Cited by 224Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisStudies on Chitinases and ChitosanasesPulmonary Hypertension Research and Treatments

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Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis

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Zhou, Yang, Peng, Hong, Sun, Huanxing, Peng, Xueyan, Tang, Chuyan, Gan, Ye, Chen, Xiaosong, Mathur, Aditi, Hu, Buqu, Slade, Martin D., Montgomery, Ruth R., Shaw, Albert C., Homer, Robert J., White, Eric S., Lee, Chang-Min, Moore, Meagan W., Gulati, Mridu, Geun Lee, Chun, Elias, Jack A., Herzog, Erica L.·2014·Science Translational Medicine

DOI 10.1126/scitranslmed.3007096PMC PMC4340473

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Abstract

Chitinase 3–like 1 protects against lung injury but has a profibrotic role during the repair phase.

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Authors: Zhou, Y., Peng, H., Sun, H., Peng, X., Tang, C., Gan, Y., Chen, X., Mathur, A., Hu, B., Slade, M. D., Montgomery, R. R., Shaw, A. C., Homer, R. J., White, E. S., Lee, C.-M., Moore, M. W., Gulati, M., Geun Lee, C., Elias, J. A., & Herzog, E. L.
Affiliations: Yale University (US)
Second Xiangya Hospital of Central South University (CN)
University of Michigan (US)
Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Brown University (US)
Corresponding author: Zhou, Yang
Peng, Hong
Sun, Huanxing
Elias, Jack A.
Herzog, Erica L.
ORCID: Zhou, Yang
Peng, Hong
Sun, Huanxing
Peng, Xueyan
Chen, Xiaosong
Hu, Buqu
Slade, Martin D.
Montgomery, Ruth R.
Shaw, Albert C.
Homer, Robert J.
White, Eric S.
Lee, Chang-Min
Gulati, Mridu
Elias, Jack A.
Herzog, Erica L.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-06-11
Volume: 6
Issue: 240
Pages: 240ra76-240ra76
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3007096
PMC: PMC4340473
OpenAlex: W2159203930
Cited by: 215
References: 64
Citations by year: 2026: 12 · 2025: 21 · 2024: 21 · 2023: 17 · 2022: 23 · 2021: 34 · 2020: 14 · 2019: 13 · 2018: 17 · 2017: 16 · 2016: 8 · 2015: 14 · 2014: 4
FWCI: 11.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000142)
U.S. Public Health Service (N01-HHS N272201100019C)
National Institute on Aging (K24AG042489)
National Heart, Lung, and Blood Institute (R01HL093017, U01HL108638, U01HL111016, U01HL112702, R01HL109233, HL-109033, R01HL109118, HL093017, U01HL109118, R01HL085083, P01HL114501, T32HL007749)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
Keywords: YKL-40, idiopathic pulmonary fibrosis, pulmonary fibrosis, epithelial damage, fibroproliferation, alternative macrophage activation, myofibroblast transformation, fibroblast proliferation, apoptosis, disease progression, acute exacerbation, bleomycin-induced lung injury, circulating monocytes, extracellular matrix deposition, inflammation
MeSH terms: Chitinase-3-Like Protein 1, Animals, Enzyme-Linked Immunosorbent Assay, Female, Fibroblasts, Flow Cytometry, Humans, Lung, Pulmonary Fibrosis, Bone Marrow Transplantation, Apoptosis, Mice, Knockout, In Situ Nick-End Labeling, Lectins, Cell Proliferation, Mice, Adipokines

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Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis

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