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STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis
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Nuclear cotranslocation with STAT3 enables YAP/TAZ to activate genes involved in tumor vascularization.
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“The JAK-STAT pathway is known to regulate metastasis and tumor angiogenesis35–37”
From Endothelial Pim3 kinase protects the vascular barrier during lung metastasis (2024) · cites this paper as [36]
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Self-citation
Metadata
- Authors
- Shen, Y., Wang, X., Liu, Y., Singhal, M., Gürkaşlar, C., Valls, A. F., Lei, Y., Hu, W., Schermann, G., Adler, H., Yu, F.-X., Fischer, T., Zhu, Y., Augustin, H. G., Schmidt, T., & de Almodóvar, C. R.
- Affiliations
- Heidelberg University (DE)
- Tianjin Medical University (CN)
- German Cancer Research Center (DE)
- Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Laboratory of Molecular Ophthalmology, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070 Tianjin, China.
- Shanghai Medical College of Fudan University (CN)
- Australian National University (AU)
- European Center for Angioscience, Medicine Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
- Corresponding author
- Shen, Ying
- Wang, Xiaohong
- Schmidt, Thomas
- ORCID
- Venue
- Science Signaling
- Published
- 2021-12-07
- Volume
- 14
- Issue
- 712
- Pages
- eabj8393-eabj8393
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W4200618391
- Cited by
- 121
- References
- 69
- Citations by year
- 2026: 16 · 2025: 30 · 2024: 32 · 2023: 26 · 2022: 17
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Science Signaling (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- STAT3, YAP/TAZ signaling, tumor angiogenesis, endothelial cells, colorectal cancer, melanoma, verteporfin, tumor vascularization, conditional gene deletion
- MeSH terms
- YAP-Signaling Proteins, Humans, Neoplasms, Phosphoproteins, Signal Transduction, Endothelial Cells, Adaptor Proteins, Signal Transducing, STAT3 Transcription Factor
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