Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance
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Fibrosis resolution is impaired by aging and is mediated by altered cellular redox homeostasis because of a Nox4-Nrf2 imbalance that promotes an apoptosis-resistant myofibroblast phenotype.
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Bleomycin lung injury induces a molecular signature of senescence, and age-dependent accumulation of senescent myofibroblasts may impede fibrosis resolution following bleomycin exposure.
“Bleomycin lung injury induces a molecular signature of senescence1617 and age-dependent accumulation of senescent myofibroblasts may impede fibrosis resolution following bleomycin exposure3.”
From Cellular senescence mediates fibrotic pulmonary disease (2017) · cites this paper as [3]
Impaired capacity to resolve fibrotic bleomycin injury has been associated with accumulation of apoptosis-resistant, senescent myofibroblasts.
“Critically, impaired capacity to resolve fibrotic bleomycin injury has been associated with accumulation of apoptosis-resistant, senescent myofibroblasts3.”
From Cellular senescence mediates fibrotic pulmonary disease (2017) · cites this paper as [3]
Cellular senescence has been linked to the pathogenesis of chronic lung diseases such as COPD or IPF.
“cellular senescence has been linked to the pathogenesis of chronic lung diseases such as chronic obstructive pulmonary disease [14, 15] or IPF [16–20].”
From Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis <i>ex vivo</i> (2017) · cites this paper as [17]
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- Authors
- Hecker, L., Logsdon, N. J., Kurundkar, D., Kurundkar, A., Bernard, K., Hock, T., Meldrum, E., Sanders, Y. Y., & Thannickal, V. J.
- Affiliations
- University of Alabama at Birmingham (US)
- Genkyotex (Switzerland) (CH)
- Corresponding author
- Hecker, Louise
- Thannickal, Victor J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2014-04-09
- Volume
- 6
- Issue
- 231
- Pages
- 231ra47-231ra47
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4545252
- OpenAlex
- W2056269088
- Cited by
- 686
- References
- 48
- Citations by year
- 2026: 32 · 2025: 51 · 2024: 57 · 2023: 69 · 2022: 53 · 2021: 70 · 2020: 70 · 2019: 58 · 2018: 53 · 2017: 58 · 2016: 53 · 2015: 36 · 2014: 24 · 2013: 1
- FWCI
- 45.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK2 BX001477)
- National Heart, Lung, and Blood Institute (R01HL094230, P50HL107181, P01HL114470)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR048311)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- aging, NOX4, Nrf2, redox homeostasis, idiopathic pulmonary fibrosis, myofibroblasts, cellular senescence, apoptosis resistance, reactive oxygen species, NADPH oxidase, fibrosis resolution
- MeSH terms
- NADPH Oxidase 4, Aging, Animals, Antioxidants, Female, Fibroblasts, Humans, Mice, Inbred C57BL, Models, Biological, Oxidation-Reduction, Phenotype, Apoptosis, Oxidative Stress, NADPH Oxidases, NF-E2-Related Factor 2, Idiopathic Pulmonary Fibrosis, Lung Injury, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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