Cited by 1,424Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Alzheimer’s Disease: The Challenge of the Second Century

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Holtzman, David M., Morris, John C., Goate, Alison M.·2011·Science Translational Medicine

DOI 10.1126/scitranslmed.3002369PMC PMC3130546

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Abstract

In the first of our State of the Art Review series, David M. Holtzman, John C. Morris, and Alison M. Goate explore the rapid pace of Alzheimer’s disease research and the challenges to translating research breakthroughs into clinical treatments.

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RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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Authors: Holtzman, D. M., Morris, J. C., & Goate, A. M.
Affiliations: Washington University in St. Louis (US)
ORCID: Holtzman, David M.
Morris, John C.
Goate, Alison M.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-04-06
Volume: 3
Issue: 77
Pages: 77sr1-77sr1
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3002369
PMC: PMC3130546
OpenAlex: W2005483591
Cited by: 1,424
References: 225
Citations by year: 2026: 53 · 2025: 81 · 2024: 99 · 2023: 102 · 2022: 93 · 2021: 93 · 2020: 100 · 2019: 124 · 2018: 116 · 2017: 101 · 2016: 92 · 2015: 95 · 2014: 95 · 2013: 86 · 2012: 69
FWCI: 9.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG035083, RC1AG035654, P50AG005681, P01AG003991, R37AG013956, U19AG032438, U01AG032438, R01AG016208, P01AG026276)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, dementia, disease prevalence, pathogenesis, translational research, early detection
MeSH terms: Alzheimer Disease, Humans, Amyloid beta-Peptides, tau Proteins, Disease Progression, Presenilins

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Alzheimer’s Disease: The Challenge of the Second Century

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