Cited by 287Extracellular vesicles in diseaseNeuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

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Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

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Dickens, Alex M., Tovar-y-Romo, Luis B., Yoo, Seung-Wan, Trout, Amanda L., Bae, Mihyun, Kanmogne, Marlene, Megra, Bezawit, Williams, Dionna W., Witwer, Kennith W., Gacias, Mar, Tabatadze, Nino, Cole, Robert N., Casaccia, Patrizia, Berman, Joan W., Anthony, Daniel C., Haughey, Norman J.·2017·Science Signaling

DOI 10.1126/scisignal.aai7696PMC PMC5590230

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Abstract

Vesicles shed from astrocytes after brain trauma trigger hepatic cytokine release to mobilize the peripheral immune response.

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Authors: Dickens, A. M., Tovar-y-Romo, L. B., Yoo, S.-W., Trout, A. L., Bae, M., Kanmogne, M., Megra, B., Williams, D. W., Witwer, K. W., Gacias, M., Tabatadze, N., Cole, R. N., Casaccia, P., Berman, J. W., Anthony, D. C., & Haughey, N. J.
Affiliations: Johns Hopkins University (US)
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Albert Einstein College of Medicine (US)
Icahn School of Medicine at Mount Sinai (US)
University of Oxford (GB)
Corresponding author: Dickens, Alex M.
Haughey, Norman J.
ORCID: Dickens, Alex M.
Tovar-y-Romo, Luis B.
Yoo, Seung-Wan
Trout, Amanda L.
Bae, Mihyun
Kanmogne, Marlene
Williams, Dionna W.
Witwer, Kennith W.
Gacias, Mar
Tabatadze, Nino
Cole, Robert N.
Casaccia, Patrizia
Berman, Joan W.
Anthony, Daniel C.
Haughey, Norman J.
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2017-04-04
Volume: 10
Issue: 473
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.aai7696
PMC: PMC5590230
OpenAlex: W2604553302
Cited by: 285
References: 68
Citations by year: 2026: 24 · 2025: 24 · 2024: 35 · 2023: 39 · 2022: 41 · 2021: 35 · 2020: 30 · 2019: 25 · 2018: 21 · 2017: 11
FWCI: 9.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH Clinical Center (award283882)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: leukocyte transmigration, IL-1β, PPARα, NF-κB, microRNA cargo, neuroinflammation
MeSH terms: Extracellular Vesicles, Animals, Animals, Newborn, Astrocytes, Brain, Cells, Cultured, Ceramides, Leukocytes, Mononuclear, Male, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Microscopy, Fluorescence, Sphingomyelin Phosphodiesterase, Blotting, Western, Cytokines, Mice, Knockout, Inflammation Mediators, RNA Interference, Interleukin-1beta, Transcellular Cell Migration

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Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

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