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Ultrasound‐Induced Mechanical Compaction in Acoustically Responsive Scaffolds Promotes Spatiotemporally Modulated Signaling in Triple Negative Breast Cancer

Humphries, B. A., Aliabouzar, M., Quesada, C., Bevoor, A. S., Ho, K. K. Y., Farfel, A. P., Buschhaus, J. M., Rajendran, S., Fabiilli, M. L., & Luker, G. D. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202101672 · Cited by 11 · see citing works

Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling

Spinosa, P. C., Kinnunen, P. C., Humphries, B. A., Luker, G. D., Luker, K. E., & Linderman, J. J. (2021) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-020-00640-1 · Cited by 10 · see citing works

Characterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays

Kinnunen, P. C., Humphries, B. A., Luker, G. D., Luker, K. E., & Linderman, J. J. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00369-x · Cited by 12 · see citing works

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2

Neves, M., Perpiñá-Viciano, C., Penela, P., Hoffmann, C., & Mayor, F. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00021 · Cited by 8 · see citing works

Computational methods for characterizing and learning from heterogeneous cell signaling data

Kinnunen, P. C., Luker, K. E., Luker, G. D., & Linderman, J. J. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.04.009 · Cited by 8 · see citing works

Oscillatory ERK Signaling and Morphology Determine Heterogeneity of Breast Cancer Cell Chemotaxis via MEK-ERK and p38-MAPK Signaling Pathways

Ho, K. K. Y., Srivastava, S., Kinnunen, P. C., Garikipati, K., Luker, G. D., & Luker, K. E. (2023) · Bioengineering · doi:10.3390/bioengineering10020269 · Cited by 8 · see citing works

Substrate stiffness regulates triple-negative breast cancer signaling through CXCR4 receptor dynamics

Ho, K. K. Y., Buschhaus, J. M., Zhang, A., Cutter, A. C., Humphries, B. A., & Luker, G. D. (2025) · Scientific Reports · doi:10.1038/s41598-025-14495-x · Cited by 7 · see citing works

Optimal phenotypic adaptation in fluctuating environments

George, J. T. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.10.019 · Cited by 6 · see citing works

Molecular sensors for detection of tumor-stroma crosstalk

Fuller, B. T., Buczynksi, E. M., Beshay, P. E., & Song, J. W. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2022.01.001 · Cited by 5 · see citing works

Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells

Eckley, S. S., Buschhaus, J. M., Humphries, B. A., Robison, T. H., Luker, K. E., & Luker, G. D. (2019) · Tomography · doi:10.18383/j.tom.2019.00019 · Cited by 6 · see citing works

Inference of weak-form partial differential equations describing migration and proliferation mechanisms in wound healing experiments on cancer cells

Srivastava, S., Kinnunen, P. C., Wang, Z., Ho, K. K. Y., Humphries, B. A., Chen, S., Linderman, J. J., Luker, G. D., Luker, K. E., & Garikipati, K. (2025) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1013607 · Cited by 5 · see citing works

Mechanisms of resistance to bruton’s tyrosine kinase inhibitors: synergistic effects of tumor microenvironment regulation and signaling pathways

Dong, X., Tang, S., Chen, M., Chen, Q., Wang, Y., Shi, Y., Deng, Y., Chen, Y., He, Z., Yu, L., et al. (2026) · Annals of Hematology · doi:10.1007/s00277-026-06775-x · Cited by 4 · see citing works

Computational modeling implicates protein scaffolding in p38 regulation of Akt

Kinnunen, P. C., Luker, G. D., Luker, K. E., & Linderman, J. J. (2022) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2022.111294 · Cited by 4 · see citing works

Integrating inverse reinforcement learning into data-driven mechanistic computational models: a novel paradigm to decode cancer cell heterogeneity

Kinnunen, P. C., Ho, K. K. Y., Srivastava, S., Huang, C., Shen, W., Garikipati, K., Luker, G. D., Banović, N., Huan, X., Linderman, J. J., et al. (2024) · Frontiers in Systems Biology · doi:10.3389/fsysb.2024.1333760 · Cited by 3 · see citing works

Application of advanced light source based X-ray imaging technology in single-cell research

Zhang, S., Guo, Y., Wang, Y., & Chen, C. (2023) · Scientia Sinica Chimica · doi:10.1360/ssc-2023-0124 · Cited by 2 · see citing works

Quantitative Spatiotemporal Analysis of Intracellular Kinase Activity in Metastatic Breast Cancer Cells Using a Microfluidic-Based Lateral Diffusion Assay

Fuller, B. T., Jones, T. H., Chan, E. T., D'souza, M. W., Luker, K. E., Luker, G. D., & Song, J. W. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c01060 · Cited by 1 · see citing works

Molecular Imaging of Cellular Signaling Pathways

Luker, K. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816386-3.00044-2

Cell-to-cell variability of dynamic CXCL12-CXCR4 signaling and morphological processes in chemotaxisPreprint

Ho, K. K. Y., Srivastava, S., Kinnunen, P. C., Garikipati, K., Luker, G. D., & Luker, K. E. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.19.492090

Optimal Cellular Phenotypic Adaptation in Fluctuating EnvironmentsPreprint

George, J. T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.17.524479

Escitalopram disrupts PDK1–Akt signaling in B cells through a structure-dependent mechanism independent of SERT

Tseng, Y., & Chiang, M.-L. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.120086

Remembering the past for CXCR4 signaling

Wong, W. (2019) · Science · doi:10.1126/science.365.6449.135-r

Cell-to-cell variability of dynamic CXCL12-CXCR4 signaling and morphological processes in chemotaxisPreprint

Ho, K. K. Y., Srivastava, S., Kinnunen, P. C., Garikipati, K., Luker, G. D., & Luker, K. E. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.19.492090

Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling

Spinosa, P. C., Kinnunen, P. C., Humphries, B. A., Luker, G. D., Luker, K. E., & Linderman, J. J. (2021) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-020-00640-1 · Cited by 10 · see citing works

CXCL12 Induces Tyrosine Phosphorylation of Cortactin, Which Plays a Role in CXC Chemokine Receptor 4-mediated Extracellular Signal-regulated Kinase Activation and Chemotaxis

Luo, C., Pan, H., Mines, M. A., Watson, K., Zhang, J., & Fan, G.-H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605837200 · Cited by 38 · see citing works

Stroma-Derived SDF-1 Confers Chemoresistance to CXCR4-Expressing Breast Cancer Cells

Schraufstätter, I. U. (2007) · doi:10.21236/ada487272