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Metabolic Signatures of Exercise in Human Plasma
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Measurement by mass spectrometry of 200 blood metabolites reveals that individuals who are more fit respond more effectively to exercise, as shown by larger exercise-induced increase in glycerol.
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“Interestingly, several well‐established accumulation signatures of succinate, malate, hypoxanthine, and xanthine induced by endurance exercise (Lewis et al, 2010) were found to be decreased by endurance exercise (Figs 1D and EV1A–D).”
From Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation (2020) · cites this paper as Lewis et al, 2010
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“In addition, we observed increased levels of xanthosine associated with BDCM and total brominated THM and total THM, which is consistent with results from two previous studies (Daskalaki et al., 2015, Lewis et al., 2010).”
From Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study (2018) · cites this paper as Lewis et al., 2010
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“It transcriptionally directs a switch in metabolism from oxidative phosphorylation to glycolysis, which allows rapid ATP production without the need for oxygen15.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [15]
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Metadata
- Authors
- Lewis, G. D., Farrell, L., Wood, M. J., Martinovic, M., Arany, Z., Rowe, G. C., Souza, A., Cheng, S., McCabe, E. L., Yang, E., Shi, X., Deo, R., Roth, F. P., Asnani, A., Rhee, E. P., Systrom, D. M., Semigran, M. J., Vasan, R. S., Carr, S. A., Wang, T. J., Sabatine, M. S., Clish, C. B., & Gerszten, R. E.
- Affiliations
- Broad Institute (US)
- Massachusetts General Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Brigham and Women's Hospital (US)
- Framingham Heart Study (US)
- Harvard University (US)
- Boston University (US)
- Corresponding author
- Lewis, Gregory D.
- Gerszten, Robert E.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2010-05-26
- Volume
- 2
- Issue
- 33
- Pages
- 33ra37-33ra37
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3010398
- OpenAlex
- W2171282332
- Cited by
- 432
- References
- 63
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 22 · 2023: 26 · 2022: 28 · 2021: 31 · 2020: 51 · 2019: 34 · 2018: 24 · 2017: 30 · 2016: 19 · 2015: 26 · 2014: 18 · 2013: 26 · 2012: 28
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (R01HL072872, N01‐HC25195, U01HL083141, N01-HC-025195, R01HL083141, K23HL091106)
- National Human Genome Research Institute (HG004233, HG0017115, R01HG003224, HG003224, P50HG004233)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK081572)
- National Institute of Neurological Disorders and Stroke (R01NS054052, NS054052)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- physical activity, plasma metabolites, metabolic signatures, glycogenolysis, glucose-6-phosphate, TCA cycle, succinic acid, malate, fumarate, lipolysis, glycerol, insulin sensitivity, nicotinamide, pantothenic acid, fatty acid oxidation, exercise fitness, myocardial ischemia, Nur77, lipid metabolism, cardiovascular disease susceptibility, marathon running
- MeSH terms
- Adult, Aged, Animals, Blood, Cell Line, Energy Metabolism, Humans, Male, Middle Aged, Psychomotor Performance, Exercise, Muscle, Skeletal, Mice, Metabolomics, Nuclear Receptor Subfamily 4, Group A, Member 1
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