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Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions
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Vesicles shed from astrocytes after brain trauma trigger hepatic cytokine release to mobilize the peripheral immune response.
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“EVs have functional roles in neuron–glia and CNS–periphery communication following neurotrauma by regulating neuronal function, axonal regeneration and remyelination, metabolic activity, and the inflammatory milieu [192, 193].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [192]
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Metadata
- Authors
- Dickens, A. M., Tovar-y-Romo, L. B., Yoo, S.-W., Trout, A. L., Bae, M., Kanmogne, M., Megra, B., Williams, D. W., Witwer, K. W., Gacias, M., Tabatadze, N., Cole, R. N., Casaccia, P., Berman, J. W., Anthony, D. C., & Haughey, N. J.
- Affiliations
- Johns Hopkins University (US)
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
- Albert Einstein College of Medicine (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of Oxford (GB)
- Corresponding author
- Dickens, Alex M.
- Haughey, Norman J.
- ORCID
- Venue
- Science Signaling
- Published
- 2017-04-04
- Volume
- 10
- Issue
- 473
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5590230
- OpenAlex
- W2604553302
- Cited by
- 285
- References
- 68
- Citations by year
- 2026: 24 · 2025: 24 · 2024: 35 · 2023: 39 · 2022: 41 · 2021: 35 · 2020: 30 · 2019: 25 · 2018: 21 · 2017: 11
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Clinical Center (award283882)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- leukocyte transmigration, IL-1β, PPARα, NF-κB, microRNA cargo, neuroinflammation
- MeSH terms
- Extracellular Vesicles, Animals, Animals, Newborn, Astrocytes, Brain, Cells, Cultured, Ceramides, Leukocytes, Mononuclear, Male, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Microscopy, Fluorescence, Sphingomyelin Phosphodiesterase, Blotting, Western, Cytokines, Mice, Knockout, Inflammation Mediators, RNA Interference, Interleukin-1beta, Transcellular Cell Migration
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