Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155 · see citing works

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

Robert, C., Thomas, L., Bondarenko, I., O'Day, S., Weber, J., Garbe, C., Lebbe, C., Baurain, J.-F., Testori, A., Grob, J.-J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1104621 · Cited by 4,496 · see citing works

Nivolumab plus Ipilimumab in Advanced Melanoma

Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230 · see citing works

TGFβ in Cancer

Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907 · see citing works

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

FOXP3+ regulatory T cells in the human immune system

Sakaguchi, S., Miyara, M., Costantino, C. M., & Hafler, D. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2785 · Cited by 2,443 · see citing works

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

Miyara, M., Yoshioka, Y., Kitoh, A., Shima, T., Wing, K., Niwa, A., Parizot, C., Taflin, C., Heike, T., Valeyre, D., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.019 · Cited by 2,291 · see citing works

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,199 · see citing works

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

Nakamura, K., Kitani, A., & Strober, W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.629 · Cited by 1,596 · see citing works

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Jakowlew, S. B., Álvarez‐Mon, M., Derynck, R., Sporn, M. B., & Fauci, A. S. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.5.1037 · Cited by 1,581 · see citing works

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

Simpson, T. R., Li, F., Montalvo-Ortiz, W., Sepulveda, M. A., Bergerhoff, K., Arce, F., Roddie, C., Henry, J. Y., Yagita, H., Wolchok, J. D., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130579 · Cited by 1,472 · see citing works

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J. K., Schlawe, K., Chang, H., Bopp, T., Schmitt, E., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050038 · Cited by 1,272 · see citing works

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Zheng, Y., Josefowicz, S. Z., Chaudhry, A., Peng, X. P., Forbush, K. A., & Rudensky, A. Y. (2010) · Nature · doi:10.1038/nature08750 · Cited by 1,170 · see citing works

Humanized mice for immune system investigation: progress, promise and challenges

Shultz, L. D., Brehm, M. A., García, J. V., & Greiner, D. L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3311 · Cited by 985 · see citing works

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells

Selby, M. J., Engelhardt, J. J., Quigley, M., Henning, K. A., Chen, T., Srinivasan, M., & Korman, A. J. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0013 · Cited by 857 · see citing works

TGF-β Activation and Function in Immunity

Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856 · see citing works

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

Li, M. O., Sanjabi, S., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.011 · Cited by 794 · see citing works

T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

Li, M. O., Wan, Y. Y., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.014 · Cited by 728 · see citing works

Foxp3 in control of the regulatory T cell lineage

Zheng, Y., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1455 · Cited by 699 · see citing works

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells

Baron, U., Floess, S., Wieczorek, G., Baumann, K., Grützkau, A., Dong, J., Thiel, A., Boeld, T. J., Hoffmann, P., Edinger, M., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200737594 · Cited by 694 · see citing works

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

Nakamura, K., Kitani, A., Fuss, I. J., Pedersen, A., Harada, N., Nawata, H., & Strober, W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.834 · Cited by 630 · see citing works

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

Piccirillo, C. A., Letterio, J. J., Thornton, A. M., McHugh, R. S., Mamura, M., Mizuhara, H., & Shevach, E. M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020590 · Cited by 589 · see citing works

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Liu, Y., Zhang, P., Li, J., Kulkarni, A. B., Perruche, S., & Chen, W. (2008) · Nature Immunology · doi:10.1038/ni.1607 · Cited by 547 · see citing works

Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region.

Tao, M., & Morrison, S. L. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.8.2595 · Cited by 531 · see citing works

Immune Modulation in Cancer with Antibodies

Page, D. B., Postow, M. A., Callahan, M. K., Allison, J. P., & Wolchok, J. D. (2013) · Annual Review of Medicine · doi:10.1146/annurev-med-092012-112807 · Cited by 516 · see citing works

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

Fahlén, L., Read, S., Gorelik, L., Hurst, S. D., Coffman, R. L., Flavell, R. A., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040685 · Cited by 516 · see citing works

Phase I study of GC1008 (fresolimumab): a human anti‐transforming growth factor‐beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma

Morris, J. C., Tan, A. R., Olencki, T. E., Shapiro, G. I., Dezube, B. J., Reiss, M., Hsu, F. J., Berzofsky, J. A., & Lawrence, D. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090353 · Cited by 487 · see citing works

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Marie, J. C., Liggitt, D., & Rudensky, A. Y. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.012 · Cited by 480 · see citing works

GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3 + regulatory T cells

Tran, D. Q., Andersson, J., Wang, R., Ramsey, H. E., Unutmaz, D., & Shevach, E. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901944106 · Cited by 473 · see citing works

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

Wieczorek, G., Asemissen, A. M., Model, F., Türbachova, I., Floess, S., Liebenberg, V., Baron, U., Stauch, D., Kotsch, K., Pratschke, J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2361 · Cited by 315 · see citing works

Membrane protein GARP is a receptor for latent TGF‐β on the surface of activated human Treg

Stockis, J., Colau, D., Coulie, P. G., & Lucas, S. (2009) · European Journal of Immunology · doi:10.1002/eji.200939684 · Cited by 252 · see citing works

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

Jacobs, J. F. M., Nierkens, S., Figdor, C. G., de Vries, I. J. M., & Adema, G. J. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70155-3 · Cited by 248 · see citing works

Crosstalk between Human IgG Isotypes and Murine Effector Cells

Overdijk, M. B., Verploegen, S. A. B. W., Buijsse, A. O., Vink, T., Leusen, J. H. W., Bleeker, W. K., & Parren, P. W. H. I. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200356 · Cited by 224 · see citing works

TREG-cell therapies for autoimmune rheumatic diseases

Miyara, M., Ito, Y., & Sakaguchi, S. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.105 · Cited by 214 · see citing works

GARP regulates the bioavailability and activation of TGFβ

Wang, R., Zhu, J., Dong, X., Shi, M., Lu, C., & Springer, T. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-12-1018 · Cited by 180 · see citing works

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins

Macaulay, I. C., Tijssen, M. R., Thijssen‐Timmer, D. C., Gusnanto, A., Steward, M., Burns, P., Langford, C. F., Ellis, P. D., Dudbridge, F., Zwaginga, J. J., et al. (2006) · Blood · doi:10.1182/blood-2006-07-036269 · Cited by 168 · see citing works

Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression

Wang, R., Wan, Q., Kozhaya, L., Fujii, H., & Unutmaz, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002705 · Cited by 161 · see citing works

Selection of highly transfectable variant from mouse mastocytoma P815

Pel, A. V., Plaen, E. D., & Boon, T. (1985) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01534840 · Cited by 131 · see citing works

GARP: a key receptor controlling FOXP3 in human regulatory T cells

Probst‐Kepper, M., Geffers, R., Kröger, A., Viegas, N., Erck, C., Hecht, H., Lünsdorf, H., Roubin, R., Moharregh-Khiabani, D., Wagner, K., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00782.x · Cited by 123 · see citing works

Enhancement of IgG anti‐carrier responses by IgG2 anti‐hapten antibodies in mice

Coulie, P. G., & Snick, J. V. (1985) · European Journal of Immunology · doi:10.1002/eji.1830150810 · Cited by 108 · see citing works

Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8

Edwards, J. P., Thornton, A. M., & Shevach, E. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401102 · Cited by 99 · see citing works

Regulation of the Expression of GARP/Latent TGF-β1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation

Edwards, J. P., Fujii, H., Zhou, A. X., Creemers, J. W. M., Unutmaz, D., & Shevach, E. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300199 · Cited by 94 · see citing works

Antibody Targeting of TGF-β in Cancer Patients

Lonning, S. M., Mannick, J. B., & McPherson, J. M. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111798808392 · Cited by 84 · see citing works

Targeting regulatory T cells

Ménétrier‐Caux, C., Curiel, T. J., Faget, J., Manuel, M., Caux, C., & Zou, W. (2012) · Targeted Oncology · doi:10.1007/s11523-012-0208-y · Cited by 79 · see citing works

Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents

de Vries, I. J. M., Castelli, C., Huygens, C., Jacobs, J. F. M., Stockis, J., Schuler‐Thurner, B., Adema, G. J., Punt, C. J. A., Rivoltini, L., Schuler, G., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2227 · Cited by 78 · see citing works

Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins

O'Connor, M. N., Salles, I. I., Cvejic, A., Watkins, N. A., Walker, A. R., Garner, S. F., Jones, C. I., Macaulay, I. C., Steward, M., Zwaginga, J. J., et al. (2008) · Blood · doi:10.1182/blood-2008-06-162693 · Cited by 77 · see citing works

Comparison of stable human Treg and Th clones by transcriptional profiling

Stockis, J., Fink, W., François, V., Connerotte, T., Smet, C. D., Knoops, L., van der Bruggen, P., Boon, T., Coulie, P. G., & Lucas, S. (2009) · European Journal of Immunology · doi:10.1002/eji.200838807 · Cited by 69 · see citing works

Infusion of clinical‐grade enriched regulatory T cells delays experimental xenogeneic graft‐versus‐host disease

Hannon, M., Lechanteur, C., Lucas, S., Somja, J., Seidel, L., Belle, L., Bruck, F., Baudoux, É., Giet, O., Chantillon, A., et al. (2013) · Transfusion · doi:10.1111/trf.12279 · Cited by 62 · see citing works

Application of Monoclonal Antibodies in Functional and Comparative Investigations of Heavy-Chain Immunoglobulins in New World Camelids

Daley, L. P., Gagliardo, L. F., Duffy, M. S., Smith, M. C., & Appleton, J. A. (2005) · Clinical and Vaccine Immunology · doi:10.1128/cdli.12.3.380-386.2005 · Cited by 58 · see citing works

Four individually druggable MET hotspots mediate HGF-driven tumor progression

Basilico, C., Hultberg, A., Blanchetot, C., Jonge, N. D., Festjens, E., Hanssens, V., Osepa, S.-I., Boeck, G. D., Mira, A., Cazzanti, M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72316 · Cited by 54 · see citing works

GARP Is Regulated by miRNAs and Controls Latent TGF-β1 Production by Human Regulatory T Cells

Gauthy, E., Cuende, J., Stockis, J., Huygens, C., Lethé, B., Collet, J., Bommer, G. T., Coulie, P. G., & Lucas, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076186 · Cited by 38 · see citing works

Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein

Roubin, R., Pizette, S., Ollendorff, V., Planche, J., Birnbaum, D., & deLapeyrière, O. (1996) · The International Journal of Developmental Biology · doi:10.1387/ijdb.8840187 · Cited by 33 · see citing works

Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 inL. majorinfection

Uyttenhove, C., Marillier, R. G., Tacchini‐Cottier, F., Charmoy, M., Caspi, R. R., Damsker, J. M., Goriely, S., Su, D., Damme, J. V., Struyf, S., et al. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1210699 · Cited by 29 · see citing works

Induction of autoantibodies against mouse soluble proteins after immunization with living cells presenting the autoantigen at the cell surface in fusion with a human type 2 transmembrane protein

Lemaire, M. M., Vanhaudenarde, A., Nizet, Y., Dumoutier, L., & Renauld, J. (2011) · Journal of Immunological Methods · doi:10.1016/j.jim.2011.02.001 · Cited by 14 · see citing works

Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13

Kehrmann, A., Truong, H., Repenning, A., Boger, R. J., Klein‐Hitpaß, L., Pascheberg, U., Beckmann, A., Opalka, B., & Kleine‐Lowinski, K. (2013) · Cancer Genetics · doi:10.1016/j.cancergen.2013.06.002 · Cited by 10 · see citing works

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366 · see citing works

Targeting TGF-β signal transduction for fibrosis and cancer therapy

Peng, D., Fu, M., Wang, M., Wei, Y., & Wei, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01569-x · Cited by 1,106 · see citing works

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works

TGF-β1 – A truly transforming growth factor in fibrosis and immunity

Lodyga, M., & Hinz, B. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.010 · Cited by 462 · see citing works

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

Robertson, I. B., & Rifkin, D. B. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021907 · Cited by 403 · see citing works

Overcoming TGFβ-mediated immune evasion in cancer

Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377 · see citing works

Platelets subvert T cell immunity against cancer via GARP-TGFβ axis

Rachidi, S., Metelli, A., Riesenberg, B., Wu, B. X., Nelson, M. H., Wallace, C., Paulos, C. M., Rubinstein, M. P., Garrett-Mayer, E. S., Hennig, M., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aai7911 · Cited by 338 · see citing works

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies

Koyama, S., & Nishikawa, H. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002591 · Cited by 305 · see citing works

The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells

Okeke, E. B., & Uzonna, J. E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00680 · Cited by 266 · see citing works

Therapeutic targeting of regulatory T cells in cancer

Shan, F., Somasundaram, A., Bruno, T. C., Workman, C. J., & Vignali, D. A. A. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.06.008 · Cited by 249 · see citing works

Transforming growth factor–β1 in regulatory T cell biology

Moreau, J. M., Velegraki, M., Bolyard, C. M., Rosenblum, M. D., & Li, Z. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi4613 · Cited by 247 · see citing works

Targeting TGF-β Signaling for Therapeutic GainPreprint

Akhurst, R. J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022301 · Cited by 243 · see citing works

Treg-mediated acquired resistance to immune checkpoint inhibitors

Saleh, R., & Elkord, E. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.003 · Cited by 238 · see citing works

Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape

Martin, C. J., Datta, A., Littlefield, C., Kalra, A., Chapron, C., Wawersik, S., Dagbay, K. B., Brueckner, C. T., Nikiforov, A., Danehy, F. T., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay8456 · Cited by 224 · see citing works

Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

Campbell, M. G., Cormier, A., Ito, S., Seed, R., Bondesson, A. J., Lou, J., Marks, J. D., Baron, J. L., Cheng, Y., & Nishimura, S. L. (2020) · Cell · doi:10.1016/j.cell.2019.12.030 · Cited by 176 · see citing works

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

Downs‐Canner, S., Berkey, S. E., Delgoffe, G. M., Edwards, R. P., Curiel, T. J., Odunsi, K. O., Bartlett, D. L., & Obermajer, N. (2017) · Nature Communications · doi:10.1038/ncomms14649 · Cited by 176 · see citing works

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

Liénart, S., Merceron, R., Vanderaa, C., Lambert, F., Colau, D., Stockis, J., van der Woning, B., de Haard, H., Saunders, M. J., Coulie, P. G., et al. (2018) · Science · doi:10.1126/science.aau2909 · Cited by 153 · see citing works

TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer

Slattery, K., Woods, E., Zaiatz-Bittencourt, V., Marks, S. J., Chew, S. M., Conroy, M. R., Goggin, C., Eochagáin, C. M., Kennedy, J., Lucas, S., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002044 · Cited by 153 · see citing works

Foxp3+ T Regulatory Cells: Still Many Unanswered Questions—A Perspective After 20 Years of Study

Shevach, E. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01048 · Cited by 150 · see citing works

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

Turner, J., Victor, E. S., Wang, S., Rivas, M. N., Abdel-Gadir, A., Harb, H., Cui, Y., Fanny, M., Charbonnier, L., Fong, J. J. H., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.002 · Cited by 147 · see citing works

Regulation of Innate and Adaptive Immunity by TGFβ

Kelly, A., Houston, S. A., Sherwood, E., Casulli, J., & Travis, M. A. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.01.001 · Cited by 142 · see citing works

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Miyazono, K., Katsuno, Y., Koinuma, D., Ehata, S., & Morikawa, M. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0646-8 · Cited by 141 · see citing works

Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

de Streel, G., Bertrand, C., Chalon, N., Liénart, S., Bricard, O., Lecomte, S., Devreux, J., Gaignage, M., Boeck, G. D., Mariën, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17811-3 · Cited by 141 · see citing works

TGF-β and mesenchymal stromal cells in regenerative medicine, autoimmunity and cancer

Farias, V., Carrillo-Gálvez, A. B., Martı́n, F., & Anderson, P. O. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.06.002 · Cited by 138 · see citing works

Targeting immunosuppression by TGF-β1 for cancer immunotherapy

de Streel, G., & Lucas, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114697 · Cited by 129 · see citing works

Controlling Immunity and Inflammation through Integrin-Dependent Regulation of TGF-β

Nolte, M. A., & Margadant, C. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.10.002 · Cited by 121 · see citing works

Integrin αvβ8–expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells

Takasaka, N., Seed, R. I., Cormier, A., Bondesson, A. J., Lou, J., Elattma, A., Ito, S., Yanagisawa, H., Hashimoto, M., Ma, R., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122591 · Cited by 119 · see citing works

Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing

Li, Z., Song, W., Rubinstein, M. P., & Liu, D. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0684-3 · Cited by 118 · see citing works

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

Brown, N. F., & Marshall, J. F. (2019) · Cancers · doi:10.3390/cancers11091221 · Cited by 116 · see citing works

Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer

Metelli, A., Salem, M. A., Wallace, C. H., Wu, B. X., Li, A., Li, X., & Li, Z. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0570-z · Cited by 116 · see citing works

Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

Marín, E., Bouchet‐Delbos, L., Renoult, O., Louvet, C., Nerrière‐Daguin, V., Managh, A. J., Even, A., Giraud, M., Manh, T. V., Aguesse, A., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.011 · Cited by 114 · see citing works

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Stockis, J., Liénart, S., Colau, D., Collignon, A., Nishimura, S. L., Sheppard, D., Coulie, P. G., & Lucas, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710680114 · Cited by 111 · see citing works

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model

Grégoire, C., Ritacco, C., Hannon, M., Seidel, L., Delens, L., Belle, L., Dubois, S., Vériter, S., Lechanteur, C., Briquet, A., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00619 · Cited by 110 · see citing works

Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism

Zhang, M., Pan, X., Fujiwara, K., Jurcak, N. R., Muth, S. T., Zhou, J., Xiao, Q., Li, A., Che, X., Li, Z., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00769-z · Cited by 101 · see citing works

Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice

Ehx, G., Somja, J., Warnatz, H.-J., Ritacco, C., Hannon, M., Delens, L., Fransolet, G., Delvenne, P., Muller, J., Beguin, Y. P., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01943 · Cited by 95 · see citing works

TGF-β signaling networks in the tumor microenvironment

Chan, M. K.-K., Chung, J. Y.-F., Tang, P. C.-T., Chan, A. S.-W., Ho, J. Y.-Y., Lin, T. P.-T., Chen, J., Leung, K.-T., To, K.-F., Lan, H.-Y., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215925 · Cited by 90 · see citing works

Harnessing the biology of regulatory T cells to treat disease

Wardell, C. M., Boardman, D. A., & Levings, M. K. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01089-x · Cited by 90 · see citing works

A microfluidic platform for functional testing of cancer drugs on intact tumor slices

Rodriguez, A. D., Horowitz, L. F., Castro, K., Kenerson, H., Bhattacharjee, N., Gandhe, G., Raman, A., Monnat, R. J., Yeung, R., Rostomily, R. C., et al. (2020) · Lab on a Chip · doi:10.1039/c9lc00811j · Cited by 77 · see citing works

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

van den Bulk, J., de Miranda, N. F. C. C., & ten Dijke, P. (2021) · Clinical Science · doi:10.1042/cs20201236 · Cited by 75 · see citing works

Translational landscape of glioblastoma immunotherapy for physicians: guiding clinical practice with basic scientific evidence

Kreatsoulas, D. C., Bolyard, C. M., Wu, B. X., Çam, H., Giglio, P., & Li, Z. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01298-0 · Cited by 73 · see citing works

Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy

Yang, D., Dai, F., Yuan, M., Zheng, Y., Liu, S., Deng, Z., Tan, W., Chen, L., Zhang, Q., Zhao, X., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.689181 · Cited by 78 · see citing works

GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon

Salem, M., Wallace, C. H., Velegraki, M., Li, A., Ansa-Addo, E. A., Metelli, A., Kwon, H., Riesenberg, B., Wu, B. X., Zhang, Y., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2623 · Cited by 69 · see citing works

GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing

Sun, L., Jin, H., & Li, H. (2016) · Oncotarget · doi:10.18632/oncotarget.8753 · Cited by 68 · see citing works

Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects

Ehx, G., Fransolet, G., de Leval, L., D’Hondt, S., Lucas, S., Hannon, M., Delens, L., Dubois, S., Drion, P. V., Beguin, Y. P., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1314425 · Cited by 63 · see citing works

Targeting tumor-infiltrating tregs for improved antitumor responses

Qin, D., Zhang, Y., Shu, P., Lei, Y., Li, X., & Wang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1325946 · Cited by 61 · see citing works

Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA

Dedobbeleer, O., Stockis, J., van der Woning, B., Coulie, P. G., & Lucas, S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601882 · Cited by 60 · see citing works

TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma

Bao, S., Jiang, X., Jin, S., Tu, P., & Lu, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.694145 · Cited by 59 · see citing works

Role of GARP in the activation of latent TGF-β1

Stockis, J., Dedobbeleer, O., & Lucas, S. (2017) · Molecular BioSystems · doi:10.1039/c7mb00251c · Cited by 59 · see citing works

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

Dawson, N. A. J., Vent‐Schmidt, J., & Levings, M. K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01460 · Cited by 56 · see citing works

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

Li, Y., Strick‐Marchand, H., Lim, A. I., Ren, J., Masse‐Ranson, G., Li, D., Jouvion, G., Rogge, L., Lucas, S., Li, B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01570-9 · Cited by 58 · see citing works

Comparative Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Advanced Cancer: A Systematic Review and Meta-Analysis

Yang, Y., Jin, G., Pang, Y., Huang, Y., Wang, W., Zhang, H., Tuo, G., Wu, P., Wang, Z., & Zhu, Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00040 · Cited by 57 · see citing works

Pro-tumor γδ T Cells in Human Cancer: Polarization, Mechanisms of Action, and Implications for Therapy

Chabab, G., Barjon, C., Bonnefoy, N., & Lafont, V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02186 · Cited by 55 · see citing works

Dynamic allostery drives autocrine and paracrine TGF-β signaling

Jin, M., Seed, R., Cai, G., Shing, T., Wang, L., Ito, S., Cormier, A., Wankowicz, S. A. M., Jespersen, J. M., Baron, J. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.036 · Cited by 55 · see citing works

Effects of the interactions between platelets with other cells in tumor growth and progression

Li, Y., Wang, H., Zhao, Z., Yang, Y., Meng, Z., & Qin, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1165989 · Cited by 55 · see citing works

Matters of context guide future research in TGFβ superfamily signaling

Akhurst, R. J., & Padgett, R. W. (2015) · Science Signaling · doi:10.1126/scisignal.aad0416 · Cited by 52 · see citing works

Blockade of TGF-β signaling: a potential target for cancer immunotherapy?

Ungefroren, H. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1636034 · Cited by 51 · see citing works

Regulatory T cells: Master thieves of the immune system

Akkaya, B., & Shevach, E. M. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104160 · Cited by 48 · see citing works

Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients

Samid, M. A. A., Chaudhary, B., Khaled, Y. S., Ammori, B. J., & Elkord, E. (2016) · Oncotarget · doi:10.18632/oncotarget.7334 · Cited by 47 · see citing works

Cuproptosis status affects treatment options about immunotherapy and targeted therapy for patients with kidney renal clear cell carcinoma

Zhang, G., Chen, X., Fang, J., Tai, P., Chen, A., & Cao, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954440 · Cited by 45 · see citing works

Platelet-derived TGF-β1 induces functional reprogramming of myeloid-derived suppressor cells in immune thrombocytopenia

Wang, L., Wang, H., Zhu, M., Ni, X., Sun, L., Wang, W., Xie, J., Li, Y., Xu, Y., Wang, R., et al. (2024) · Blood · doi:10.1182/blood.2023022738 · Cited by 46 · see citing works

Activation of latent transforming growth factor-β1, a conserved function for pregnancy-specific beta 1-glycoproteins

Warren, J., Im, M., Ballesteros, Á., Ha, C. T., Moore, T., Lambert, F., Lucas, S., Hinz, B., & Dveksler, G. S. (2018) · Molecular Human Reproduction · doi:10.1093/molehr/gay044 · Cited by 46 · see citing works

Human iPSC-derived CD4+ Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model

Yano, H., Koga, K., Sato, T., Shinohara, T., Iriguchi, S., Matsuda, A., Nakazono, K., Shioiri, M., Miyake, Y., Kassai, Y., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.05.004 · Cited by 43 · see citing works

Structural biology of the TGFβ family

Goebel, E. J., Hart, K. N., McCoy, J. C., & Thompson, T. B. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219880894 · Cited by 42 · see citing works

The GARP/Latent TGF‐β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance

Edwards, J. P., Hand, T. W., da Fonseca, D. M., Glass, D. D., Belkaid, Y., & Shevach, E. M. (2016) · European Journal of Immunology · doi:10.1002/eji.201546204 · Cited by 41 · see citing works

GARP on hepatic stellate cells is essential for the development of liver fibrosis

Zhang, X., Sharma, P., Maschmeyer, P., Hu, Y., Lou, M., Kim, J., Fujii, H., Unutmaz, D., Schwabe, R. F., & Winau, F. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.05.043 · Cited by 39 · see citing works

The function and potential drug targets of tumour-associated Tregs for cancer immunotherapy

Yan, S., Zhang, Y., & Sun, B. (2019) · Science China Life Sciences · doi:10.1007/s11427-018-9428-9 · Cited by 38 · see citing works

Identification of proteins associated with development of metastasis from cutaneous squamous cell carcinomas (cSCCs) via proteomic analysis of primary cSCCs*

Shapanis, A. G., Lai, C., Smith, S. P., Coltart, G. S., Sommerlad, M., Schofield, J. P. R., Parkinson, E. P., Skipp, P. J. S., & Healy, E. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19485 · Cited by 37 · see citing works

Vitamin D-modulated dendritic cells delay lethal graft-versus-host disease through induction of regulatory T cells

Vanherwegen, A.-S., Cook, D. P., Ferreira, G. B., Gysemans, C. A., & Mathieu, C. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.12.013 · Cited by 36 · see citing works

The role of platelet and endothelial GARP in thrombosis and hemostasis

Vermeersch, E., Denorme, F., Maes, W., Meyer, S. F. D., Vanhoorelbeke, K., Edwards, J. P., Shevach, E. M., Unutmaz, D., Fujii, H., Deckmyn, H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173329 · Cited by 36 · see citing works

Targeted Resequencing and Functional Testing Identifies Low-Frequency Missense Variants in the Gene Encoding GARP as Significant Contributors to Atopic Dermatitis Risk

Manz, J., Rodríguez, E., ElSharawy, A., Oesau, E.-M., Petersen, B., Baurecht, H., Gabriele Mayr, B., Weber, S., Harder, J., Reischl, E., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.07.009 · Cited by 35 · see citing works

Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy

Yu, X., Zhai, X., Wu, J., Feng, Q., Hu, C., Zhu, L., & Zhou, Q. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166881 · Cited by 34 · see citing works

Transcriptional meta‐analysis of regulatory B cells

Dubois, F., Limou, S., Chesneau, M., Degauque, N., Brouard, S., & Danger, R. (2020) · European Journal of Immunology · doi:10.1002/eji.201948489 · Cited by 32 · see citing works

Transforming growth factor‐β signalling in tumour resistance to the anti‐PD ‐(L)1 therapy: Updated

Mortezaee, K., & Majidpoor, J. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17666 · Cited by 32 · see citing works

Garp as a therapeutic target for modulation of T regulatory cell function

Shevach, E. M. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1275568 · Cited by 30 · see citing works

TGFβ: Signaling Blockade for Cancer Immunotherapy

Chen, S., Mamaï, O., & Akhurst, R. J. (2021) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070620-103554 · Cited by 28 · see citing works

Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells

Huygens, C., Liénart, S., Dedobbeleer, O., Stockis, J., Gauthy, E., Coulie, P. G., & Lucas, S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.655340 · Cited by 27 · see citing works

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

Jackson, J., Streich, F. C., Pal, A., Coricor, G., Boston, C., Brueckner, C., Canonico, K., Chapron, C., Cote, S. M., Dagbay, K. B., et al. (2024) · Science Signaling · doi:10.1126/scisignal.adn6052 · Cited by 28 · see citing works

Pathophysiology and preclinical relevance of experimental graft-versus-host disease in humanized mice

Ehx, G., Ritacco, C., & Baron, F. (2024) · Biomarker Research · doi:10.1186/s40364-024-00684-9 · Cited by 26 · see citing works

Novel approaches for preventing acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Servais, S., Beguin, Y. P., Delens, L., Ehx, G., Fransolet, G., Hannon, M., Willems, É., Humblet‐Baron, S., Belle, L., & Baron, F. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2016.1182498 · Cited by 26 · see citing works

Itacitinib prevents xenogeneic GVHD in humanized mice

Courtois, J., Ritacco, C., Dubois, S., Canti, L., Vandenhove, B., Seidel, L., Daulne, C., Caers, J., Servais, S., Beguin, Y. P., et al. (2021) · Bone Marrow Transplantation · doi:10.1038/s41409-021-01363-1 · Cited by 26 · see citing works

Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis

Lecomte, S., Devreux, J., de Streel, G., van Baren, N., Havelange, V., Schröder, D., Vaherto, N., Vanhaver, C., Vanderaa, C., Dupuis, N., et al. (2022) · Blood · doi:10.1182/blood.2022017097 · Cited by 25 · see citing works

In Vitro Th17-Polarized Human CD4+ T Cells Exacerbate Xenogeneic Graft-versus-Host Disease

Delens, L., Ehx, G., Somja, J., Vrancken, L., Belle, L., Seidel, L., Grégoire, C., Fransolet, G., Ritacco, C., Hannon, M., et al. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.10.007 · Cited by 25 · see citing works

Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis

Wu, B. X., Li, A., Lei, L., Kaneko, S., Wallace, C. H., Li, X., & Li, Z. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.797613 · Cited by 24 · see citing works

GARP Correlates With Tumor-Infiltrating T-Cells and Predicts the Outcome of Gastric Cancer

Jiang, S., Zhang, Y., Zhang, X., Lu, B., Sun, P., Wu, Q., Ding, X., & Huang, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660397 · Cited by 24 · see citing works

A Humanized Antibody against LRG1 that Inhibits Angiogenesis and Reduces Retinal Vascular LeakagePreprint

Kallenberg, D. M., Tripathi, V., Javaid, F., Pilotti, C., George, J., Davis, S., Blackburn, J. W. D., O’Connor, M., Dowsett, L., Bowers, C. E., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.25.218149 · Cited by 22 · see citing works

VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy

Bosco, J., Zhou, Z., Gabriëls, S., Verma, M., Liu, N., Miller, B. K., Gu, S., Lundberg, D. M., Huang, Y. H., Brown, E., et al. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.03.013 · Cited by 20 · see citing works

IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance

Kuhn, C., Rezende, R. M., M’Hamdi, H., da Cunha, A. P., & Weiner, H. L. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600921 · Cited by 20 · see citing works

Loss of LRRC33-Dependent TGFβ1 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy

Jiang, A., Qin, Y., & Springer, T. A. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0593 · Cited by 18 · see citing works

Molecular Pathways and Mechanisms of TGFβ in Cancer Therapy

Barcellos‐Hoff, M. H., & Gulley, J. L. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3750 · Cited by 19 · see citing works

Human LAP+GARP+FOXP3+ regulatory T cells attenuate xenogeneic graft versus host disease

Wang, H. H., Song, H. W., Pham, A. V., Cooper, L. J. N., Schulze, J., Olek, S., & Tran, D. Q. (2019) · Theranostics · doi:10.7150/thno.30254 · Cited by 19 · see citing works

Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32

Lehmkuhl, P., Gentz, M., Caballero-Oteyza, A., Grimbacher, B., Schulze‐Koops, H., & Skapenko, A. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00701-z · Cited by 19 · see citing works

Treg-Resistant Cytotoxic CD4+ T Cells Dictate T Helper Cells in Their Vicinity: TH17 Skewing and Modulation of Proliferation

Hoeks, C., Vanheusden, M., Peeters, L. M., Stinissen, P., Broux, B., & Hellings, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115660 · Cited by 17 · see citing works

Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors

Bertrand, C., Meerbeeck, P. V., de Streel, G., Vaherto, N., Benhaddi, F., Rouaud, L., Noël, A., Coulie, P. G., van Baren, N., & Lucas, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.704050 · Cited by 17 · see citing works

The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4+CD25+ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment

Yang, J., Sheng, G., Xiao, D., Shi, H., Wu, W., Lu, H., Cao, H., & Li, L. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.100 · Cited by 17 · see citing works

GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment

Bouchard, A., Collin, B., Garrido, C., Bellaye, P., & Kohli, É. (2021) · Biology · doi:10.3390/biology10090836 · Cited by 16 · see citing works

Alterations of the Primary Cilia Gene SPAG17 and SOX9 Locus Noncoding RNAs Identified by RNA‐Sequencing Analysis in Patients With Systemic Sclerosis

Roberson, E. D. O., Carns, M. A., Cao, L. H., Aren, K., Goldberg, I. A., Morales-Heil, D. J., Korman, B. D., Atkinson, J. P., & Varga, J. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42281 · Cited by 15 · see citing works

Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors

Vermeersch, E., Liénart, S., Collignon, A., Lucas, S., Gallimore, A., Gysemans, C. A., Unutmaz, D., Vanhoorelbeke, K., Meyer, S. F. D., Maes, W., et al. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.07.011 · Cited by 15 · see citing works

Low-Dose Blue Light (420 nm) Reduces Metabolic Activity and Inhibits Proliferation of Human Dermal Fibroblasts

Brüning, A. K. E., Schiefer, J. L., Fuchs, P. C., Petzsch, P., Köhrer, K., Suschek, C. V., Stuermer, E. K., & Opländer, C. (2023) · Life · doi:10.3390/life13020331 · Cited by 14 · see citing works

Overexpression of IRF3 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma

Wu, J., Leng, X., Pan, Z., Xu, L., & Zhang, H. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s328225 · Cited by 14 · see citing works

Redox Regulation of Tolerogenic Dendritic Cells and Regulatory T Cells in the Pathogenesis and Therapy of Autoimmunity

Saksida, T., Jevtić, B., Djedović, N., Miljković, D. M., & Stojanović, I. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7999 · Cited by 13 · see citing works

Abstract B036: Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

Liénart, S., Cuende, J., Saunders, M. J., van der Woning, B., de Haard, H., Coulie, P. G., & Lucas, S. (2016) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr15-b036

Blocking immunosuppression by human Tregs with antibodies against GArP/latent TGF-β1 complexes

Liénart, S. (2018) · DIAL (Catholic University of Leuven)

Targeting GARP on human Tregs: a novel approach for the immunotherapy of cancer?

Lucas, S., & PIVAC-19 (2019) · DIAL (Catholic University of Leuven)

Cancer immunotherapy with monoclonal antibodies blocking the GARP-dependent production of TGF-β1

de Streel, G. (2020) · Digital Access to Libraries

Anti-GARP Antibodies Inhibit Release of TGF-β by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro

Igney, F. H., Ebenhoch, R., Schiele, F., & Nar, H. (2023) · ImmunoHorizons · doi:10.4049/immunohorizons.2200072 · Cited by 5 · see citing works