Cited by 176Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

New developments in the medical treatment of endometriosis

Open access
Bedaiwy, Mohamed A., Alfaraj, Sukinah, Yong, Paul, Casper, Robert·2017·Fertility and Sterility

Abstract

Endometriosis affects 1 in 10 women of reproductive-age. The current treatments are surgical and hormonal but have limitations, including the risk of recurrence, side effects, contraceptive action for women who desire pregnancy, and cost. New treatments include gonadotropin-releasing hormone analogues, selective progesterone (or estrogen) receptor modulators, aromatase inhibitors, immunomodulators, and antiangiogenic agents. Further research is needed into central sensitization, local neurogenesis, and the genetics of endometriosis to identify additional treatment targets. A wider range of medical options allows for the possibility of precision health and a more personalized treatment approach for women with endometriosis.

Integrity signals

Registry

Crossref · 10.1016/j.fertnstert.2016.12.025

Cites

112 of 112 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Almost all available agents result in only temporary symptom relief.

    “Almost all available agents result in only temporary symptom relief (Bedaiwy et al., 2017).”

    From Endometriosis and nuclear receptors (2019) · cites this paper as Bedaiwy et al., 2017

  • Any drug is better than placebo for pain relief.

    “Moreover, allocating suffering women to a placebo arm is ethically questionable, and it has already been repeatedly demonstrated that any drug is better than placebo for pain relief [102,103].”

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Authors
Bedaiwy, M. A., Alfaraj, S., Yong, P., & Casper, R.
Affiliations
  • University of British Columbia (CA)
  • University of Toronto (CA)
Corresponding author
Bedaiwy, Mohamed A.
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2017-03
Volume
107
Issue
3
Pages
555-565
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2582275704
Cited by
176
References
112
Citations by year
2026: 7 · 2025: 13 · 2024: 18 · 2023: 19 · 2022: 34 · 2021: 24 · 2020: 20 · 2019: 15 · 2018: 19 · 2017: 7
FWCI
2.70
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometriosis, medical treatment, GnRH analogues, selective progesterone receptor modulators, selective estrogen receptor modulators, aromatase inhibitors, immunomodulators, angiogenesis inhibitors, central sensitization, neurogenesis, precision medicine, treatment side effects
MeSH terms
Animals, Contraceptives, Oral, Hormonal, Endometriosis, Endometrium, Female, Humans, Immunologic Factors, Treatment Outcome, Angiogenesis Inhibitors, Aromatase Inhibitors

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