STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

MEME SUITE: tools for motif discovery and searching

Bailey, T. L., Boden, M., Buske, F. A., Frith, M., Grant, C. E., Clementi, L., Ren, J., Li, W. W., & Noble, W. S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp335 · Cited by 10,648

Comprehensive molecular characterization of human colon and rectal cancer

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data

Colaprico, A., Silva, T. C., Olsen, C., Garofano, L., Cava, C., Garolini, D., Sabedot, T. S., Malta, T. M., Pagnotta, S. M., Castiglioni, I., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1507 · Cited by 4,205

Stat3 as an Oncogene

Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790

TEAD mediates YAP-dependent gene induction and growth control

Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498

Revisiting STAT3 signalling in cancer: new and unexpected biological functions

Yu, H., Lee, H., Herrmann, A., Buettner, R., & Jove, R. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3818 · Cited by 2,137

YAP/TAZ at the Roots of Cancer

Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970

The Biology of YAP/TAZ: Hippo Signaling and Beyond

Piccolo, S., Dupont, S., & Cordenonsi, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00005.2014 · Cited by 1,873

Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications

Fang, J., Lu, Y., Zheng, J., Jiang, X., Shen, H., Xi, S., Lu, Y., & Fu, P. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06119-x · Cited by 220

Endothelial cells in tumor microenvironment: insights and perspectives

Leone, P., Malerba, E., Susca, N., Favoino, E., Perosa, F., Brunori, G., Prete, M., & Racanelli, V. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1367875 · Cited by 158

Role of CD14 in human disease

Sharygin, D. A., Koniaris, L. G., Wells, C. D., Zimmers, T. A., & Hamidi, T. (2023) · Immunology · doi:10.1111/imm.13634 · Cited by 147

Targeting PI3K/Akt signaling in prostate cancer therapy

Hashemi, M., Taheriazam, A., Daneii, P., Hassanpour, A., Kakavand, A., Rezaei, S., Hejazi, E. S., Aboutalebi, M., Gholamrezaie, H., Saebfar, H., et al. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00702-1 · Cited by 100

Three‐Step Regenerative Strategy: Multifunctional Bilayer Hydrogel for Combined Photothermal/Photodynamic Therapy to Promote Drug‐Resistant Bacteria‐Infected Wound Healing

Zha, K., Zhang, W., Hu, W., Tan, M., Zhang, S., Yongsheng, Y., Gou, S., Bu, P., Zhou, B., Zou, Y., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202308145 · Cited by 92

Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer

Baroja, I., Kyriakidis, N. C., Halder, G. A., & Moya, I. M. (2024) · Nature Communications · doi:10.1038/s41467-024-46531-1 · Cited by 96

The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment

Mokhtari, R. B., Ashayeri, N., Baghaie, L., Sambi, M., Satari, K., Baluch, N., Bosykh, D. A., Szewczuk, M. R., & Chakraborty, S. (2023) · Cancers · doi:10.3390/cancers15133468 · Cited by 92

New insights into the ambivalent role of YAP/TAZ in human cancers

Luo, J., Deng, L., Zou, H., Guo, Y., Tong, T., Huang, M., Ling, G., & Li, P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02704-2 · Cited by 89

Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies

Cai, C., Wu, F., He, J., Zhang, Y., Shi, N., Peng, X., Ou, Q., Li, Z., Jiang, X., Zhong, J., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.75402 · Cited by 77

Effects of RNA methylation on Tumor angiogenesis and cancer progression

Han, M., Sun, H., Zhou, Q., Liu, J., Hu, J., Yuan, W., & Sun, Z. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01879-8 · Cited by 59

Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy

Lei, Y., Liu, Q., Chen, B., Wu, F., Li, Y., Dong, X., Ma, N., Wu, Z., Zhu, Y., Wang, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53601-x · Cited by 64

Astragalus polysaccharide ameliorates CD8+ T cell dysfunction through STAT3/Gal-3/LAG3 pathway in inflammation‐induced colorectal cancer

Li, Q., Zhang, C., Xu, G., Shang, X., Nan, X., Li, Y., Liu, J., Hong, Y., Wang, Q., & Peng, G. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116172 · Cited by 57

The fibroinflammatory response in cancer

Xiao, Z., & Puré, E. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00798-8 · Cited by 65

Angiogenesis and targeted therapy in the tumour microenvironment: From basic to clinical practice

Yang, S., Fang, Y., Ma, Y., Wang, F., Wang, Y., Jia, J., Yang, Y., Sun, W., Zhou, Q., & Li, Z. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70313 · Cited by 61

Pulmonary vascular fibrosis in pulmonary hypertension – The role of the extracellular matrix as a therapeutic target

Jandl, K., Radic, N., Zeder, K., Kovács, G., & Kwapiszewska, G. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108438 · Cited by 54

Tumor-associated macrophages induce inflammation and drug resistance in a mechanically tunable engineered model of osteosarcoma

Chim, L. K., Williams, I. L., Bashor, C. J., & Mikos, A. G. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122076 · Cited by 47

The multifaceted role of YAP in the tumor microenvironment and its therapeutic implications in cancer

Kim, H., & Nam, J. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01551-9 · Cited by 55

Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2

Li, R., Shao, J., Jin, Y., Kawase, H., Ong, Y. T., Troidl, K., Quan, Q., Wang, L., Bonnavion, R., Wietelmann, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37671-x · Cited by 40

Empagliflozin activates Wnt/β-catenin to stimulate FUNDC1-dependent mitochondrial quality surveillance against type-3 cardiorenal syndrome

Cai, C., Wu, F., Zhuang, B., Ou, Q., Peng, X., Shi, N., Peng, L., Li, Z., Wang, J., Cai, S., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101553 · Cited by 34

Endothelial Stat3 activation promotes osteoarthritis development

Li, J., Zhang, W.-C., Liu, X., Li, G., Gu, Y., Zhang, K., Shen, F., Wu, X., Jiang, Y., Zhang, Q., et al. (2023) · Cell Proliferation · doi:10.1111/cpr.13518 · Cited by 34

The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis

Zhou, X., Yan, Z., Hou, J., Zhang, L., Chen, Z., Gao, C., Ahmad, N. H., Guo, M., Wang, W., Han, T., et al. (2024) · Oncogene · doi:10.1038/s41388-023-02923-z · Cited by 34

Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies

Khan, F., Pandey, P., Verma, M., & Upadhyay, T. K. (2024) · Biomolecules · doi:10.3390/biom14020200 · Cited by 31

The role of vascular endothelial cells in tumor metastasis

Feng, Y. J., Luo, S., Fan, D., Guo, X., & Ma, S. (2023) · Acta Histochemica · doi:10.1016/j.acthis.2023.152070 · Cited by 28

EFHD1 , a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma

Meng, K., Hu, Y., Wang, D.-K., Li, Y., Shi, F., Lu, J., Wang, Y., Cao, Y., Zhang, C. Z., & He, Q. (2023) · Cancer Science · doi:10.1111/cas.15749 · Cited by 29

Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway

Yuan, H., Zhao, Z., Xu, J., Zhang, R., Ma, L., Han, J., Zhao, W., Guo, M., & Song, Y. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02821-y · Cited by 27

MicroRNA-19a-3p inhibits endothelial dysfunction in atherosclerosis by targeting JCAD

Luo, J., Wang, L., Cui, C., Chen, H., Zeng, W., & Li, X. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04063-y · Cited by 25

Targeting Hippo pathway: A novel strategy for Helicobacter pylori-induced gastric cancer treatment

Liu, Y., Zhang, B., Zhou, Y., Xing, Y., Wang, Y., Jia, Y., & Liu, D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114549 · Cited by 24

Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells

Lidonnici, J., Santoro, M. M., & Oberkersch, R. E. (2022) · Cancers · doi:10.3390/cancers14112735 · Cited by 24

The effectiveness of blood-activating and stasis-transforming traditional Chinese medicines (BAST) in lung cancer progression-a comprehensive review

Wu, S., Sun, Z., Guo, Z., Li, P., Mao, Q., Tang, Y., Chen, H., Peng, H., Wang, S., & Cao, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116565 · Cited by 25

Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm’s canal cell pathobiology

Li, H., Kuhn, M. N., Kelly, R. A., Singh, A., Palanivel, K. K., Salama, I., Ieso, M. L. D., Stamer, W. D., Ganapathy, P. S., & Herberg, S. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00438.2023 · Cited by 24

Nucleoporin93 limits Yap activity to prevent endothelial cell senescence

Nguyen, T., Rao, M. K., Dhyani, S. P., Banks, J. M., Winek, M. A., Michalkiewicz, J., & Lee, M. Y. (2024) · Aging Cell · doi:10.1111/acel.14095 · Cited by 22

Endothelial cell diversity: the many facets of the crystal

Pérez, L., Li, P., & Ferrara, N. (2022) · FEBS Journal · doi:10.1111/febs.16660 · Cited by 22

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

Qian, H., Ding, C., Liu, F., Chen, S., Huang, C., Xiao, M., Hong, X.-L., Wang, M., Yan, F., Ding, K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01805-4 · Cited by 21

Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

Lei, Y., Hu, J., Zhao, J., Liu, Q., Zhang, S. W., Wu, F., Liu, Y., Ren, H., Qin, X., Wu, X., et al. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.01.009 · Cited by 19

CHRDL2 promotes cell proliferation by activating the YAP/TAZ signaling pathway in gastric cancer

Wang, L., Xu, W., Mei, Y., Wang, X., Liu, W., Yan, C., Ni, Z., Zhu, Z., & Ni, Z. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.006 · Cited by 15

Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury

Li, W., Ps, X., Kong, L., Feng, S., Shen, N., Huang, H., Wang, W., Xu, X., Wang, X., Wang, G., et al. (2023) · Translational research · doi:10.1016/j.trsl.2023.02.002 · Cited by 18

Targeting myeloperoxidase limits myeloid cell immunosuppression enhancing immune checkpoint therapy for pancreatic cancer

Basnet, A., Landreth, K. M., Nohoesu, R., Santiago, S. P., Geldenhuys, W. J., Boone, B. A., & Liu, T. W. B. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03647-z · Cited by 18

Kindlin-2 Phase Separation in Response to Flow Controls Vascular Stability

Ma, N., Wu, F., Liu, J., Wu, Z., Wang, L., Li, B., Liu, Y., Dong, X., Hu, J., Fang, X., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.324773 · Cited by 17

Brassinin Promotes the Degradation of Tie2 and FGFR1 in Endothelial Cells and Inhibits Triple-Negative Breast Cancer Angiogenesis

Gu, Y. J., Becker, V., Qiu, M., Tang, T., Ampofo, E., Menger, M. D., & Laschke, M. W. (2022) · Cancers · doi:10.3390/cancers14143540 · Cited by 17

Role of N6-methyladenosine in tumor neovascularization

Zhao, L., Li, Q., Zhou, T.-L., Liu, X., Guo, J., Fang, Q., Cao, X., Geng, Q., Yu, Y., Zhang, S., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06931-z · Cited by 17

Mechanotransduction pathways regulating YAP nuclear translocation under Yoda1 and vibration in osteocytes

Lin, C.-Y., Sassi, A., Wu, Y., Seaman, K., Tang, W., Song, X., Bienenstock, R., Yokota, H., Sun, Y., Geng, F., et al. (2024) · Bone · doi:10.1016/j.bone.2024.117283 · Cited by 17

YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders

Ajongbolo, A. O., & Langhans, S. A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1522705 · Cited by 21

Gambogic acid suppresses nasopharyngeal carcinoma via rewiring molecular network of cancer malignancy and immunosurveillance

Ren, T., Bai, X.-Y., Yang, M.-Z., Xu, N., Guo, X.-Z., Qin, L.-J., Huang, Z.-L., Zhong, Q.-Y., Huang, Y.-J., Lin, W., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113012 · Cited by 16

Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes

He, K., Dong, X., Yang, T., Li, Z., Liu, Y., He, J., Wu, M., Wei-Zhang, S., Kaysar, P., Cui, B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58074-0 · Cited by 20

Resistance Mechanisms of the Metastatic Tumor Microenvironment to Anti-Angiogenic Therapy

Schiffmann, L. M., Bruns, C. J., & Schmidt, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.897927 · Cited by 15

Vascular mimicry as a facilitator of melanoma brain metastasis

Provance, O. K., Oria, V. O., Tran, T. T. T., Caulfield, J. I., Zito, C. R., Aguirre, A., Schalper, K. A., Kluger, H. M., & Jilaveanu, L. B. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05217-z · Cited by 16

Anti-Cancer Activity of Verteporfin in Cholangiocarcinoma

Golino, J. L., Wang, X., Bian, J., Ruf, B., Kelly, M. E., Karim, B. O., Cam, M. C., & Xie, C. (2023) · Cancers · doi:10.3390/cancers15092454 · Cited by 15

Forced Overexpression of Signal Transducer and Activator of Transcription 3 (STAT3) Activates Yes-Associated Protein (YAP) Expression and Increases the Invasion and Proliferation Abilities of Small Cell Lung Cancer (SCLC) Cells

Hsu, P., Li, J., & Yang, C. (2022) · Biomedicines · doi:10.3390/biomedicines10071704 · Cited by 14

Dysregulated Hippo Signaling Pathway and YAP Activation in Atopic Dermatitis: Insights from Clinical and Animal Studies

Jeong, G. H., & Lee, J. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417322 · Cited by 14

YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis through Activating YAP Signaling in Vascular Endothelial Cells

Yan, Y., Song, Q., Li, Y., Zhao, L., & Cai, H. (2022) · Analytical Cellular Pathology · doi:10.1155/2022/5942379 · Cited by 14

The regulation of yes-associated protein/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium

Zhang, W., Li, Q., Gao, H., Wang, Y., Cheng, M., & Wang, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.925254 · Cited by 12

STAT3–mediated up-regulation of DAB2 via SRC-YAP1 signaling axis promotes Helicobacter pylori-driven gastric tumorigenesis

Duan, Y., Kong, P., Huang, M., Yan, Y., Dou, Y., Huang, B., Guo, J., Kang, W., Zhu, C., Wang, Y., et al. (2024) · Biomarker Research · doi:10.1186/s40364-024-00577-x · Cited by 11

Astragalus polysaccharide‐containing 3D ‐printed scaffold for traumatized skin repair and proteomic study

Du, W., Wang, Z., Han, M., Zheng, Y., Tao, B., Pan, N., Bao, G., Zhuang, W., & Quan, R. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70023 · Cited by 11

The role of YAP/TAZ mechanosignaling in trabecular meshwork and Schlemm’s canal cell dysfunction

Ghosh, R., & Herberg, S. (2024) · Vision Research · doi:10.1016/j.visres.2024.108477 · Cited by 13

The Role of Yes‐Associated Protein in Inflammatory Diseases and Cancer

Zhong, B., Du, J., Liu, F., & Sun, S. (2025) · MedComm · doi:10.1002/mco2.70128 · Cited by 10

3D Mechanical Response Stem Cell Complex Repairs Spinal Cord Injury by Promoting Neurogenesis and Regulating Tissue Homeostasis

Jiu, J., Liu, H., Li, D., Li, X., Zhang, J., Yan, L., Fan, Z., Li, S., Du, G., Li, J. J., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202404925 · Cited by 10

Fe-doped carbon dots: a novel fluorescent nanoprobe for cellular hypochlorous acid imaging

Yang, Y. M., Yuan, Y., Zhou, J. Y., Huang, C. Z., Zhen, S. J., & Zhan, L. (2023) · Analytical Sciences · doi:10.1007/s44211-023-00484-5 · Cited by 10

Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer

Wei, G., Nie, Y., Sun, M., Zhou, W., Zhao, H., Chen, F., & Zhu, C. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-06064-z · Cited by 11

The effects of STAT3 acetylation on the transcriptional activity and tumorigenesis

Yan, H., Tang, L., Zhu, Y., & Zhang, Y. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117076 · Cited by 9

YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations

Cunningham, R., Jia, S., Purohit, K. P., Salem, O., Hui, N. S., Lin, Y., Carragher, N. O., & Hansen, C. G. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1190 · Cited by 11

Magnetically Integrated Tumor–Vascular Interface System to Mimic Pro-angiogenic Endothelial Dysregulations for On-Chip Drug Testing

Surendran, V., Safarulla, S., Griffith, C. M., Ali, R., Madan, A., Polacheck, W. J., & Chandrasekaran, A. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c01766 · Cited by 9

Endothelial Pim3 kinase protects the vascular barrier during lung metastasis

Santio, N. M., Ganesh, K., Kaipainen, P. P., Halme, A., Seyednasrollah, F., Arbash, E., Hänninen, S., Kivelä, R., Carpen, O., & Saharinen, P. (2024) · Nature Communications · doi:10.1038/s41467-024-54445-1 · Cited by 9

DUOX2-Induced Oxidative Stress Inhibits Intestinal Angiogenesis through MMP3 in a Low-Birth-Weight Piglet Model

Zou, D., Yang, Y., Ji, F., Lv, R., Xu, T., & Hu, C. (2023) · Antioxidants · doi:10.3390/antiox12101800 · Cited by 8

Hitchhiking of Cas9 with nucleus-localized proteins impairs its controllability and leads to efficient genome editing of NLS-free Cas9

Zhang, W., Wang, H., Luo, Z., Jian, Y.-Z., Gong, C., Wang, H., Lin, X., Liu, M., Wang, Y., & Shao, H. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.008 · Cited by 8

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells

Ferrand, N., Fert, A., Morichon, R., Radosevic‐Robin, N., Zaoui, M., & Sabbah, M. (2022) · Cancers · doi:10.3390/cancers14061487 · Cited by 11

YAP1/TAZ activity maintains vascular integrity and organismal survival

Uemura, S., Yamashita, M., Aoyama, K., Yokomizo‐Nakano, T., Oshima, M., Nishio, M., Masuko, M., Takizawa, J., Sone, H., Yamada, Y., et al. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.06.050 · Cited by 8

Recent insight into the role and therapeutic potential of YAP/TAZ in gastrointestinal cancers

Wang, Y., Chen, H., Yu, J. Q., Kang, W., & To, K. F. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188787 · Cited by 8

Klotho promotes AMPK activity and maintains renal vascular integrity by regulating the YAP signaling pathway

Luo, L., Guo, J., Li, Y., Liu, T., & Lai, L. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.80220 · Cited by 8

Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy ResponsesPreprint

McAndrews, K. M., Mahadevan, K. K., & Kalluri, R. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041411 · Cited by 8

Matrix Stiffness Regulates Interleukin‐10 Secretion in Human Microglia (HMC3) via YAP‐Mediated Mechanotransduction

Fang, X., Jia, H., Pan, S., Liu, Q., Wang, Q., Feng, Y., Ding, W., & Luo, T. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70061 · Cited by 7

Nuclear localization of YAP in pancreatic cancer: More players besides Hippo pathway

Xie, Y., Qin, C. Y., Zhang, X., Li, Z., Zhao, B., Li, T., Zhao, Y., Yan, Y., Shi, H., Huang, L., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217864 · Cited by 7

RGS16 regulates Hippo-YAP activity to promote esophageal cancer cell proliferation and migration

Zhang, Y., Zhu, Q. J., Cao, X., & Ni, B. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.033 · Cited by 7

Unravelling the molecular interplay: SUMOylation, PML nuclear bodies and vascular cell activity in health and disease

Berkholz, J., & Karle, W. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111156 · Cited by 7

PATJ regulates cell stress responses and vascular remodeling post-stroke

Zhang, M., Jiang, W. I., Arkelius, K., Swanson, R. A., Dengke, K., & Singhal, N. S. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103709 · Cited by 7

Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer

Ni, L., Xu, J., Li, Q., Ge, X., Wang, F., Deng, X., & Miao, L. (2024) · Cancer Management and Research · doi:10.2147/cmar.s474348 · Cited by 6

Expression of YAP suppresses cell proliferation and elevates the sensitivity of chemotherapy in retinoblastoma cells through lipid-peroxidation induced ferroptosis

Zhong, L., Meng, X., Huang, J., Hao, W., & Zuo, Y. (2023) · Chinese Clinical Oncology · doi:10.21037/cco-23-97 · Cited by 6

Editorial: Tumor Vessels as Directors of the Tumor Microenvironment: New Findings, Current Challenges & Perspectives

Treps, L., Ager, A., & Hida, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.885670 · Cited by 6

Th9-arterial endothelial cell crosstalk promotes psoriatic atherosclerosis

Baral, I., Baumer, Y., Burma, A. M., Sylvester, M., Jones, K., Kitakule, M. M., Dey, A. K., Rodante, J. A., Gutierrez‐Huerta, C. A., Taramangalam, B., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.11.008 · Cited by 6

CD48 is a novel immune checkpoint on tumour‐associated macrophages in hepatocellular carcinoma

Shi, G., Xiao, Y., Li, Z., Qiu, Y., Zhou, Y., Zhang, J., Li, W., He, L., Xie, F., Cao, H., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-336744 · Cited by 7

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Weng, P., Wen, Y., Yuan, Z., Ma, L., Yang, L. M., Li, C., Zhang, W., & Yu, C. (2025) · Theranostics · doi:10.7150/thno.113303 · Cited by 5

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Göttert, R., Kikhia, M., Herzog, M., Pan, W. Q., Klaus‐Bergmann, A., Weiner, J. M., Beule, D., Knauß, S., Kronenberg, G., Potente, M., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.040079 · Cited by 6

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Tang, L., Zhou, M., Xu, Y., Peng, B., Gao, Y., & Mo, Y. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149525 · Cited by 5

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Wang, X.-L., Yang, X. Z., & Chen, X. (2024) · Current Eye Research · doi:10.1080/02713683.2024.2309217 · Cited by 5

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Zhang, Y., Ren, Y., Li, X., Li, M., Fu, M., Zhou, W., Yu, Y., & Xiong, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132473 · Cited by 5

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Wu, J., Wang, B., Sha, X.-W., Wang, P., Du, S., Lu, X.-J., Miao, Z., Zhou, Y., & Zhao, X.-D. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117375 · Cited by 4

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Liu, H., Tian, Y., Bao, X., & Li, Y.-K. (2025) · Scientific Reports · doi:10.1038/s41598-025-24633-0 · Cited by 4

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Wang, Z., Qin, X., Liu, S., Wen, Y., Lan, B., Liao, H., & Wei, H. (2025) · European Journal of Histochemistry · doi:10.4081/ejh.2025.4196 · Cited by 3

Mechanical stress and mechanosensitive protein in skin tumors

Li, B., Zhao, S., Zhang, L., Xie, D., & Jiang, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189419 · Cited by 3

Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis

Zhu, Y., Zhao, L., Qin, J., Guo, B., Luo, X., Feng, Z., Wei, J., Huang, X., Chen, X., Lin, Y., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.12.013 · Cited by 5

DNAJB4/HLJ1 deficiency sensitizes diethylnitrosamine-induced hepatocarcinogenesis with peritumoral STAT3 activation

Luo, W., Hsu, W.-L., Lu, C.-Y., Chien, M.-H., Chang, J., & Su, K. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09978-y · Cited by 3

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Kim, S., & Lee, J. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146840 · Cited by 3

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Wang, K., Wang, X., Li, J., Wang, Y., & Gao, P. (2025) · Current Cancer Drug Targets · doi:10.2174/0115680096339892241202092052 · Cited by 3

An allosteric inhibitor targeting the STAT3 coiled-coil domain selectively suppresses proliferation of breast cancer

Huang, M., Wang, W., Cao, L., Liu, J., Du, C., & Zhang, J. (2025) · RSC Medicinal Chemistry · doi:10.1039/d4md00926f · Cited by 2

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Wang, Y.-T., Zhao, J.-C., Song, D.-M., & Chen, J.-J. (2025) · Scientific Reports · doi:10.1038/s41598-025-11317-y · Cited by 2

Neurotrophin NGF/TrkA and BDNF/TrkB signaling orchestrates the immune microenvironment in osteosarcoma

Liu, H., Wang, G., Wang, C., Hou, D., Li, S., Fan, Y., & Liu, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1727434 · Cited by 2

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Jeon, Y., Kwon, H., Yoo, J. E., Park, K., Chung, T., Park, Y. N., Sim, J., Kim, T., Ham, J., & Kim, Y. H. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117679 · Cited by 2

Nuclear PD-L1 regulates YAP-driven transcription via the PGE2-EP4-YAP-importin α3 axis in solid tumors

Satapathy, S. R., & Sjölander, A. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116963 · Cited by 2

Liquid-liquid phase separation of EphB4 drives pulmonary hypertension via YAP activation

Liu, J.-Y., Chen, J., Chen, Q.-Y., Li, H., Gui, L., Zhou, J., & Lin, M. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116992 · Cited by 2

Complement factor H inhibits endothelial cell migration through suppression of STAT3 signaling

Li, J., Huang, H., Xu, S., Fan, M., Wang, K., Wang, X., Zhang, J., Huang, S., Gatt, A., & Liu, J. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12107 · Cited by 2

A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated MechanotransductionPreprint

Pan, D., Gascard, P. D., Caruso, J. A., Chen‐Tanyolac, C., Sangwan, V., Bertos, N., Camilleri‐Broët, S., Bérubé, J., Oikonomopoulos, S., Strasser, M. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.661192 · Cited by 2

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells

He, J., Bao, Q., Zhang, Y., Liu, M., Lv, H., Liu, Y., Yao, L., Li, B., Zhang, C., He, S., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.311950 · Cited by 132

NF-YA promotes invasion and angiogenesis by upregulating EZH2-STAT3 signaling in human melanoma cells

Xu, Z., Sun, Y., Guo, Y., Qin, G., Mu, S., FAN, R., Wang, B., Gao, W., Wu, H., WANG, G., et al. (2016) · Oncology Reports · doi:10.3892/or.2016.4761 · Cited by 25

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

Kim, J., Kim, Y. H., Kim, J., Park, D. Y., Bae, H., Lee, D. H., Kim, K. H., Hong, S. P., Jang, S. P., Kubota, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93825 · Cited by 406

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

Kujawski, M., Kortylewski, M., Lee, H., Herrmann, A., Kay, H. D., & Yu, H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35213 · Cited by 594

Endothelial Epac1 facilitates YAP/TAZ controlled melanoma growth and angiogenesis

Wibowo, Y. C., Ma, N., Ren, Y., Cordero, J., Gahn, J., Chen, Z., Levay, M., Ola, R., Feng, Y., Dobreva, G. D., et al. (2026) · Angiogenesis · doi:10.1007/s10456-026-10080-6