Cited by 171Endometriosis Research and TreatmentEstrogen and related hormone effectsEffects and risks of endocrine disrupting chemicals

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Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

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Zhao, Yuechao, Gong, Ping, Chen, Yiru, Nwachukwu, Jerome C., Srinivasan, Sathish, Ko, CheMyong, Bagchi, Milan K., Taylor, Robert N., Korach, Kenneth S., Nettles, Kendall W., Katzenellenbogen, John A., Katzenellenbogen, Benita S.·2015·Science Translational Medicine

DOI 10.1126/scitranslmed.3010626PMC PMC4790140

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Abstract

The estrogen-dependent inflammatory and neuroangiogenic activities that drive endometriosis can be suppressed by estrogen receptor ligands in mice.

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Authors: Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A., & Katzenellenbogen, B. S.
Affiliations: University of Illinois Urbana-Champaign (US)
Scripps Research Institute (US)
Wake Forest University Health Sciences (US)
National Institute of Environmental Health Sciences (US)
Corresponding author: Katzenellenbogen, Benita S.
ORCID: Zhao, Yuechao
Gong, Ping
Chen, Yiru
Nwachukwu, Jerome C.
Ko, CheMyong
Bagchi, Milan K.
Taylor, Robert N.
Korach, Kenneth S.
Nettles, Kendall W.
Katzenellenbogen, John A.
Katzenellenbogen, Benita S.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-01-21
Volume: 7
Issue: 271
Pages: 271ra9-271ra9
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3010626
PMC: PMC4790140
OpenAlex: W2152982261
Cited by: 170
References: 47
Citations by year: 2026: 10 · 2025: 16 · 2024: 18 · 2023: 11 · 2022: 14 · 2021: 9 · 2020: 15 · 2019: 17 · 2018: 18 · 2017: 12 · 2016: 19 · 2015: 11
FWCI: 22.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (U54 HD055787, PHS 5R01DK015556, 5R01DK077085)
Frenchman's Creek Women for Cancer Research
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: endometriosis, estrogen receptor ligands, estrogen receptor alpha, estrogen receptor beta, anti-inflammatory activity, angiogenesis, neurogenesis, endometriotic stromal cells, fertility preservation
MeSH terms: Letrozole, Animals, Anti-Inflammatory Agents, Cell Survival, Cells, Cultured, Disease Models, Animal, Drug Therapy, Combination, Endometriosis, Estrogens, Female, Fertility, Humans, Indazoles, Inflammation, Ligands, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Nitriles, Receptors, Estrogen, Triazoles, Treatment Outcome, Stromal Cells, Disease Progression, Embryonic Stem Cells

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Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

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