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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Abstract
Bispecific antibodies engineered to both bind to the primate transferrin receptor and inhibit β-secretase are taken up by the nonhuman primate brain and reduce brain β-amyloid.
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“including anti-TfR-BACE1 antibody in Alzheimer's Tg2576 mice (34) and nonhuman primates (672)”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [672]
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“By targeting TfR, a transcytosis efficient membrane protein expressed on endothelial cells in brain, these bsAb constructs drastically improved CNS delivery in both rodents and NHPs.94”
From Tutorial on monoclonal antibody pharmacokinetics and its considerations in early development (2018) · cites this paper as [94]
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Cites
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Liu, P., Jenkins, N. A., & Copeland, N. G. (2003) · Genome Research · doi:10.1101/gr.749203 · Cited by 1,013
‘Knobs-into-holes’ engineering of antibody C H 3 domains for heavy chain heterodimerization
Ridgway, J. B., Presta, L. G., & Carter, P. M. (1996) · Protein Engineering Design and Selection · doi:10.1093/protein/9.7.617 · Cited by 816
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
Yu, Y. J., Zhang, Y., Kenrick, M., Hoyte, K., Luk, W., Lu, Y., Atwal, J., Elliott, J. M., Prabhu, S., Watts, R. J., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002230 · Cited by 794
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Yan, R., & Vassar, R. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70276-x · Cited by 645
Niewoehner, J., Bohrmann, B., Collin, L., Urich, E., Sade, H., Maier, P., Rueger, P., Stracke, J. O., Lau, W., Tissot, A. C., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.061 · Cited by 622
Blood–Brain Barrier Transport of Therapeutics via Receptor-Mediation
Jones, A. R., & Shusta, E. V. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9379-0 · Cited by 549
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Bien‐Ly, N., Yu, Y. J., Bumbaca, D., Elstrott, J., Boswell, C. A., Zhang, Y., Luk, W., Lu, Y., Dennis, M. S., Weimer, R. M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131660 · Cited by 356
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Atwal, J. K., Chen, Y., Chiu, C., Mortensen, D. L., Meilandt, W. J., Liu, Y., Heise, C. E., Hoyte, K., Luk, W., Lu, Y., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002254 · Cited by 274
Self-citationDeveloping Therapeutic Antibodies for Neurodegenerative Disease
Yu, Y. J., & Watts, R. J. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0187-4 · Cited by 231
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Self-citationJi, Y., Gao, Q., Ma, Y., Wang, F., Tan, X., Song, D., Hoo, R. L. C., Wang, Z., Ge, X., Han, H., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106720 · Cited by 114
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Modarres, H. P., Janmaleki, M., Novin, M., Saliba, J., Moussa, F. E. H., Charan, M. R., Seyfoori, A., SadAbadi, H., Vandal, M., Nguyen, M. D., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.024 · Cited by 77
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Baghirov, H. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113595 · Cited by 82
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Yang, F., Wen, W., & Qin, W. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010048 · Cited by 75
Thom, G., Burrell, M. R., Haqqani, A. S., Yogi, Á., Lessard, E., Brunette, E., Delaney, C. E., Baumann, E., Callaghan, D., Melero, N. R., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00937 · Cited by 76
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Zhang, X., Zhang, X., Gao, H., & Qing, G. (2022) · Theranostics · doi:10.7150/thno.68636 · Cited by 75
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Metadata
- Authors
- Yu, Y. J., Atwal, J. K., Zhang, Y., Tong, R. K., Wildsmith, K. R., Tan, C., Bien-Ly, N., Hersom, M., Maloney, J. A., Meilandt, W. J., Bumbaca, D., Gadkar, K., Hoyte, K., Luk, W., Lu, Y., Ernst, J. A., Scearce-Levie, K., Couch, J. A., Dennis, M. S., & Watts, R. J.
- Affiliations
- Genentech (US)
- Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- Corresponding author
- Yu, Y. Joy
- Atwal, Jasvinder K.
- Watts, Ryan J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2014-11-05
- Volume
- 6
- Issue
- 261
- Pages
- 261ra154-261ra154
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2138037217
- Cited by
- 371
- References
- 17
- Citations by year
- 2026: 21 · 2025: 43 · 2024: 28 · 2023: 31 · 2022: 34 · 2021: 32 · 2020: 36 · 2019: 23 · 2018: 37 · 2017: 33 · 2016: 28 · 2015: 20 · 2014: 4
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- bispecific antibodies, blood-brain barrier, transferrin receptor, beta-secretase, BACE1, amyloid-beta, Alzheimer's disease, humanized monoclonal antibody, non-human primates, cerebrospinal fluid
- MeSH terms
- Animals, Antibody Specificity, Biological Transport, Blood-Brain Barrier, Capillary Permeability, Cricetulus, Cross Reactions, Humans, Macaca fascicularis, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Peptide Fragments, Receptors, Transferrin, Transfection, Down-Regulation, Antigens, CD, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, CHO Cells, Antibodies, Bispecific, Amyloid Precursor Protein Secretases, HEK293 Cells, Administration, Intravenous
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