The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
The microbiome and gut homeostasis
Abstract
Changes in the composition of the gut microbiota are associated with many human diseases. So far, however, we have failed to define homeostasis or dysbiosis by the presence or absence of specific microbial species. The composition and function of the adult gut microbiota is governed by diet and host factors that regulate and direct microbial growth. The host delivers oxygen and nitrate to the lumen of the small intestine, which selects for bacteria that use respiration for energy production. In the colon, by contrast, the host limits the availability of oxygen and nitrate, which results in a bacterial community that specializes in fermentation for growth. Although diet influences microbiota composition, a poor diet weakens host control mechanisms that regulate the microbiota. Hence, quantifying host parameters that control microbial growth could help define homeostasis or dysbiosis and could offer alternative strategies to remediate dysbiosis.
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The gut–liver axis and gut microbiota in health and liver disease
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Bile acids as modulators of gut microbiota composition and function
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Metadata
- Authors
- Lee, J.-Y., Tsolis, R. M., & Bäumler, A. J.
- Venue
- Science
- Published
- 2022-07
- Volume
- 377
- Issue
- 6601
- Pages
- eabp9960-eabp9960
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4283731082
- Cited by
- 428
- References
- 140
- FWCI
- 23.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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