Alzheimer’s Disease: The Challenge of the Second Century

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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A default mode of brain function

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

The Clinical Dementia Rating (CDR): Current version and scoring rules

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Finding the missing heritability of complex diseases

Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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Factors influencing accuracy of cortical thickness in the diagnosis of Alzheimer's disease

Mahanand, B. S., Fischl, B. R., Salat, D. H., & Initiative, A. D. N. (2017) · Human Brain Mapping · doi:10.1002/hbm.23922 · Cited by 23

The Alz-tau Biomarker for Alzheimer’s Disease: Study in a Caucasian Population

Guzmán‐Martínez, L., Tapia, J. P., Farias, G. A., González, A., Estrella, M., & Maccioni, R. B. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180637 · Cited by 23

Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors

Patil, D. N., Patil, S. A., Sistla, S., & Jadhav, J. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215291 · Cited by 23

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties

Herrera‐Arozamena, C., Estrada, M., Pérez, C., Lagartera, L., Morales-Garcia, J. A., Pérez‐Castillo, A., Franco‐Gonzalez, J. F., Michalska, P., Duarte, P., Leon, R. M., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112090 · Cited by 23

Computational Investigation of Gantenerumab and Crenezumab Recognition of Aβ Fibrils in Alzheimer’s Disease Brain Tissue

Chen, Y., Wei, G., Zhao, J., Nussinov, R., & Ma, B. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00364 · Cited by 23

Protein Interaction Network Biology in Neuroscience

Basu, A., Ash, P. E. A., Wolozin, B. L., & Emili, A. (2020) · PROTEOMICS · doi:10.1002/pmic.201900311 · Cited by 23

In silico analyses for molecular genetic mechanism and candidate genes in patients with Alzheimer’s disease

Chi, L.-M., Wang, X., & Nan, G. (2016) · Acta Neurologica Belgica · doi:10.1007/s13760-016-0613-6 · Cited by 23

Design and synthesis of new theranostic agents for near-infrared imaging of β-amyloid plaques and inhibition of β-amyloid aggregation in Alzheimer's disease

Dao, P., Ye, F., Du, Z. Y., Qian, C., Zhang, K., Dong, C., Meunier, B., & Chen, H. (2017) · Dyes and Pigments · doi:10.1016/j.dyepig.2017.07.071 · Cited by 23

A standard model of Alzheimer’s disease?

Walker, L. C., Lynn, D. G., & Chernoff, Y. O. (2018) · Prion · doi:10.1080/19336896.2018.1525256 · Cited by 23

MEG biomarker of Alzheimer's disease: Absence of a prefrontal generator during auditory sensory gating

Golubić, S. J., Aine, C. J., Stephen, J. M., Adair, J. C., Knoefel, J. E., & Supek, S. (2017) · Human Brain Mapping · doi:10.1002/hbm.23724 · Cited by 22

Molecular Insights into Cell Type-specific Roles in Alzheimer’s Disease: Human Induced Pluripotent Stem Cell-based Disease Modelling

Qu, W., Canoll, P., & Hargus, G. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.006 · Cited by 24

Role of Microbiota-Modified Bile Acids in the Regulation of Intracellular Organelles and Neurodegenerative Diseases

Kiriyama, Y., & Nochi, H. (2023) · Genes · doi:10.3390/genes14040825 · Cited by 22

Alzheimer's disease‐induced phagocytic microglia express a specific profile of coding and non‐coding RNAs

Scoyni, F., Giudice, L., Väänänen, M., Downes, N. L., Korhonen, P., Choo, X. Y., Välimäki, N., Mäkinen, P. I., Korvenlaita, N., Rozemüller, A. J. M., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13502 · Cited by 22

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

Ohki, Y., Shimada, N., Tominaga, A., Osawa, S., Higo, T., Yokoshima, S., Fukuyama, T., Tomita, T., & Iwatsubo, T. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-7 · Cited by 22

Identifying genetic interactions associated with late-onset Alzheimer’s disease

Floudas, C. S., Um, N., Kamboh, M. I., Barmada, M. M., & Visweswaran, S. (2014) · BioData Mining · doi:10.1186/s13040-014-0035-z · Cited by 22

Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice

Cai, H., Wang, Y., He, J., Cai, T., Wu, J., Fang, J., Zhang, R., Guo, Z., Guan, L., Zhan, Q., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21515 · Cited by 22

Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer’s Disease

Kamara, D. M., Gangishetti, U., Gearing, M., Willis‐Parker, M., Zhao, L., Hu, W. T., & Walker, L. C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170954 · Cited by 22

Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10 months of age: a 13C NMR metabolomic study

Zhou, Q., Zheng, H. X., Chen, J., Li, C., Du, Y., Xia, H., & Gao, H. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0274-7 · Cited by 22

NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

Bellozi, P. M. Q., Gomes, G. F., de Oliveira, L. R., Olmo, I. G., Vieira, É. L. M., Ribeiro, F. M., Fiebich, B. L., & de Oliveira, A. C. P. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01345 · Cited by 22

The prospective role of mesenchymal stem cells exosomes on circumvallate taste buds in induced Alzheimer’s disease of ovariectomized albino rats

Hassan, R., Rabea, A. A., Ragae, A., & Sabry, D. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.104596 · Cited by 22

Amyloid Targeting “Artificial Chaperone” Impairs Oligomer Mediated Neuronal Damage and Mitochondrial Dysfunction Associated with Alzheimer’s Disease

Mondal, S., Vashi, Y., Ghosh, P., Roy, D., Barthakur, M., Kumar, S., & Iyer, P. K. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00387 · Cited by 22

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt

Cimini, S., Sclip, A., Mancini, S., Colombo, L., Messa, M., Cagnotto, A., Fede, G. D., Tagliavini, F., Salmona, M., & Borsello, T. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.12.013 · Cited by 22

MS4A6A genotypes are associated with the atrophy rates of Alzheimer's disease related brain structures

Ma, J., Initiative, A. D. N., Zhang, W., Tan, L., Wang, H.-F., Wan, Y., Sun, F.-R., Tan, C.-C., Yu, J.-T., & Tan, L. (2016) · Oncotarget · doi:10.18632/oncotarget.9563 · Cited by 23

Left-handed polyproline-II helix revisited: proteins causing proteopathies

Adzhubei, A. A., Anashkina, A. A., & Makarov, A. А. (2016) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2016.1229220 · Cited by 22

Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry

Long, X., Jiang, C., & Zhang, L. (2018) · Behavioural Neurology · doi:10.1155/2018/3954101 · Cited by 22

Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer’s Disease?

Hegde, V. K., Dhurandhar, N. V., & Reddy, P. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190808 · Cited by 22

Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2

Li, X., Tang, X., Zeng, J., Duan, L., Hou, Z., Li, L., Guo, Y., Chai, C., Liu, J., Wang, Y., et al. (2026) · Cell · doi:10.1016/j.cell.2025.12.020 · Cited by 21

Serotonergic Regulation in Alzheimer’s Disease

Долгачева, Л. П., Зинченко, В. П., Nadeev, A. D., & Goncharov, N. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115218 · Cited by 21

Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer’s Disease Brain

Diner, I., Dooyema, J. M., Gearing, M., Walker, L. C., & Seyfried, N. T. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00500 · Cited by 21

Emotional Lability as a Unique Presenting Sign of Suspected Chronic Traumatic Encephalopathy

Yuan, S. H., & Wang, S. G. (2018) · Case Reports in Neurological Medicine · doi:10.1155/2018/2621416 · Cited by 21

The Use of Pluripotent Stem Cell-Derived Organoids to Study Extracellular Matrix Development during Neural Degeneration

Yan, Y., Bejoy, J., Marzano, M., & Li, Y. (2019) · Cells · doi:10.3390/cells8030242 · Cited by 21

The Role of the Gut Microbiota and Microbial Metabolites in the Pathogenesis of Alzheimer’s Disease

Wang, Y. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220417005115 · Cited by 21

A Review of the Pathogenesis and Chinese Medicine Intervention of Alzheimer's Disease

Zhao, J., Yang, J., Li, D., Wang, F., & Li, L. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2201002 · Cited by 21

Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000–2022

Zhang, L., Yao, Q., Hu, J., Qiu, B., Xiao, Y., Zhang, Q., Zeng, Y., Zheng, S., Zhang, Y., Wan, Y., et al. (2024) · European journal of medical research · doi:10.1186/s40001-023-01602-9 · Cited by 21

Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid

Arora, K., Cheng, J., & Nichols, R. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.634162 · Cited by 21

γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells

Ran, Y., Cruz, P. E., Ladd, T. B., Fauq, A. H., Jung, J. I., Matthews, J., Felsenstein, K. M., & Golde, T. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.512921 · Cited by 21

CSF Biomarkers of Alzheimer’s Disease: Impact on Disease Concept, Diagnosis, and Clinical Trial Design

Fagan, A. M. (2014) · Advances in Geriatrics · doi:10.1155/2014/302712 · Cited by 21

Induced Pluripotent Stem Cells Derived from Alzheimer’s Disease Patients: The Promise, the Hope and the Path Ahead

Freude, K., Pires, C., Hyttel, P., & Hall, V. J. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041402 · Cited by 21

The acceptability of TV-based game platforms as an instrument to support the cognitive evaluation of senior adults at home

Costa, C. R., Iglesias, M. J. F., Anido, L., Carballa, M. G., & Valladares‐Rodríguez, S. (2017) · PeerJ · doi:10.7717/peerj.2845 · Cited by 21

The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults

Harrington, K., Dang, C., Lim, Y. Y., Ames, D. J., Laws, S. M., Pietrzak, R. H., Rainey‐Smith, S. R., Robertson, J. S., Rowe, C. C., Salvado, O., et al. (2018) · Intelligence · doi:10.1016/j.intell.2018.07.004 · Cited by 21

Effective Use of Data Science Toward Early Prediction of Alzheimer's Disease

Mahyoub, M., Randles, M., Baker, T., & Yang, P. (2018) · IEEE International Conference on High Performance Computing and Communications; IEEE International Conference on Smart City; IEEE International Conference on Data Science and Systems (HPCC/SmartCity/DSS) · doi:10.1109/hpcc/smartcity/dss.2018.00240 · Cited by 21

Dynamics of Inter-Molecular Interactions Between Single Aβ42 Oligomeric and Aggregate Species by High-Speed Atomic Force Microscopy

Feng, L., Watanabe, H., Molino, P. J., Wallace, G. G., Phung, S. L., Uchihashi, T., & Higgins, M. J. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.04.044 · Cited by 21

Amyloid‐β oligomers suppress subunit‐specific glutamate receptor increase during LTP

Tanaka, H., Sakaguchi, D., & Hirano, T. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.10.003 · Cited by 21

Longitudinal survival analysis and two-group comparison for predicting the progression of mild cognitive impairment to Alzheimer's disease

Platero, C. A., & Tobar, M. C. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108698 · Cited by 21

The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer’s Disease

Golzari-Sorkheh, M., Brown, C. E., Weaver, D. F., & Reed, M. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210660 · Cited by 21

Histone H3 Ser57 and Thr58 phosphorylation in the brain of 5XFAD mice

Anderson, K. W., Mast, N., Pikuleva, I. A., & Turko, I. V. (2015) · FEBS Open Bio · doi:10.1016/j.fob.2015.06.009 · Cited by 22

Effects of growth hormone–releasing hormone on sleep and brain interstitial fluid amyloid-β in an APP transgenic mouse model

Liao, F., Zhang, T. J., Mahan, T. E., Jiang, H., & Holtzman, D. M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.005 · Cited by 21

Preliminary evidence of altered steroidogenesis in women with Alzheimer’s disease: Have the patients “OLDER” adrenal zona reticularis?

Vaňková, M., Hill, M., Velíková, M., Včelák, J., Vacínová, G., Dvořáková, K., Lukášová, P., Vejražková, D., Rusina, R., Holmerová, I., et al. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.12.011 · Cited by 21

Cognitive Improvements in a Mouse Model with Substituted 1,2,3-Triazole Agonists for Nicotinic Acetylcholine Receptors

Arunrungvichian, K., Boonyarat, C., Fokin, V. V., Taylor, P., & Vajragupta, O. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00059 · Cited by 21

Expression of Alzheimer’s disease risk genes in ischemic brain degeneration

Ułamek-Kozioł, M., Pluta, R. M., Januszewski, S., Kocki, J., Bogucka‐Kocka, A., & Czuczwar, S. J. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.09.006 · Cited by 20

Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6

Dangi, A., Balmik, A. A., Ghorpade, A. K., Gorantla, N. V., Sonawane, S. K., Chinnathambi, S., & Marelli, U. K. (2020) · RSC Advances · doi:10.1039/d0ra03809a · Cited by 20

Cross-sectional associations of tau protein biomarkers with semantic and episodic memory in older adults without dementia: A systematic review and meta-analysis

Pelgrim, T. A. D., Beran, M., Twait, E. L., Geerlings, M. I., & Vonk, J. M. J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101449 · Cited by 21

Advances in Genetic and Molecular Understanding of Alzheimer’s Disease

Ibáñez, L., Cruchaga, C., & Fernández, M. V. (2021) · Genes · doi:10.3390/genes12081247 · Cited by 20

Early Mitochondrial Defects in the 5xFAD Mouse Model of Alzheimer’s Disease

Sharma, N., Banerjee, R., & Davis, R. L. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220884 · Cited by 20

Artemisia annua Extract Improves the Cognitive Deficits and Reverses the Pathological Changes of Alzheimer’s Disease via Regulating YAP Signaling

Zhou, W., Lei, B., Yang, C., Silva, M., Xing, X., Yu, H., Lu, J., & Zheng, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065259 · Cited by 20

Ketogenic Diet as a Promising Non-Drug Intervention for Alzheimer’s Disease: Mechanisms and Clinical Implications

Xu, Y., Zheng, F., Zhong, Q., & Zhu, Y. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230002 · Cited by 20

Impairments in Neurogenesis Are Not Tightly Linked to Depressive Behavior in a Transgenic Mouse Model of Alzheimer's Disease

Iascone, D. M., Padidam, S., Pyfer, M. S., Zhang, X., Zhao, L., & Chin, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079651 · Cited by 20

Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke

Kanegan, M. J. V., Dunn, D., Kaltenbach, L. S., Shah, B. D., Dong, H., McCoy, D. D., Yang, P., Peng, J., Shen, L., Du, L., et al. (2016) · Scientific Reports · doi:10.1038/srep25626 · Cited by 20

Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer’s disease?

Ba, M., Kong, M., Li, X., Ng, K. P., Rosa‐Neto, P., & Gauthier, S. G. (2016) · Translational Neurodegeneration · doi:10.1186/s40035-016-0067-z · Cited by 20

A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer’s Genetic Risk ( CLU + CR1 + PICALM ) Intensifies Cognitive Aging Genetic Risk ( COMT + BDNF ) Selectively for APOE ɛ 4 Carriers

Sapkota, S., & Dixon, R. A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170909 · Cited by 20

TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes

Takasugi, N., Araya, R., Kamikubo, Y., Kaneshiro, N., Imaoka, R., Jin, H., Kashiyama, T., Hashimoto, Y., Kurosawa, M., Uehara, T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200988 · Cited by 20

Non-conventional compounds with potential therapeutic effects against Alzheimer’s disease

de Castro, A. A., Soares, F. V., Pereira, A. F., Polisel, D. A., Caetano, M. S., Leal, D. H. S., da Cunha, E. F. F., Nepovimová, E., Kuča, K., & Ramalho, T. C. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1608823 · Cited by 20

Reduced Acoustic Startle Response and Prepulse Inhibition in the Tg4-42 Model of Alzheimer’s Disease

Sichler, M. E., Löw, M. J., Schleicher, E. M., Bayer, T. A., & Bouter, Y. (2019) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-190132 · Cited by 20

Computational analysis of Alzheimer-causing mutations in amyloid precursor protein and presenilin 1

Mehra, R., & Kepp, K. P. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108168 · Cited by 20

Alzheimer’s Disease—Rationales for Potential Treatment with the Thrombin Inhibitor Dabigatran

Grossmann, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094805 · Cited by 20

Haptoglobin Modulates Beta-Amyloid Uptake by U-87 MG Astrocyte Cell Line

Maresca, B., Spagnuolo, M. S., & Cigliano, L. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0465-6 · Cited by 20

Microdevice Platform for In Vitro Nervous System and Its Disease Model

Choi, J., Choi, J., & Cho, H. (2017) · Bioengineering · doi:10.3390/bioengineering4030077 · Cited by 20

The Progression of Dementia and Cognitive Decline in a Dutch 2-Year Cohort Study of People with Young-Onset Dementia

Gerritsen, A. A. J., Bakker, C., Verhey, F. R. J., Bor, H. H. J., Pijnenburg, Y. A. L., de Vugt, M. E., & Koopmans, R. T. C. M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170859 · Cited by 20

Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer’s diseasePreprint

Dávila-Velderrain, J., Mathys, H., Mohammadi, S., Ruzicka, B., Jiang, X., Ng, A. P., Bennett, D. A., Tsai, L., & Kellis, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.01.450715 · Cited by 21

Current insights into apolipoprotein E and the immune response in Alzheimer's disease

Lin, P. B., & Holtzman, D. M. (2024) · Immunological Reviews · doi:10.1111/imr.13414 · Cited by 19

APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids

Meyer-Acosta, K. K., Díaz‐Guerra, E., Varma, P., Aruk, A., Mirsadeghi, S., Perez, A. M., Rafati, Y., Hosseini, A., Nieto‐Estévez, V., Giugliano, M., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102537 · Cited by 19

The Role of Astrocytes in Synaptic Dysfunction and Memory Deficits in Alzheimer’s Disease

de León-López, C. A. M., Navarro‐Lobato, I., & Khan, Z. U. (2025) · Biomolecules · doi:10.3390/biom15070910 · Cited by 19

Nanomedicine against Alzheimer’s and Parkinson’s Disease

Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201021140904 · Cited by 20

Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer’s Disease

Tams, A. L. M., Sanz‐Morello, B., Westi, E. W., Mouhammad, Z. A., Andersen, J. V., Freude, K., Vohra, R., Hannibal, J., Aldana, B. I., & Kolko, M. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01126-y · Cited by 19

Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging

Lee, M. J., Wang, C., Carroll, M. J., Brubaker, D. K., Hyman, B. T., & Lauffenburger, D. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.727784 · Cited by 19

Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer’s disease

Velueta-Viveros, M., Martínez‐Bailén, M., Puerta, A., Romero-Hernández, L. L., Křen, V., Merino‐Montiel, P., Montiel‐Smith, S., Fernandes, M. X., Moreno‐Vargas, A. J., Padrón, J. M., et al. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105983 · Cited by 19

New insights into macrophage subsets in atherosclerosis

Wang, Y., Wang, Q. A., & Xu, D. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02224-0 · Cited by 19

Paraoxonase 1 activity in patients with Alzheimer disease: Systematic review and meta-analysis

Zuin, M., Rosta, V., Trentini, A., Bosi, C., Zuliani, G., & Cervellati, C. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110601 · Cited by 19

Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer’s Neuropathology in the APPSWE/PS1DE9 Mouse: A Novel Therapeutic Intervention for Alzheimer’s Disease

Zhang, J., Chen, Y., Zhao, Y., Wang, P., Ding, H., Liu, C., Lyu, J., & Le, W. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01145-3 · Cited by 19

Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment

Mayo, P., Pascual-Guerra, J., Crisman, E., Domínguez, C., López, M. G., & Leon, R. M. (2024) · Medicinal Research Reviews · doi:10.1002/med.22045 · Cited by 19

Meta-analysis of PvuII, XbaI variants in ESR1 gene and the risk of Alzheimer's disease: The regional European difference

Wang, T. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.05.017 · Cited by 19

Extracellular environment modulates the formation and propagation of particular amyloid structures

Westergard, L., & True, H. L. (2014) · Molecular Microbiology · doi:10.1111/mmi.12579 · Cited by 19

Prion-like transmission of pathogenic protein aggregates in genetic models of neurodegenerative disease

Pearce, M. M. P. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.03.011 · Cited by 19

Retinal Microvascular Alterations as the Biomarkers for Alzheimer Disease: Are We There Yet?

Jiang, H., Wang, J., Levin, B. E., Baumel, B. S., Camargo, C. J., Signorile, J. F., & Rundek, T. (2020) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000001140 · Cited by 19

The Effect of a Novel Mica Nanoparticle, STB-MP, on an Alzheimer’s Disease Patient-Induced PSC-Derived Cortical Brain Organoid Model

Kim, N. G., Jung, D. J., Jung, Y.-K., & Kang, K. (2023) · Nanomaterials · doi:10.3390/nano13050893 · Cited by 19

Drugs Induced Alzheimer’s Disease in Animal Model

Malekzadeh, S., Edalatmanesh, M. A., Mehrabani, D., & Shariati, M. (2017) · Galen Medical Journal · doi:10.31661/gmj.v6i3.820 · Cited by 19

Characterization of the Early CNS Stress Biomarkers and Profiles Associated with Neuropsychiatric Diseases

Lowe, X. R., & Wyrobek, A. J. (2012) · Current Genomics · doi:10.2174/138920212802510448 · Cited by 19

Medicinal Chemistry Focusing on Aggregation of Amyloid-β

Sohma, Y. (2015) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c15-00742 · Cited by 19

Assessing Neuroprotective Agents for Aβ-Induced Neurotoxicity

Forest, K. H., & Nichols, R. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.013 · Cited by 19

Transport of cargo from periphery to brain by circulating monocytes

Cintron, A. F., Dalal, N. V., Dooyema, J. M., Betarbet, R. S., & Walker, L. C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.06.047 · Cited by 19

PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s disease

Li, K., Ran, B., Wang, Y., Liu, L., & Li, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999061 · Cited by 18

Insulin Signaling in Alzheimer’s Disease: Association with Brain Insulin Resistance

Pliszka, M., & Szablewski, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031222 · Cited by 18

Apolipoprotein Eε4 Does Not Modulate Amyloid-β–Associated Neurodegeneration in Preclinical Alzheimer Disease

Desikan, R. S., McEvoy, L. K., Holland, D., Thompson, W., Brewer, J. B., Aisen, P. S. S., Andreassen, O. A., Hyman, B. T., Sperling, R. A., Dale, A. M., et al. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3267 · Cited by 18

Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions

Zhou, Y., Chawla, M. K., Rios-Monterrosa, J. L., Wang, L., Zempare, M. A., Hruby, V. J., Barnes, C. A., & Cai, M. (2021) · Molecules · doi:10.3390/molecules26206266 · Cited by 18

Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer’s disease

Banik, A., Amaradhi, R., Lee, D. D., Sau, M., Wang, W., Dingledine, R. J., & Ganesh, T. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02297-7 · Cited by 18

Can Activation of Acetylcholinesterase by β-Amyloid Peptide Decrease the Effectiveness of Cholinesterase Inhibitors?

Zueva, I. V., Vasilieva, E. A., Gaynanova, G. A., Moiseenko, A. V., Burtseva, A. D., Boyko, K. M., Zakharova, L. Y., & Petrov, K. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216395 · Cited by 18

Single‐cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases

He, Z., Chen, Q., Wang, K., Lin, J., Peng, Y., Zhang, J., Yan, X., & Yan, J. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16242 · Cited by 18

Tau proteins and senescent Cells: Targeting aging pathways in Alzheimer’s disease

Singh, M., Ali, H., Jyothi, S. R., Kaur, I., Kumar, S., Sharma, N., Prasad, G. V. S., Pramanik, A., Almalki, W. H., & Imran, M. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149165 · Cited by 18

Translating Mendelian and complex inheritance of Alzheimer's disease genes for predicting unique personal genome variants

Regan, K., Wang, K., Doughty, E., Li, H., Li, J., Lee, Y., Kann, M. G., & Lussier, Y. A. (2012) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2011-000656 · Cited by 18

Immununochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases

Gómez‐Pinedo, U., Villar‐Quiles, R. N., Galán, L., Matías‐Guiu, J. A., Benito‐Martín, M. S., Guerrero-Sola, A., Moreno‐Ramos, T., & Matías‐Guiu, J. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00195 · Cited by 18

Mapping the Road Forward in Alzheimer’s Disease

Holtzman, D. M., Goate, A., Kelly, J. W., & Sperling, R. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3003529 · Cited by 81

Progress of translational research on the diagnosis and treatment of Alzheimer's disease and other dementias

Li, B., Xu, W., Deng, Y., Ma, J., Wang, G., Tang, H., Ding, J., Cheng, Q., & Chen, S. (2018) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1

Challenges in Early Diagnosis and Treatment of Alzheimer’s Disease

Jiang, A. (2023) · Highlights in Science Engineering and Technology · doi:10.54097/3knv6p63 · Cited by 4

Alzheimer's disease

Kumar, S., Hasan, M., Singhal, S., & Anupam, A. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns8.10006 · Cited by 2

The molecular basis and genetic determinants of Alzheimer’s disease

Bayer, A. J. (1999) · Reviews in Clinical Gerontology · doi:10.1017/s0959259899009429