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Aberrant Progranulin, YKL-40, Cathepsin D and Cathepsin S in Gaucher Disease

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Peeling Back the Layers of the Bleomycin Model of Lung Fibrosis: Lessons Learned, Factors to Consider, and Future Directions

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YKL-40/CHI3L1 facilitates migration and invasion in HER2 overexpressing breast epithelial progenitor cells and generates a niche for capillary-like network formation

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Inflammatory‐sensitive CHI3L1 protects nucleus pulposus via AKT3 signaling during intervertebral disc degeneration

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CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer’s disease

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A Natural CHI3L1—Targeting Compound, Ebractenoid F, Inhibits Lung Cancer Cell Growth and Migration and Induces Apoptosis by Blocking CHI3L1/AKT Signals

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A longitudinal assessment of circulating YKL ‐40 levels in preschool children with wheeze

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Integrative transcriptomic and proteomic analysis reveals mechanisms of silica-induced pulmonary fibrosis in rats

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Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects

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Fully human chitinase-3 like-1 monoclonal antibody inhibits tumor growth, fibrosis, angiogenesis, and immune cell remodeling in lung, pancreatic, and colorectal cancers

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Implementation of Proteomics Biomarkers in Nephrology: From Animal Models to Human Application?

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Expression of proteins associated with airway fibrosis differs between children with allergic asthma and allergic rhinitis

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Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit

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Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells

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Type 2 innate immunity promotes the development of pulmonary fibrosis in Hermansky-Pudlak syndrome

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Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19

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Chitinase 3–like-1 Inhibits Innate Antitumor and Tissue Remodeling Immune Responses by Regulating CD47-SIRPα– and CD24-Siglec10–Mediated Phagocytosis

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Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during fungal-associated allergic airway inflammation

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Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation

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Associations of serum monocyte-to-high-density lipoprotein cholesterol ratio with digital ulcers and skin fibrosis in patients with systemic sclerosis

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M2 macrophages have unique transcriptomes but conditioned media does not promote profibrotic responses in lung fibroblasts or alveolar epithelial cells in vitro

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Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis

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Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis

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Anti-Fibrotic Activity of an Antimicrobial Peptide in a Drosophila Model

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Investigation of Causal Effects of Protein Biomarkers on Cardiovascular Disease in Persons With HIV

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Chitinase 3-like-1 (CHI3L1) in the pathogenesis of epidermal growth factor receptor mutant non-small cell lung cancer

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Aberrant Chitinase 3‐Like 1 Expression in Basal Cells Contributes to Systemic Sclerosis Fibrosis

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Macrophage activation determines muscle wasting in pancreatic cancer

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Emerging insights in sarcoidosis: moving forward through reverse translational research

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Myeloid Heterogeneity Mediates Acute Exacerbations of Pulmonary Fibrosis

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The potential roles and mechanisms of Chitinase-3-like-1 in the pathogenesis of type 2-biased airway diseases

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Autophagy and Cellular Senescence in Lung Diseases

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Two Sides of a Coin: The Dual Roles of Chitinase 3-Like 1 in Idiopathic Pulmonary Fibrosis

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NSUN2 promotes PM2.5-induced epithelial-mesenchymal transition through methylating chitinase 3-like-1 mRNA

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Serum YKL-40 and Serum Krebs von den Lungen-6 as Potential Predictive Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease

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Cardiac Overexpression of Chil1 Improves Wound Healing to Prevent Cardiac Rupture After Myocardial Infarction

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Serum CHI3L1 levels correlate with disease activity in rheumatoid arthritis and reveal potential molecular mechanisms

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The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities

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Degrees of macrophage‐facilitated healing in aneurysm occlusion devices

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Personalized translational medicine: Investigating YKL-40 as early biomarker for clinical risk stratification in hepatocellular carcinoma recurrence post-liver transplantation

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Identification of unique biomarkers for proliferative diabetic retinopathy with tractional retinal detachment by proteomics profiling of vitreous humor

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Chitinase 3‐like 1 polymorphisms and risk of chronic obstructive pulmonary disease and asthma in a Chinese population

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Combining Microfluidic Assessment with Encoded Hydrogel Microparticle-Based Immunoassay for Anti-Interleukin Drug Repurposing of Pulmonary Fibrosis Therapy

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Characterization of YKL-40 Binding to Extracellular Matrix Glycosaminoglycans

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Role of Chitinase 3–like‐1 in Myelofibrosis via Fibroblast‐Produced Extracellular Matrix Enhancement

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Mechanistic studies on the role of CHI3L1 in eosinophilic inflammation in chronic sinusitis

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Cross-disease integration of single-cell RNA sequencing data from lung myeloid cells reveals TAM signature in in vitro model

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Decellularized Human-Sized Pulmonary Scaffolds for Lung Tissue Engineering: A Comprehensive Review

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Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis

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Functional Improvement at One Year in Fibrotic Interstitial Lung Diseases—Prognostic Value of Baseline Biomarkers and Anti-Inflammatory Therapies

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Dual Effect of Bleomycin on Histopathological Features of Lungs and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model

Elewa, Y. H. A., Ichii, O., Nakamura, T., & Kon, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.665100 · Cited by 3

Single-cell epigenomic dysregulation of Systemic Sclerosis fibroblasts via CREB1/EGR1 axis in self-assembled human skin equivalentsPreprint

Abel, T. R., Kosarek, N. N., Parvizi, R., Jarnagin, H. C., Torres, G. M., Bhandari, R., Huang, M., Toledo, D. M., Smith, A., Popovich, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.22.586316 · Cited by 3

Cardiomyocyte‐Specific Plakophilin‐2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy

(2026) · doi:10.1161/jaha.125.047447 · Cited by 2

Bispecific targeting of CHI3L1 and PD-1 as a therapeutic strategy for pulmonary fibrosis

Jeong, H.-S., Sadanaga, T., Lee, J. H., Kamle, S., Ma, B., Zhou, Y., Shin, S. J., Elias, J. A., & Lee, C. G. (2026) · JCI Insight · doi:10.1172/jci.insight.201609 · Cited by 3

Alternative splicing of CHI3L1 regulates protein secretion through conformational changes

Jung, H., Kim, Y., Kim, E., & Kim, K. K. (2025) · Genes & Genomics · doi:10.1007/s13258-025-01635-w · Cited by 2

Ex Vivo Lung Bioengineering

Wagner, D. E., Uhl, F. E., Königshoff, M., & Weiss, D. J. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-16232-4_8 · Cited by 2

Role of Chitinase 3-like-1 in IL-18-induced pulmonary Type- 1, -2 and -17 inflammation, alveolar destruction and airway fibrosis in the murine lung

Kang, M., Yoon, C. M., Nam, M., Kim, D.-H., Choi, J., Lee, C. G., & Elias, J. A. (2015) · Cited by 2

A Nerve-Fibroblast Axis in Mammalian Lung FibrosisPreprint

Ishikawa, G., Peng, X., Ghincea, A., McGovern, J., Zielonka, J., Jeevanandam, A., Shao, S., Woo, S., Okuno, D., Yu, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.09.611003 · Cited by 3

Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy

Bertoli, G., Phadke, K., Cospito, A., Rizk, J. A., Zhang, M., Miliotou, E., Cammer, M., Deng, Y., Mezzano, V., Alu, M., et al. (2025) · doi:10.1101/2025.10.22.682160 · Cited by 2

A Lower IL-34 Expression Is Associated with Non-Healing Diabetic Foot Ulcers

Zheng, A., Xu, Y., Cen, N., & Wu, B. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073273222231005065757 · Cited by 1

Collaborative functionality between three types of inflammation in idiopathic pulmonary fibrosis

Fabre, T., Wynn, T. A., & Hart, K. M. (2026) · Nature Immunology · doi:10.1038/s41590-026-02616-1 · Cited by 2

Acellular Lung Scaffolds in Lung Bioengineering

Wagner, D. E., Uhl, F. E., & Weiss, D. J. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21082-7_18 · Cited by 1

Biobanking for Pulmonary, Critical Care, and Sleep Medicine

Winkler, J., & Herzog, E. L. (2020) · Respiratory medicine · doi:10.1007/978-3-030-31507-8_9 · Cited by 1

Molecular Biomarkers in Interstitial Lung Diseases

Zanini, U., Faverio, P., & Luppi, F. (2025) · Respiratory medicine · doi:10.1007/978-3-031-87183-2_4 · Cited by 1

Arginase 1 is negatively regulated by β-catenin signaling in the lungPreprint

Sennello, J. A., Flozak, A. S., Misharin, A. V., Gottardi, C. J., & Lam, A. P. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/137539 · Cited by 1

Is the microbiome-induced glycolytic pathway a harbinger of acute exacerbation of idiopathic pulmonary fibrosis?

Naikawadi, R. P. (2020) · Thorax · doi:10.1136/thoraxjnl-2019-214374 · Cited by 1

Anti-fibrotic activity of an antimicrobial peptide in a Drosophila modelPreprint

Khalili, D., Kalcher, C., Baumgartner, S., & Theopold, U. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.19.436168 · Cited by 1

Zoledronic acid targets the mevalonate pathway causing reduced cell recruitment and attenuation of pulmonary fibrosisPreprint

Tanner, L., Bergwik, J., Bhongir, R. K. V., & Egesten, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.01.470755 · Cited by 1

α1 adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with IPFPreprint

Ishikawa, G., Peng, X., McGovern, J., Woo, S., Perry, C., Liu, A., Yu, S., Ghincea, A., Sun, H., Ryu, C., et al. (2022) · medRxiv · doi:10.1101/2022.04.06.22273471 · Cited by 1

CRTH2 in Pulmonary Fibrosis: Friend or Foe?

He, C., & Carter, A. B. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2022-0232ed · Cited by 1

CRISPR correction of GBA mutation in hiPSCs restores normal function to Gaucher macrophages and increases their susceptibility to Mycobacterium tuberculosisPreprint

Ramalingam, S., Kumar, A., Krug, S., Mohan, H., Rao, D. N., Bishai, W. R., & Chandrasegaran, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.26.517656 · Cited by 1

Functional analysis of IL-34 in diabetic ulcer healing: A bioinformatic studyPreprint

Zheng, A., Xu, Y., & Wu, B. (2022) · Research Square · doi:10.21203/rs.3.rs-2390347/v1 · Cited by 1

Multiomic Analysis of Monocyte-Derived Alveolar Macrophages in Idiopathic Pulmonary FibrosisPreprint

Zhang, M., Zhang, J., Hu, H., Zhou, Y., Lin, Z., Jing, H., & Sun, B. (2024) · Research Square · doi:10.21203/rs.3.rs-3883875/v1 · Cited by 1

Kasugamycin inhibits melanoma lung metastasis and regulates CHI3L1-driven M2-like tumor-associated macrophage differentiationPreprint

Sadanaga, T., Jeong, H.-S., Cortez, R., Lee, J. H., Kamle, S., Ma, B., Shin, S. J., Elias, J. A., & Lee, C. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.26.654629 · Cited by 1

Bispecific Targeting of CHI3L1 and PD-1/PD-L1 Axis as a Novel Therapeutic Strategy for Idiopathic Pulmonary FibrosisPreprint

Jeong, H.-S., Sadanaga, T., Lee, J. H., Kamle, S., Ma, B., Zhou, Y., Shin, S. J., Elias, J. A., & Lee, C. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.17.676854 · Cited by 1

Potential Mechanistic Links Between Aging and IPF

Pan, H., Gulati, M., & Herzog, E. L. (2015) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814635011_0016

Flash-induced absorbance changes in thylakoid membranes. The gramicidin insensitive component.

Vredenberg, W. J., Versluis, W., & Ooms, J. J. J. (1990) · Socio-Environmental Systems Modeling

Adaptive Immunity in Interstitial Lung Disease

Winkler, J., & Herzog, E. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00018-4

Vascular niche-mediated contributions to organ regeneration and fibrosis

Chen, Y., & Ding, B. (2022) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0345

Effective-Compound Combination Inhibits M2-Like Polarization of Macrophages and Attenuates Pulmonary Fibrosis Development Through Increasing Autophagy via Regulating mTOR SignalingPreprint

Zhao, P., Cai, Z., Tian, Y., Li, J., Li, K., Li, M., Bai, Y., & Li, J. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3932102

Pulmonary Fibrosis: One Manifestation, Various Diseases

Ruaro, B., Matucci‐Cerinic, M., Baratella, E., Confalonieri, M., Salton, F., & Hughes, M. (2022) · Frontiers research topics · doi:10.3389/978-2-83250-654-7

Chitinase 3-like 1 suppresses injury and promotes fibro-proliferative responses in pulmonary fibrosis

Erica, L. (2015) · Journal of Clinical & Cellular Immunology

CRTH2 Mediates Profibrotic Macrophage Differentiation and Promotes Lung Fibrosis

Cao, Y., Rudrakshala, J., Williams, R., Rodriguez, S., Sorkhdini, P., Yang, A. X., Mundy, M. A., Yang, D., Palmisciano, A. J., Walsh, T. P., et al. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0504oc · Cited by 22

Targeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis

Lee, S., Lee, C.-M., Ma, B., Kamle, S., Elias, J. A., Zhou, Y., & Lee, C. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.826471 · Cited by 27

Bispecific Targeting of CHI3L1 and PD-1/PD-L1 Axis as a Novel Therapeutic Strategy for Idiopathic Pulmonary FibrosisPreprint

Jeong, H.-S., Sadanaga, T., Lee, J. H., Kamle, S., Ma, B., Zhou, Y., Shin, S. J., Elias, J. A., & Lee, C. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.17.676854 · Cited by 1

Bispecific targeting of CHI3L1 and PD-1 as a therapeutic strategy for pulmonary fibrosis

Jeong, H.-S., Sadanaga, T., Lee, J. H., Kamle, S., Ma, B., Zhou, Y., Shin, S. J., Elias, J. A., & Lee, C. G. (2026) · JCI Insight · doi:10.1172/jci.insight.201609 · Cited by 3