The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism
Open accessAbstract
Mice carrying a genetic mutation that causes autistic symptoms show improved sociability after being treated with oxytocin, a hormone promoting mothering and trust.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“mimic the prosocial effects of OT in a mouse model of autism (41)”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [41]
In the citing paper
“When compared to WT controls, Cntnap2−/− mice show abnormal migration of neurons in the corpus callosum and somatosensory cortex, have fewer parvalbumin-immunoreactive interneurons in the hippocampus and striatum, fewer GABAergic interneurons in the somatosensory cortex [278] and fewer oxytocin-expressing neurons in the hypothalamic paraventricular nucleus [279].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [279]
In the citing paper
“Altered levels of OXT and OXTR in specific regions of the brain have been reported in a number of animal models of psychiatric and neurodevelopmental disorders [116-119].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [118]
In the citing paper
“hypothalamic disruptions of OT neurons have been reported in human patients with ASD related disorders such as Prader Willi syndrome (Swaab et al., 1995), as well as in knockout mice for ASD risk genes including Fmr1 (Francis et al., 2014), Cntnap2 (Peñagarikano et al., 2015), and Pten (Page et al., 2009)”
From Parallel social information processing circuits are differentially impacted in autism (2020) · cites this paper as Peñagarikano et al., 2015
In the citing paper
“Indeed, accumulating evidence from mouse models of autism suggests that stimulating oxytocin neurons can rescue social deficits.”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [29]
In the citing paper
“while chemogenetic stimulation of oxytocin neurons or pharmacologically-evoked release of endogenous oxytocin rescues the deficits [29].”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [29]
In the citing paper
“Cntnap2 knockout mice show deficits in social behavior and reduced numbers of oxytocin neurons”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [29]
In the citing paper
“These mice display social deficits in addition to epilepsy and cortical dysplasia and show a reduction in neurons expressing OT in the PVN.”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Penagarikano et al. 2015
In the citing paper
“Also, daily chronic intranasal administration of OT early in life (between P7 and P21) in Cntnap2 knockout mice rescues their social interest and social approach.”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Penagarikano et al. 2015
In the citing paper
“More recently, researchers showed that chronic exogenous OT administration to Cntnap2 knockout mice, a mouse model of autism, rescues their social deficits (Penagarikano et al. 2015).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Penagarikano et al. 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,842
Synaptic, transcriptional and chromatin genes disrupted in autism
Study, T. D., De Rubeis, S., Autism, H. M. C. F., UK10K Consortium, The Autism Sequencing Consortium, He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Ercument Cicek, A., et al. (2014) · Nature · doi:10.1038/nature13772 · Cited by 2,746
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606
The contribution of de novo coding mutations to autism spectrum disorder
Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., et al. (2014) · Nature · doi:10.1038/nature13908 · Cited by 2,585
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013) · Nature · doi:10.1038/nature12518 · Cited by 1,161
Peñagarikano, O., Abrahams, B. S., Herman, E. I., Winden, K. D., Gdalyahu, A., Dong, H., Sonnenblick, L. I., Gruver, R., Almajano, J., Bragin, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.040 · Cited by 1,075
Self-citationEvoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044
Cited by
Sorted by citations
Roth, B. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.040 · Cited by 1,742
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163
Advancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827
Self-citationSgritta, M., Dooling, S. W., Buffington, S. A., Momin, E. N., Francis, M. B., Britton, R. A., & Costa-Mattioli, M. (2019) · Neuron · doi:10.1016/j.neuron.2018.11.018 · Cited by 865
Gating of social reward by oxytocin in the ventral tegmental area
Hung, L. W., Neuner, S., Polepalli, J. S., Beier, K. T., Wright, M., Walsh, J. J., Lewis, E. M., Luo, L., Deisseroth, K., Dölen, G., et al. (2017) · Science · doi:10.1126/science.aan4994 · Cited by 578
Metadata
- Authors
- Peñagarikano, O., Lázaro, M. T., Lu, X.-H., Gordon, A., Dong, H., Lam, H. A., Peles, E., Maidment, N. T., Murphy, N. P., Yang, X. W., Golshani, P., & Geschwind, D. H.
- Affiliations
- University of California, Los Angeles (US)
- Weizmann Institute of Science (IL)
- Corresponding author
- Geschwind, Daniel H.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-01-21
- Volume
- 7
- Issue
- 271
- Pages
- 271ra8-271ra8
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4498455
- OpenAlex
- W2097364496
- Cited by
- 378
- References
- 77
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 31 · 2023: 34 · 2022: 32 · 2021: 43 · 2020: 24 · 2019: 36 · 2018: 32 · 2017: 43 · 2016: 36 · 2015: 25
- FWCI
- 74.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (NIH/NS50220)
- National Institute of Mental Health (NIMH) (R01 MH081754-02R)
- NIH/National Institute of Neurological Disorders and Stroke (NINDS) (R01 NS049501, R01 NS074312)
- Autism Speaks
- Simons Foundation Autism Research Initiative
- McKnight Foundation
- NIH Autism Centers of Excellence (ACE) (1P50-HD055784-01)
- Network (5R01-MH081754-04)
- UCLA Center for Autism Research and Treatment (CART) Pilot
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin, CNTNAP2, autism spectrum disorder, social behavior deficits, paraventricular nucleus, oxytocin neurons, DREADD, drug screening
- MeSH terms
- Animals, Animals, Newborn, Autistic Disorder, Behavior, Animal, Disease Models, Animal, Humans, Membrane Proteins, Mice, Mutant Strains, Nerve Tissue Proteins, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Social Behavior, Mice, Knockout
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
