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Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
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Neutrophils form gasdermin D pores and expel antimicrobial neutrophil extracellular traps to defend against cytosolic bacteria.
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“A gasdermin family member closely related to GSDMD, GSDME, was recently shown to execute pyroptosis during chemotherapy (40) and uncontrolled apoptosis (41).”
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Gasdermin D plays a vital role in the generation of neutrophil extracellular traps
Sollberger, G., Choidas, A., Burn, G. L., Habenberger, P., Di Lucrezia, R., Kordes, S., Menninger, S., Eickhoff, J., Nussbaumer, P., Klebl, B., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar6689 · Cited by 758
Self-citation
Metadata
- Authors
- Chen, K. W., Monteleone, M., Boucher, D., Sollberger, G., Ramnath, D., Condon, N. D., von Pein, J. B., Broz, P., Sweet, M. J., & Schroder, K.
- Venue
- Science Immunology
- Published
- 2018-08-03
- Volume
- 3
- Issue
- 26
- ISSN
- 2470-9468 (ISSN-L)
- OpenAlex
- W2888168693
- Cited by
- 639
- References
- 51
- FWCI
- 17.70
- Type
- journal article
- Language
- en
- Open access
- green
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