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Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
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Common changes in signaling pathway–associated gene expression may explain why chronic pain or stress can lead to depression.
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“LAMB2 is involved in neuropathic pain and influencing gene expression changes in brain pathways implicated in depression.36”
From Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions (2021) · cites this paper as [36]
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Metadata
- Authors
- Descalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Zachariou, Venetia
- ORCID
- Venue
- Science Signaling
- Published
- 2017-03-21
- Volume
- 10
- Issue
- 471
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5524975
- OpenAlex
- W2600178581
- Cited by
- 188
- References
- 171
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 21 · 2023: 22 · 2022: 18 · 2021: 28 · 2020: 17 · 2019: 26 · 2018: 12 · 2017: 6
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (award287707)
- National Institute of Neurological Disorders and Stroke (award287708)
- Banting Research Foundation (award287709)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- neuropathic pain, depression, chronic stress, gene expression, transcriptome, nucleus accumbens, medial prefrontal cortex, periaqueductal gray, spared nerve injury, chronic unpredictable mild stress, signaling pathways, anxiety
- MeSH terms
- Adaptation, Physiological, Animals, Brain, Depression, Gene Expression Regulation, Mice, Inbred C57BL, Nerve Net, Neuralgia, Nucleus Accumbens, Periaqueductal Gray, Stress, Psychological, Signal Transduction, Cluster Analysis, Prefrontal Cortex, Mice, Knockout, Gene Expression Profiling, Chronic Pain
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