Cited by 432Metabolomics and Mass Spectrometry StudiesCardiovascular and exercise physiologyExercise and Physiological Responses

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Metabolic Signatures of Exercise in Human Plasma

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Lewis, Gregory D., Farrell, Laurie, Wood, Malissa J., Martinovic, Maryann, Arany, Zoltan, Rowe, Glenn C., Souza, Amanda, Cheng, Susan, McCabe, Elizabeth L., Yang, Elaine, Shi, Xu, Deo, Rahul, Roth, Frederick P., Asnani, Aarti, Rhee, Eugene P., Systrom, David M., Semigran, Marc J., Vasan, Ramachandran S., Carr, Steven A., Wang, Thomas J., Sabatine, Marc S., Clish, Clary B., Gerszten, Robert E.·2010·Science Translational Medicine

DOI 10.1126/scitranslmed.3001006PMC PMC3010398

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Abstract

Measurement by mass spectrometry of 200 blood metabolites reveals that individuals who are more fit respond more effectively to exercise, as shown by larger exercise-induced increase in glycerol.

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Authors: Lewis, G. D., Farrell, L., Wood, M. J., Martinovic, M., Arany, Z., Rowe, G. C., Souza, A., Cheng, S., McCabe, E. L., Yang, E., Shi, X., Deo, R., Roth, F. P., Asnani, A., Rhee, E. P., Systrom, D. M., Semigran, M. J., Vasan, R. S., Carr, S. A., Wang, T. J., Sabatine, M. S., Clish, C. B., & Gerszten, R. E.
Affiliations: Broad Institute (US)
Massachusetts General Hospital (US)
Beth Israel Deaconess Medical Center (US)
Brigham and Women's Hospital (US)
Framingham Heart Study (US)
Harvard University (US)
Boston University (US)
Corresponding author: Lewis, Gregory D.
Gerszten, Robert E.
ORCID: Lewis, Gregory D.
Farrell, Laurie
Wood, Malissa J.
Arany, Zoltan
Rowe, Glenn C.
Cheng, Susan
Shi, Xu
Deo, Rahul
Roth, Frederick P.
Asnani, Aarti
Rhee, Eugene P.
Systrom, David M.
Vasan, Ramachandran S.
Carr, Steven A.
Wang, Thomas J.
Sabatine, Marc S.
Clish, Clary B.
Gerszten, Robert E.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-05-26
Volume: 2
Issue: 33
Pages: 33ra37-33ra37
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3001006
PMC: PMC3010398
OpenAlex: W2171282332
Cited by: 432
References: 63
Citations by year: 2026: 19 · 2025: 32 · 2024: 22 · 2023: 26 · 2022: 28 · 2021: 31 · 2020: 51 · 2019: 34 · 2018: 24 · 2017: 30 · 2016: 19 · 2015: 26 · 2014: 18 · 2013: 26 · 2012: 28
FWCI: 9.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (n01hc25195-41-0-1)
National Heart, Lung, and Blood Institute (R01HL072872, N01‐HC25195, U01HL083141, N01-HC-025195, R01HL083141, K23HL091106)
National Human Genome Research Institute (HG004233, HG0017115, R01HG003224, HG003224, P50HG004233)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK081572)
National Institute of Neurological Disorders and Stroke (R01NS054052, NS054052)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: physical activity, plasma metabolites, metabolic signatures, glycogenolysis, glucose-6-phosphate, TCA cycle, succinic acid, malate, fumarate, lipolysis, glycerol, insulin sensitivity, nicotinamide, pantothenic acid, fatty acid oxidation, exercise fitness, myocardial ischemia, Nur77, lipid metabolism, cardiovascular disease susceptibility, marathon running
MeSH terms: Adult, Aged, Animals, Blood, Cell Line, Energy Metabolism, Humans, Male, Middle Aged, Psychomotor Performance, Exercise, Muscle, Skeletal, Mice, Metabolomics, Nuclear Receptor Subfamily 4, Group A, Member 1

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Metabolic Signatures of Exercise in Human Plasma

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