Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease
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Abstract
Alzheimer's disease (AD) is a form of dementia characterized by amyloid-β plaques and tau neurofibrillary tangles that progressively disrupt neural circuits in the brain. The signaling networks underlying AD pathological changes are poorly characterized at the phosphoproteome level. Using mass spectrometry, we analyzed the proteome and tyrosine, serine and threonine phosphoproteomes of temporal cortex tissue from patients with AD and aged-matched controls. We identified cocorrelated peptide clusters that were linked to varying levels of phospho-tau, oligodendrocyte, astrocyte, microglia and neuron pathologies. We found that neuronal synaptic protein abundances were strongly anti-correlated with markers of microglial reactivity. We also observed that phosphorylation sites on kinases targeting tau and other new signaling factors were correlated with these peptide modules. Finally, we used data-driven statistical modeling to identify individual peptides and peptide clusters that were predictive of AD histopathologies. Together, these results build a map of pathology-associated phosphorylation signaling events occurring in AD.
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PKC substrates make up over half of the core molecules in AD.
“Studies have shown that PKC is one of the key kinases activated in AD, and PKC substrates make up over half of the core molecules in AD. 75 , 76”
From Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes (2025) · cites this paper as [75]
In “AD kinase networks overlap with substrate and mouse model phosphoproteomes” (page unavailable), the paper reports that PKCA-regulated phosphosites are associated with AD-related cluster centroids. It does not say that PKC substrates constitute over half of any set of “core molecules” in AD; the proportion and category are unsupported. (LLM, conf=0.79)
Experimental — accuracy not yet measuredPKC is one of the key kinases activated in AD.
“Studies have shown that PKC is one of the key kinases activated in AD, and PKC substrates make up over half of the core molecules in AD. 75 , 76”
From Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes (2025) · cites this paper as [75]
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- Authors
- Morshed, N., Lee, M. J., Rodriguez, F. H., Lauffenburger, D. A., Mastroeni, D., & White, F. M.
- Affiliations
- Koch Institute for Integrative Cancer Research At MIT (US)
- Massachusetts Institute of Technology (US)
- New Mexico State University (US)
- Arizona State University (US)
- Corresponding author
- White, Forest M.
- ORCID
- Venue
- Nature Aging
- Published
- 2021-06-14
- Volume
- 1
- Issue
- 6
- Pages
- 550-565
- ISSN
- 2662-8465 (ISSN-L)
- OpenAlex
- W3170458329
- Cited by
- 58
- References
- 124
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 12 · 2023: 7 · 2022: 6 · 2021: 5
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Nature Aging (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- United States Department of Defense | United States Army | Research, Development and Engineering Command (W911NF-19-2-0026)
- NSF | Directorate for Education & Human Resources | Division of Graduate Education (1745302)
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (T32GM008334)
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (U24 NS072026)
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (P30 AG19610)
- Arizona Department of Health Services (211002)
- ADHS | Arizona Biomedical Research Commission (contracts 4001, 0011, 05-901 and 1001)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, phosphoproteomics, kinase signaling networks, temporal cortex, tau phosphorylation, microglial activation, amyloid plaques, neurofibrillary tangles, disease progression, predictive biomarkers
- MeSH terms
- Alzheimer Disease, Humans, Neurons, Amyloid beta-Peptides, Neurofibrillary Tangles, tau Proteins, Plaque, Amyloid
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