FAK-mediated signaling controls amyloid beta overload, learning and memory deficits in a mouse model of Alzheimer’s disease
Open accessAbstract
The non-receptor focal adhesion kinase (FAK) is highly expressed in the central nervous system during development, where it regulates neurite outgrowth and axon guidance, but its role in the adult healthy and diseased brain, specifically in Alzheimer’s disease (AD), is largely unknown. Using the 3xTg-AD mouse model, which carries three mutations associated with familial Alzheimer’s disease (APP KM670/671NL Swedish, PSEN1 M146V, MAPT P301L) and develops age-related progressive neuropathology including amyloid plaques and Tau tangles, we describe here, for the first time, the in vivo role of FAK in AD pathology. Our data demonstrate that while site-specific knockdown in the hippocampi of 3xTg-AD mice has no effect on learning and memory, hippocampal overexpression of the protein leads to a significant decrease in learning and memory capabilities, which is accompanied by a significant increase in amyloid β (Aβ) load. Furthermore, neuronal morphology is altered following hippocampal overexpression of FAK in these mice. High-throughput proteomics analysis of total and phosphorylated proteins in the hippocampi of FAK overexpressing mice indicates that FAK controls AD-like phenotypes by inhibiting cytoskeletal remodeling in neurons which results in morphological changes, by increasing Tau hyperphosphorylation, and by blocking astrocyte differentiation. FAK activates cell cycle re-entry and consequent cell death while downregulating insulin signaling, thereby increasing insulin resistance and leading to oxidative stress. Our data provide an overview of the signaling networks by which FAK regulates AD pathology and identify FAK as a novel therapeutic target for treating AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple canonical focal adhesion signaling molecules are actively engaged in the AD brain.
“Interestingly, previous work has uncovered that multiple canonical focal ad hesion signaling molecules are actively engaged in the AD brain.”
From Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis (2026) · cites this paper as Saleh et al., 2022
Dynamic FAK signaling is commonly seen surrounding Aβ plaques in human AD patients.
“For instance, dynamic FAK signaling is commonly seen sur rounding Aβ plaques in human AD patients (Grace and Busciglio, 2003; Saleh et al., 2022)”
From Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis (2026) · cites this paper as Saleh et al., 2022
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works
2021 Alzheimer's disease facts and figures
Anonymous (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12328 · Cited by 2,236 · see citing works
Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works
Regulation of NMDA receptor trafficking by amyloid-β
Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · see citing works
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
Oddo, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.012 · Cited by 980 · see citing works
Treatment of Alzheimer's disease; current status and new perspectives
Scarpini, E. A., Scheltens, P., & Feldman, H. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00502-7 · Cited by 720 · see citing works
Moechars, D., Dewachter, I., Lorent, K., Reversé, D., Baekelandt, V., Naidu, A., Tesseur, I., Spittaels, K., Haute, C. V. D., Checler, F., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6483 · Cited by 668 · see citing works
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
Schaller, M. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.045112 · Cited by 599 · see citing works
González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 525 · see citing works
The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice
LaFerla, F. M., Tinkle, B. T., Bieberich, C. J., Haudenschild, C. C., & Jay, G. (1995) · Nature Genetics · doi:10.1038/ng0195-21 · Cited by 513 · see citing works
Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
Nagele, R. G., D’Andrea, M. R., Lee, H., Venkataraman, V., & Wang, H.-Y. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02361-8 · Cited by 416 · see citing works
Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling
Palazzo, A. F., Eng, C. H., Schlaepfer, D. D., Marcantonio, E. E., & Gundersen, G. G. (2004) · Science · doi:10.1126/science.1091325 · Cited by 416 · see citing works
A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis
He, F., Ge, W., Martinowich, K., Becker-Catania, S. G., Coskun, V., Zhu, W., Wu, H., Castro, D. S., Guillemot, F., Fan, G., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1440 · Cited by 398 · see citing works
Zhu, X., Rottkamp, C. A., Boux, H., Takeda, A., Perry, G., & Smith, M. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.10.880 · Cited by 378 · see citing works
Role of focal adhesion kinase in integrin signaling
Guan, J. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00051-4 · Cited by 352 · see citing works
Molecular mechanisms of dendrite stability
Koleske, A. J. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3486 · Cited by 351 · see citing works
Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.
McCall, M. A., Gregg, R. G., Behringer, R. R., Brenner, M., Delaney, C. L., Galbreath, E. J., Zhang, C. L., Pearce, R. A., Chiu, S. Y., & Messing, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6361 · Cited by 349 · see citing works
Britsch, S., Li, L., Kirchhoff, S., Theuring, F., Brinkmann, V., Birchmeier, C., & Riethmacher, D. (1998) · Genes & Development · doi:10.1101/gad.12.12.1825 · Cited by 344 · see citing works
How does brain insulin resistance develop in Alzheimer's disease?
De Felice, F. G., Lourenco, M. V., & Ferreira, S. T. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.12.004 · Cited by 337 · see citing works
Lee, J. K., & Kim, N. (2017) · Molecules · doi:10.3390/molecules22081287 · Cited by 323 · see citing works
An, W.-L., Cowburn, R. F., Li, L., Braak, H., Alafuzoff, I., Iqbal, K., Iqbal, I.-G., Winblad, B., & Pei, J.-J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63687-5 · Cited by 312 · see citing works
Aberrant insulin signaling in Alzheimer's disease: current knowledge
Bedse, G., Domenico, F. D., Serviddio, G., & Cassano, T. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00204 · Cited by 294 · see citing works
Picanço, L. C. D. S., Ozela, P. F., Brito, M. D. F. D. B., Pinheiro, A. A., Padilha, E. C., Braga, F. S., da Silva, C. H. T. D. P., Santos, C. B. R., Rosa, J. M. C., & Hage-Melim, L. I. D. S. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666161213101126 · Cited by 285 · see citing works
The Role of Cdk5 in Alzheimer’s Disease
Liu, S., Wang, C., Jiang, T., Tan, L., Xing, A., & Yu, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9369-x · Cited by 273 · see citing works
Lin, Y., & Koleske, A. J. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153204 · Cited by 241 · see citing works
Insulin Resistance in Alzheimer's Disease
Ferreira, L. S. S., Fernandes, C., Vieira, M. N. N., & Felice, F. G. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00830 · Cited by 229 · see citing works
Williamson, R., Scales, T., Clark, B. R., Gibb, G., Reynolds, C. H., Kellie, S., Bird, I. N., Varndell, I. M., Sheppard, P. W., Everall, I., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00010.2002 · Cited by 227 · see citing works
Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?
Stanley, M., Macauley, S. L., & Holtzman, D. M. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160493 · Cited by 199 · see citing works
Actin dynamics and cofilin‐actin rods in alzheimer disease
Bamburg, J. R., & Bernstein, B. W. (2016) · Cytoskeleton · doi:10.1002/cm.21282 · Cited by 181 · see citing works
Shi, Y., Pontrello, C. G., DeFea, K., Reichardt, L. F., & Ethell, I. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4681-08.2009 · Cited by 166 · see citing works
p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
Hooper, C., Meimaridou, E., Tavassoli, M., Melino, G., Lovestone, S., & Killick, R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.026 · Cited by 165 · see citing works
Herskowitz, J. H., Feng, Y., Mattheyses, A. L., Hales, C. M., Higginbotham, L. A., Duong, D. M., Montine, T. J., Troncoso, J. C., Thambisetty, M., Seyfried, N. T., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2508-13.2013 · Cited by 150 · see citing works
DNA Damage and Repair in Alzheimers Disease
Coppede, F., & Migliore, L. (2009) · Current Alzheimer Research · doi:10.2174/156720509787313970 · Cited by 148 · see citing works
p38 MAPK and PI3K/AKT Signalling Cascades inParkinson's Disease.
Jha, S. K., Jha, N. K., Kar, R., Ambasta, R. K., & Kumar, P. (2015) · Europe PMC (PubMed Central) · Cited by 143 · see citing works
Targeting the JAK2/STAT3 axis in Alzheimer's disease
Chiba, T., Yamada, M., & Aiso, S. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903213426 · Cited by 136 · see citing works
Grant, S. G. N., Karl, K. A., Kiebler, M. A., & Kandel, E. R. (1995) · Genes & Development · doi:10.1101/gad.9.15.1909 · Cited by 136 · see citing works
The role of the DNA damage response in neuronal development, organization and maintenance
Barzilai, A., Biton, S., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.005 · Cited by 135 · see citing works
Ehrengruber, M. U., Hennou, S., Büeler, H., Naim, H. Y., Déglon, N., & Lundstrom, K. H. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.0982 · Cited by 133 · see citing works
The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death
Xiao, L., Chen, D., Hu, P., Wu, J., Liu, W., Zhao, Y. L., Cao, M., Fang, Y., Bi, W., Zheng, Z., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0035-11.2011 · Cited by 123 · see citing works
Henderson, B. W., Gentry, E. G., Rush, T., Troncoso, J. C., Thambisetty, M., Montine, T. J., & Herskowitz, J. H. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13688 · Cited by 120 · see citing works
Gupta, A. K., & Dey, C. S. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-05-0337 · Cited by 119 · see citing works
Neurons in Vulnerable Regions of the Alzheimer’s Disease Brain Display Reduced ATM Signaling
Shen, X., Chen, J., Li, J., Kofler, J., & Herrup, K. (2016) · eNeuro · doi:10.1523/eneuro.0124-15.2016 · Cited by 118 · see citing works
Grace, E. A., & Busciglio, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00493.2003 · Cited by 113 · see citing works
Alfonso, S. I., Callender, J. A., Hooli, B., Antal, C. E., Mullin, K., Sherman, M. A., Lesné, S. E., Leitges, M., Newton, A. C., Tanzi, R. E., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aaf6209 · Cited by 103 · see citing works
Focal adhesions regulate Aβ signaling and cell death in Alzheimer's disease
Caltagarone, J., Jing, Z., & Bowser, R. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.11.007 · Cited by 102 · see citing works
Caccamo, A., Branca, C., Talboom, J. S., Shaw, D. M., Turner, D., Ma, L., Messina, A. A., Huang, Z., Wu, J., & Oddo, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2781-15.2015 · Cited by 101 · see citing works
Neuroinflammation, immune system and Alzheimer disease: searching for the missing link
Guerriero, F., Sgarlata, C. S., Francis, M., Maurizi, N., Faragli, A., Perna, S., Rondanelli, M., Rollone, M., & Ricevuti, G. (2016) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0637-z · Cited by 97 · see citing works
p70 Ribosomal protein S6 kinase ( Rps6kb1 ): an update
Bahrami-B, F., Ataie-Kachoie, P., Pourgholami, M. H., & Morris, D. L. (2014) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2014-202560 · Cited by 96 · see citing works
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease
Wang, B.-J., Her, G. M., Hu, M., Chen, Y.-W., Tung, Y.-T., Wu, P., Hsu, W., Lee, H., Jin, L., Hwang, S. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618804114 · Cited by 92 · see citing works
Hanson, J. E., Ma, K., Elstrott, J., Weber, M., Saillet, S., Khan, A. S., Simms, J. A., Liu, B., Kim, T. A., Yu, G.-Q., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.030 · Cited by 86 · see citing works
Marzia Perluigi, A., Barone, E., Domenico, F. D., & Butterfield, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.005 · Cited by 85 · see citing works
Altered subcellular distribution of c-Abl in Alzheimer’s disease
Jing, Z., Caltagarone, J., & Bowser, R. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1062 · Cited by 83 · see citing works
ROCK1 and ROCK2 inhibition alters dendritic spine morphology in hippocampal neurons
Swanger, S. A., Mattheyses, A. L., Gentry, E. G., & Herskowitz, J. H. (2015) · Cellular Logistics · doi:10.1080/21592799.2015.1133266 · Cited by 80 · see citing works
p70 S6 Kinase and Tau in Alzheimer's Disease
Pei, J.-J., Björkdahl, C., Zhang, H., Zhou, X., & Winblad, B. G. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14405 · Cited by 75 · see citing works
Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease
Kang, D. E., & Woo, J. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190585 · Cited by 67 · see citing works
Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production
Herskowitz, J. H., Seyfried, N. T., Gearing, M., Kahn, R., Peng, J., Levey, A. I., & Lah, J. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.167239 · Cited by 55 · see citing works
Keeler, A. B., Schreiner, D., & Weiner, J. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.642306 · Cited by 50 · see citing works
IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model
Sohrabi, M., Floden, A. M., Manocha, G. D., Klug, M. G., & Combs, C. K. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00200 · Cited by 49 · see citing works
The rise and fall of insulin signaling in Alzheimer’s disease
Chami, B., Steel, A. J., de la Monte, S. M., & Sutherland, G. T. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9806-1 · Cited by 48 · see citing works
Toutant, M., Studler, J., Burgaya, F., COSTA, A., Ezan, P., Gelman, M., & Girault, J. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3480119 · Cited by 48 · see citing works
Monje, F. J., Kim, E., Pollak, D. D., Cabatic, M., Li, L., Baston, A., & Lübec, G. (2011) · Neurosignals · doi:10.1159/000330193 · Cited by 46 · see citing works
Dystroglycan promotes filopodial formation and process branching in differentiating oligodendroglia
Eyermann, C. E., Czaplinski, K., & Colognato, H. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07600.x · Cited by 45 · see citing works
Burgaya, F., & Girault, J. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00273-u · Cited by 41 · see citing works
Brzdąk, P., Wójcicka, O., Zaręba-Kozioł, M., Minge, D., Henneberger, C., Włodarczyk, J., Mozrzymas, J. W., & Wójtowicz, T. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx324 · Cited by 34 · see citing works
Integrins mediate β‐amyloid‐induced cell‐cycle activation and neuronal death
Frasca, G., Carbonaro, V., Merlo, S., Copani, A., & Sortino, M. A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21487 · Cited by 33 · see citing works
DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants
Kwan, V., Meka, D. P., White, S. H., Hung, C. L.-K., Holzapfel, N. T., Walker, S., Murtaza, N., Unda, B. K., Schwanke, B., Yuen, R. K. C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.047 · Cited by 30 · see citing works
Reliable and durable Golgi staining of brain tissue from human autopsies and experimental animals
Rosoklija, G. B., Petruševski, V. M., Stankov, A., Dika, A., Jakovski, Z., Pavlovski, G., Davcheva, N., Lipkin, R., Schnieder, T. P., Scobie, K., et al. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.04.006 · Cited by 30 · see citing works
Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer’s disease
Yu, W., Shin, M. R., & Sesti, F. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0886-1 · Cited by 28 · see citing works
Focal adhesion kinase negatively regulates neuronal insulin resistance
Gupta, A. K., Bisht, B., & Dey, C. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.011 · Cited by 27 · see citing works
Li, S., Du, D., Hasan, M. T., & Köhr, G. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu229 · Cited by 18 · see citing works
Xu, Y.-X., Wang, H.-Q., Yan, J., Sun, X.-B., Guo, J.-C., & Zhu, C.-Q. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.09.022 · Cited by 15 · see citing works
PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling
Mansour, M., Nievergall, E., Gegenbauer, K., Llerena, C., Atapattu, L., Hallé, M., Tremblay, M. L., Janes, P. W., & Lackmann, M. (2015) · Journal of Cell Science · doi:10.1242/jcs.174490 · Cited by 11 · see citing works
Commentary on Giralt et al.: PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease
Polis, B., & Gil-Henn, H. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.011 · Cited by 8 · see citing works
Self-citationYue, L., Sam, C., Arora, N., Winkler, D. F. H., & Pelech, S. (2017) · Clinical Proteomics and Bioinformatics · doi:10.15761/cpb.1000119 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
3 of the 77 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Badesso, S., Cartas‐Cejudo, P., Espelosin, M., Santamaría, E., Cuadrado‐Tejedor, M., & García‐Osta, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010082 · Cited by 17 · see citing works
Ivanova, M., Belaya, I., Kucháriková, N., Maciel, I. D. S., Saveleva, L., Alatalo, A., Juvonen, I., Thind, N., Andrès, C., Lampinen, R., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106410 · Cited by 12 · see citing works
Neuronal insulin signaling and resistance: a balancing act of kinases and phosphatases
Sharma, M., Yadav, Y., & Dey, C. S. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0151 · Cited by 9 · see citing works
The potential and therapeutic advances of the integrin family in neurological disorders
Zhang, X., Gao, L., Wang, Y., Meng, Q., Bai, M., Xu, D., Wang, Y., Wang, J., Bi, H., & Ding, Y. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00020 · Cited by 7 · see citing works
Afxenti, S., Zachariou, M., Athieniti, E., Lambrianides, A., Pantzaris, M., & Spyrou, G. M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06937-x · Cited by 6 · see citing works
Non-conducting functions of potassium channels in cancer and neurological disease
Sesti, F., Bortolami, A., & Forzisi, E. (2023) · Current topics in membranes · doi:10.1016/bs.ctm.2023.09.007 · Cited by 3 · see citing works
Dogra, V., Choudhary, M., Parashar, A., & Choudhary, N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.26.542404
Anti-inflammatory and immunomodulating agents
Britten, J. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30008-0.00014-4
Zhang, H. E., Xiao, M. L., Ji, J., Cheng, Y., & Fang, L. (2025) · BMC Neurology · doi:10.1186/s12883-025-04582-x
Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis
Walsh, A. E., Davis, B. A., Samuels, J. D., Mills, W. A., Thanos, J. M., Johnson, A. M., Moore, K. A., Puchalski, M. A., Steacy, E. J., Wendell, B. W., et al. (2026) · Journal of Experimental Medicine · doi:10.1084/jem.20260104
- Authors
- Saleh, B., Srikanth, K. D., Sneh, T., Yue, L., Pelech, S., Elliott, E., & Gil-Henn, H.
- Affiliations
- Bar-Ilan University (IL)
- University of British Columbia (CA)
- Corresponding author
- Gil-Henn, Hava
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-08-13
- Volume
- 23
- Issue
- 16
- Pages
- 9055
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9408823
- OpenAlex
- W4293515870
- Cited by
- 10
- References
- 77
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Weisfeld Family Foundation
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- focal adhesion kinase, Alzheimer's disease, amyloid-beta, 3xTg-AD mice, learning and memory impairment, hippocampus, neuronal morphology, cytoskeletal remodeling, tau hyperphosphorylation, astrocyte differentiation, cell cycle re-entry, neuronal cell death, insulin resistance, oxidative stress, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Memory Disorders, Mice, Transgenic, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Mice, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesion Kinase 1, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
