The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.
Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
Open accessAbstract
Common changes in signaling pathway–associated gene expression may explain why chronic pain or stress can lead to depression.
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“LAMB2 is involved in neuropathic pain and influencing gene expression changes in brain pathways implicated in depression.36”
From Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions (2021) · cites this paper as [36]
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Cites
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Causal analysis approaches in Ingenuity Pathway Analysis
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Cellular and Molecular Mechanisms of Pain
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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
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Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
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Research works printed but not linked: 1
- Committee on Advancing Pain Research and Education Relieving Pain in America: A Blueprint for Transforming Prevention Care Education and Research (The National Academies Press 2011).
Cited by
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Role of the Prefrontal Cortex in Pain Processing
Ong, W., Stohler, C. S., & Herr, D. R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1130-9 · Cited by 824
Levey, D. F., Stein, M. B., Wendt, F. R., Pathak, G. A., Zhou, H., Aslan, M., Quaden, R., Harrington, K. M., Nuñez, Y. Z., Overstreet, C., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00860-2 · Cited by 422
Zhou, X., Wahane, S., Friedl, M.-S., Kluge, M., Friedel, C. C., Avrampou, K., Zachariou, V., Guo, L., Zhang, B., He, X., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0597-7 · Cited by 275
Self-citationThe Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities
Serafini, R. A., Pryce, K. D., & Zachariou, V. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.10.018 · Cited by 252
Self-citationThe Role of the Locus Coeruleus in Pain and Associated Stress-Related Disorders
Suárez‐Pereira, I., Llorca-Torralba, M., Bravo, L., Camarena-Delgado, C., Soriano‐Mas, C., & Berrocoso, E. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.023 · Cited by 181
Metadata
- Authors
- Descalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Zachariou, Venetia
- ORCID
- Venue
- Science Signaling
- Published
- 2017-03-21
- Volume
- 10
- Issue
- 471
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5524975
- OpenAlex
- W2600178581
- Cited by
- 188
- References
- 171
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 21 · 2023: 22 · 2022: 18 · 2021: 28 · 2020: 17 · 2019: 26 · 2018: 12 · 2017: 6
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (award287707)
- National Institute of Neurological Disorders and Stroke (award287708)
- Banting Research Foundation (award287709)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- neuropathic pain, depression, chronic stress, gene expression, transcriptome, nucleus accumbens, medial prefrontal cortex, periaqueductal gray, spared nerve injury, chronic unpredictable mild stress, signaling pathways, anxiety
- MeSH terms
- Adaptation, Physiological, Animals, Brain, Depression, Gene Expression Regulation, Mice, Inbred C57BL, Nerve Net, Neuralgia, Nucleus Accumbens, Periaqueductal Gray, Stress, Psychological, Signal Transduction, Cluster Analysis, Prefrontal Cortex, Mice, Knockout, Gene Expression Profiling, Chronic Pain
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