The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Abstract
Bispecific antibodies engineered to both bind to the primate transferrin receptor and inhibit β-secretase are taken up by the nonhuman primate brain and reduce brain β-amyloid.
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“including anti-TfR-BACE1 antibody in Alzheimer's Tg2576 mice (34) and nonhuman primates (672)”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [672]
In the citing paper
“By targeting TfR, a transcytosis efficient membrane protein expressed on endothelial cells in brain, these bsAb constructs drastically improved CNS delivery in both rodents and NHPs.94”
From Tutorial on monoclonal antibody pharmacokinetics and its considerations in early development (2018) · cites this paper as [94]
Citations
Cites
A Highly Efficient Recombineering-Based Method for Generating Conditional Knockout MutationsPreprint
Liu, P., Jenkins, N. A., & Copeland, N. G. (2003) · Genome Research · doi:10.1101/gr.749203 · Cited by 1,013
‘Knobs-into-holes’ engineering of antibody C H 3 domains for heavy chain heterodimerization
Ridgway, J. B., Presta, L. G., & Carter, P. M. (1996) · Protein Engineering Design and Selection · doi:10.1093/protein/9.7.617 · Cited by 816
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
Yu, Y. J., Zhang, Y., Kenrick, M., Hoyte, K., Luk, W., Lu, Y., Atwal, J., Elliott, J. M., Prabhu, S., Watts, R. J., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002230 · Cited by 794
Self-citationTargeting the β secretase BACE1 for Alzheimer's disease therapy
Yan, R., & Vassar, R. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70276-x · Cited by 645
Niewoehner, J., Bohrmann, B., Collin, L., Urich, E., Sade, H., Maier, P., Rueger, P., Stracke, J. O., Lau, W., Tissot, A. C., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.061 · Cited by 622
Blood–Brain Barrier Transport of Therapeutics via Receptor-Mediation
Jones, A. R., & Shusta, E. V. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9379-0 · Cited by 549
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
Bien‐Ly, N., Yu, Y. J., Bumbaca, D., Elstrott, J., Boswell, C. A., Zhang, Y., Luk, W., Lu, Y., Dennis, M. S., Weimer, R. M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131660 · Cited by 356
Self-citationAddressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier
Couch, J. A., Yu, Y. J., Zhang, Y., Tarrant, J. M., Fuji, R. N., Meilandt, W. J., Solanoy, H. O., Tong, R. K., Hoyte, K., Luk, W., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005338 · Cited by 278
Self-citationA Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo
Atwal, J. K., Chen, Y., Chiu, C., Mortensen, D. L., Meilandt, W. J., Liu, Y., Heise, C. E., Hoyte, K., Luk, W., Lu, Y., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002254 · Cited by 274
Self-citationDeveloping Therapeutic Antibodies for Neurodegenerative Disease
Yu, Y. J., & Watts, R. J. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0187-4 · Cited by 231
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Cited by
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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Bispecific antibodies: a mechanistic review of the pipeline
Labrijn, A. F., Janmaat, M. L., Reichert, J. M., & Parren, P. W. H. I. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0028-1 · Cited by 1,303
Strategies for delivering therapeutics across the blood–brain barrier
Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138
Helms, H. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P.-O., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16630991 · Cited by 843
Metadata
- Authors
- Yu, Y. J., Atwal, J. K., Zhang, Y., Tong, R. K., Wildsmith, K. R., Tan, C., Bien-Ly, N., Hersom, M., Maloney, J. A., Meilandt, W. J., Bumbaca, D., Gadkar, K., Hoyte, K., Luk, W., Lu, Y., Ernst, J. A., Scearce-Levie, K., Couch, J. A., Dennis, M. S., & Watts, R. J.
- Affiliations
- Genentech (US)
- Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- Corresponding author
- Yu, Y. Joy
- Atwal, Jasvinder K.
- Watts, Ryan J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2014-11-05
- Volume
- 6
- Issue
- 261
- Pages
- 261ra154-261ra154
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2138037217
- Cited by
- 371
- References
- 17
- Citations by year
- 2026: 21 · 2025: 43 · 2024: 28 · 2023: 31 · 2022: 34 · 2021: 32 · 2020: 36 · 2019: 23 · 2018: 37 · 2017: 33 · 2016: 28 · 2015: 20 · 2014: 4
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- bispecific antibodies, blood-brain barrier, transferrin receptor, beta-secretase, BACE1, amyloid-beta, Alzheimer's disease, humanized monoclonal antibody, non-human primates, cerebrospinal fluid
- MeSH terms
- Animals, Antibody Specificity, Biological Transport, Blood-Brain Barrier, Capillary Permeability, Cricetulus, Cross Reactions, Humans, Macaca fascicularis, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Peptide Fragments, Receptors, Transferrin, Transfection, Down-Regulation, Antigens, CD, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, CHO Cells, Antibodies, Bispecific, Amyloid Precursor Protein Secretases, HEK293 Cells, Administration, Intravenous
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