Cited by 236Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Increased in Vivo Amyloid-β42 Production, Exchange, and Loss in Presenilin Mutation Carriers

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Potter, Rachel, Patterson, Bruce W., Elbert, Donald L., Ovod, Vitaliy, Kasten, Tom, Sigurdson, Wendy, Mawuenyega, Kwasi, Blazey, Tyler +7 more·2013·Science Translational Medicine

Abstract

Aβ42 kinetics are altered in the central nervous system of patients with autosomal dominant Alzheimer’s disease.

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Authors
Potter, R., Patterson, B. W., Elbert, D. L., Ovod, V., Kasten, T., Sigurdson, W., Mawuenyega, K., Blazey, T., Goate, A., Chott, R., Yarasheski, K. E., Holtzman, D. M., Morris, J. C., Benzinger, T. L. S., & Bateman, R. J.
Affiliations
Washington University in St. Louis (US)
Corresponding author
  • Potter, Rachel
  • Patterson, Bruce W.
  • Bateman, Randall J.
Venue
Science Translational Medicine
Published
2013-06-12
Volume
5
Issue
189
Pages
189ra77-189ra77
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2164765564
Cited by
236
References
47
Citations by year
2026: 10 · 2025: 12 · 2024: 14 · 2023: 21 · 2022: 17 · 2021: 17 · 2020: 30 · 2019: 15 · 2018: 22 · 2017: 21 · 2016: 19 · 2015: 16 · 2014: 16 · 2013: 6
FWCI
13.23
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5p60dk020579-35, 5p41rr000954-34, UL1TR000448)
  • National Institute on Aging (5P01 AG026272, 5P01AG026276-S1, P01AG026276, U24AG021886)
  • National Institute of General Medical Sciences (R24GM136766, P41GM103422)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P60-DK-020579, P30DK056341, P30DK020579)
  • National Institute of Neurological Disorders and Stroke (R01NS065667)
  • National Center for Research Resources (P41-RR000954, UL1RR024992)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
amyloid-beta 42, Aβ40, presenilin mutations, autosomal dominant Alzheimer's disease, presenilin 1, presenilin 2, amyloid plaques, cerebrospinal fluid amyloid, Pittsburgh compound B PET, mutation carriers
MeSH terms
Adult, Alzheimer Disease, Amyloid, Female, Humans, Male, Middle Aged, Mutation, Amyloid beta-Peptides, Positron-Emission Tomography, Presenilins

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