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Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling
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The adaptor protein Act1 functions as a ubiquitin ligase to mediate interleukin-17 receptor–dependent activation of nuclear factor-κB.
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“GATA4 induced the expression of TRAF3IP2, an E3 ubiquitin ligase for TRAF6 (51) (Fig. 4C)”
From The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. (2015) · cites this paper as [51]
In the citing paper
“Act1 has E3 Ubiquitin ligase activity”
From The IL-17 Family of Cytokines in Health and Disease (2019) · cites this paper as Liu et al., 2009
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Metadata
- Authors
- Liu, C., Qian, W., Qian, Y., Giltiay, N. V., Lu, Y., Swaidani, S., Misra, S., Deng, L., Chen, Z. J., & Li, X.
- Affiliations
- Cleveland Clinic (US)
- Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44915, USA.
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Liu, Caini
- Qian, Youcun
- Li, Xiaoxia
- ORCID
- Venue
- Science Signaling
- Published
- 2009-10-13
- Volume
- 2
- Issue
- 92
- Pages
- ra63-ra63
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3182834
- OpenAlex
- W2145468317
- Cited by
- 224
- References
- 34
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 3 · 2023: 9 · 2022: 15 · 2021: 12 · 2020: 8 · 2019: 18 · 2018: 13 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 15
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL098935)
- National Institute of General Medical Sciences (R01GM080271)
- National Institute of Allergy and Infectious Diseases (R01AI065470)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- Act1, U-box E3 ubiquitin ligase, IL-17 signaling, IL-17 receptor, TRAF6, NF-κB activation, Th17 cells, ubiquitination, inflammation
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Mice, Transgenic, Molecular Sequence Data, Mutation, Signal Transduction, Cytokines, Sequence Homology, Amino Acid, Interleukin-17, Ubiquitin-Protein Ligases, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, TNF Receptor-Associated Factor 6, Adaptor Proteins, Signal Transducing, Mice
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