Cytomegalovirus Antibody Levels, Inflammation, and Mortality Among Elderly Latinos Over 9 Years of Follow-up

Roberts, E. T.; Haan, M. N.; Dowd, J. B.; Aiello, A. E.

doi:10.1093/aje/kwq177

Cited by 281Cytomegalovirus and herpesvirus researchViral-associated cancers and disordersImmune responses and vaccinations

Cytomegalovirus Antibody Levels, Inflammation, and Mortality Among Elderly Latinos Over 9 Years of Follow-up

Open access

Roberts, E. T., Haan, M. N., Dowd, J. B., Aiello, A. E.·2010·American Journal of Epidemiology

DOI 10.1093/aje/kwq177PMC PMC2950794

Open this paper in CoChat — free account Open PDF

Abstract

This study examined the relation between immune response to cytomegalovirus (CMV) and all-cause and cardiovascular disease (CVD) mortality, and possible mediating mechanisms. Data were derived from the Sacramento Area Latino Study on Aging, a population-based study of older Latinos (aged 60-101 years) in California followed in 1998-2008. CMV immunoglobulin G (IgG), tumor necrosis factor, and interleukin-6 were assayed from baseline blood draws. Data on all-cause and CVD mortality were abstracted from death certificates. Analyses included 1,468 of 1,789 participants. For individuals with CMV IgG antibody titers in the highest quartile compared with lower quartiles, fully adjusted models showed that all-cause mortality was 1.43 times (95% confidence interval: 1.14, 1.79) higher over 9 years. In fully adjusted models, the hazard of CVD mortality was also elevated (hazard ratio = 1.35, 95% confidence interval: 1.01, 1.80). A composite measure of tumor necrosis factor and interleukin-6 mediated a substantial proportion of the association between CMV and all-cause (18.9%, P < 0.001) and CVD (29.0%, P = 0.02) mortality. This study is the first known to show that high CMV IgG antibody levels are significantly related to mortality and that the relation is largely mediated by interleukin-6 and tumor necrosis factor. Further studies investigating methods for reducing IgG antibody response to CMV are warranted.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/aje/kwq177

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Some studies have found that human CMV infection in older individuals is associated with increased cardiovascular and all-cause mortality, negative immune risk profile, inflammageing, and lower antibody responses to influenza.
“Some studies have found that human CMV infection in older individuals is associated with increased cardiovascular and all-cause mortality, negative immune risk profile, inflammageing, and lower antibody responses to influenza125–129.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [125]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations.
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.51.6.1173 · Cited by 91,542 · see citing works
The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532 · see citing works
SPSS and SAS procedures for estimating indirect effects in simple mediation models
Preacher, K. J., & Hayes, A. F. (2004) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03206553 · Cited by 17,383 · see citing works
Blood pressure, stroke, and coronary heart disease
Collins, R., Peto, R., MacMahon, S., Godwin, J., Qizilbash, N., Collins, R., MacMahon, S., Hebert, P., Eberlein, K. A., Taylor, J. O., et al. (1990) · The Lancet · doi:10.1016/0140-6736(90)90944-z · Cited by 4,491 · see citing works
Blood pressure, stroke, and coronary heart disease *1Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias
MACMAHON, S. (1990) · The Lancet · doi:10.1016/0140-6736(90)90878-9 · Cited by 4,253 · cited 1× · see citing works
“Smoking status, hypertension, low density lipoprotein cholesterol, and high density lipoprotein cholesterol were assessed as covariates because they are associated with death (22, 23) and CMV infection.”
Background
Mortality in relation to smoking: 50 years' observations on male British doctors
Doll, R., Peto, R., Boreham, J., & Sutherland, I. (2004) · BMJ · doi:10.1136/bmj.38142.554479.ae · Cited by 2,920 · cited 1× · see citing works
“Smoking status, hypertension, low density lipoprotein cholesterol, and high density lipoprotein cholesterol were assessed as covariates because they are associated with death (22, 23) and CMV infection.”
Background
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Mortality in relation to smoking: 40 years' observations on male British doctors
Doll, R., Peto, R., Wheatley, K., Gray, R., & Sutherland, I. (1994) · BMJ · doi:10.1136/bmj.309.6959.901 · Cited by 1,321 · see citing works
Stress and immunity in humans: a meta-analytic review.
Herbert, T. B., & Cohen, S. (1993) · Psychosomatic Medicine · doi:10.1097/00006842-199307000-00004 · Cited by 1,093 · see citing works
Seroprevalence of Cytomegalovirus Infection in the United States, 1988-1994
Staras, S. A. S., Dollard, S. C., Radford, K. W., Flanders, W. D., Pass, R. F., & Cannon, M. J. (2006) · Clinical Infectious Diseases · doi:10.1086/508173 · Cited by 1,008 · see citing works
Inflammatory Markers and Onset of Cardiovascular Events: Results From the Health ABC Study
Cesari, M., Penninx, B. W. J. H., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Rubin, S. M., Ding, J., Simonsick, E. M., Harris, T. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000097109.90783.fc · Cited by 978 · see citing works
Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474 · see citing works
Self-report and medical record report agreement of selected medical conditions in the elderly.
Bush, T. L., Miller, S. R., Golden, A. L., & Hale, W. E. (1989) · American Journal of Public Health · doi:10.2105/ajph.79.11.1554 · Cited by 465 · see citing works
Prevalence of Dementia in Older Latinos: The Influence of Type 2 Diabetes Mellitus, Stroke and Genetic Factors
Haan, M. N., Mungas, D. M., Gonzalez, H. M., Ortiz, T. A., Acharya, A., & Jagust, W. J. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51054.x · Cited by 420 · see citing works
Self-citation
C‐reactive protein and coronary heart disease: a critical review
Casas, J. P., Shah, T., Hingorani, A. D., Danesh, J., & Pepys, M. B. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.02015.x · Cited by 365 · see citing works
Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer?
Söderberg‐Nauclér, C. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01618.x · Cited by 351 · see citing works
Manifestations of Human Cytomegalovirus Infection: Proposed Mechanisms of Acute and Chronic Disease
Britt, W. J. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-77349-8_23 · Cited by 346 · see citing works
Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination—an impact of immunosenescence
Trzonkowski, P., Myśliwska, J. M., Szmit, E., Wickiewicz, J., Łukaszuk, K., Brydak, L. B., Machała, M. K., & Myśliwski, A. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00309-8 · Cited by 341 · see citing works
Cytomegalovirus and human immunosenescence
Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J., & Wikby, A. (2008) · Reviews in Medical Virology · doi:10.1002/rmv.598 · Cited by 339 · see citing works
Resting Heart Rate is a Risk Factor for Cardiovascular and Noncardiovascular Mortality: The Chicago Heart Association Detection Project In Industry
Greenland, P., Daviglus, M. L., Dyer, A. R., Liu, K., Huang, C., Goldberger, J. J., & Stamler, J. F. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009901 · Cited by 319 · see citing works
High Prevalence of Human Cytomegalovirus in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma
Samanta, M., Harkins, L. E., Klemm, K. M., Britt, W. J., & Cobbs, C. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000080263.46164.97 · Cited by 316 · see citing works
Cohort Study of Cytomegalovirus Infection as a Risk Factor for Carotid Intimal-Medial Thickening, a Measure of Subclinical Atherosclerosis
Nieto, F. J., Adam, E., Sorlie, P. D., Farzadegan, H., Melnick, J. L., Comstock, G. W., & Szklo, M. (1996) · Circulation · doi:10.1161/01.cir.94.5.922 · Cited by 303 · see citing works
The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning
Wikby, A., Nilsson, B.-O., Forsey, R. J., Thompson, J., Strindhall, J., Löfgren, S., Ernerudh, J., Pawelec, G., Ferguson, F. G., & Johansson, B. E. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.04.003 · Cited by 284 · see citing works
Chronic herpesvirus reactivation occurs in aging
Stowe, R., KOZLOVA, E., Yetman, D. L., Walling, D. M., Goodwin, J. S., & Glaser, R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.005 · Cited by 279 · see citing works
The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years
Aiello, A. E., Haan, M. N., Blythe, L., Moore, K., Gonzalez, J. M., & Jagust, W. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00796.x · Cited by 210 · see citing works
Self-citation
Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III
DOWD, J. B., AIELLO, A. E., & ALLEY, D. E. (2009) · Epidemiology and Infection · doi:10.1017/s0950268808000551 · Cited by 210 · see citing works
Self-citation
A Prospective Study of Cytomegalovirus, Herpes Simplex Virus 1, and Coronary Heart Disease
Sorlie, P. D., Nieto, F. J., Adam, E., Folsom, A. R., Shahar, E., & Massing, M. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.13.2027 · Cited by 170 · see citing works
C-Reactive Protein and Prediction of Coronary Heart Disease and Global Vascular Events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
Sattar, N. A., Murray, H. M., McConnachie, A., Blauw, G. J., Bollen, E. L. E. M., Buckley, B. M., Cobbe, S. M., Ford, I., Gaw, A., Hyland, M., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.643114 · Cited by 128 · see citing works
High Anti-Cytomegalovirus (CMV) IgG Antibody Titer is Associated With Coronary Artery Disease and May Predict Post-Coronary Balloon Angioplasty Restenosis
Blum, A., Giladi, M., Weinberg, M., Kaplan, G., Pasternack, H., Laniado, S., & Miller, H. I. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00019-8 · Cited by 127 · see citing works
Cytomegalovirus Antibody Level and Mortality Among Community-Dwelling Older Adults With Stable Cardiovascular Disease
Strandberg, T. E., Pitkälä, K. H., & Tilvis, R. S. (2009) · JAMA · doi:10.1001/jama.2009.4 · Cited by 116 · see citing works
Trends in U.S. Smoking Rates in Occupational Groups: The National Health Interview Survey 1987–1994
Lee, D. J., LeBlanc, W. G., Fleming, L. E., Gómez-Marı́n, O., & Pitman, T. (2004) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000128152.01896.ae · Cited by 110 · see citing works
Burden of infection and insulin resistance in healthy middle-aged men
Fernández-Real, J.-M., López-Bermejo, A., Vendrell, J., Ferri, M.-J., Recasens, M., & Ricart, W. (2006) · Diabetes Care · doi:10.2337/dc05-2068 · Cited by 106 · see citing works
Persistent Infection, Inflammation, and Functional Impairment in Older Latinos
Aiello, A. E., Haan, M. N., Pierce, C. M., Simanek, A. M., & Liang, J. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.6.610 · Cited by 96 · see citing works
Self-citation
Human Immunosenescence
Pawelec, G., Koch, S. D., Franceschi, C., & Wikby, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.009 · Cited by 94 · see citing works
Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols
Nilsson, B.-O., Ernerudh, J., Johansson, B. E. A., Evrin, P., Löfgren, S., Ferguson, F. G., & Wikby, A. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00024-1 · Cited by 87 · see citing works
Immune activation following cytomegalovirus infection: More important than direct viral effects in cardiovascular disease?
Stassen, F. R. M., Vega-Córdova, X., Vliegen, I., & Bruggeman, C. A. (2006) · Journal of Clinical Virology · doi:10.1016/j.jcv.2005.11.007 · Cited by 76 · see citing works
Socioeconomic Gradients in Immune Response to Latent Infection
Dowd, J. B., Haan, M. N., Blythe, L., Moore, K., & Aiello, A. E. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm247 · Cited by 72 · see citing works
Self-citation
Cytomegalovirus Is Present in a Very High Proportion of Brains from Vascular Dementia Patients
Lin, W., Wozniak, M. A., Wilcock, G. K., & Itzhaki, R. F. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0465 · Cited by 72 · see citing works
Human cytomegalovirus vaccine: time to look for alternative options
Khanna, R., & Diamond, D. J. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.11.006 · Cited by 70 · see citing works
Persistent pathogens linking socioeconomic position and cardiovascular disease in the US
Simanek, A. M., Dowd, J. B., & Aiello, A. E. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn273 · Cited by 63 · see citing works
Self-citation
Presence and Severity of Chlamydia pneumoniae and Cytomegalovirus Infection in Coronary Plaques Are Associated With Acute Coronary Syndromes
Liu, R., Moroi, M., Yamamoto, M., Kubota, T., Ono, T., Funatsu, A., Komatsu, H., Tsuji, T., Hara, H., Hara, H., et al. (2006) · International Heart Journal · doi:10.1536/ihj.47.511 · Cited by 54 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

Pawelec G, Koch S, Franceschi C, et al. Human immunose- nescence: does it have an infectious component? Ann N Y Acad Sci. 2006;1067:56-65.
Rothman KJ, Greenland S, eds. Modern Epidemiology. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1998.

Sorted by citations

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Age-dependent dysregulation of innate immunity
Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061 · see citing works
T cell responses to cytomegalovirus
Klenerman, P., & Oxenius, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.38 · Cited by 483 · see citing works
Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States
Simanek, A. M., Dowd, J. B., Pawelec, G., Melzer, D. R., Dutta, A., & Aiello, A. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016103 · Cited by 398 · see citing works
Self-citation
Pathogens and atherosclerosis: Update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis
Campbell, L. A., & Rosenfeld, M. E. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-06-0392 · Cited by 363 · see citing works
Cytomegalovirus infection enhances the immune response to influenza
Furman, D., Jojic, V., Sharma, S., Shen-Orr, S. S., L. Angel, C. J., Onengut-Gumuscu, S., Kidd, B. A., Maecker, H. T., Concannon, P., Dekker, C. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa2293 · Cited by 332 · see citing works
Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation
Jaremka, L. M., Fagundes, C. P., Glaser, R., Bennett, J. M., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.016 · Cited by 318 · see citing works
The Impact of Bisphenol A and Triclosan on Immune Parameters in the U.S. Population, NHANES 2003–2006
Clayton, E. M. R., Todd, M. A., Dowd, J. B., & Aiello, A. E. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002883 · Cited by 304 · see citing works
Self-citation
The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection
Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., Sayer, A. A., Cooper, C., & Lord, J. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00849.x · Cited by 278 · see citing works
Immune aging, dysmetabolism, and inflammation in neurological diseases
Deleidi, M., JÃ¤ggle, M., & Rubino, G. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00172 · Cited by 260 · see citing works
RETRACTED: Chronic Inflammation: Accelerator of Biological Aging
Fougère, B., Boulanger, É., Nourhashémi, F., Guyonnet, S., & Cesari, M. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw240 · Cited by 247 · see citing works
Retracted
T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection
Wang, G. C., Dash, P., McCullers, J. A., Doherty, P. C., & Thomas, P. G. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003647 · Cited by 238 · see citing works
Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016
Wang, H., Peng, G., Bai, J., He, B., Huang, K., Hu, X., & Liu, D. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005025 · Cited by 197 · see citing works
Cytomegalovirus Coinfection Is Associated With an Increased Risk of Severe Non–AIDS-Defining Events in a Large Cohort of HIV-Infected Patients
Lichtner, M., Cicconi, P., Vita, S., Cozzi‐Lepri, A., Galli, M., Caputo, S. L., Saracino, A., Luca, A. D., Moioli, M. C., Maggiolo, F., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu417 · Cited by 187 · see citing works
CMV and Immunosenescence: from basics to clinics
Solana, R., Tarazona, R., Aiello, A. E., Akbar, A. N., Appay, V., Beswick, M., Bosch, J. A., Campos, C., Cantisán, S., Čičin‐Šain, L., et al. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-23 · Cited by 181 · see citing works
Self-citation
Cytomegalovirus Infection and Risk of Alzheimer Disease in Older Black and White Individuals
Barnes, L. L., Capuano, A. W., Aiello, A. E., Turner, A. D., Yolken, R. H., Torrey, Ε. F., & Bennett, D. A. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu437 · Cited by 178 · see citing works
Self-citation
Cytomegalovirus and HIV: A Dangerous Pas de Deux
Gianella, S., & Letendre, S. L. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw217 · Cited by 146 · see citing works
The impact of CMV infection on survival in older humans
Pawelec, G., McElhaney, J. E., Aiello, A. E., & Derhovanessian, E. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.002 · Cited by 145 · see citing works
Self-citation
Memory T cell inflation: understanding cause and effect
O’Hara, G. A., Welten, S. P. M., Klenerman, P., & Arens, R. (2012) · Trends in Immunology · doi:10.1016/j.it.2011.11.005 · Cited by 137 · see citing works
Pathogenic features of CD4+CD28– T cells in immune disorders
Broux, B., Markovic-Plese, S., Stinissen, P., & Hellings, N. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.06.003 · Cited by 131 · see citing works
Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging
Cicin-Sain, L., Brien, J. D., Uhrlaub, J. L., Drabig, A., Marandu, T. F., & Nikolich-Zugich, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002849 · Cited by 126 · see citing works
Seropositivity and Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Mortality in the Population-Based European Prospective Investigation of Cancer–Norfolk Cohort
Gkrania‐Klotsas, E., Langenberg, C., Sharp, S. J., Luben, R., Khaw, K., & Wareham, N. J. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit083 · Cited by 130 · see citing works
Why the elderly appear to be more severely affected by <scp>COVID</scp>‐19: The potential role of immunosenescence and <scp>CMV</scp>
Kadambari, S., Klenerman, P., & Pollard, A. J. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2144 · Cited by 118 · see citing works
Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years
Parry, H. M., Zuo, J., Frumento, G., Mirajkar, N., Inman, C., Edwards, E., Griffiths, M., Pratt, G., & Moss, P. (2016) · Immunity & Ageing · doi:10.1186/s12979-015-0056-6 · Cited by 125 · see citing works
Cytomegalovirus Immunoglobulin G Antibody Is Associated With Subclinical Carotid Artery Disease Among HIV-Infected Women
Parrinello, C. M., Sinclair, E., LANDAY, A. L., Lurain, N. S., Sharrett, A. R., Gange, S. J., Xue, X., Hunt, P. W., Deeks, S. G., Hodis, H. N., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis276 · Cited by 125 · see citing works
Inflammation and reactivation of latent herpesviruses in older adults
Bennett, J. M., Glaser, R., Malarkey, W. B., Beversdorf, D. Q., Peng, J., & Kiecolt-Glaser, J. K. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.007 · Cited by 118 · see citing works
Cytomegalovirus infection in immunocompetent critically ill adults: literature review
Al‐Omari, A., Aljamaan, F., Alhazzani, W. A., Salih, S., & Arabi, Y. M. (2016) · Annals of Intensive Care · doi:10.1186/s13613-016-0207-8 · Cited by 111 · see citing works
Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people
Derhovanessian, E., Maier, A. B., Hähnel, K., Zelba, H., de Craen, A. J. M., Roelofs, H., Slagboom, E. P., Westendorp, R. G. J., & Pawelec, G. (2013) · AGE · doi:10.1007/s11357-012-9425-7 · Cited by 102 · see citing works
Danger Signaling in Atherosclerosis
Zimmer, S., Grebe, A., & Latz, E. (2015) · Circulation Research · doi:10.1161/circresaha.116.301135 · Cited by 101 · see citing works
Safety and Efficacy of Antiviral Therapy for Prevention of Cytomegalovirus Reactivation in Immunocompetent Critically Ill Patients
Cowley, N. J., Owen, A., Shiels, S. C., Millar, J., Woolley, R. L., Ives, N. J., Osman, H. K. E., Moss, P. A. H., & Bion, J. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.0895 · Cited by 97 · see citing works
Lifelong Persistent Viral Infection Alters the Naive T Cell Pool, Impairing CD8 T Cell Immunity in Late Life
Smithey, M. J., Li, G., Venturi, V., Davenport, M. P., & Nikolich‐Žugich, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201867 · Cited by 93 · see citing works
Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
Ellis, R. J., Marquine, M. J., Kaul, M., Fields, J. A., & Schlachetzki, J. C. M. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00879-y · Cited by 98 · see citing works
TTV DNA plasma load and its association with age, gender, and HCMV IgG serostatus in healthy adults
Haloschan, M., Bettesch, R., Görzer, I., Weseslindtner, L., Kundi, M., & Puchhammer‐Stöckl, E. (2014) · AGE · doi:10.1007/s11357-014-9716-2 · Cited by 92 · see citing works
Relationship between functional ability in older people, immune system status, and intensity of response to CMV
Moro‐García, M. A., Alonso‐Arias, R., López‐Vázquez, A., Suárez-García, F. M., Solano-Jaurrieta, J. J., Baltar, J., & López‐Larrea, C. (2011) · AGE · doi:10.1007/s11357-011-9240-6 · Cited by 92 · see citing works
The Sordid Affair Between Human Herpesvirus and HIV
Gianella, S., Massanella, M., Wertheim, J. O., & Smith, D. M. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv148 · Cited by 90 · see citing works
Associations Between Cytomegalovirus Infection and Functional Impairment and Frailty in the BELFRAIL Cohort
Matheï, C., Vaes, B., Wallemacq, P. E., & Degryse, J. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03719.x · Cited by 78 · see citing works
Childhood adversity and cell-mediated immunity in young adulthood: does type and timing matter?
Slopen, N., McLaughlin, K. A., Dunn, E. C., & Koenen, K. C. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.10.018 · Cited by 77 · see citing works
Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
Chen, S., de Craen, A. J. M., Raz, Y., Derhovanessian, E., Vossen, A. C. T. M., Rudi, G. J. W., Pawelec, G., & Maier, A. B. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-18 · Cited by 77 · see citing works
Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample
Rector, J. L., Dowd, J. B., Loerbroks, A., Burns, V. E., Moss, P. A. H., Jarczok, M. N., Tobias Stalder, A., Hoffman, K. R., Fischer, J. E., & Bosch, J. A. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.01.012 · Cited by 76 · see citing works
Self-citation
How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?
Aiello, A. E., Chiu, Y.-L., & Frasca, D. (2017) · GeroScience · doi:10.1007/s11357-017-9983-9 · Cited by 73 · see citing works
Self-citation
Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types
Belzile, J.-P., Sabalza, M., Craig, M., Clark, E., Morello, C. S., & Spector, D. H. (2015) · Journal of Virology · doi:10.1128/jvi.02651-15 · Cited by 75 · see citing works
Cytomegalovirus Exposure and Cardiovascular Disease in Kidney Transplant Recipients
Courivaud, C., Bamoulid, J., Chalopin, J., Gaiffe, É., Tiberghien, P., Saas, P., & Ducloux, D. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit064 · Cited by 74 · see citing works
Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus
Isnard, S., Ramendra, R., Dupuy, F. P., Lin, J. C.-Y., Fombuena, B., Kokinov, N., Kema, I. P., Jenabian, M.-A., Lebouché, B., Costiniuk, C. T., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz423 · Cited by 70 · see citing works
Cytomegalovirus reactivation in critically ill immunocompetent hosts: A decade of progress and remaining challenges
Cook, C. H., & Trgovcich, J. (2011) · Antiviral Research · doi:10.1016/j.antiviral.2011.03.179 · Cited by 70 · see citing works
“The ancient and the new”: is there an interaction between cytomegalovirus and SARS-CoV-2 infection?
Moss, P. A. H. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00185-x · Cited by 66 · see citing works
Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome
Nikitskaya, E., Lebedeva, А., Ivanova, O., Maryukhnich, E., Shpektor, A., Grivel, J., Margolis, L. B., & Vasilieva, E. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003759 · Cited by 66 · see citing works
Does Regular Exercise Counter T Cell Immunosenescence Reducing the Risk of Developing Cancer and Promoting Successful Treatment of Malignancies?
Turner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 65 · see citing works
Cytomegalovirus vaccines under clinical development
Schleiss, M. R. (2016) · Journal of Virus Eradication · doi:10.1016/s2055-6640(20)30872-4 · Cited by 65 · see citing works
Immunosenescence in atherosclerosis: A role for chronic viral infections
Talepoor, A. G., & Doroudchi, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945016 · Cited by 64 · see citing works
Family poverty is associated with cytomegalovirus antibody titers in U.S. Children.
Dowd, J. B., Palermo, T., & Aiello, A. E. (2011) · Health Psychology · doi:10.1037/a0025337 · Cited by 59 · see citing works
Self-citation
Chronic CMV infection in older women: Longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8+ T-cell frequencies with twelve year follow-up
Li, H., Weng, P., Najarro, K. M., Xue, Q., Semba, R. D., Margolick, J. B., & Leng, S. X. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.010 · Cited by 57 · see citing works
Inflammatory breast cancer: New factors contribute to disease etiology: A review
Mohamed, M. M., Al‐Raawi, D., Sabet, S., & El‐Shinawi, M. (2013) · Journal of Advanced Research · doi:10.1016/j.jare.2013.06.004 · Cited by 56 · see citing works
Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort
Dowd, J. B., Bosch, J. A., Steptoe, A., Jayabalasingham, B., Lin, J., Yolken, R. H., & Aiello, A. E. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix255 · Cited by 56 · see citing works
Self-citation
Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study
Haarala, A., Kähönen, M. A. P., Lehtimäki, T. J., Aittoniemi, J., Jylhävä, J., Hutri‐Kähönen, N., Taittonen, L. M., Laitinen, T. P., Juonala, M., Viikari, J. S. A., et al. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04513.x · Cited by 55 · see citing works
The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence
Heath, J., & Grant, M. D. (2020) · Cells · doi:10.3390/cells9030766 · Cited by 56 · see citing works
Age-associated inflammation and implications for skeletal muscle responses to exercise
Kunz, H. E., & Lanza, I. R. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112177 · Cited by 56 · see citing works
Social support and socioeconomic status interact to predict Epstein-Barr virus latency in women awaiting diagnosis or newly diagnosed with breast cancer.
Fagundes, C. P., Bennett, J. M., Alfano, C. M., Glaser, R., Povoski, S. P., Lipari, A. M., Agnese, D. M., Yee, L. D., Carson, W. E., Farrar, W. B., et al. (2011) · Health Psychology · doi:10.1037/a0025599 · Cited by 51 · see citing works
Attachment anxiety is related to Epstein–Barr virus latency
Fagundes, C. P., Jaremka, L. M., Glaser, R., Alfano, C. M., Povoski, S. P., Lipari, A. M., Agnese, D. M., Yee, L. D., Carson, W. E., Farrar, W. B., et al. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.002 · Cited by 54 · see citing works
Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus
Wistuba-Hamprecht, K., Frasca, D., Blomberg, B., Pawelec, G., & Derhovanessian, E. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-26 · Cited by 52 · see citing works
Childhood adversity and herpesvirus latency in breast cancer survivors.
Fagundes, C. P., Glaser, R., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2012) · Health Psychology · doi:10.1037/a0028595 · Cited by 53 · see citing works
Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size
Chiu, Y., Lin, C.-H., Sung, B.-Y., Chuang, Y., Schneck, J. P., Kern, F., Pawelec, G., & Wang, G. C. (2016) · Scientific Reports · doi:10.1038/srep19227 · Cited by 53 · see citing works
Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
Söderberg‐Nauclér, C. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00218-z · Cited by 50 · see citing works
Cytomegalovirus Enhances Macrophage TLR Expression and MyD88-Mediated Signal Transduction To Potentiate Inducible Inflammatory Responses
Smith, P. D., Shimamura, M., Musgrove, L. C., Dennis, E. A., Bimczok, D., Novak, L., Ballestas, M. E., Fenton, A. N., Dandekar, S., Britt, W. J., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302608 · Cited by 50 · see citing works
Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults
Chen, S., Pawelec, G., Trompet, S., Goldeck, D., Mortensen, L. H., Slagboom, P. E., Christensen, K., Gussekloo, J., Kearney, P. M., Buckley, B. M., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa480 · Cited by 49 · see citing works
Cytomegalovirus infection and cognitive abilities in old age
Gow, A. J., Firth, C. M., Harrison, R., Starr, J. M., Moss, P., & Deary, I. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.011 · Cited by 45 · see citing works
Cytomegalovirus infection is associated with an increase in systolic blood pressure in older individuals
Firth, C., Harrison, R., Ritchie, S. J., Wardlaw, J. M., Ferro, C. J., Starr, J. M., Deary, I. J., & Moss, P. A. H. (2016) · QJM · doi:10.1093/qjmed/hcw026 · Cited by 45 · see citing works
Church attendance and CMV herpes virus latency among bereaved and non-bereaved adults.
Garcini, L. M., Stowe, R. P., Chirinos, D. A., Murdock, K. W., LeRoy, A. S., Chen, M. A., Zhang, J., & Fagundes, C. P. (2018) · Psychology of Religion and Spirituality · doi:10.1037/rel0000222 · Cited by 44 · see citing works
Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls
Booiman, T., Wit, F. W. N. M., Girigorie, A. F., Maurer, I., Francesco, D. D., Sabin, C. A., Harskamp, A. M., Prins, M., Franceschi, C., Deeks, S. G., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183357 · Cited by 45 · see citing works
Relationship Between T-Cell Responses to CMV, Markers of Inflammation, and Frailty in HIV-uninfected and HIV-infected Men in the Multicenter AIDS Cohort Study
Margolick, J. B., Bream, J. H., Nilles, T. L., Li, H., Langan, S. J., Deng, S., Wang, R., Wada, N., & Leng, S. X. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy005 · Cited by 44 · see citing works
Infectious reactivation of cytomegalovirus explaining age- and sex-specific patterns of seroprevalence
van Boven, M., van de Kassteele, J., Korndewal, M. J., van Dorp, C. H., Kretzschmar, M., van der Klis, F. R. M., de Melker, H. E., Vossen, A. C. T. M., & van Baarle, D. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005719 · Cited by 44 · see citing works
Fatigue and herpesvirus latency in women newly diagnosed with breast cancer
Fagundes, C. P., Glaser, R., Alfano, C. M., Bennett, J. M., Povoski, S. P., Lipari, A. M., Agnese, D. M., Yee, L. D., Carson, W. E., Farrar, W. B., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.014 · Cited by 44 · see citing works
Persistent socioeconomic and racial and ethnic disparities in pathogen burden in the United States, 1999–2014
Stebbins, R. C., Noppert, G. A., Aiello, A. E., Cordoba, E., Ward, J. B., & Feinstein, L. (2019) · Epidemiology and Infection · doi:10.1017/s0950268819001894 · Cited by 43 · see citing works
Self-citation
Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults
Pablo-Bernal, R. S. D., Cañizares, J., Rosado‐Sánchez, I., Galvá, M. I., Álvarez‐Ríos, A. I., Carrillo‐Vico, A., Ferrando‐Martínez, S., Muñoz‐Fernández, M. Á., Benhnia, M. R., Pacheco, Y. M., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv121 · Cited by 42 · see citing works
The association between cytomegalovirus infection, obesity, and metabolic syndrome in U.S. adult females
Fleck‐Derderian, S., McClellan, W., & Wojcicki, J. M. (2017) · Obesity · doi:10.1002/oby.21764 · Cited by 42 · see citing works
Cytomegalovirus as an immunomodulator across the lifespan
Semmes, E. C., Hurst, J. H., Walsh, K. M., & Permar, S. R. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.07.013 · Cited by 42 · see citing works
Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases
Tan, J., Ren, J., Fan, L., Wei, Y., Hu, S., Zhu, S., Yang, Y., & Cai, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.884298 · Cited by 41 · see citing works
Antiviral Therapy Can Reverse the Development of Immune Senescence in Elderly Mice with Latent Cytomegalovirus Infection
Beswick, M., Pachnio, A., Lauder, S. N., Sweet, C., & Moss, P. A. H. (2012) · Journal of Virology · doi:10.1128/jvi.02427-12 · Cited by 41 · see citing works
Higher Anti-Cytomegalovirus Immunoglobulin G Concentrations Are Associated With Worse Neurocognitive Performance During Suppressive Antiretroviral Therapy
Letendre, S. L., Bharti, A., Valero, I., Hanson, B. A., Franklin, D. R., Woods, S. P., Gianella, S., Oliveira, M. F., Heaton, R. K., Grant, I., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy170 · Cited by 41 · see citing works
HIV infection and atherosclerosis: evaluating the drivers of inflammation
Maniar, A., Ellis, C. L., Asmuth, D. M., Pollard, R. B., & Rutledge, J. C. (2012) · European Journal of Preventive Cardiology · doi:10.1177/2047487312447843 · Cited by 41 · see citing works
Immunosenescence and aging in HIV
Tsoukas, C. M. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000077 · Cited by 40 · see citing works
Report from the second cytomegalovirus and immunosenescence workshop
Wills, M. R., Akbar, A. N., Beswick, M., Bosch, J. A., Caruso, C., Colonna‐Romano, G., Dutta, A., Franceschi, C., Fülöp, T., Gkrania‐Klotsas, E., et al. (2011) · Immunity & Ageing · doi:10.1186/1742-4933-8-10 · Cited by 40 · see citing works
Clinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection
Schnittman, S. R., & Hunt, P. W. (2021) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000678 · Cited by 39 · see citing works
Excess body mass is associated with T cell differentiation indicative of immune ageing in children
Spielmann, G., Johnston, C., O’Connor, D. P., Foreyt, J. P., & Simpson, R. J. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12267 · Cited by 39 · see citing works
Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort
Stockdale, L. K., Nash, S., Nalwoga, A., Painter, H., Asiki, G., Fletcher, H. A., & Newton, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192086 · Cited by 39 · see citing works
No relation between CMV infection and mortality in the oldest old: results from the Belfrail study
Matheï, C., Adriaensen, W. J., Vaes, B., Pottelbergh, G. V., Wallemacq, P. E., & Degryse, J. (2014) · Age and Ageing · doi:10.1093/ageing/afu094 · Cited by 37 · see citing works
Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals
Li, Z., Zhong, W.-F., Lv, Y., Kraus, V. B., Gao, X., Chen, P., Huang, Q., Ni, J.-D., Shi, X.-M., Mao, C., et al. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0168-5 · Cited by 37 · see citing works
Infectious-like spread of an agent leading to increased medical hospital admission in the North East Essex area of the East of England
Jones, R. (2016) · Fractal Geometry and Nonlinear Analysis in Medicine and Biology · doi:10.15761/fgnamb.1000117 · Cited by 36 · see citing works
Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation
Kristiani, L., Kim, M., & Kim, Y. (2020) · Cells · doi:10.3390/cells9030718 · Cited by 36 · see citing works
Genetic Factors Influence Serological Measures of Common Infections
Rubicz, R. C., Leach, C. T., Kraig, E., Dhurandhar, N. V., Duggirala, R., Blangero, J., Yolken, R. H., & Göring, H. H. H. (2011) · Human Heredity · doi:10.1159/000331220 · Cited by 36 · see citing works
Aging of the human innate immune system in HIV infection
Zapata, H. J., & Shaw, A. C. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.06.007 · Cited by 34 · see citing works
Levels of anti-CMV antibodies are modulated by the frequency and intensity of virus reactivations in kidney transplant patients
Iglesias-Escudero, M., Moro‐García, M. A., Marcos-Fernández, R., García‐Torre, A., Álvarez-Argüelles, M. E., Suárez-Fernández, M. L., Martínez‐Camblor, P., Rodríguez, M., & Alonso‐Arias, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194789 · Cited by 35 · see citing works
‘From immunosenescence to immune modulation’: a re-appraisal of the role of cytomegalovirus as major regulator of human immune function
Moss, P. A. H. (2019) · Medical Microbiology and Immunology · doi:10.1007/s00430-019-00612-x · Cited by 35 · see citing works
Adaptive immunity and atherosclerosis: aging at its crossroads
Snijckers, R., & Foks, A. C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1350471 · Cited by 39 · see citing works
Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement
Gusev, E., & Sarapultsev, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126389 · Cited by 39 · see citing works
Persistent skewing of the T-cell profile in adolescents adopted internationally from institutional care
Reid, B. M., Coe, C. L., Doyle, C., Sheerar, D. S., Slukvina, A., Donzella, B., & Gunnar, M. R. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.01.001 · Cited by 34 · see citing works
Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort
Dowd, J. B., Bosch, J. A., Steptoe, A., Blackburn, E. H., Lin, J., Rees-Clayton, E., & Aiello, A. E. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.01.016 · Cited by 33 · see citing works
Self-citation
Inflammation in Chronic HIV Infection: What Can We Do?
Erlandson, K. M., & Campbell, T. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv007 · Cited by 33 · see citing works
Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27‐year‐long longitudinal study
Samson, L. D., van den Berg, S. P. H., Engelfriet, P. M., Boots, A. M. H., Hendriks, M., de Rond, L., de Zeeuw‐Brouwer, M., Verschuren, W. M. M., Borghans, J. A. M., Buisman, A., et al. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1193 · Cited by 30 · see citing works
Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation
Patel, E. U., Gianella, S., Newell, K., Tobian, A. A. R., Kirkpatrick, A. R., Nalugoda, F., Grabowski, M. K., Gray, R. H., Serwadda, D., Quinn, T. C., et al. (2017) · AIDS · doi:10.1097/qad.0000000000001412 · Cited by 32 · see citing works
Seropositivity for CMV and IL-6 levels are associated with grip strength and muscle size in the elderly
Kilgour, A. H. M., Firth, C. M., Harrison, R., Moss, P. A. H., Bastin, M. E., Wardlaw, J. M., Deary, I. J., & Starr, J. M. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-33 · Cited by 31 · see citing works

Original Contribution Cytomegalovirus Antibody Levels, Inflammation, and Mortality Among Elderly Latinos Over 9 Years of Follow-up
Roberts, E. T., Haan, M. N., Dowd, J. B., & Aiello, A. E. (2009)
Self-citation
Cytomegalovirus antibody levels and mortality among hospitalised elderly patients
González-Quijada, S., de Lagos, M. D. Á. M., Álvarez-Llabrés, M., & Pérez-González, L. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1811888 · Cited by 9 · see citing works
Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults
Chen, S., Pawelec, G., Trompet, S., Goldeck, D., Mortensen, L. H., Slagboom, P. E., Christensen, K., Gussekloo, J., Kearney, P. M., Buckley, B. M., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa480 · Cited by 49 · see citing works
Invited Commentary: Human Cytomegalovirus, Inflammation, Cardiovascular Disease, and Mortality
Crumpacker, C. S. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq174 · Cited by 18 · see citing works
Seropositivity and Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Mortality in the Population-Based European Prospective Investigation of Cancer–Norfolk Cohort
Gkrania‐Klotsas, E., Langenberg, C., Sharp, S. J., Luben, R., Khaw, K., & Wareham, N. J. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit083 · Cited by 130 · see citing works

Authors: Roberts, E. T., Haan, M. N., Dowd, J. B., & Aiello, A. E.
Affiliations: University of Michigan (US)
City University of New York (US)
Corresponding author: Aiello, A. E.
ORCID: Haan, M. N.
Dowd, J. B.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2010-07-21
Volume: 172
Issue: 4
Pages: 363-371
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/aje/kwq177
PMC: PMC2950794
OpenAlex: W2116172333
Cited by: 281
References: 40
Citations by year: 2026: 7 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 18 · 2020: 22 · 2019: 22 · 2018: 17 · 2017: 21 · 2016: 21 · 2015: 16 · 2014: 23 · 2013: 18 · 2012: 23
FWCI: 16.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: American Journal of Epidemiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: City University of New York
School of Public Health, University of Michigan
National Institutes of Health (NIH5P60 DK20572, DK20572)
National Institute on Aging (AG-12975, R01AG012975, R03AG033751)
National Institute of Nursing Research (R21NR011181)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-60753, DK20572, P60DK020572, R01DK060753)
National Institute on Minority Health and Health Disparities (P60MD002249)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: cytomegalovirus, CMV IgG antibodies, all-cause mortality, cardiovascular mortality, TNF-α, interleukin-6, inflammation, mediation analysis, Latino older adults, aging, Sacramento Area Latino Study on Aging
MeSH terms: Age Factors, Aged, Aged, 80 and over, California, Cardiovascular Diseases, Cytomegalovirus Infections, Cytomegalovirus, Female, Follow-Up Studies, Hispanic or Latino, Humans, Immunoglobulin G, Inflammation, Male, Middle Aged, Mortality, Prospective Studies, Tumor Necrosis Factor-alpha, Interleukin-6

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cytomegalovirus Antibody Levels, Inflammation, and Mortality Among Elderly Latinos Over 9 Years of Follow-up

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks