New developments in the medical treatment of endometriosis
Open accessAbstract
Endometriosis affects 1 in 10 women of reproductive-age. The current treatments are surgical and hormonal but have limitations, including the risk of recurrence, side effects, contraceptive action for women who desire pregnancy, and cost. New treatments include gonadotropin-releasing hormone analogues, selective progesterone (or estrogen) receptor modulators, aromatase inhibitors, immunomodulators, and antiangiogenic agents. Further research is needed into central sensitization, local neurogenesis, and the genetics of endometriosis to identify additional treatment targets. A wider range of medical options allows for the possibility of precision health and a more personalized treatment approach for women with endometriosis.
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Almost all available agents result in only temporary symptom relief.
“Almost all available agents result in only temporary symptom relief (Bedaiwy et al., 2017).”
From Endometriosis and nuclear receptors (2019) · cites this paper as Bedaiwy et al., 2017
Any drug is better than placebo for pain relief.
“Moreover, allocating suffering women to a placebo arm is ethically questionable, and it has already been repeatedly demonstrated that any drug is better than placebo for pain relief [102,103].”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [103]
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Flagged first, then by citations
Cited by
Sorted by citations
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Endometriosis and nuclear receptors
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Time to redefine endometriosis including its pro-fibrotic nature
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Medical treatment of endometriosis-related pain
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Endometrial stem/progenitor cells and their role in the pathogenesis of endometriosis
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Self-citationFrom pathogenesis to clinical practice: Emerging medical treatments for endometriosis
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Oral and depot progestin therapy for endometriosis: towards a personalized medicine
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Treatment of thoracic endometriosis syndrome: A meta-analysis and review
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Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis
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- Authors
- Bedaiwy, M. A., Alfaraj, S., Yong, P., & Casper, R.
- Affiliations
- University of British Columbia (CA)
- University of Toronto (CA)
- Corresponding author
- Bedaiwy, Mohamed A.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 107
- Issue
- 3
- Pages
- 555-565
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2582275704
- Cited by
- 176
- References
- 112
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 18 · 2023: 19 · 2022: 34 · 2021: 24 · 2020: 20 · 2019: 15 · 2018: 19 · 2017: 7
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, medical treatment, GnRH analogues, selective progesterone receptor modulators, selective estrogen receptor modulators, aromatase inhibitors, immunomodulators, angiogenesis inhibitors, central sensitization, neurogenesis, precision medicine, treatment side effects
- MeSH terms
- Animals, Contraceptives, Oral, Hormonal, Endometriosis, Endometrium, Female, Humans, Immunologic Factors, Treatment Outcome, Angiogenesis Inhibitors, Aromatase Inhibitors
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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