Cited by 300PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerMuscle metabolism and nutrition

The role of mammalian target of rapamycin (mTOR) in insulin signaling

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Yoon, Mee-Sup·2017·Nutrients

Abstract

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate each other through a feedback loop to control cell growth. This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism.

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Authors
Yoon, M.-S.
Affiliations
Gachon University (KR)
Corresponding author
Yoon, Mee-Sup
Venue
Nutrients
Publisher
MDPI AG
Published
2017-10-27
Volume
9
Issue
11
Pages
1176
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2766921609
Cited by
300
References
142
Citations by year
2026: 17 · 2025: 33 · 2024: 28 · 2023: 30 · 2022: 47 · 2021: 46 · 2020: 43 · 2019: 34 · 2018: 20 · 2016: 1
FWCI
2.48
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1D1A1A01058313)
  • the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare (HI17C0426)
  • the Gachon University Gil Medical Center (2015-15)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
mTOR, insulin signaling, mTORC1, mTORC2, raptors, Rictor, Grb10, IRS-1, IGF-1 receptor, insulin receptor, cell growth regulation, whole-body metabolism, feedback loops
MeSH terms
Mechanistic Target of Rapamycin Complex 1, Regulatory-Associated Protein of mTOR, Mechanistic Target of Rapamycin Complex 2, Rapamycin-Insensitive Companion of mTOR Protein, Animals, Humans, Insulin, Receptor, Insulin, Signal Transduction, Receptor, IGF Type 1, F-Box Proteins, Cell Proliferation, GRB10 Adaptor Protein, Insulin Receptor Substrate Proteins, TOR Serine-Threonine Kinases

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