Alzheimer’s Disease: The Challenge of the Second Century

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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A default mode of brain function

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

The Clinical Dementia Rating (CDR): Current version and scoring rules

Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

Finding the missing heritability of complex diseases

Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806

Episodix: a serious game to detect cognitive impairment in senior adults. A psychometric study

Valladares‐Rodríguez, S., Iglesias, M. J. F., Anido, L., Facal-Mayo, D., & Pérez-Rodríguez, R. (2018) · PeerJ · doi:10.7717/peerj.5478 · Cited by 30

Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer’s disease model mice

Lee, J. S., Lee, Y., André, E. A., Lee, K. J., Nguyen, T., Feng, Y., Jia, N., Harris, B. T., Burns, M. P., & Pak, D. T. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219691 · Cited by 30

Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys

Kavanagh, K., Day, S. M., Pait, M. C., Mortiz, W. R., Newgard, C. B., Ilkayeva, O., McClain, D. A., & Macauley, S. L. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00843 · Cited by 30

The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration

Guix, F. X. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24526 · Cited by 30

Interplay between microglia and environmental risk factors in Alzheimer's disease

Zhang, M., Liang, C., Chen, X., Cai, Y., & Cui, L. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389745 · Cited by 30

Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EV ISF ) reveals sex‐dependent changes in microglial EV proteome in response to Aβ pathology

Pait, M. C., Kaye, S. D., Su, Y., Kumar, A., Singh, S., Gironda, S. C., Vincent, S., Anwar, M., Carroll, C. M., Snipes, J. A., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12398 · Cited by 29

The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease

Naik, R. A., Mir, M. N., Malik, I. A., Bhardwaj, R., Alshabrmi, F. M., Mahmoud, M. A., Alhomrani, M., Alamri, A. S., Alsanie, W. F., Hjazi, A. M., et al. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl25551 · Cited by 29

Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study

Liu, C., Li, C., Kung, S.-F., Kuo, H., Huang, N.-C., Sun, Y., & Hu, S. C. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16162828 · Cited by 29

Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Rescue Memory Defects inDrosophila-Expressing Alzheimer’s Disease-Related Transgenes Independently of the Canonical Renin Angiotensin System

Lee, S. H., Gomes, S. M., Ghalayini, J., Iliadi, K. G., & Boulianne, G. L. (2020) · eNeuro · doi:10.1523/eneuro.0235-20.2020 · Cited by 30

Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease

Yuede, C. M., Wallace, C. E., Davis, T. A., Gardiner, W. D., Hettinger, J. C., Edwards, H. M., Hendrix, R. D., Doherty, B. M., Yuede, K. M., Burstein, E. S., et al. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15260 · Cited by 29

Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration

Drieu, A., Du, S., Kipnis, M., Bosch, M. E., Herz, J., Lee, C., Jiang, H., Manis, M., Ulrich, J. D., Kipnis, J., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202302087 · Cited by 29

Hydrazone–Sulfonate Hybrids as Potential Cholinesterase Inhibitors: Design, Synthesis and Molecular Modeling Simulation

Omar, M. A., El‐Shiekh, R. A., Dawood, D. H., Temirak, A., & Srour, A. M. (2023) · Future Medicinal Chemistry · doi:10.4155/fmc-2023-0238 · Cited by 29

Body fluid biomarkers in Alzheimer's disease.

Lu, H., Zhu, X., Jiang, T., Yu, J., & Tan, L. (2015) · PubMed Central · doi:10.3978/j.issn.2305-5839.2015.02.13 · Cited by 29

Translational semantics and infrastructure: another search for the emperor's new clothes?

Mullane, K., & Williams, M. J. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.01.004 · Cited by 29

Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice

Zhang, W., Junhong, G., Niu, X., Jie, W., Zhaojun, W., Meina, W., Yang, W., Zhang, J., & Qi, J. (2017) · BioMed Research International · doi:10.1155/2017/1238687 · Cited by 29

Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease

Kumar, A., Sharma, V., Singh, V. P., Kaundal, M., Gupta, M., Bariwal, J. B., & Deshmukh, R. R. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.05.009 · Cited by 29

The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks

Constantino, N. J., Ashley, C. C., & Macauley, S. L. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70294 · Cited by 29

Design of nonapeptide LVFFARKHH: A bifunctional agent against Cu2+‐mediated amyloid β‐protein aggregation and cytotoxicity

Zhang, H., Zhang, C., Dong, X., Zheng, J., & Sun, Y. P. (2018) · Journal of Molecular Recognition · doi:10.1002/jmr.2697 · Cited by 28

Effect of atorvastatin on Aβ1–42-induced alteration of SESN2, SIRT1, LC3II and TPP1 protein expressions in neuronal cell cultures

Çelik, H., Karahan, H., & Kelicen‐Uğur, P. (2019) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13208 · Cited by 28

Pathogenic Aβ generation in familial Alzheimer’s disease: novel mechanistic insights and therapeutic implications

Trambauer, J., Fukumori, A., & Steiner, H. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.01.011 · Cited by 28

DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation

Lv, J., Wang, W., Zhu, X., Xu, X., Yan, Q., Lu, J., Shi, X., Wang, Z., Zhou, J., Huang, X., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.041 · Cited by 28

Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain

Radhakrishnan, H., Ubele, M. F., Krumholz, S. M., Boaz, K., Mefford, J. L., Jones, E. D., Meacham, B., Smiley, J. R., Puskás, L. G., Powell, D. K., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0361-21.2021 · Cited by 28

On the relationships between epilepsy, sleep, and Alzheimer’s disease: A narrative review

Hanke, J.-M., Schindler, K. A., & Seiler, A. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.108609 · Cited by 28

Contribution of the γ-Secretase Subunits to the Formation of Catalytic Pore of Presenilin 1 Protein

Takeo, K., Watanabe, N., Tomita, T., & Iwatsubo, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336347 · Cited by 28

Synthesis of the Alzheimer Drug Posiphen into its Primary Metabolic Products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their Inhibition of Amyloid Precursor Protein, α -Synuclein Synthesis, Interleukin-1β Release, and Cholinergic Action.

Yu, Q., Reale, M., Kamal, M. A., Holloway, H. W., Luo, W., Sambamurti, K., Ray, B., Lahiri, D. K., Rogers, J. T., & Greig, N. H. (2013) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523011312020003 · Cited by 28

Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates

Martins, A. F., Oliveira, A. C., Morfin, J., Laurents, D. V., Tóth, É., & Geraldes, C. F. G. C. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-015-1316-9 · Cited by 28

Protection against β‐amyloid neurotoxicity by a non‐toxic endogenous N‐terminal β‐amyloid fragment and its active hexapeptide core sequence

Forest, K. H., Alfulaij, N., Arora, K., Taketa, R., Sherrin, T., Todorovic, C., Lawrence, J. L. M., Yoshikawa, G. T., Ng, H. L., Hruby, V. J., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14257 · Cited by 28

Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis

Liang, H., Soliman, M. L., Geiger, N. H., Miller, N., Afghah, Z., Lakpa, K. L., Chen, X., & Geiger, J. D. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180941 · Cited by 28

Beta-amyloid toxicity modifier genes and the risk of Alzheimer's disease.

Rosenthal, S. L., Wang, X., Demirci, F. Y., Barmada, M. M., Ganguli, M., López, O. L., & Kamboh, M. I. (2012) · Europe PMC (PubMed Central) · Cited by 30

Effects of altered RTN3 expression on BACE1 activity and Alzheimer’s neuritic plaques

Sharoar, M. G., & Yan, R. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0054 · Cited by 28

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Basak, J. M., Kim, J., Pyatkivskyy, Y., Wildsmith, K. R., Jiang, H., Parsadanian, M., Patterson, B. W., Bateman, R. J., & Holtzman, D. M. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-14 · Cited by 27

Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing

Lee, Y., Lee, J. S., Lee, K. J., Turner, R. S., Hoe, H.-S., & Pak, D. T. S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.027 · Cited by 27

Reduced slow-wave activity and autonomic dysfunction during sleep precede cognitive deficits in Alzheimer’s disease transgenic mice

Chen, C.-W., Kwok, Y., Cheng, Y., Huang, Y., Kuo, T. B. J., Wu, C.-H., Du, P.-J., Yang, A. C., & Yang, C. C. H. (2023) · Scientific Reports · doi:10.1038/s41598-023-38214-6 · Cited by 27

An Expanded Role for Neuroimaging in the Evaluation of Memory Impairment

Desikan, R. S., Rafii, M. S., Brewer, J. B., & Hess, C. P. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3644 · Cited by 27

Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer’s disease

Lei, M., Teo, J. D., Song, H., McEwen, H. P., Yup Lee, J., Couttas, T. A., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0524-19.2019 · Cited by 27

Transcriptional response of murine microglia in Alzheimer’s disease and inflammation

Shippy, D. C., Watters, J. J., & Ulland, T. K. (2022) · BMC Genomics · doi:10.1186/s12864-022-08417-8 · Cited by 27

Comparison of Oleocanthal-Low EVOO and Oleocanthal against Amyloid-β and Related Pathology in a Mouse Model of Alzheimer’s Disease

Abdallah, I. M., Al-Shami, K. M., Alkhalifa, A. E., Al-Ghraiybah, N. F., Guillaume, C., & Kaddoumi, A. (2023) · Molecules · doi:10.3390/molecules28031249 · Cited by 27

The Eye as a Diagnostic Tool for Alzheimer’s Disease

Hussain, A., Sheikh, Z., & Subramanian, M. L. (2023) · Life · doi:10.3390/life13030726 · Cited by 27

Diagnostic performance of new and classic CSF biomarkers in age-related dementias

Marchegiani, F., Matacchione, G., Ramini, D., Marcheselli, F., Recchioni, R., Casoli, T., Mercuri, E., Lazzarini, M., Giorgetti, B., Cameriere, V., et al. (2019) · Aging · doi:10.18632/aging.101925 · Cited by 27

Dual-probe (colorimetric and fluorometric) detection of ferritin using antibody-modified gold@carbon dot nanoconjugates

Priyadarshini, E., Rawat, K., Bohidar, H. B., & Rajamani, P. (2019) · Microchimica Acta · doi:10.1007/s00604-019-3802-1 · Cited by 27

PLGA Microspheres with Alginate-Coated Large Pores for the Formulation of an Injectable Depot of Donepezil Hydrochloride

Kim, D., Han, T. H., Hong, S., Park, S. J., Lee, Y. H., Kim, H., Park, M.-W., & Lee, J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040311 · Cited by 27

Early Mitochondrial Fragmentation and Dysfunction in a Drosophila Model for Alzheimer’s Disease

Wang, X., & Davis, R. L. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02107-w · Cited by 27

Scope of β-Secretase (BACE1)-Targeted Therapy in Alzheimer’s Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition

Das, S., Sengupta, S., & Chakraborty, S. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00579 · Cited by 27

Omnidirectional improvement of mitochondrial health in Alzheimer's disease by multi-targeting engineered activated neutrophil exosomes

Zhang, L., Lin, J., Xiang, K., Shi, T., & Guo, B. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.033 · Cited by 26

Beyond cardiovascular risk: Implications of Familial hypercholesterolemia on cognition and brain function

de Oliveira, J., Moreira, E. L. G., & Bem, A. F. D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102149 · Cited by 26

Signalling Pathways Implicated in Alzheimer′s Disease Neurodegeneration in Individuals with and without Down Syndrome

Martínez‐Cué, C., & Rueda, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186906 · Cited by 26

Melatonin protects against methamphetamine-induced Alzheimer's disease-like pathological changes in rat hippocampus

Panmak, P., Nopparat, C., Permpoonpattana, K., Namyen, J., & Govitrapong, P. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105121 · Cited by 26

Thunbergia laurifolia Leaf Extract Inhibits Glutamate-Induced Neurotoxicity and Cell Death through Mitophagy Signaling

Vongthip, W., Sillapachaiyaporn, C., Kim, K., Sukprasansap, M., & Tencomnao, T. (2021) · Antioxidants · doi:10.3390/antiox10111678 · Cited by 26

Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease

Marei, H. E. S., Khan, M. U. A., & Hasan, A. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00504-2 · Cited by 27

Beta amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease mice

Briggs, C. A., Schneider, C., Richardson, J. C., & Stutzmann, G. E. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.013 · Cited by 26

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production

Tominaga, A., Cai, T., Takagi‐Niidome, S., Iwatsubo, T., & Tomita, T. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.5090-14.2016 · Cited by 26

Dual‐specificity phosphatase 26 ( DUSP 26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia

Jung, S., Nah, J., Han, J., Choi, S.-G., Kim, H., Park, J., Pyo, H.-K., & Jung, Y. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13597 · Cited by 26

Computational integration of nanoscale physical biomarkers and cognitive assessments for Alzheimer’s disease diagnosis and prognosis

Yue, T., Jia, X., Petrosino, J. M., Sun, L., Fan, Z., Fine, J. N., Davis, R., Galster, S. M., Kuret, J., Scharre, D. W., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700669 · Cited by 26

Late Onset Alzheimer’s Disease Risk Variants in Cognitive Decline: The PATH Through Life Study

Andrews, S. J., Das, D., Anstey, K. J., & Easteal, S. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160774 · Cited by 26

Effects of physical and social environments on the risk of dementia among Taiwanese older adults: a population-based case-control study

Liu, C., Sun, Y., Kung, S.-F., Kuo, H., Huang, N.-C., Li, C., & Hu, S. C. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01624-6 · Cited by 26

Anticoagulants for Treatment of Alzheimer’s Disease

Grossmann, K. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200610 · Cited by 27

Lipid Raft Size and Lipid Mobility in Non-raft Domains Increase during Aging and Are Exacerbated in APP/PS1 Mice Model of Alzheimer's Disease. Predictions from an Agent-Based Mathematical Model

Santos, G., Díaz, M. L., & Torres, N. V. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00090 · Cited by 26

Modulation of Amyloid Aggregates into Nontoxic Coaggregates by Hydroxyquinoline Appended Polyfluorene

Chowdhury, S. R., Agarwal, M., Meher, N., Balakrishnan, M., & Iyer, P. K. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b03668 · Cited by 26

A Metallo Pro‐Drug to Target CuII in the Context of Alzheimer's Disease

Conte‐Daban, A., Ambike, V., Guillot, R., Delsuc, N., Policar, C., & Hureau, C. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201706049 · Cited by 27

Decoding sTREM2: its impact on Alzheimer’s disease – a comprehensive review of mechanisms and implications

Lin, C., Kong, Y., Chen, Q., Zeng, J., Pan, X., & Miao, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1420731 · Cited by 24

Perspective

Rubin, E. H., & Zorumski, C. F. (2012) · Academic Medicine · doi:10.1097/acm.0b013e3182441697 · Cited by 25

Alzheimer's classification using dynamic ensemble of classifiers selection algorithms: A performance analysis

P., M. N. K., & Thiyagarajan, P. (2021) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2021.102729 · Cited by 25

Microfluidic Platforms to Unravel Mysteries of Alzheimer’s Disease: How Far Have We Come?

Prasanna, P., Rathee, S., Rahul, V., Mandal, D., Goud, M. S. C., Yadav, P., Hawthorne, S. J., Sharma, A., Gupta, P. K., Ojha, S. K., et al. (2021) · Life · doi:10.3390/life11101022 · Cited by 25

Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease

Colavitta, M. F., & Barrantes, F. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082052 · Cited by 25

Magnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis

Liao, W., Wei, J., Liu, C., Luo, H., Ruan, Y., Mai, Y., Yu, Q., Cao, Z., Xu, J., Zheng, D., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.391310 · Cited by 25

C/ EBPβ : A transcription factor associated with the irreversible progression of Alzheimer's disease

Yao, Q., Long, C., Yi, P., Zhang, G., Wan, W., Rao, X., Ying, J., Liang, W., & Hua, F. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14721 · Cited by 25

Heterogeneous multimodal biomarkers analysis for Alzheimer’s disease via Bayesian network

Initiative, T. A. D. N., Jin, Y., Su, Y., Zhou, X., & Huang, S. (2016) · EURASIP Journal on Bioinformatics and Systems Biology · doi:10.1186/s13637-016-0046-9 · Cited by 25

Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ1−42 and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae

Nery, L. R., Silva, N. E., Fonseca, R. S., & Vianna, M. R. M. R. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2327-4 · Cited by 25

Alternative hypotheses related to Alzheimer’s disease

Cubinkova, V., Valachova, B., Uhrinova, I., Brezováková, V., Smolek, T., Jadhav, S., & Žilka, N. (2018) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2018_039 · Cited by 25

Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis

Ge, M., Zhang, Y., Hao, Q., Zhao, Y., & Dong, B. (2018) · Brain and Behavior · doi:10.1002/brb3.982 · Cited by 25

Association between blood lead level and subsequent Alzheimer’s disease mortality

Horton, C. J., Weng, H., & Wells, E. M. (2019) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000045 · Cited by 25

The Role of PGRN in Alzheimer’s Disease

Jing, H., Tan, M., Yu, J., & Tan, L. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9358-0 · Cited by 25

Small Molecule Inhibition of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)

Genung, N. E., & Guckian, K. M. (2017) · Progress in medicinal chemistry · doi:10.1016/bs.pmch.2016.11.004 · Cited by 25

UsingDrosophilaModels of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer’s Disease

O’Keefe, L. V., & Denton, D. (2018) · BioMed Research International · doi:10.1155/2018/5195416 · Cited by 25

Therapeutic efficacy of novel memantine nitrate MN-08 in animal models of Alzheimer’s disease

Wu, L., Zhou, X., Cao, Y., MAK, S. H., Zha, L., Li, N., Su, Z., Han, Y., Wang, Y., Man Hoi, M. P., et al. (2021) · Aging Cell · doi:10.1111/acel.13371 · Cited by 24

Zinc utilization by microglia in Alzheimer’s disease

Shippy, D. C., Oliai, S. F., & Ulland, T. K. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107306 · Cited by 25

Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer’s Disease

Matei, N., Leahy, S., Blair, N. P., Burford, J. L., Rahimi, M., & Shahidi, M. (2022) · Cells · doi:10.3390/cells11152413 · Cited by 24

Neuroprotective Effects of Green Tea Seed Isolated Saponin Due to the Amelioration of Tauopathy and Alleviation of Neuroinflammation: A Therapeutic Approach to Alzheimer’s Disease

Khan, M. I., Khan, M. Z., Shin, J. H., Shin, T. S., Lee, Y. B., Kim, M. Y., & Kim, J. D. (2022) · Molecules · doi:10.3390/molecules27072079 · Cited by 24

Patchouli alcohol as a selective estrogen receptor β agonist ameliorates AD-like pathology of APP/PS1 model mice

Yan, Q., Lv, J., Shen, X., Yang, J., Yang, J.-Z., Nie, R.-F., Lu, J., Huang, Y.-J., Wang, J.-Y., & Shen, X. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00857-4 · Cited by 24

UiO-66-NH 2 Metal–Organic Framework for the Detection of Alzheimer’s Biomarker Aβ (1-42)

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Unlocking the Epigenetic Symphony: Histone Acetylation’s Impact on Neurobehavioral Change in Neurodegenerative Disorders

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