevity mechanism

Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works

A mitochondrial specific stress response in mammalian cells

Zhao, Q., Wang, J., Levichkin, I. V., Stasinopoulos, S., Ryan, M. T., & Hoogenraad, N. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf445 · Cited by 1,026 · see citing works

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969 · see citing works

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

Cantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., Zierath, J. R., & Auwerx, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.006 · Cited by 921 · see citing works

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.014 · Cited by 889 · see citing works

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.004 · Cited by 837 · see citing works

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Zhang, G., Li, J., Purkayastha, S., Tang, Y., Zhang, H., Yin, Y., Li, B., Liu, G., & Cai, D. (2013) · Nature · doi:10.1038/nature12143 · Cited by 834 · see citing works

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., & Brand, M. D. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00097.x · Cited by 761 · see citing works

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734 · see citing works

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Pyo, J.-O., Yoo, S.-M., Ahn, H.-H., Nah, J., Hong, S.-H., Kam, T.-I., Jung, S., & Jung, Y.-K. (2013) · Nature Communications · doi:10.1038/ncomms3300 · Cited by 721 · see citing works

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

Sebastián, D., Hernández-Alvarez, M. I., Segalés, J., Sorianello, E., Muñoz, J. P., Sala, D., Waget, A., Liesa, M., Paz, J. C., Gopalacharyulu, P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108220109 · Cited by 673 · see citing works

Oxidative capacity and ageing in human muscle

Conley, K. E., Jubrias, S. A., & Esselman, P. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00203.x · Cited by 651 · see citing works

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

Yoneda, T., Benedetti, C., Urano, F., Clark, S. G., Harding, H. P., & Ron, D. (2004) · Journal of Cell Science · doi:10.1242/jcs.01275 · Cited by 636 · see citing works

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

Chang, H.-C., & Guarente, L. (2013) · Cell · doi:10.1016/j.cell.2013.05.027 · Cited by 615 · see citing works

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice ¹

Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J. (2000) · Endocrinology · doi:10.1210/endo.141.7.7586 · Cited by 611 · see citing works

PGC1α and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders

Austin, S., & St‐Pierre, J. (2012) · Journal of Cell Science · doi:10.1242/jcs.113662 · Cited by 606 · see citing works

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

Mair, W. B., & Dillin, A. G. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061206.171059 · Cited by 600 · see citing works

The Molecular Basis for Oxidative Stress-Induced Insulin Resistance

Evans, J. L., Maddux, B. A., & Goldfine, I. D. (2005) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2005.7.1040 · Cited by 587 · see citing works

Mechanisms of Insulin Resistance in Aging

Fink, R. I., Kolterman, O., Griffin, J., & Olefsky, J. M. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110908 · Cited by 555 · see citing works

Metabolism and cancer: the circadian clock connection

Sahar, S., & Sassone-Corsi, P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2747 · Cited by 551 · see citing works

Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells

St‐Pierre, J., Lin, J. D., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301850200 · Cited by 543 · see citing works

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532 · see citing works

Metabolic flexibility and insulin resistance

Galgani, J. E., Moro, C., & Ravussin, E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90558.2008 · Cited by 532 · see citing works

The metabolic footprint of aging in mice

Houtkooper, R. H., Argmann, C., Houten, S. M., Cantó, C., Jeninga, E. H., Andreux, P. A., Thomas, C., Doenlen, R., Schoonjans, K., & Auwerx, J. (2011) · Scientific Reports · doi:10.1038/srep00134 · Cited by 528 · see citing works

Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis

Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523 · see citing works

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance

Schneeberger, M., Dietrich, M. O., Sebastián, D., Imbernón, M., Castaño, C., Garcia, A., Esteban, Y., Gonzalez-Franquesa, A., Rodríguez, I. C., Bortolozzi, A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.003 · Cited by 519 · see citing works

Mitochondrial diseases

Schapira, A. H. V. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61305-6 · Cited by 499 · see citing works

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

Muñoz, J. P., Ivanova, S., Sánchez‐Wandelmer, J., Martínez‐Cristóbal, P., Noguera, E., Sancho, A., Díaz‐Ramos, A., Hernández‐Alvarez, M. I., Sebastián, D., Mauvezin, C., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.168 · Cited by 451 · see citing works

ER stress-induced inflammation: does it aid or impede disease progression?

Garg, A. D., Kaczmarek, A., Krysko, O., Vandenabeele, P., Krysko, D., & Agostinis, P. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.06.010 · Cited by 429 · see citing works

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420 · see citing works

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 414 · see citing works

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

Vermulst, M., Wanagat, J., Kujoth, G. C., Bielas, J. H., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2008) · Nature Genetics · doi:10.1038/ng.95 · Cited by 411 · see citing works

Characterization of the insulin resistance of aging.

Rowe, J. W., Minaker, K. L., Pallotta, J. A., & Flier, J. S. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110914 · Cited by 396 · see citing works

Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

Corradetti, M. N., & Guan, K.-L. (2006) · Oncogene · doi:10.1038/sj.onc.1209885 · Cited by 387 · see citing works

The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

Yee, C., Yang, W., & Hekimi, S. (2014) · Cell · doi:10.1016/j.cell.2014.02.055 · Cited by 356 · see citing works

Pten positively regulates brown adipose function, energy expenditure, and longevity

Ortega-Molina, A., Efeyan, A., Lopez-Guadamillas, E., Muñoz-Martin, M., Gómez-López, G., Cañamero, M., Mulero, F., Pastor, J., Martinez, S., Romanos, E., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.001 · Cited by 356 · see citing works

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00449.x · Cited by 353 · see citing works

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.031 · Cited by 345 · see citing works

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

Wu, J., Liu, J., Chen, E. B., Wang, J., Cao, L., Narayan, N., Fergusson, M. M., Rovira, I. I., Allen, M. D., Springer, D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.030 · Cited by 328 · see citing works

Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates

Bruss, M. D., Khambatta, C. F., Ruby, M. A., Aggarwal, I., & Hellerstein, M. K. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00524.2009 · Cited by 321 · see citing works

Linking mitochondrial bioenergetics to insulin resistance via redox biology

Fisher-Wellman, K. H., & Neufer, P. D. (2012) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2011.12.008 · Cited by 316 · see citing works

Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice

Dell'Agnello, C., Leo, S., Agostino, A., Szabadkai, G., Tiveron, C., Zulian, A., Prelle, A., Roubertoux, P., Rizzuto, R., & Zeviani, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl477 · Cited by 308 · see citing works

Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity

Dietrich, M. O., Liu, Z.-W., & Horvath, T. L. (2013) · Cell · doi:10.1016/j.cell.2013.09.004 · Cited by 306 · see citing works

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

Lee, S., Jeong, S.-Y., Lim, W.-C., Kim, S., Park, Y.-Y., Sun, X., Youle, R. J., & Cho, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700679200 · Cited by 298 · see citing works

Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity

Ikeno, Y., Bronson, R. T., Hubbard, G. B., Lee, S., & Bartke, A. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.4.b291 · Cited by 298 · see citing works

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

Viscomi, C. F., Bottani, E., Civiletto, G., Cerutti, R., Moggio, M. G., Fagiolari, G., Schon, E. A., Lamperti, C., & Zeviani, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.011 · Cited by 291 · see citing works

Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models

Berryman, D. E., Christiansen, J. S., Johannsson, G., Thorner, M. O., & Kopchick, J. J. (2008) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.05.005 · Cited by 288 · see citing works

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

Bai, P., Cantó, C., Brunyánszki, A., Huber, A., Szántó, M., Cen, Y., Yamamoto, H., Houten, S. M., Kiss, B., Oudart, H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.013 · Cited by 250 · see citing works

Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice

Ikeno, Y., Hubbard, G. B., Lee, S., Cortez, L. A., Lew, C. M., Webb, C. R., Berryman, D. E., List, E. O., Kopchick, J. J., & Bartke, A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp017 · Cited by 238 · see citing works

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice

Edgar, D., Shabalina, I. G., Cámara, Y., Wredenberg, A., Calvaruso, M. A., Nijtmans, L. G. J., Nedergaard, J., Cannon, B., Larsson, N., & Trifunović, A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.010 · Cited by 230 · see citing works

Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis

Lanza, I. R., Zabielski, P., Klaus, K. A., Morse, D. M., Heppelmann, C. J., Bergen, H. R., Dasari, S., Walrand, S., Short, K. R., Johnson, M. L., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.003 · Cited by 227 · see citing works

Autophagy and mitophagy in cellular damage control

Zhang, J. (2013) · Redox Biology · doi:10.1016/j.redox.2012.11.008 · Cited by 222 · see citing works

TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling

Riera, C. E., Huising, M. O., Follett, P., Leblanc, M., Halloran, J. J., Andel, R. V., Filho, C. D. D. M., Merkwirth, C., & Dillin, A. G. (2014) · Cell · doi:10.1016/j.cell.2014.03.051 · Cited by 218 · see citing works

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

Pipatpiboon, N., Pratchayasakul, W., Chattipakorn, N., & Chattipakorn, S. C. (2011) · Endocrinology · doi:10.1210/en.2011-1502 · Cited by 212 · see citing works

Early Mitochondrial Dysfunction in Long-lived Mclk1+/- Mice

Lapointe, J., & Hekimi, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803287200 · Cited by 207 · see citing works

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

Zhang, Y., Ikeno, Y., Qi, W., Chaudhuri, A., Li, Y., Bokov, A., Thorpe, S. R., Baynes, J., Epstein, C. J., Richardson, A. G., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp132 · Cited by 206 · see citing works

Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice

Fang, Y., Westbrook, R., Hill, C., Boparai, R. K., Arum, O., Spong, A., Wang, F., Javors, M. A., Chen, J., Sun, L. Y., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.008 · Cited by 195 · see citing works

Review: Obesity and Alzheimer’s Disease: A Link Between Body Weight and Cognitive Function in Old Age

Naderali, E. K., Ratcliffe, S. H., & Dale, M. C. (2009) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317509348208 · Cited by 182 · see citing works

Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice

Dominici, F. P., Hauck, S., Argentino, D., Bartke, A., & Turyn, D. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1730081 · Cited by 176 · see citing works

Insulin resistance and cancer: Epidemiological evidence

Tsugane, S., & Inoue, M. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01521.x · Cited by 171 · see citing works

PGC-1α in aging and anti-aging interventions

Anderson, R., & Prolla, T. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.005 · Cited by 162 · see citing works

The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating Energy Dissipation

Nicholls, D. G., BERNSON, V. S. M., & Heaton, G. M. (1978) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-5559-4_9 · Cited by 160 · see citing works

Insulin resistance and pathological brain ageing

Cholerton, B., Baker, L. D., & Craft, S. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03464.x · Cited by 160 · see citing works

Mitochondrial function as a determinant of life span

Lanza, I. R., & Nair, K. S. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0724-5 · Cited by 148 · see citing works

A Morphometric Study of Age-Dependent Changes in Mitochondrial Populations of Mouse Liver and Heart

Herbener, G. H. (1976) · Journal of Gerontology · doi:10.1093/geronj/31.1.8 · Cited by 148 · see citing works

Insulin resistance and cancer: epidemiological evidence

Inoue, M., & Tsugane, S. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0142 · Cited by 137 · see citing works

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

Kleinridders, A., Lauritzen, H. P. M. M., Ussar, S., Christensen, J. H., Mori, M. A., Bross, P., & Kahn, C. R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67615 · Cited by 130 · see citing works

Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease

Gates, A. C., Bernal‐Mizrachi, C., Chinault, S. L., Chu, F., Schneider, J. G., Coleman, T., Malone, J. P., Townsend, R. R., Chakravarthy, M. V., & Semenkovich, C. F. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.010 · Cited by 113 · see citing works

Mitochondrial alteration in type 2 diabetes and obesity: An epigenetic link

Cheng, Z., & Almeida, F. A. (2014) · Cell Cycle · doi:10.4161/cc.28189 · Cited by 94 · see citing works

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

Foukas, L. C., Bilanges, B., Bettedi, L., Pearce, W., Ali, K., Sancho, S., Withers, D. J., & Vanhaesebroeck, B. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201953 · Cited by 91 · see citing works

Effectors of Thermogenesis

Girardier, L., & Seydoux, J. (1978) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-5559-4 · Cited by 83 · see citing works

The Immunosuppressant Rapamycin Represses Human Immunodeficiency Virus Type 1 Replication

Roy, J., Paquette, J., Fortin, J., & Tremblay, M. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.11.3447-3455.2002 · Cited by 79 · see citing works

Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

Hsieh, C.-C., DeFord, J. H., Flurkey, K., Harrison, D. E., & Papaconstantinou, J. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00036-2 · Cited by 76 · see citing works

Mammalian models of extended healthy lifespan

Selman, C., & Withers, D. J. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0243 · Cited by 71 · see citing works

The mitochondrial unfolded protein response in mammalian physiology

Mottis, A., Jovaisaite, V., & Auwerx, J. H. (2014) · Mammalian Genome · doi:10.1007/s00335-014-9525-z · Cited by 68 · see citing works

Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

Kolesar, J. E., Safdar, A., Abadi, A., MacNeil, L., Crane, J. D., Tarnopolsky, M. A., & Kaufman, B. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.038 · Cited by 63 · see citing works

Hypoinsulinemia of Hypothyroidism

Shah, J. H. (1973) · Archives of Internal Medicine · doi:10.1001/archinte.1973.03650110017004 · Cited by 24 · see citing works

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works

Evidence for the Domains Supporting the Construct of Intrinsic Capacity

Cesari, M., Araujo de Carvalho, I., Amuthavalli Thiyagarajan, J., Cooper, C., Martin, F. C., Reginster, J.-Y., Vellas, B., & Beard, J. R. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly011 · Cited by 745 · see citing works

Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

Chaix, A., Lin, T. C., Le, H. D., Chang, M. W., & Panda, S. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.004 · Cited by 678 · see citing works

Skeletal muscle fiber type: using insights from muscle developmental biology to dissect targets for susceptibility and resistance to muscle disease

Talbot, J. C., & Maves, L. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.230 · Cited by 439 · see citing works

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

Grunewald, M., Kumar, S., Sharife, H., Volinsky, E., Gileles‐Hillel, A., Licht, T., Permyakova, A., Hinden, L., Azar, S., Friedmann, Y., et al. (2021) · Science · doi:10.1126/science.abc8479 · Cited by 370 · see citing works

Mitochondrial function in hypoxic ischemic injury and influence of aging

Ham, P. B., & Raju, R. P. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.006 · Cited by 367 · see citing works

Microbial Genetic Composition Tunes Host Longevity

Han, B., Sivaramakrishnan, P., Lin, C.-C., Neve, I. A. A., He, J., Tay, L. W. R., Sowa, J. N., Sizovs, A., Du, G., Wang, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.036 · Cited by 349 · see citing works

The metabolic regulation of aging

Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works

Molecular and biological hallmarks of ageing

Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 323 · see citing works

Assessing Cardiac Metabolism

Taegtmeyer, H., Young, M. E., Lopaschuk, G. D., Abel, E. D., Brunengraber, H., Darley-Usmar, V. M., Rosiers, C. D., Gerszten, R. E., Glatz, J. F. C., Griffin, J. L., et al. (2016) · Circulation Research · doi:10.1161/res.0000000000000097 · Cited by 283 · see citing works

Endoplasmic reticulum proteostasis impairment in aging

Martínez, G., Duran-Aniotz, C. A., Cabral‐Miranda, F., Vivar, J. P., & Hetz, C. A. (2017) · Aging Cell · doi:10.1111/acel.12599 · Cited by 206 · see citing works

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

Roichman, A., Elhanati, S., Aon, M. A., Abramovich, I., Francesco, A. D., Shahar, Y., Avivi, M. Y., Shurgi, M., Rubinstein, A., Wiesner, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23545-7 · Cited by 210 · see citing works

Signaling networks determining life span

Riera, C. E., Merkwirth, C., De Magalhaes Filho, C. D., & Dillin, A. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014451 · Cited by 161 · see citing works

The biology of the metabolic syndrome and aging

Dominguez, L. J., & Barbagallo, M. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000243 · Cited by 152 · see citing works

Neuropsychology of aging

Cohen, R. A., Marsiske, M., & Smith, G. E. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00010-8 · Cited by 124 · see citing works

Regulation of longevity by FGF21: interaction between energy metabolism and stress responses

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.004 · Cited by 121 · see citing works

Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease

Moskalev, A., Chernyagina, E., de Magalhães, J. P., Barardo, D., Thoppil, H., Shaposhnikov, M. V., Budovsky, A., Fraifeld, V. E., Garazha, A., Tsvetkov, V. O., et al. (2015) · Aging · doi:10.18632/aging.100799 · Cited by 121 · see citing works

The Mediterranean Diet Slows Down the Progression of Aging and Helps to Prevent the Onset of Frailty: A Narrative Review

Capurso, C. A., Bellanti, F., Buglio, A. L., & Vendemiale, G. (2019) · Nutrients · doi:10.3390/nu12010035 · Cited by 120 · see citing works

mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process

Marafie, S. K., Al‐Mulla, F., & Abubaker, J. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116141 · Cited by 110 · see citing works

Healthy aging and muscle function are positively associated with NAD+ abundance in humans

Janssens, G. E., Grevendonk, L., Perez, R. Z., Schomakers, B. V., de Vogel-van den Bosch, J., Geurts, J. M. W., van Weeghel, M., Schrauwen, P., Houtkooper, R. H., & Hoeks, J. (2022) · Nature Aging · doi:10.1038/s43587-022-00174-3 · Cited by 103 · see citing works

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity

Monaghan, R. M., Barnes, R. G., Fisher, K., Andreou, T., Rooney, N., Poulin, G. B., & Whitmarsh, A. J. (2015) · Nature Cell Biology · doi:10.1038/ncb3170 · Cited by 90 · see citing works

MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis

Xu, L., Wu, Z., He, Y., Chen, Z., Xu, K., Yu, W., Fang, W., Ma, C., Moqbel, S. A. A., Ran, J., et al. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.11.011 · Cited by 87 · see citing works

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

Ewald, C. Y., Hourihan, J. M., Bland, M. S., Obieglo, C., Katic, I., Mazzeo, L. E. M., Alcedo, J., Blackwell, T. K., & Hynes, N. E. (2017) · eLife · doi:10.7554/elife.19493 · Cited by 84 · see citing works

Deciphering the decline of metabolic elasticity in aging and obesity

Zhou, Q., Yu, L., Cook, J. R., Qiang, L., & Sun, L. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.08.001 · Cited by 80 · see citing works

Identification of key pathways and metabolic fingerprints of longevity in C. elegans

Gao, A. W., Smith, R. L., van Weeghel, M., Kamble, R., Janssens, G. E., & Houtkooper, R. H. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.10.003 · Cited by 80 · see citing works

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Gao, A. W., Chatzispyrou, I. A., Kamble, R., Liu, Y. J., Herzog, K., Smith, R. L., van Lenthe, H., Vervaart, M. A. T., van Cruchten, A., Luyf, A. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02539-w · Cited by 77 · see citing works

The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development

Tebbenkamp, A. T. N., Varela, L., Choi, J., Paredes, M. I., Giani, A. M., Song, J. E., Šestan-Peša, M., Franjic, D., Sousa, A. M. M., Liu, Z.-W., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.014 · Cited by 71 · see citing works

Mitochondrial fatty acid oxidation drives senescence

Yamauchi, S., Sugiura, Y., Yamaguchi, J., Zhou, X., Takenaka, S., Odawara, T., Fukaya, S., Fujisawa, T., Naguro, I., Uchiyama, Y., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado5887 · Cited by 71 · see citing works

Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging.

Son, J. M., Sarsour, E. H., Kakkerla Balaraju, A., Fussell, J., Kalen, A. L., Wagner, B. A., Buettner, G. R., & Goswami, P. C. (2017) · Aging Cell · doi:10.1111/acel.12649 · Cited by 71 · see citing works

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance

van Beek, H., Kirkwood, T. B. L., & Bassingthwaighte, J. B. (2016) · Interface Focus · doi:10.1098/rsfs.2015.0079 · Cited by 68 · see citing works

Physiological links of circadian clock and biological clock of aging

Liu, F., & Chang, H.-C. (2017) · Protein & Cell · doi:10.1007/s13238-016-0366-2 · Cited by 68 · see citing works

Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing

Pazoki–Toroudi, H., Amani, H., Ajami, M., Nabavi, S. F., Braidy, N., Kasi, P. D., & Nabavi, S. M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.07.004 · Cited by 68 · see citing works

Targeting glucose metabolism for healthy aging

Brewer, R. A., Gibbs, V. K., & Smith, D. L. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160007 · Cited by 65 · see citing works

Questions and controversies in innate immune research: what is the physiological role of NLRP3?

Coll, R. C., O'Neill, L. A. J., & Schroder, K. (2016) · Cell Death Discovery · doi:10.1038/cddiscovery.2016.19 · Cited by 67 · see citing works

Mitochondrial health, the epigenome and healthspan

Aon, M. A., Cortassa, S., Juhaszova, M., & Sollott, S. J. (2016) · Clinical Science · doi:10.1042/cs20160002 · Cited by 66 · see citing works

Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease

Song, J., & Kim, J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00065 · Cited by 66 · see citing works

Muscoloskeletal aging, sarcopenia and cancer

Colloca, G. A., Capua, B. D., Bellieni, A., Cesari, M., Marzetti, E., Valentini, V., & Calvani, R. (2018) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2018.11.007 · Cited by 64 · see citing works

Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity

Wilson, C. H., Nikolic, A., Kentish, S. J., Keller, M., Hatzinikolas, G., Dorstyn, L., Page, A. J., & Kumar, S. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.518 · Cited by 61 · see citing works

Lacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans

Zhang, J., Zhao, Y., Sun, Z., & Sun, T. (2022) · Communications Biology · doi:10.1038/s42003-022-04031-2 · Cited by 60 · see citing works

Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice

Yeh, C., Shen, Z., Wang, T.-W., Kao, C., Teng, Y., Yeh, T., Lu, C.-K., & Tsai, T. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00838-7 · Cited by 61 · see citing works

Circadian Rhythms in Cardiovascular Metabolism

Lal, H., Verma, S. K., Wang, Y., Xie, M., & Young, M. E. (2024) · Circulation Research · doi:10.1161/circresaha.123.323520 · Cited by 62 · see citing works

The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases

Yan, J., Nie, Y., Cao, J., Luo, M., Yan, M., Chen, Z., & He, B. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.655575 · Cited by 53 · see citing works

Translational Targeted Proteomics Profiling of Mitochondrial Energy Metabolic Pathways in Mouse and Human Samples

Wolters, J. C., Čiapaitė, J., van Eunen, K., Niezen‐Koning, K. E., Matton, A. P. M., Porte, R. J., Horvatovich, P. L., Bakker, B. M., Bischoff, R., & Permentier, H. P. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00419 · Cited by 52 · see citing works

Lipid and glucose metabolism in senescence

Liu, B., Meng, Q., Gao, X., Sun, H., Xu, Z., Wang, Y., & Zhou, H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1157352 · Cited by 53 · see citing works

The Cardiac Circadian Clock

Young, M. E. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.03.024 · Cited by 47 · see citing works

HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis

Lin, X.-W., Tang, L., Yang, J., & Xu, W. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.07.007 · Cited by 45 · see citing works

How Inflammation Blunts Innate Immunity in Aging

Goldberg, E. L., Shaw, A. C., & Montgomery, R. R. (2020) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000504480 · Cited by 45 · see citing works

Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

Neal, S. J., Takeishi, A., O’Donnell, M. P., Park, J., Hong, M., Butcher, R. A., Kim, K., & Sengupta, P. (2015) · eLife · doi:10.7554/elife.10110 · Cited by 44 · see citing works

Mitochondrial form, function and signalling in aging

Amigo, I., da Cunha, F. M., Forni, M. F., Garcia-Neto, W., Kakimoto, P. A., Luévano‐Martínez, L. A., Macedo, F. P., Menezes‐Filho, S. L., Peloggia, J., & Kowaltowski, A. J. (2016) · Biochemical Journal · doi:10.1042/bcj20160451 · Cited by 42 · see citing works

Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis

Fame, R. M., & Lehtinen, M. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.780207 · Cited by 47 · see citing works

ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans

Zaarur, N., Desevin, K., Mackenzie, J., Lord, A., Grishok, A., & Kandror, K. V. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.07.001 · Cited by 41 · see citing works

Pharmacological potentials of lycopene against aging and aging‐related disorders: A review

Abir, M. H., Mahamud, A. G. M. S. U., Tonny, S., Anu, M., Hossain, K., Protic, I. A., Khan, M. S. U., Baroi, A., Moni, A., & Uddin, M. J. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3523 · Cited by 37 · see citing works

A bacterial polysaccharide biosynthesis-related gene inversely regulates larval settlement and metamorphosis of Mytilus coruscus

Peng, L.-H., Liang, X. H., Chang, R.-H., Mu, J.-Y., Chen, H.-E., Yoshida, A., Osatomi, K., & Yang, J.-L. (2020) · Biofouling · doi:10.1080/08927014.2020.1807520 · Cited by 39 · see citing works

Dialogue between E. coli free radical pathways and the mitochondria of C. elegans

Govindan, J. A., Jayamani, E., Zhang, X. L., Mylonakis, E. E., & Ruvkun, G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517448112 · Cited by 37 · see citing works

Nutrient sensing and utilization: getting to the heart of metabolic flexibility

Griffin, T. M., Humphries, K. M., Kinter, M., Lim, H.-Y., & Szweda, L. I. (2016) · Biochimie · doi:10.1016/j.biochi.2015.10.013 · Cited by 36 · see citing works

‘Inside Out’– a dialogue between mitochondria and bacteria

Han, B., Lin, C.-C., Hu, G., & Wang, M. C. (2018) · FEBS Journal · doi:10.1111/febs.14692 · Cited by 35 · see citing works

Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30

Otarigho, B., & Aballay, A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109187 · Cited by 37 · see citing works

Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis

Vidali, S., Chéret, J., Giesen, M., Haeger, S., Alam, M. A., Watson, R. E. B., Langton, A. K., Klinger, M. H. F., Knuever, J., Funk, W., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.118 · Cited by 35 · see citing works

The role of lipids in aging-related metabolic changes

de Diego, I., Peleg, S., & Fuchs, B. (2019) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2019.05.005 · Cited by 34 · see citing works

Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo

Enot, D. P., Niso‐Santano, M., Durand, S., Chery, A., Pietrocola, F., Vacchelli, E., Madeo, F., Galluzzi, L., & Kroemer, G. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1064206 · Cited by 31 · see citing works

Intermittent fasting improves metabolic flexibility in short-term high-fat diet-fed mice

Dedual, M. A., Wueest, S., Borsigova, M., & Konrad, D. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2019 · Cited by 31 · see citing works

TGF-β and BMP signals regulate insect diapause through Smad1-POU-TFAM pathway

Li, H., Lin, X.-W., Geng, S., & Xu, W. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.06.002 · Cited by 29 · see citing works

Deciphering clock genes as emerging targets against aging

Zhu, Y., Liu, Y., Escames, G., Yang, Z. Z., Zhao, H., Lu, Q., Xue, C., Xu, D., Acuña-Castroviejo, D., & Yang, Y. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101725 · Cited by 31 · see citing works

Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells

Docherty, C. K., Salt, I. P., & Mercer, J. R. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0323-2 · Cited by 29 · see citing works

Uncoupling protein 2 protects mice from aging

Hirose, M., Schilf, P., Lange, F., Mayer, J., Reichart, G., Maity, P., Jöhren, O., Schwaninger, M., Scharffetter‐­Kochanek, K., Sina, C., et al. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.06.004 · Cited by 27 · see citing works

The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review

Soh, J., Raventhiran, S., Lee, J. H., Lim, Z. X., Goh, J., Kennedy, B. K., & Maier, A. B. (2023) · GeroScience · doi:10.1007/s11357-023-00970-8 · Cited by 27 · see citing works

JNK modifies neuronal metabolism to promote proteostasis and longevity

Wang, L., Davis, S. S., Jensen, M. B., Rodriguez‐Fernandez, I. A., Apaydin, C., Juhász, G., Gibson, B. W., Schilling, B., Ramanathan, A., Ghaemmaghami, S., et al. (2019) · Aging Cell · doi:10.1111/acel.12849 · Cited by 24 · see citing works

Targeting immunosenescence for improved tumor immunotherapy

Liu, Z., Zuo, L., Zhou, Z., Liu, S., Ba, Y., Zuo, A., Ren, Y., Zhang, C., Chen, Y., Ma, H., et al. (2024) · MedComm · doi:10.1002/mco2.777 · Cited by 24 · see citing works

Grape-Seed Proanthocyanidin Extract Reverts Obesity-Related Metabolic Derangements in Aged Female Rats

Sierra‐Cruz, M., Miguéns‐Gómez, A., Grau‐Bové, C., Rodríguez‐Gallego, E., Blay, M., Pinent, M., Ardèvol, A., Terra, X., & Beltrán‐Debón, R. (2021) · Nutrients · doi:10.3390/nu13062059 · Cited by 23 · see citing works

Obesity, Metabolism, and Aging: A Multiscalar Approach

Bentley, R. A., Ross, C. N., & O’Brien, M. J. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.016 · Cited by 21 · see citing works

Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease

Pang, Y., Yang, J., Liu, J., Xie, Z., & Wang, J. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1731771 · Cited by 21 · see citing works

Tuning up an aged clock: Circadian clock regulation in metabolism and aging

Sato, S., Solanas, G., Sassone‐Corsi, P., & Benitah, S. A. (2021) · Translational Medicine of Aging · doi:10.1016/j.tma.2021.11.003 · Cited by 21 · see citing works

An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock

Garcia, R. A. P., Darley-Usmar, V. M., & Young, M. E. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.013 · Cited by 20 · see citing works

Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives

Olivero, P., Lozano, C., Sotomayor‐Zárate, R., Meza-Concha, N., Marcelo Arancibia, M., Córdova, C., González‐Arriagada, W. A., Ramírez-Barrantes, R., & Marchant, I. (2018) · Neural Plasticity · doi:10.1155/2018/6798712 · Cited by 20 · see citing works

A Handheld Metabolic Device (Lumen) to Measure Fuel Utilization in Healthy Young Adults: Device Validation Study

Lorenz, K. A., Yeshurun, S., Aziz, R., Ortiz-Delatorre, J., Bagley, J. R., Mor, M., & Kern, M. (2021) · Interactive Journal of Medical Research · doi:10.2196/25371 · Cited by 19 · see citing works

Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link?

Wu, N. N., & Ren, J. T. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-6260-6_15 · Cited by 19 · see citing works

Senoinflammation: A major mediator underlying age-related metabolic dysregulation

Kim, D. H., Bang, E., Arulkumar, R., Ha, S., Chung, K. W., Park, M. H., Choi, Y. J., Yu, B. P., & Chung, H. Y. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110891 · Cited by 19 · see citing works

Parallelized, real-time, metabolic-rate measurements from individual Drosophila

Fiorino, A., Thompson, D., Yadlapalli, S., Jiang, C., Shafer, O. T., Reddy, P., & Meyhöfer, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-32744-0 · Cited by 17 · see citing works

The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans

Phan, H., Nguyen, T. T. M., Lee, S., Seo, M., An, Y., & de Guzman, A. C. V. (2023) · Metabolomics · doi:10.1007/s11306-023-02022-w · Cited by 17 · see citing works

Double-Face of Vasohibin-1 for the Maintenance of Vascular Homeostasis and Healthy Longevity

Sato, Y. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.43398 · Cited by 17 · see citing works

Divergent evolution of life span associated with mitochondrial DNA evolution

Stojković, B., Sayadi, A., Đorđević, M., Jović, J., Savković, U., & Arnqvist, G. (2016) · Evolution · doi:10.1111/evo.13102 · Cited by 17 · see citing works

The microbiota and aging microenvironment in pancreatic cancer: Cell origin and fate

Chen, Z., Wang, Z., Du, Y., Shi, H., & Zhou, W. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188826 · Cited by 17 · see citing works

Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

Takeda, E., Suzuki, Y., Yamada, T., Katagiri, H., & Sato, Y. (2017) · Journal of Aging Research · doi:10.1155/2017/9851380 · Cited by 16 · see citing works

Circadian Control of Cardiac Metabolism: Physiologic Roles and Pathologic Implications

Young, M. E. (2017) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-13-1-15 · Cited by 16 · see citing works

Identification of a previously undetected metabolic defect in the Complex II Caenorhabditis elegans mev-1 mutant strain using respiratory control analysis

Fong, S., Ng, L. F., Ng, L. T., Moore, P. K., Halliwell, B. B., & Gruber, J. (2016) · Biogerontology · doi:10.1007/s10522-016-9672-6 · Cited by 15 · see citing works

Gonadal hormones influence core body temperature during calorie restriction

Cintrón-Colón, R., Shankar, K., Sánchez-Alavez, M., & Conti, B. (2019) · Temperature · doi:10.1080/23328940.2019.1607653 · Cited by 15 · see citing works

Caenorhabditis elegans as a Model for the Effects of Phytochemicals on Mitochondria and Aging

Schmitt, F., & Eckert, G. P. (2022) · Biomolecules · doi:10.3390/biom12111550 · Cited by 14 · see citing works

Chaotic aging: intrinsically disordered proteins in aging-related processes

Manyilov, V. D., Ilyinsky, N. S., Nesterov, S. V., Saqr, B. M. G. A., Dayhoff, G. W., Zinovev, E. V., Matrenok, S. S., Fonin, A. V., Kuznetsova, I. M., Turoverov, K. K., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04897-3 · Cited by 14 · see citing works

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Grilo, L. F., Zimmerman, K. D., Puppala, S., Chan, J., Huber, H. F., Li, G., Jadhav, A. Y. L., Wang, B., Li, C., Clarke, G. D., et al. (2024) · Advanced Science · doi:10.1002/advs.202309211 · Cited by 13 · see citing works

The ability of decline in intrinsic capacity to indicate the risk of mortality in older adults: A meta-analysis

Li, Y., Yang, T., Wang, X., He, X., Dong, J., Qian, Q., Zhang, X., Zheng, J., Fan, X., & Ma, Y. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.108109 · Cited by 13 · see citing works

Diurnal, metabolic and thermogenic alterations in a murine model of accelerated aging

Allison, D. B., Ren, G., Garcia, R. A. P., Mia, S., McGinnis, G. R., Davis, J. A., Gamble, K. L., Kim, J., & Young, M. E. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1796699 · Cited by 13 · see citing works

Immunosenescence and immunotherapy in elderly patients with hepatocellular carcinoma

Zhang, D., Zhu, Y., Shen, Z., Ma, S., Liu, S., & Lu, Z. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.02.010 · Cited by 12 · see citing works

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells

Jackson, J., Wischhof, L., Scifo, E., Pellizzer, A., Wang, Y., Piazzesi, A., Gentile, D., Siddig, S., Stork, M., Hopkins, C. E., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101503 · Cited by 12 · see citing works

Metabolic Regulation of Cardiovascular Aging

Gao, M., & Finkel, T. (2025) · Current Cardiology Reports · doi:10.1007/s11886-025-02279-8 · Cited by 10 · see citing works

The protease Lon prolongs insect lifespan by responding to reactive oxygen species and degrading mitochondrial transcription factor A

Su, X.-L., Su, Z., & Xu, W. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119648 · Cited by 10 · see citing works

Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation

Shi, P., Xu, S., Yang, Z., Wang, L., Wu, Y., Li, Y., & Zhu, Z. (2024) · iMetaOmics. · doi:10.1002/imo2.36 · Cited by 11 · see citing works

Therapeutic Role of Fibroblast Growth Factor 21 (FGF21) in the Amelioration of Chronic Diseases

Opoku, Y. K., Liu, Z., Afrifa, J., Khoso, M. H., Ren, G., & Li, D. (2019) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-019-09820-8 · Cited by 10 · see citing works

Use of Intrinsic Capacity Domains as a Screening Tool in Public Health

do Nascimento, L. M., da Cruz, T. G. C., Silva, J. F. D. L. E., Silva, L. P., Inácio, B. B., Sadamitsu, C. M. O., & Scheicher, M. E. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20054227 · Cited by 10 · see citing works

Multifactorial processes to slowing the biological clock: Insights from a comparative approach

Sanchez, J. R., Milton, S., Corbit, K. C., & Buffenstein, R. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.08.017 · Cited by 10 · see citing works

Circadian rhythms in cardiac metabolic flexibility

Young, M. E., & Latimer, M. N. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1939366 · Cited by 9 · see citing works

Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration

Troulinaki, K., & Bano, D. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00244 · Cited by 24 · see citing works

Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions

Tomtheelnganbee, E., Sah, P., & Sharma, R. (2022) · Biogerontology · doi:10.1007/s10522-022-09978-7 · Cited by 24 · see citing works

Mitochondrial energy metabolism and ageing

Bratic, I., & Trifunović, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.004 · Cited by 268 · see citing works

The metabolic regulation of aging

Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works

Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing

Bettedi, L., & Foukas, L. C. (2017) · Biogerontology · doi:10.1007/s10522-017-9724-6 · Cited by 54 · see citing works