The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
Open accessAbstract
A double punch against SARS-CoV-2: Monoclonal antibodies are an important weapon in the battle against COVID-19. However, these large proteins are difficult to produce in the needed quantities and at low cost. Attention has turned to nanobodies, which are aptly named, single-domain antibodies that are easier to produce and have the potential to be administered by inhalation. Koenig et al. describe four nanobodies that bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prevent infection of cells (see the Perspective by Saelens and Schepens). Structures show that the nanobodies target two distinct epitopes on the SARS-CoV-2 spike protein. Multivalent nanobodies neutralize virus much more potently than single nanobodies, and multivalent nanobodies that bind two epitopes prevent the emergence of viral escape mutants. Science , this issue p. eabe6230 ; see also p. 681
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Metadata
- Authors
- Koenig, P.-A., Das, H., Liu, H., Kümmerer, B. M., Gohr, F. N., Jenster, L.-M., Schiffelers, L. D. J., Tesfamariam, Y. M., Uchima, M., Wuerth, J. D., Gatterdam, K., Ruetalo, N., Christensen, M. H., Fandrey, C. I., Normann, S., Tödtmann, J. M. P., Pritzl, S., Hanke, L., Boos, J., Yuan, M., Zhu, X., Schmid-Burgk, J. L., Kato, H., Schindler, M., Wilson, I. A., Geyer, M., Ludwig, K. U., Hällberg, B. M., Wu, N. C., & Schmidt, F. I.
- Venue
- Science
- Published
- 2021-02-12
- Volume
- 371
- Issue
- 6530
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3119147846
- Cited by
- 396
- References
- 75
- FWCI
- 25.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Koenig, P.-A., Das, H., Liu, H., Kümmerer, B. M., Gohr, F. N., Jenster, L.-M., Schiffelers, L. D. J., Tesfamariam, Y. M., Uchima, M., Wuerth, J. D., Gatterdam, K., Ruetalo, N., Christensen, M. H., Fandrey, C. I., Normann, S., Tödtmann, J. M. P., Pritzl, S., Hanke, L., Boos, J., . . . Schmidt, F. I. (2021). Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science. https://doi.org/10.1126/science.abe6230
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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