The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions
Open accessAbstract
Vesicles shed from astrocytes after brain trauma trigger hepatic cytokine release to mobilize the peripheral immune response.
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“EVs have functional roles in neuron–glia and CNS–periphery communication following neurotrauma by regulating neuronal function, axonal regeneration and remyelination, metabolic activity, and the inflammatory milieu [192, 193].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [192]
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1 retracted
Ottani, A., Giuliani, D., Mioni, C., Galantucci, M., Minutoli, L., Bitto, A., Altavilla, D., Zaffe, D., Botticelli, A. R., Squadrito, F., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.140 · Cited by 65
RetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,402
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Cited by
Sorted by citations
Gurunathan, S., Kang, M.-H., Jeyaraj, M., Qasim, M., & Kim, J. (2019) · Cells · doi:10.3390/cells8040307 · Cited by 1,160
Banks, W. A., Sharma, P., Bullock, K. M., Hansen, K. M., Ludwig, N., & Whiteside, T. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124407 · Cited by 561
“An efflux system would explain why CNS-derived exosomes are found in the circulation [7], raising the question of their role in disease states and supporting their usefulness as biomarkers of CNS diseases.”
BackgroundInfluentialChen, Z., Venkat, P., Seyfried, D., Chopp, M., Yan, T., & Chen, J. (2017) · Circulation Research · doi:10.1161/circresaha.117.311170 · Cited by 574
Bidirectional Microglia–Neuron Communication in Health and Disease
Szepesi, Z., Manouchehrian, O., Bachiller, S., & Deierborg, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00323 · Cited by 459
Imaging extracellular vesicles: current and emerging methods
Chuo, S. T., Chien, J. C.-Y., & Lai, C. P. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0494-5 · Cited by 371
Metadata
- Authors
- Dickens, A. M., Tovar-y-Romo, L. B., Yoo, S.-W., Trout, A. L., Bae, M., Kanmogne, M., Megra, B., Williams, D. W., Witwer, K. W., Gacias, M., Tabatadze, N., Cole, R. N., Casaccia, P., Berman, J. W., Anthony, D. C., & Haughey, N. J.
- Affiliations
- Johns Hopkins University (US)
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
- Albert Einstein College of Medicine (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of Oxford (GB)
- Corresponding author
- Dickens, Alex M.
- Haughey, Norman J.
- ORCID
- Venue
- Science Signaling
- Published
- 2017-04-04
- Volume
- 10
- Issue
- 473
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5590230
- OpenAlex
- W2604553302
- Cited by
- 285
- References
- 68
- Citations by year
- 2026: 24 · 2025: 24 · 2024: 35 · 2023: 39 · 2022: 41 · 2021: 35 · 2020: 30 · 2019: 25 · 2018: 21 · 2017: 11
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Clinical Center (award283882)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- leukocyte transmigration, IL-1β, PPARα, NF-κB, microRNA cargo, neuroinflammation
- MeSH terms
- Extracellular Vesicles, Animals, Animals, Newborn, Astrocytes, Brain, Cells, Cultured, Ceramides, Leukocytes, Mononuclear, Male, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Microscopy, Fluorescence, Sphingomyelin Phosphodiesterase, Blotting, Western, Cytokines, Mice, Knockout, Inflammation Mediators, RNA Interference, Interleukin-1beta, Transcellular Cell Migration
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