Cited by 224NF-κB Signaling PathwaysPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

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Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling

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Liu, Caini, Qian, Wen, Qian, Youcun, Giltiay, Natalia V., Lu, Yi, Swaidani, Shadi, Misra, Saurav, Deng, Li, Chen, Zhijian J., Li, Xiaoxia·2009·Science Signaling

DOI 10.1126/scisignal.2000382PMC PMC3182834

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Abstract

The adaptor protein Act1 functions as a ubiquitin ligase to mediate interleukin-17 receptor–dependent activation of nuclear factor-κB.

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Authors: Liu, C., Qian, W., Qian, Y., Giltiay, N. V., Lu, Y., Swaidani, S., Misra, S., Deng, L., Chen, Z. J., & Li, X.
Affiliations: Cleveland Clinic (US)
Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44915, USA.
The University of Texas Southwestern Medical Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Liu, Caini
Qian, Youcun
Li, Xiaoxia
ORCID: Liu, Caini
Qian, Youcun
Giltiay, Natalia V.
Lu, Yi
Swaidani, Shadi
Misra, Saurav
Deng, Li
Chen, Zhijian J.
Li, Xiaoxia
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-10-13
Volume: 2
Issue: 92
Pages: ra63-ra63
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.2000382
PMC: PMC3182834
OpenAlex: W2145468317
Cited by: 224
References: 34
Citations by year: 2026: 10 · 2025: 21 · 2024: 3 · 2023: 9 · 2022: 15 · 2021: 12 · 2020: 8 · 2019: 18 · 2018: 13 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 15
FWCI: 5.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL098935)
National Institute of General Medical Sciences (R01GM080271)
National Institute of Allergy and Infectious Diseases (R01AI065470)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: Act1, U-box E3 ubiquitin ligase, IL-17 signaling, IL-17 receptor, TRAF6, NF-κB activation, Th17 cells, ubiquitination, inflammation
MeSH terms: Amino Acid Sequence, Animals, Humans, Mice, Transgenic, Molecular Sequence Data, Mutation, Signal Transduction, Cytokines, Sequence Homology, Amino Acid, Interleukin-17, Ubiquitin-Protein Ligases, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, TNF Receptor-Associated Factor 6, Adaptor Proteins, Signal Transducing, Mice

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Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling

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