The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Metabolic Signatures of Exercise in Human Plasma
Open accessAbstract
Measurement by mass spectrometry of 200 blood metabolites reveals that individuals who are more fit respond more effectively to exercise, as shown by larger exercise-induced increase in glycerol.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Interestingly, several well‐established accumulation signatures of succinate, malate, hypoxanthine, and xanthine induced by endurance exercise (Lewis et al, 2010) were found to be decreased by endurance exercise (Figs 1D and EV1A–D).”
From Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation (2020) · cites this paper as Lewis et al, 2010
In the citing paper
“In addition, we observed increased levels of xanthosine associated with BDCM and total brominated THM and total THM, which is consistent with results from two previous studies (Daskalaki et al., 2015, Lewis et al., 2010).”
From Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study (2018) · cites this paper as Lewis et al., 2010
In the citing paper
“It transcriptionally directs a switch in metabolism from oxidative phosphorylation to glycolysis, which allows rapid ATP production without the need for oxygen15.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
HMDB: the Human Metabolome Database
Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl923 · Cited by 3,219
Grundy, S. M., Benjamin, I. J., Burke, G. L., Chait, A., Eckel, R. H., Howard, B. V., Mitch, W., Smith, S. C., & Sowers, J. R. (1999) · Circulation · doi:10.1161/01.cir.100.10.1134 · Cited by 2,698
ACC/AHA 2002 Guideline Update for Exercise Testing: Summary Article
Gibbons, R. J., Balady, G. J., Bricker, J. T., CHAITMAN, B. R., Fletcher, G. F., Froelicher, V. F., Mark, D. B., McCallister, B. D., Mooss, A. N., O’Reilly, M. G., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034670.06526.15 · Cited by 2,583
Principles of Exercise Testing and Interpretation.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-4-646 · Cited by 2,366
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,269
Thompson, P. D., Buchner, D., Piña, I. L., Balady, G. J., Williams, M. A., Marcus, B. H., Berra, K., Blair, S. N., Costa, F., Franklin, B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000075572.40158.77 · Cited by 2,132
Bruce, R. A., Kusumi, F., & Hosmer, D. W. (1973) · American Heart Journal · doi:10.1016/0002-8703(73)90502-4 · Cited by 2,057
Fletcher, G. F., Balady, G. J., Amsterdam, E. A., Chaitman, B., Eckel, R., Fleg, J., Froelicher, V. F., Leon, A. S., Piña, I. L., Rodney, R., et al. (2001) · Circulation · doi:10.1161/hc3901.095960 · Cited by 1,923
Cited by
Sorted by citations
Metabolomics for Investigating Physiological and Pathophysiological Processes
Wishart, D. S. (2019) · Physiological Reviews · doi:10.1152/physrev.00035.2018 · Cited by 1,295
Metabolic Control of Longevity
López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772
Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739
Roberts, L. D., Souza, A. L., Gerszten, R. E., & Clish, C. B. (2012) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb3002s98 · Cited by 762
Self-citation
Metadata
- Authors
- Lewis, G. D., Farrell, L., Wood, M. J., Martinovic, M., Arany, Z., Rowe, G. C., Souza, A., Cheng, S., McCabe, E. L., Yang, E., Shi, X., Deo, R., Roth, F. P., Asnani, A., Rhee, E. P., Systrom, D. M., Semigran, M. J., Vasan, R. S., Carr, S. A., Wang, T. J., Sabatine, M. S., Clish, C. B., & Gerszten, R. E.
- Affiliations
- Broad Institute (US)
- Massachusetts General Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Brigham and Women's Hospital (US)
- Framingham Heart Study (US)
- Harvard University (US)
- Boston University (US)
- Corresponding author
- Lewis, Gregory D.
- Gerszten, Robert E.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2010-05-26
- Volume
- 2
- Issue
- 33
- Pages
- 33ra37-33ra37
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3010398
- OpenAlex
- W2171282332
- Cited by
- 432
- References
- 63
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 22 · 2023: 26 · 2022: 28 · 2021: 31 · 2020: 51 · 2019: 34 · 2018: 24 · 2017: 30 · 2016: 19 · 2015: 26 · 2014: 18 · 2013: 26 · 2012: 28
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (R01HL072872, N01‐HC25195, U01HL083141, N01-HC-025195, R01HL083141, K23HL091106)
- National Human Genome Research Institute (HG004233, HG0017115, R01HG003224, HG003224, P50HG004233)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK081572)
- National Institute of Neurological Disorders and Stroke (R01NS054052, NS054052)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- physical activity, plasma metabolites, metabolic signatures, glycogenolysis, glucose-6-phosphate, TCA cycle, succinic acid, malate, fumarate, lipolysis, glycerol, insulin sensitivity, nicotinamide, pantothenic acid, fatty acid oxidation, exercise fitness, myocardial ischemia, Nur77, lipid metabolism, cardiovascular disease susceptibility, marathon running
- MeSH terms
- Adult, Aged, Animals, Blood, Cell Line, Energy Metabolism, Humans, Male, Middle Aged, Psychomotor Performance, Exercise, Muscle, Skeletal, Mice, Metabolomics, Nuclear Receptor Subfamily 4, Group A, Member 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
